<italic style="font-style: italic">Rumex acetosella</italic> Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

Bo-Ra Jeon; Muhammad Irfan; Seung Eun Lee; Jeong Hoon Lee; Man Hee Rhee

doi:10.1007/s11655-021-2873-0

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Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

Original Article | Updated：2022-09-08

- Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling
- Chinese Journal of Integrative Medicine Vol. 28, Issue 9, Pages: 802-808(2022)
- Affiliations：
  
  1.Laboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu(41566), Republic of Korea
  2.Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science(NIHHS), Eumseong (27709), Republic of Korea
- Author bio：
  
  Man Hee Rhee, E-mail: rheemh@knu.ac.kr
- Funds：
- DOI：10.1007/s11655-021-2873-0
  CLC：
- Published：2022-09，
  
  Published Online：21 September 2021，
  
  Accepted：02 April 2020
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Bo-Ra Jeon, Muhammad Irfan, Seung Eun Lee, et al. Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling. [J]. Chinese Journal of Integrative Medicine 28(9):802-808(2022)
DOI：

Bo-Ra Jeon, Muhammad Irfan, Seung Eun Lee, et al. Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling. [J]. Chinese Journal of Integrative Medicine 28(9):802-808(2022) DOI： 10.1007/s11655-021-2873-0.

摘要

Abstract

Objective:

To examine the antiplatelet and antithrombotic activity of

Rumex acetosella

extract.

Methods:

Standard light aggregometry was used for platelet aggregation

intracellular calcium mobilization assessed using Fura-2/AM

granule secretion (ATP release) by luminometer

and fibrinogen binding to integrin α

Ⅱb

detected using flow cytometry. Western blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/Akt signaling.

Results:

Rumex acetosella

displayed the ability to inhibit platelet aggregation

calcium mobilization

granule secretion

and fibrinogen binding to integrin α

Ⅱb

Rumex acetosella

has also down-regulated MAPK and PI3K/Akt phosphorylation (all

0.01).

Conclusion:

Rumex acetosella

extract exhibits antiplatelet activity via modulating GPVI signaling

and it may protect against the development of platelet-related cardiovascular diseases.

关键词

Keywords

antiplateletethnomedicineintegrin αⅡbβ3mitogen-activated protein kinaseRumex acetosella L.

references

Maione F, De Feo V, Caiazzo E, De Martino L, Cicala C,Mascolo N. Tanshinone ⅡA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway. J Ethnopharmacol 2014;155:1236-1242.

Pagidipati NJ, Gaziano TA. Estimating deaths from cardiovascular disease: a review of global methodologies of mortality measurement. Circulation 2013;127:749-756.

Shafiq G, Tatinati S, Ang WT, Veluvolu KC. Automatic identification of systolic time intervals in seismocardiogram.Sci Rep 2016;6:37524.

Franchi F, Angiolillo DJ. Novel antiplatelet agents in acute coronary syndrome. Nat Rev Cardiol 2015;12:30-47.

Shin JH, Kwon HW, Rhee MH, Park HJ. Inhibitory effects of thromboxane A2 generation by ginsenoside Ro due to attenuation of cytosolic phospholipase A2 phosphorylation and arachidonic acid release. J Ginseng Res 2019;43:236-241.

Smith JN, Negrelli JM, Manek MB, Hawes EM, Viera AJ.Diagnosis and management of acute coronary syndrome: an evidence-based update. J Am Board Fam Med 2015;28:283-293.

Barrett NE, Holbrook L, Jones S, Kaiser WJ, Moraes LA,Rana R, et al. Future innovations in anti-platelet therapies.Br J Pharmacol 2008;154:918-939.

Estruch R, Ros E, Salas-Salvado J, Covas MI, Corella D, Aros F, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368:1279-1290.

Irfan M, Jeong D, Saba E, Kwon HW, Shin JH, Jeon BR, et al. Gintonin modulates platelet function and inhibits thrombus formation via impaired glycoprotein Ⅵ signaling. Platelets 2019;30:589-598.

Irfan M, Kim M, Rhee MH. Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases. J Ginseng Res 2020;44:24-32.

Irfan M, Kwon TH, Yun BS, Park NH, Rhee MH. Eisenia bicyclis (brown alga) modulates platelet function and inhibits thrombus formation via impaired P2Y12 receptor signaling pathway. Phytomedicine 2018;40:79-87.

Kim JH. Pharmacological and medical applications of Panax ginseng and ginsenosides: a review for use in cardiovascular diseases. J Ginseng Res 2018;42:264-269.

Rastogi S, Pandey MM, Rawat AK. Traditional herbs: a remedy for cardiovascular disorders. Phytomedicine 2015;23:1082-1089.

Guarrera PM. Food medicine and minor nourishment in the folk traditions of Central Italy (Marche, Abruzzo and Latium). Fitoterapia 2003;74:515-544.

Leporatti ML, Ivancheva S. Preliminary comparative analysis of medicinal plants used in the traditional medicine of Bulgaria and Italy. J Ethnopharmacol 2003;87:123-142.

Mantle D, Eddeb F, Pickering AT. Comparison of relative antioxidant activities of British medicinal plant species in vitro. J Ethnopharmacol 2000;72:47-51.

Miraldi E, Ferri S, Mostaghimi V. Botanical drugs and preparations in the traditional medicine of West Azerbaijan(Iran). J Ethnopharmacol 2001;75:77-87.

Baig H, Ahmed D, Zara S, Aujla MI, Asghar MN. In vitro evaluation of antioxidant properties of different solvent extracts of Rumex acetosella leaves. Orient J Chem 2011;27:1509.

Vasas A, Orbán-Gyapai O, Hohmann J. The Genus Rumex: Review of traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 2015;175:198-228.

Endale M, Lee WM, Kamruzzaman SM, Kim SD, Park JY,Park MH, et al. Ginsenoside-Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein Ⅵ signalling pathway, tyrosine phosphorylation and MAPK activation. Br J Pharmacol 2012;167:109-127.

Kim DS, Irfan M, Sung YY, Kim SH, Park SH, Choi YH, et al. Schisandra chinensis and Morus alba synergistically inhibit in vivo thrombus formation and platelet aggregation by impairing the glycoprotein Ⅵ pathway. Evid Based Complement Alternat Med 2017;2017:7839658.

Schaeffer J, Blaustein MP. Platelet free calcium concentrations measured with fura-2 are influenced by the transmembrane sodium gradient. Cell Calcium 1989;10:101-113.

Jeong D, Irfan M, Kim SD, Kim S, Oh JH, Park CK, et al.Ginsenoside Rg3-enriched red ginseng extract inhibits platelet activation and in vivo thrombus formation. J Ginseng Res 2017;41:548-555.

Packham MA. Role of platelets in thrombosis and hemostasis. Can J Physiol Pharm 1994;72:278-284.

Flaumenhaft R. Molecular basis of platelet granule secretion.Arterioscler Thromb Vasc Biol 2003;23:1152-1160.

Oury C, Toth-Zsamboki E, Vermylen J, Hoylaerts MF.P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen. Blood 2002;100:2499-2505.

Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002;8:1227-1234.

Mazharian A, Roger S, Maurice P, Berrou E, Popoff MR,Hoylaerts MF, et al. Differential involvement of ERK2 and p38 in platelet adhesion to collagen. J Biol Chem 2005;280:26002-26010.

Watson SP, Gibbins J. Collagen receptor signalling in platelets: extending the role of the ITAM. Immunol Today 1998;19:260-264.

Seo EJ, Ngoc TM, Lee SM, Kim YS, Jung YS.Chrysophanol-8-O-glucoside, an anthraquinone derivative in rhubarb, has antiplatelet and anticoagulant activities. J Pharmacol Sci 2012;118:245-254.

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Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

DOI：10.1007/s11655-021-2873-0

摘要

Abstract

关键词

Keywords

references