FOLLOWUS
Regulatory T Cells: A New Target of Chinese Medicine in Treatment of Atherosclerosis*
- Chinese Journal of Integrative Medicine Vol. 27, Issue 11, Pages: 867-873(2021)
- Affiliations：
1.State Key Laboratory of Dampness Syndrome of Chinese Medicine, Department of Cardiology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou (510020), China
2.Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangzhou (510020), China
3.The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou (510405), China
4.The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou (510020), China
- Author bio：
Dr. JIANG Wei, E-mail: drjiangwei@126.com
- Funds：
DOI：10.1007/s11655-021-2877-9
CLC：Published：01 November 2021，
Published Online：16 September 2021，
Accepted：30 July 2021
Scan for full text
Zhao-ying LIANG, Cai-wen QIAN, Tao-hua LAN, et al. Regulatory T Cells: A New Target of Chinese Medicine in Treatment of Atherosclerosis*. [J]. Chinese Journal of Integrative Medicine 27(11):867-873(2021)
Zhao-ying LIANG, Cai-wen QIAN, Tao-hua LAN, et al. Regulatory T Cells: A New Target of Chinese Medicine in Treatment of Atherosclerosis*. [J]. Chinese Journal of Integrative Medicine 27(11):867-873(2021) DOI： 10.1007/s11655-021-2877-9.
摘要
炎症反应和免疫紊乱在动脉粥样硬化(atherosclerosis
AS)发生和进展中是必不可少的. 调节性T细胞 (regulatory T cells
Tregs) 在抑制炎症和免疫调节中的作用日渐受到重视
大量研究显示Tregs的数量减少和功能障碍参与了AS的病变过程. 中医药在调节炎症和免疫反应方面具有双向、多靶点、低毒性的特点
动物与临床研究均表明
中医药可通过调节Tregs发挥抗动脉粥样硬化作用. 因此
本文简要介绍了Tregs的研究现状、Tregs与AS发生发展的关系以及中医药通过调节Tregs防治动脉粥样硬化性心脑血管疾病的研究进展. 尽管相关研究仍处于开始阶段
但已有的证据显示中医药干预Tregs以调节免疫功能可能是治疗AS疾病具有前景的方法之一.
Abstract
Inflammation and immune disorders are integral to the occurrence and progression of atherosclerosis (AS). With the role of regulatory T cells (Tregs) in immune regulation attracting attention
it has been widely accepted that Treg decrease and dysfunction are involved in AS pathogenesis. Chinese medicine (CM) has the advantages of being dual-directional
multi-targeted
and having minimal side effects in immune regulation. The anti-atherosclerosis effects of CM via Treg modulation have been revealed in clinical and animal studies. Therefore
this article reviews existing research on Tregs
the relationship between Tregs and AS
and the progress of CM for treating and prevention of atherosclerotic cardio-cerebrovascular diseases by regulating Tregs. Although the underlying mechanisms remain to be elucidated
CM treatment targeting Treg cells might provide a promising and novel future approach for prevention and treatment of AS.
关键词
Keywords
Chinese medicineatherosclerosisregulatory T cellsimmunizationinflammation
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