Role of Mitophagy in Myocardial Ischemia/Reperfusion Injury and Chinese Medicine Treatment

XIA Jun-yan; CHEN Cong; LIN Qian; CUI Jie; WAN Jie; LI Yan; LI Dong

doi:10.1007/s11655-021-3301-1

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Role of Mitophagy in Myocardial Ischemia/Reperfusion Injury and Chinese Medicine Treatment

Review | Updated：2023-01-05

- Role of Mitophagy in Myocardial Ischemia/Reperfusion Injury and Chinese Medicine Treatment
- Chinese Journal of Integrative Medicine Vol. 29, Issue 1, Pages: 81-88(2023)
- Affiliations：
  
  1.Department of Cardiology, Dongfang Hospital, the Second Affiliated Hospital of Beijing University of Chinese Medicine,Beijing (100078), China
  2.Department of Cardiology,Dongzhimen Hospital, the First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing (100007), China
- Author bio：
  
  Dr. LI Dong, E-mail: dongdong871103@163.com
- Funds：
- DOI：10.1007/s11655-021-3301-1
  CLC：
- Published：01 January 2023，
  
  Published Online：03 November 2021，
  
  Accepted：09 December 2020
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XIA Jun-yan, CHEN Cong, LIN Qian, et al. Role of Mitophagy in Myocardial Ischemia/Reperfusion Injury and Chinese Medicine Treatment. [J]. Chinese Journal of Integrative Medicine 29(1):81-88(2023)
DOI：

XIA Jun-yan, CHEN Cong, LIN Qian, et al. Role of Mitophagy in Myocardial Ischemia/Reperfusion Injury and Chinese Medicine Treatment. [J]. Chinese Journal of Integrative Medicine 29(1):81-88(2023) DOI： 10.1007/s11655-021-3301-1.

摘要

Abstract

Mitophagy is one of the important targets for the prevention and treatment of myocardial ischemia/ reperfusion injury (MIRI). Moderate mitophagy can remove damaged mitochondria

inhibit excessive reactive oxygen species accumulation

and protect mitochondria from damage. However

excessive enhancement of mitophagy greatly reduces adenosine triphosphate production and energy supply for cell survival

and aggravates cell death. How dysfunctional mitochondria are selectively recognized and engulfed is related to the interaction of adaptors on the mitochondrial membrane

which mainly include phosphatase and tensin homolog deleted on chromosome ten (PTEN)-induced kinase 1/Parkin

hypoxia-inducible factor-1α/Bcl-2 and adenovirus e1b19k Da interacting protein 3

FUN-14 domain containing protein 1 receptor-mediated mitophagy pathway and so on. In this review

the authors briefly summarize the main pathways currently studied on mitophagy and the relationship between mitophagy and MIRI

and incorporate and analyze research data on prevention and treatment of MIRI with Chinese medicine

thereby provide relevant theoretical basis and treatment ideas for clinical prevention of MIRI.

关键词

Keywords

mitophagymyocardial ischemia/reperfusion injuryPTEN-induced kinase 1/Parkinhypoxiainducible factor-1α/Bcl-2 and adenovirus e1b19k Da interacting protein 3FUN-14 domain containing protein 1Chinese medicine

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