FOLLOWUS
Low Electrical Resistance Properties of Acupoints:Roles of NOergic Signaling Molecules and Neuropeptides in Skin Electrical Conductance
- Chinese Journal of Integrative Medicine Vol. 27, Issue 8, Pages: 563-569(2021)
- Affiliations：
Lundquist Institute for Biomedical Innovation at Harbor-University of California at Los Angeles (UCLA) Medical Center and Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Torrance, CA 90502, United States
- Author bio：
- Funds：
DOI：10.1007/s11655-021-3318-5
CLC：Published：01 August 2021，
Accepted：08 June 2021
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Sheng-xing MA. Low Electrical Resistance Properties of Acupoints:Roles of NOergic Signaling Molecules and Neuropeptides in Skin Electrical Conductance. [J]. Chinese Journal of Integrative Medicine 27(8):563-569(2021)
Sheng-xing MA. Low Electrical Resistance Properties of Acupoints:Roles of NOergic Signaling Molecules and Neuropeptides in Skin Electrical Conductance. [J]. Chinese Journal of Integrative Medicine 27(8):563-569(2021) DOI： 10.1007/s11655-021-3318-5.
摘要
Abstract
Early studies from several independent laboratories demonstrated that acupoints possess the characteristics of low electrical resistance. New devices are developing to increase the reliability of electrical skin impedance measurements for counteracting the factors including skin dryness
skin thickness
size of the sensing electrode
pressure applied on the electrode
interelectrode distance
room temperature
and humidity. Morphological studies have identified that blood vessels
hair follicles
and nervous components are enhanced in the meridians/acupoints
which represent areas of potentially high neuronal activity. Recent evidence shows that nitric oxide (NO) concentrations are enhanced in skin acupoints/meridians. L-arginine-derived NO synthesis modifies skin norepinephrine (NE) synthesis/release in acupoints/meridians
and NO-NE activations play an important role in mediating the skin conductance responses to electrical stimulation. NOergic signaling molecules interact with gap junction and transient receptor potential vanilloid type-1. Other studies reported that the high conductance at acupoints is a result of the release of the neuropeptides substance P and calcitonin gene-related peptide during neurogenic inflammation in the referred pain area. Pathological body conditions caused considerable changes in skin conductance or impedance at acupoints. Although systematic research with an improved equipment and research design to avoid the influencing factors are requested for a definite answer in this field
the results from anatomical and biochemical studies consistently show that acupoints exist higher levels of nervous components
and NOergic signaling molecules and neuropeptides involved in the skin low resistance at acupoints. The increased interest in the acupoints/meridians has led to an open-minded attitude towards understanding this system
which is fundamental important to establish the valid aspects of scientific basis of Chinese medicine mechanisms and therapies.
关键词
Keywords
acupuncture pointsskin electric resistancenitric oxidenorepinephrinetransient receptor potential vanilloid type-1neuropeptides
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