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Is Regular Probiotic Practice Safe for Management of Sepsis?
- Chinese Journal of Integrative Medicine Vol. 28, Issue 2, Pages: 185-192(2022)
- Affiliations：
1.Department of Pharmacology, ISF College of Pharmacy,Moga (Punjab), India
2.Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Lucknow (UP), India
- Author bio：
Dr. Alok Shiomurti Tripathi, E-mail:astripathi@lko.amity.edu
- Funds：
DOI：10.1007/s11655-021-3334-5
CLC：Published：01 February 2022，
Published Online：16 July 2021，
Accepted：28 September 2020
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Rishabh Kumar, Alok Shiomurti Tripathi, Nidhi Sharma, et al. Is Regular Probiotic Practice Safe for Management of Sepsis?. [J]. Chinese Journal of Integrative Medicine 28(2):185-192(2022)
Rishabh Kumar, Alok Shiomurti Tripathi, Nidhi Sharma, et al. Is Regular Probiotic Practice Safe for Management of Sepsis?. [J]. Chinese Journal of Integrative Medicine 28(2):185-192(2022) DOI： 10.1007/s11655-021-3334-5.
摘要
几十年来
肠道一直被认为在脓毒症的发病机制中发挥重要作用. 在大多数重症监护病房的患者中
脓毒症是一种由机体免疫反应失调引起的严重威胁生命的慢性感染疾病. 益生菌在脓毒症治疗中具有双重作用: 益生菌在许多情况下可引起脓毒症
并可能影响预后. 临床前和临床研究表明
益生菌治疗可改善脓毒症中各种炎症介质
如肿瘤坏死因子、白细胞介素-10 (IL-10)、IL-6等. 此外
益生菌也被发现可以减少与肠易激疾病相关的病理状况的严重程度
并预防脓毒症时发生心内膜炎. 相反
对于新生儿和无胸腺的成年小鼠
益生菌治疗对死亡和脓毒症引起的炎症并无任何有益的影响. 重要的是
很少的临床试验发现益生菌是通过促进炎症级联而非抑制它致使脓毒症恶化. 本综述讨论了有关益生菌治疗脓毒症有益或有害影响的各种研究.
Abstract
For decades
the gut has been thought to play an important role in sepsis pathogenesis. Sepsis is a serious life-threatening
chronic condition of an infection caused by dysregulated host immune response in most of the intensive care unit patients. Probiotics have dual roles in polymicrobial sepsis i.e. probiotics may induce sepsis in many cases and may prevent its prognosis in many cases. Experimental evidence from both pre-clinical and clinical studies have demonstrated that probiotic therapy ameliorates various inflammatory mediators such as tumor necrosis factor
interleukin-10 (IL-10)
IL-6
etc.
in septicemia. In addition
probiotic use was also found to reduce the severity of pathological conditions associated with irritable bowel disorder and prevent development of endocarditis in septicemia. On contrary
probiotic therapy in neonatal and athymic adult mice fail to provide any beneficial effects on mortality and sepsis-induced inflammation. Importantly
in few clinical trials probiotic use was found to aggravate sepsis by promoting inflammatory cascade rather than suppressing it. This review discusses various studies regarding the beneficial or harmful effects associated with probiotic therapy in sepsis.
关键词
Keywords
sepsisprobioticsmicrobial floraimmune system
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