Effect of Interactive Dynamic Scalp Acupuncture on Post-Stroke Cognitive Function, Depression, and Anxiety:A Multicenter, Randomized, Controlled Trial

Shao-hua ZHANG; Yu-long WANG; Chun-xia ZHANG; Chun-ping ZHANG; Peng XIAO; Qian-feng LI; Wei-rong LIANG; Xiao-hua PAN; Ming-chao ZHOU

doi:10.1007/s11655-021-3338-1

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Effect of Interactive Dynamic Scalp Acupuncture on Post-Stroke Cognitive Function, Depression, and Anxiety:A Multicenter, Randomized, Controlled Trial

Original Article | Updated：2022-02-22

- Effect of Interactive Dynamic Scalp Acupuncture on Post-Stroke Cognitive Function, Depression, and Anxiety:A Multicenter, Randomized, Controlled Trial
- Chinese Journal of Integrative Medicine Vol. 28, Issue 2, Pages: 106-115(2022)
- Affiliations：
  
  1.Department of Rehabilitation Medicine, Dapeng New District Nan'ao People's Hospital, Shenzhen, Guangdong Province(518121), China
  2.Department of Rehabilitation Medicine,Shenzhen Second People's Hospital, Shenzhen, Guangdong Province (518037), China
  3.Department of Rehabilitation Medicine, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong Province (518034), China
- Author bio：
  
  Prof. WANG Yu-long, E-mail: ylwang66@126.com
- Funds：
- DOI：10.1007/s11655-021-3338-1
  CLC：
- Published：01 February 2022，
  
  Published Online：07 December 2021，
  
  Accepted：19 June 2020
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Shao-hua ZHANG, Yu-long WANG, Chun-xia ZHANG, et al. Effect of Interactive Dynamic Scalp Acupuncture on Post-Stroke Cognitive Function, Depression, and Anxiety:A Multicenter, Randomized, Controlled Trial. [J]. Chinese Journal of Integrative Medicine 28(2):106-115(2022)
DOI：

Shao-hua ZHANG, Yu-long WANG, Chun-xia ZHANG, et al. Effect of Interactive Dynamic Scalp Acupuncture on Post-Stroke Cognitive Function, Depression, and Anxiety:A Multicenter, Randomized, Controlled Trial. [J]. Chinese Journal of Integrative Medicine 28(2):106-115(2022) DOI： 10.1007/s11655-021-3338-1.

摘要

目的:

比较互动式头针(IDSA)、简单联合疗法(SCT)和传统头针(TSA)对脑卒中后认知功能障碍患者认知功能、抑郁、焦虑的影响.

方法:

选取2017年5月至2020年5月在深圳市大鹏新区南澳人民医院康复科、深圳市第二人民医院康复科、广州中医药大学深圳医院住院的660例脑卒中后认知障碍患者

按入院先后顺序随机分为IDSA组(218例)、SCT组(222例)和TSA组(220例). 所有患者均接受常规脑卒中药物治疗和运动康复训练. IDSA组同时进行头针和计算机认知训练(computer-based cognitive training

CBCT)

而SCT组分别在上午和下午进行头针和计算机认知训练. TSA组患者接受传统的头针治疗

但未接受CBCT. 疗程为8周. 治疗前(M0)、治疗后1、2个月(M1、M2)及随访1、2个月(M3、M4)采用简易精神状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)评估患者认知功能; 采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、匹兹堡睡眠质量指数(PSQI)和改良Barthel指数(MBI)分别对患者的抑郁、焦虑、睡眠质量和自理能力进行评估. 在本试验中

所有不良事件(AEs)均被准确记录.

结果:

三组治疗前MMSE、MoCA、HAMD、HAMA、PSQI及MBI评分比较

差异均无统计学意义(

0.05). IDSA组M2、M3、M4时点MMSE、MoCA评分均显著高于SCT组和TSA组(均

0.01); M2-M0、M4-M0评分变化显著高于SCT组和TSA组(均

0.01); 而在M2、M3、M4时点

IDSA组HAMD、HAMA、PSQI评分均显著低于SCT组和TSA组(均

0.01)

而IDSA组MBI评分均显著高于SCT组和TSA组(均

0.01).

结论:

IDSA不仅能显著改善患者的认知功能

还能减轻患者的抑郁、焦虑

最终提高患者的自理能力

且IDSA组的疗效明显优于SCT组和TSA组. (中国临床实验中心注册号: ChiCTR1900027206).

Abstract

Objective:

To compare the clinical effects of interactive dynamic scalp acupuncture (IDSA)

simple combination therapy (SCT)

and traditional scalp acupuncture (TSA) on cognitive function

depression and anxiety in patients with post-stroke cognitive impairment.

Methods:

A total of 660 patients with post-stroke cognitive impairment who were admitted to 3 hospitals in Shenzhen City between May 2017 and May 2020 were recruited and randomly assigned to the IDSA (218 cases)

SCT (222 cases) and TSA groups (220 cases) according to a random number table. All the patients received conventional drug therapy for cerebral stroke and exercise rehabilitation training. Scalp acupuncture and computer-based cognitive training (CBCT) were performed simultaneously in the IDSA group

but separately in the morning and in the afternoon in the SCT group. The patients in the TSA group underwent scalp acupuncture only. The course of treatment was 8 weeks. Before treatment (M0)

1 (M1) and 2 months (M2) after treatment

as well as follow-up at 1 (M3) and 2 months (M4)

the cognitive function of patients was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA) Scales; depression

anxiety

sleep quality

and self-care ability of patients were assessed using Hamilton Depression Rating Scale (HAMD)

Hamilton Anxiety Rating Scale (HAMA)

Pittsburgh Sleep Quality Index (PSQI)

and Modified Barthel Index (MBI)

respectively. During this trial

all adverse events (AEs) were accurately recorded.

Results:

There were no significant differences in the MMSE

MoCA

HAMD

HAMA

PSQI

and MBI scores among the 3 groups at M0 (all

0.05). In the IDSA group

the MMSE

MoCA and MBI scores from M2 to M4 were significantly higher than those in the SCT and TSA groups

while the HAMD

HAMA and PSQI scores were significantly reduced (all

0.01). The changes of all above scores (M2–M0

M4–M0) were significantly superior to those in the SCT and TSA groups (all

0.01

except M4–M0 of HAMD). At M2

the severity of MMSE

HAMD

HAMA

PSQI and MBI in the IDSA group was significantly lower than that in the SCT and TSA groups (all

0.01). There was no serious AE during this trial.

Conclusions:

IDSA can not only significantly improve cognitive function

but also reduce depression

anxiety

which finally improves the patient's self-care ability. The effect of IDSA was significantly better than SCT and TSA. (Trial registration No. ChiCTR1900027206)

关键词

Keywords

interactive dynamic scalp acupuncturestrokecognitive functiondepressionanxietyrandomized controlled trialChinese medicine

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