Effects of Transcutaneous Electrical Acupoint Stimulation on Ovarian Responses and Pregnancy Outcomes in Patients Undergoing IVF-ET: A Randomized Controlled Trial

Zhi-jin ZHAI; Jia-en LIU; Ling-ling LEI; Shu-yu WANG

doi:10.1007/s11655-021-3457-8

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Effects of Transcutaneous Electrical Acupoint Stimulation on Ovarian Responses and Pregnancy Outcomes in Patients Undergoing IVF-ET: A Randomized Controlled Trial

Acupuncture Research | Updated：2022-06-27

- Effects of Transcutaneous Electrical Acupoint Stimulation on Ovarian Responses and Pregnancy Outcomes in Patients Undergoing IVF-ET: A Randomized Controlled Trial
- Chinese Journal of Integrative Medicine Vol. 28, Issue 5, Pages: 434-439(2022)
- Affiliations：
  
  1.Department of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing (100026),China
  2.Center for Reproductive Medicine, Beijing Jia-En De Yun Hospital, Beijing (100089), China
- Author bio：
  
  Dr. WANG Shu-yu, E-mail: wangshuyu@ccmu.edu.cn
- Funds：
- DOI：10.1007/s11655-021-3457-8
  CLC：
- Published：01 May 2022，
  
  Published Online：10 November 2021，
  
  Accepted：12 July 2021
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Zhi-jin ZHAI, Jia-en LIU, Ling-ling LEI, et al. Effects of Transcutaneous Electrical Acupoint Stimulation on Ovarian Responses and Pregnancy Outcomes in Patients Undergoing IVF-ET: A Randomized Controlled Trial. [J]. Chinese Journal of Integrative Medicine 28(5):434-439(2022)
DOI：

Zhi-jin ZHAI, Jia-en LIU, Ling-ling LEI, et al. Effects of Transcutaneous Electrical Acupoint Stimulation on Ovarian Responses and Pregnancy Outcomes in Patients Undergoing IVF-ET: A Randomized Controlled Trial. [J]. Chinese Journal of Integrative Medicine 28(5):434-439(2022) DOI： 10.1007/s11655-021-3457-8.

摘要

目的:

评价不同强度的经皮电刺激(TEAS)对不孕患者进行体外受精和胚胎移植(IVF-ET)时对卵巢反应和妊娠结局的影响.

方法:

采用随机数字法将200例IVF-ET助孕的不孕患者随机分为实验组(TEAS组:E-Ⅰ、E-Ⅱ、E-Ⅲ、E-Ⅳ

每组40例)和对照组(MOCK TEAS组

40例). 实验组患者E-Ⅰ、E-Ⅱ、E-Ⅲ、E-Ⅳ组分别给予20 mA、30 mA、40 mA、50 mA的电刺激强度

对照组给予5 mA强度刺激. 刺激穴位分别为: 关元(RN 4)、中极(RN 3)、三阴交(SP 6)、子宫(EX-CA 1)、太溪(KI 13)

刺激每日1次

每次30 min

连续治疗10-13天. 采用以下指标评价治疗效果:促性腺激素促排第六天(GN D6)的子宫内膜厚度

HCG日的子宫内膜厚度、卵泡数量

获卵数

每颗卵子所对应的雌激素含量

成熟的卵子数量除以总获卵数

优质胚胎率

临床妊娠率.

结果:

TEAS干预后

实验组HCG日子宫内膜厚度明显优于对照组(

=0.01). TEAS对获卵数有较大的影响(

=0.003)

但实验组患者优质胚胎率和临床妊娠率差异无统计学意义(

0.05).

结论:

TEAS是改善卵巢功能的有效方法. 当刺激强度在40 mA及以上时

有助于改善患者子宫内膜状况和子宫内膜容受性

并能获得更多的卵细胞. (试验注册号: ChiCTR-TRC-11001780)

Abstract

Objective:

To evaluate the influence of different transcutaneous electrical acupoint stimulation (TEAS) modes on ovarian responses and pregnancy outcomes in patients with infertility undergoing

in vitro

fertilization and embryo transfer (IVF-ET).

Methods:

Two hundred infertility patients undergoing IVF-ET were divided randomly into experimental groups (TEAS groups: E-Ⅰ

E-Ⅱ

E-Ⅲ

and E-Ⅳ

40 cases each group) and a control group (mock TEAS group

40 patients) using the random number method. The patients in the experimental groups received TEAS treatment of 20

40 and 50 mA for the E-Ⅰ

E-Ⅱ

E-Ⅲ and E-Ⅳ groups

respectively. The control group received a treatment of 5 mA. TEAS was applied at acupoints of Guanyuan (RN 4)

Zhongji (RN 3)

Sanyinjiao (SP 6)

Zigong (EX-CA 1)

and Taixi (KI 13)

once a day for 30 min each time for a treatment period of 10–13 d. Treatment effect was assessed using the following indicators: endometrial thickness on the 6th day of gonadotropin treatment (GN6 day)

endometrial thickness on the day on chorionic gonadotropin administration (HCG day)

number of ovarian follicles on HCG day

number of ova captured

amount of estrogen required for each harvested ova

number of mature ova divided by the total number of ova

percentage of high-quality embryos

and clinical pregnancy.

Results:

Endometrial thickness in the experimental groups on the HCG day was significantly better than that of the control group after TEAS stimulation (

=0.01). TEAS exhibited a greater impact on the number of ova captured (

=0.003). However

the effect of TEAS stimulation on the high-quality embryo rate and clinical pregnancy in patients was not statistically significant (

0.05).

Conclusions:

TEAS is an effective method in improving the ovarian state. When the stimulus intensity was at 40 mA and above

it could be helpful to improve the patient's endometrial condition and endometrial receptivity and to retrieve more oocytes. (Trial registration No. ChiCTR-TRC-11001780)

关键词

Keywords

acupuncturetranscutaneous electrical acupoint stimulationin vitro fertilization and embryo transferpregnancy outcomeinfertilitycontrolled ovarian hyperstimulation

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Hebei Key Laboratory of Reproductive Medicine, Hebei Institute of Reproductive Health, Hebei Reproductive Health Hospital

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