Enhancement of Swimming Endurance by Herbal Supplement M3P

Chien-ming CHU; Chih-wen CHI; Chih-hung HUANG; Yu-jen CHEN

doi:10.1007/s11655-021-3502-7

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Enhancement of Swimming Endurance by Herbal Supplement M3P

Original Article | Updated：2022-07-20

- Enhancement of Swimming Endurance by Herbal Supplement M3P
- Chinese Journal of Integrative Medicine Vol. 28, Issue 8, Pages: 725-729(2022)
- Affiliations：
  
  1.Graduate Institute of Biochemical and Biomedical Engineering,National Taipei University of Technology, Taipei (10608),Taiwan, China
  2.BioMedical Development Center, MacKay Memorial Hospital, New Taipei City (25160), Taiwan, China
  3.Department of Medical Research, MacKay Memorial Hospital,New Taipei City (25160), Taiwan, China
  4.Department of Radiation Oncology, MacKay Memorial Hospital, Taipei (10449),Taiwan, China
- Author bio：
  
  Prof. CHEN Yu-jen, E-mail: chenmdphd@gmail.com
- Funds：
- DOI：10.1007/s11655-021-3502-7
  CLC：
- Published：2022-08，
  
  Published Online：20 January 2022，
  
  Accepted：01 September 2021
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Chien-ming CHU, Chih-wen CHI, Chih-hung HUANG, et al. Enhancement of Swimming Endurance by Herbal Supplement M3P. [J]. Chinese Journal of Integrative Medicine 28(8):725-729(2022)
DOI：

Chien-ming CHU, Chih-wen CHI, Chih-hung HUANG, et al. Enhancement of Swimming Endurance by Herbal Supplement M3P. [J]. Chinese Journal of Integrative Medicine 28(8):725-729(2022) DOI： 10.1007/s11655-021-3502-7.

摘要

Abstract

Objective:

To investigate the effect of M3P (containing

Deer antler

Cordyceps sinensis

Rhodiola rosea

and

Panax ginseng

); an herbal remedy with the function of tonifying Kidney (Shen) and invigorating Spleen (Pi)

replenishing qi and nourishing blood; on fatigue alleviation

endurance capacity and toxicity.

Methods:

Swimming with weight-loading of 24 male ICR mice was used to evaluate the endurance capacity

and fatiguerelated plasma biomarkers were determined. Mice were randomly assigned to control or M3P treatment groups with 6 mice for each group and were orally administered with M3P everyday for 8 weeks at doses 0

33 or 100 mg/kg. Swimming time to exhaustion was measured in a specialized water tank. Lliver and kidney functions

body weight

and hematological profile were determined to evaluate the safety and toxicity after long-term M3P administration.

Results:

M3P supplementation 100 mg/kg significantly increased swimming endurance time up to approximate 2.4 folds of controls (

0.05). The plasma concentrations of cortisol and hepatic glycogen content were significantly increased in mice received M3P (

0.05

0.01 respectively). The lactic acid level and blood glucose were not changed after M3P treatment (

0.05). The liver and kidney functions muscle damage biomarker creatine

body weight

and hemograms were not altered in M3P supplementation (

0.05).

Conclusion:

M3P supplementation may improve swimming endurance accompanied by increasing hepatic glycogen content and serum cortisol level without major toxicity.

关键词

Keywords

swimming endurancefatiguetonifying Kidndy (Shen) and invigorating Spleen (Pi)replenishing qi and nourishing bloodM3PmiceChinese medicine

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State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Science, Xiamen University

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