FOLLOWUS
Prevention of Deep Vein Thrombosis by Panax Notoginseng Saponins Combined with Low-Molecular-Weight Heparin in Surgical Patients
- Chinese Journal of Integrative Medicine Vol. 28, Issue 9, Pages: 771-778(2022)
- Affiliations：
1.Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing (100053), China
2.Children's Hospital Capital Institute of Pediatrics, Beijing (100020), China
3.Department of Orthopaedics, Xuanwu Hospital, Capital Medical University, Beijing (100053), China
4.Centers for Disease Control and Prevention, New York City, NY (12237),USA
5.Peking University Clinical Research Institute, Peking University First Hospital, Beijing (100191), China
- Author bio：
Dr. WANG Hai-bo, E-mail: wanghb_pucri@bjmu.edu.cn
- Funds：
DOI：10.1007/s11655-022-2894-3
CLC：Published：2022-09，
Published Online：12 July 2022，
Accepted：29 October 2021
Scan for full text
Chun-mei WANG, Xiang-feng GUO, Li-min LIU, et al. Prevention of Deep Vein Thrombosis by Panax Notoginseng Saponins Combined with Low-Molecular-Weight Heparin in Surgical Patients. [J]. Chinese Journal of Integrative Medicine 28(9):771-778(2022)
Chun-mei WANG, Xiang-feng GUO, Li-min LIU, et al. Prevention of Deep Vein Thrombosis by Panax Notoginseng Saponins Combined with Low-Molecular-Weight Heparin in Surgical Patients. [J]. Chinese Journal of Integrative Medicine 28(9):771-778(2022) DOI： 10.1007/s11655-022-2894-3.
摘要
目的:
2
在外科住院患者
评估三七总皂苷 (panax notoginseng saponins
PNS) 联合低分子肝素 (low-molecular-weight heparin
LMWH) 预防深静脉血栓形成 (deep vein thrombosis
DVT) 真实世界疗效.
方法:
2
2016 年 1 月至 2018 年 11 月
在首都医科大学宣武医院外科住院患者行前瞻性队列研究. 参与者接受单独LMWH 或 PNS + LMWH 预防 DVT. 主要结果是下肢 DVT 的发生率. LMWH 组参与者通过皮下注射给予 LMWH
每天一次 4000-8000 AxaIU; PNS + LMWH组参与者给予PNS (血塞通片
100mg
每日3次) 联合LMWH
LMWH的给药方法与LMWH组相同.
结果:
2
在为研究筛选的 325 名患者中
281 名参与者被纳入最终分析. 该队列的 PNS + LMWH 组和 LMWH 组分别有 134 和 147 名参与者. 两组间 DVT 发生率有显着差异 (
P
=0.01)
PNS + LMWH 组发生 DVT 21 例 (15.7%)
LMWH 组发生 DVT 41 例 (27.9%) . 与没有 DVT 的参与者相比
诊断为 DVT 的参与者年龄更大
D-二聚体水平更高. 多变量逻辑回归模型显示
与 LMWH 组相比
PNS + LMWH 组参与者发生 DVT 的风险显着降低 (odds ratio 0.46
95% confidence interval
0.25-0.86) . 两组间血栓弹力图检测的R、K、Angle 和 MA值和严重出血事件无显着差异
研究期间未发生有症状的肺栓塞.
结论:
2
与LMWH单药治疗相比
PNS联合LMWH应用可有效降低外科住院患者DVT的发生率
且不增加出血风险.
Abstract
Objective:
2
To evaluate the efficacy of deep vein thrombosis (DVT) prevention among real-world surgical inpatients who received panax notoginseng saponins (PNS) combined with low-molecular-weight heparin (LMWH).
Methods:
2
A prospective cohort study was conducted among surgical patients between January 2016 and November 2018 in Xuanwu Hospital
Capital Medical University
Beijing
China. Participants received LMWH alone or PNS combined with LMWH for preventing DVT. The primary outcome was incidence of lower extremity DVT
which was screened once a week. Participants in the LMWH group were given LMWH (enoxaparin) via hypodermic injection
4000-8000 AxaIU once daily. Participants in the exposure group received PNS (Xuesaitong oral tablets
100 mg
3 times daily) combined with LMWH given the same as LMWH group.
Results:
2
Of the 325 patients screened for the study
281 participants were included in the final analysis. The cohort was divided into PNS + LMWH group and LMWH group with 134 and 147 participants
respectively. There was a significant difference of DVT incidence between two groups (
P
=0.01)
with 21 (15.7%) incident DVT in the PNS + LMWH group
and 41 (27.9%) incident DVT in the LMWH group. Compared with participants without DVT
the participants diagnosed with DVT were older and had higher D-dimer level. The multivariate logistic regression model showed a significant lower risk of incident DVT among participants in the PNS + LMWH group compared with the LMWH group (odds ratio 0.46
95% confidence interval
0.25-0.86). There were no significant differences in thromboelaslography values (including R
K
Angle
and MA) and differences in severe bleeding between two groups. No symptomatic pulmonary embolism occurred during the study.
Conclusion:
2
Combined application of PNS and LMWH can effectively reduce the incidence of DVT among surgical inpatients compared with LMWH monotherapy
without increased risk of bleeding.
关键词
三七总皂苷深静脉血栓形成低分子肝素血栓弹力图危险因素
Keywords
panax notoginseng saponinsdeep vein thrombosislow-molecular-weight heparinthromboelastographyrisk factor
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