Resveratrol Modulates Bone Mineral Density and Bone Mineral Content in A Rat Model of Male Hypogonadism

Hussein F. Sakr; Boudaka Ammar; Amira AlKharusi; I Al-Lawati; Mahmoud AlKhateeb; Basim H Elesawy

doi:10.1007/s11655-022-2895-2

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Resveratrol Modulates Bone Mineral Density and Bone Mineral Content in A Rat Model of Male Hypogonadism

Original Article | Updated：2023-02-01

- Resveratrol Modulates Bone Mineral Density and Bone Mineral Content in A Rat Model of Male Hypogonadism
- Chinese Journal of Integrative Medicine Vol. 29, Issue 2, Pages: 146-154(2023)
- Affiliations：
  
  1.Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat (123), Oman
  2.Medical Physiology Department, Faculty of Medicine, Mansoura, University, Mansoura (35516), Egypt
  3.Basic Medical Sciences Department, College of Medicine at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh(11481), Saudi Arabia
  4.Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif (21944), Saudi Arabia
- Author bio：
  
  Prof. Hussein F Sakr, E-mail: hsakr@squ.edu.om
- Funds：
- DOI：10.1007/s11655-022-2895-2
  CLC：
- Published：2023-02，
  
  Published Online：07 July 2022，
  
  Accepted：27 December 2020
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Hussein F. Sakr, Boudaka Ammar, Amira AlKharusi, et al. Resveratrol Modulates Bone Mineral Density and Bone Mineral Content in A Rat Model of Male Hypogonadism. [J]. Chinese Journal of Integrative Medicine 29(2):146-154(2023)
DOI：

Hussein F. Sakr, Boudaka Ammar, Amira AlKharusi, et al. Resveratrol Modulates Bone Mineral Density and Bone Mineral Content in A Rat Model of Male Hypogonadism. [J]. Chinese Journal of Integrative Medicine 29(2):146-154(2023) DOI： 10.1007/s11655-022-2895-2.

摘要

Abstract

Objective:

To determine whether resveratrol (Res) can correct osteoporosis induced in a rat model of male hypogonadism.

Methods:

Thirty-two rats were randomly divided into 4 groups

8 in each group; 1) a control sham group: underwent a similar surgical procedure for induction of orchiectomy (ORCD) without ligation of any arteries or veins or removal of the testis and epididymis; 2) a control + Res-treated group (Con+Res): underwent sham surgery similar to the control

but was then treated with Res

as described below; 3) an ORCD-induced group: bilateral ORCD surgery as described above

and 4) a ORCD+Res-treated group: bilateral ORCD surgery followed by Res treatment. Res treatment began 4 weeks after ORCD and continued for 12 weeks. After 12 weeks

bone mineral density (BMD) and bone mineral content (BMC) were measured in the tibia and femur of each rat's right hind leg. Blood levels of bone turnover indicators such as deoxypyridinoline (Dpd)

N-telopeptide of type Ⅰ collagen (NTX Ⅰ)

alkaline phosphatase (ALP)

and osteocalcin (OC)

as well as receptor activator of nuclear factor kappa B (RANK) and osteoprotegerin (OPG) were assessed.

Results:

ORCD significantly decreased BMD (

0.01) and significantly increased bone resorption

manifested by increased RANK. In addition

it inhibited serum levels of OPG and OC. Res treatment after ORCD effectively increased serum levels of bone formation markers such as OPG and OC

compared with testisectomized rats (

0.05).

Conclusion:

Res could ameliorate bone loss induced by male hypogonadism

possible via restoration of the normal balance between RANK and OPG.

关键词

Keywords

osteoporosismale hypogonadismresveratrolreceptor activator of nuclear factor-kappa

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Department of Pharmacy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University

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Peking University School of Pharmaceutical Sciences

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