Effectiveness and Safety of Chinese Medicine at Shenque(CV 8) for Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

YAN Li-jiao; FANG Min; ZHU Si-jia; WANG Zhi-jie; HU Xiao-yang; LIANG Shi-bing; WANG Dou; YANG Dan; SHEN Chen; Nicola Robinson; LIU Jian-ping

doi:10.1007/s11655-022-3319-z

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Effectiveness and Safety of Chinese Medicine at Shenque(CV 8) for Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Evidence-Based Integrative Medicine | Updated：2023-04-05

- Effectiveness and Safety of Chinese Medicine at Shenque(CV 8) for Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Chinese Journal of Integrative Medicine Vol. 29, Issue 4, Pages: 341-352(2023)
- Affiliations：
  
  1.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing (100029), China
  2.Department of Oncology, Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan (030012), China
  3.Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, SO16 5ST, United Kingdom
  4.Research Design Service South Central, National Institute of Health Research, Southampton, SO16 6YD, United Kingdom
  5.Department of Nursing, Beijing Friendship Hospital, Beijing (100050), China
  6.School of Nursing, Beijing University of Chinese Medicine, Beijing (100029), China
  7.Institute of Health and Social Care, London South Bank University, London, SE10AA, United Kingdom
- Author bio：
  
  Prof. LIU Jian-ping, E-mail: Liujp@bucm.edu.cn; jianping_l@hotmail.com
- Funds：
- DOI：10.1007/s11655-022-3319-z
  CLC：
- Published：2023-04，
  
  Published Online：15 April 2022，
  
  Accepted：09 June 2021
Scan for full text
YAN Li-jiao, FANG Min, ZHU Si-jia, et al. Effectiveness and Safety of Chinese Medicine at Shenque(CV 8) for Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [J]. Chinese Journal of Integrative Medicine 29(4):341-352(2023)
DOI：

YAN Li-jiao, FANG Min, ZHU Si-jia, et al. Effectiveness and Safety of Chinese Medicine at Shenque(CV 8) for Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [J]. Chinese Journal of Integrative Medicine 29(4):341-352(2023) DOI： 10.1007/s11655-022-3319-z.

摘要

Abstract

Background:

Primary dysmenorrhea (PD) is the most common complaint associated with menstruation and affects up to three-quarters of women at some stage of their reproductive life. In Chinese medicine

navel therapy

treatment provided at Shenque (CV 8)

is used as a treatment option for PD.

Objective:

To evaluate the effect of navel therapy on pain relief and quality of life in women with PD

compared with Western medicine (WM).

Methods:

China National Knowledge Infrastructure (CNKI)

Chinese Scientific Journal Database (VIP)

SinoMed and Wanfang Database

MEDLINE

the Cochrane Library

Embase

Web of Science

and the International Clinical Trial Registry of the U.S. National Institutes of Health were searched from their inceptions to April 1

2021. Randomized controlled trials (RCTs) assessing therapeutic effects of navel therapy on PD were eligible for inclusion. RevMan 5.4 software was used for data analyses. The certainty of the evidence was assessed using the online GRADEpro tool.

Results:

Totally 24 RCTs involving 2

614 participants were identified. Interventions applied to acupuncture point CV 8 included: herbal patching

moxibustion or combined navel therapy (using at least 2 types of stimulation). Compared to placebo

there was a significant effect in favor of navel therapy on reducing overall menstrual symptom scores at the end of treatment [mean difference: –0.82

95% confidence interval (CI): –1.00 to –0.64

=90; 1 RCT]. As compared with Western medicine

navel therapy had a superior effect on pain intensity as assessed by Visual Analogue Scale at the end of treatment [standardized mean difference (SMD): –0.64

95% CI: –1.22 to –0.06

=80%

=262; 3 RCTs]; on symptom resolution rate at 3-month follow-up (risk ratio: 1.94

95% CI: 1.47 to 2.56

=1527

=38%; 13 RCTs); and on global menstrual symptoms score at the end of treatment (SMD: –0.67

95% CI: –0.90 to –0.45

=63%

=990; 12 RCTs). Subgroup analyses showed either a better or an equivalent effect comparing navel therapy with Western medicine. No major adverse events were reported. The methodological quality of included trials was poor overall.

Conclusions:

Navel therapy appears to be more effective than Western medicine in decreasing menstrual pain and improving overall symptoms of PD. However

these findings need to be confirmed by well-designed clinical trials with adequate sample size (Systematic review registration at PROSPERO

No. CRD42021240350)

关键词

Keywords

navel therapyShenqueprimary dysmenorrheaquality of lifesystematic reviewmeta-analysis

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