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Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies
- Chinese Journal of Integrative Medicine Vol. 28, Issue 3, Pages: 263-271(2022)
- Affiliations：
1.Department of Oriental Neuropsychiatry, Dong-eui University College of Korean Medicine, Busan (47227), Republic of Korea
2.Department of Neuropsychiatry, Kyung Hee University Korean Medicine Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul (05278), Republic of Korea
- Author bio：
Prof. Sun-Yong Chung, E-mail: lovepwr@khu.ac.kr
- Funds：
DOI：10.1007/s11655-022-3506-3
CLC：Published：01 March 2022，
Published Online：27 January 2022，
Accepted：24 July 2020
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Chan-Young Kwon, Hyo-Weon Suh, Jong Woo Kim, et al. Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies. [J]. Chinese Journal of Integrative Medicine 28(3):263-271(2022)
Chan-Young Kwon, Hyo-Weon Suh, Jong Woo Kim, et al. Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies. [J]. Chinese Journal of Integrative Medicine 28(3):263-271(2022) DOI： 10.1007/s11655-022-3506-3.
摘要
Abstract
Objective:
2
To analyze the available data on the anti-anger effects of herbal medicines (HMs) as well as their underlying mechanisms in rat models.
Methods:
2
From 6 electronic databases [PubMed
EMBASE
China National Knowledge Infrastructure (CNKI)
Wanfang
Oriental Medicine Advanced Searching Integrated System (OASIS)
and Research Information Sharing Service (RISS)]
relevant animal experiments were searched by using "anger
" "rats
" and "animal" as search keywords. The last search was conducted on November 22
2019
and all experiments involving rat models of anger and treatment using HMs published until the date of the search were considered.
Results:
2
A total of 24 studies with 16 kinds of HMs were included. Most studies have used the "tail irritating method" and "social isolation and resident intruder" method to establish anger models. According to the included studies
the therapeutic mechanisms of HMs for anger regulation and important herbs by their frequency and/or preclinical evidence mainly incladed regulation of hemorheology (
Bupleuri Radix
Paeoniae Radix Alba
and
Glycyrrhizae Radix
)
regulation of sex hormones (
Bupleuri Radix
Cyperi Rhizoma
and
Paeoniae Radix Alba
)
regulation of neurotransmitters (
Cyperi Rhizoma
)
regulation of anger-related genes (
Bupleuri Radix
Glycyrrhizae Radix
and
Paeoniae Radix Alba
)
and other effects. Overall
Liver (Gan) qi-smoothing herbs including
Bupleuri Radix
and
Cyperi Rhizoma
were the most frequently used.
Conclusions:
2
This review found the frequent methods to establish an anger model
and major mechanisms of anti-anger effects of HMs. Interestingly
some Liver qi-smoothing herbs have been frequently used to investigate the anti-anger effects of HM. These findings provide insight into the role and relevance of HMs in the field of anger management.
关键词
Keywords
angeranger management therapyherbal medicineKorean traditional medicine
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