Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage

Yu-hang JIANG; Jia-kai HE; Ran LI; Ze-hao CHEN; Bao-hui JIA

doi:10.1007/s11655-022-3511-6

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Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage

Review | Updated：2022-03-18

- Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage
- Chinese Journal of Integrative Medicine Vol. 28, Issue 3, Pages: 272-280(2022)
- Affiliations：
  
  Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing (100053), China
- Author bio：
  
  Prof. JIA Bao-hui, E-mail: myrroossee@aliyun.com
- Funds：
- DOI：10.1007/s11655-022-3511-6
  CLC：
- Published：01 March 2022，
  
  Accepted：15 December 2021
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Yu-hang JIANG, Jia-kai HE, Ran LI, et al. Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage. [J]. Chinese Journal of Integrative Medicine 28(3):272-280(2022)
DOI：

Yu-hang JIANG, Jia-kai HE, Ran LI, et al. Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage. [J]. Chinese Journal of Integrative Medicine 28(3):272-280(2022) DOI： 10.1007/s11655-022-3511-6.

摘要

阿尔茨海默病(AD)是老年人中最常见的神经退行性疾病之一

约占所有痴呆类型的80%. 迄今为止

AD的发病机制仍未完全阐明. 线粒体级联假说认为线粒体损伤可能介导、驱动或加速多种AD病理进展

是导致晚发型AD的主要因素. 目前

尚无明确证实可有效治疗AD线粒体损伤的药物

越来越多的证据表明针刺可以有效改善AD线粒体结构和保护线粒体功能. 本文总结了针刺调节线粒体动力学、提高能量代谢、维持钙稳态和抑制细胞凋亡的机制

以期为针刺治疗AD提供科学的理论依据.

Abstract

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases among the elderly and it accounts for nearly 80% of all dementias. The pathogenesis of AD is complicated and enigmatic thus far. The mitochondrial cascade hypothesis assumes that mitochondrial damage may mediate

drive

or contribute to a variety of AD pathologies and may be the main factor in late-onset AD. Currently

there are no widely recognized drugs able to attenuate mitochondrial damage in AD. Notably

increasing evidence supports the efficacy of acupuncture for improving the mitochondrial structure and protecting mitochondrial functions in AD. This review reports the mechanisms by which acupuncture regulates mitochondrial dynamics

energy metabolism

calcium homeostasis and apoptosis. In conclusion

these findings suggest that AD mitochondrial dysfunction represents a reasonable therapeutic target and acupuncture could play a significant role in preventing and treating AD.

关键词

Keywords

acupunctureAlzheimer's diseasemitochondrial damagereview

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