Anti-inflammatory Effects of <italic style="font-style: italic">Ampelopsis Japonica</italic> Root on Contact Dermatitis in Mice

Yoona Oh; Hongbum Lee; Beodeul Yang; Kim Sura; Hyunwoo Jeong; Hyungwoo Kim

doi:10.1007/s11655-022-3517-0

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Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice

Original Article | Updated：2022-07-20

- Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice
- Chinese Journal of Integrative Medicine Vol. 28, Issue 8, Pages: 719-724(2022)
- Affiliations：
  
  1.Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam (50612), South Korea
  2.Department of Pathology, College of Korean Medicine, Dongshin University, Jeonnam (58245), South Korea
- Author bio：
  
  Prof. Hyungwoo Kim, E-mail: kronos7@pusan.ac.kr
- Funds：
- DOI：10.1007/s11655-022-3517-0
  CLC：
- Published：2022-08，
  
  Accepted：01 September 2021
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Yoona Oh, Hongbum Lee, Beodeul Yang, et al. Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice. [J]. Chinese Journal of Integrative Medicine 28(8):719-724(2022)
DOI：

Yoona Oh, Hongbum Lee, Beodeul Yang, et al. Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice. [J]. Chinese Journal of Integrative Medicine 28(8):719-724(2022) DOI： 10.1007/s11655-022-3517-0.

摘要

Abstract

Objective:

To investigate the anti-inflammatory potential of

Ampelopsis japonica

on contact dermatitis (CD).

Methods:

A total of 38 Balb/c mice were divided into 5 groups by using a random number table: normal mice (

=6)

CD model mice (

=8)

CD mice treated with 3 or 30 mg/kg of the ethanol extract of

A. japonica

(EEAJ

=8) and 7.5 mg/kg dexamethasone treated CD mice (DEX

=8). CD was induced using topical application of 1-fluoro-2

4-dinitrofluorobenzene in mice. EEAJ and DEX were topically applied to the shaved skin of each mouse for 6 days

and the effects of EEAJ and DEX on skin lesions and color

histopathological abnormalities such as epidermal hyperplasia and immune cell infiltration

and tumor necrosis factor (TNF)-α

interleukin-6 (IL-6)

and monocyte chemoattractant protein-1 (MCP-1) production were investigated. The effects on changes in body weights and spleen/body weight ratio were also investigated.

Results:

EEAJ at 30 mg/kg significantly prevented scaling

erythema and enlargement of skin weight compared to using carbon dioxide. EEAJ also prevented epithelial hyperplasia and immune cell infiltrations induced by repeated application of DNFB (

0.01). In addition

EEAJ significantly lowered levels of TNF-α

IL-6 and MCP-1 (

0.05 or

0.01). The anti-inflammatory effects of EEAJ were similar to those of DEX.

Conclusion:

A. japonica may be a new therapeutic agent with the potential to reduce or replace corticosteroids and its mechanisms are closely related to regulation of TNF-α production.

关键词

Keywords

Ampelopsis japonicaChinese medicineinflammationdermatosiscontact dermatitis

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Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine

Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine

Department of Integrated Traditional Chinese and Western Medicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine

Department of Neurology, The First Hospital of Quanzhou Affiliated to Fujian Medical University

Department of Neurosurgery, Fujian Medical University Union Hospital

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Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice

DOI：10.1007/s11655-022-3517-0

摘要

Abstract

关键词

Keywords

references