Indian Traditional Treatments for Psoriasis: A Critical Appraisal of Available Evidence Supporting Efficacy

Nayak Deeksha Dayanand; Arul Amuthan; Sathish Pai Ballambat; Shama Prasada Kabbekodu; Vasudha Devi

doi:10.1007/s11655-022-3519-y

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Indian Traditional Treatments for Psoriasis: A Critical Appraisal of Available Evidence Supporting Efficacy

Literature Research | Updated：2023-01-05

- Indian Traditional Treatments for Psoriasis: A Critical Appraisal of Available Evidence Supporting Efficacy
- Chinese Journal of Integrative Medicine Vol. 29, Issue 1, Pages: 69-73(2023)
- Affiliations：
  
  1.Department of Pharmacology, Kasturba Manipal Medical College, Manipal Academy of Higher Education, Manipal(576104), India
  2.Department of Dermatology, Venerology and Leprosy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal (576104), India
  3.Department of Cell and Molecular Biology, Manipal School of Life Sciences,Manipal Academy of Higher Education, Manipal (576104), India
  4.Centre for Cardiovascular Pharmacology, Manipal Academy of Higher Education, Manipal (576104), India
- Author bio：
  
  Dr. Vasudha Devi, E-mail: vasudha.devi@manipal.edu
- Funds：
- DOI：10.1007/s11655-022-3519-y
  CLC：
- Published：01 January 2023，
  
  Published Online：12 July 2022，
  
  Accepted：28 October 2021
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Nayak Deeksha Dayanand, Arul Amuthan, Sathish Pai Ballambat, et al. Indian Traditional Treatments for Psoriasis: A Critical Appraisal of Available Evidence Supporting Efficacy. [J]. Chinese Journal of Integrative Medicine 29(1):69-73(2023)
DOI：

Nayak Deeksha Dayanand, Arul Amuthan, Sathish Pai Ballambat, et al. Indian Traditional Treatments for Psoriasis: A Critical Appraisal of Available Evidence Supporting Efficacy. [J]. Chinese Journal of Integrative Medicine 29(1):69-73(2023) DOI： 10.1007/s11655-022-3519-y.

摘要

Abstract

Objective:

To examine data from studies supporting the clinical efficacy of medical approaches from India traditional systems of medicines like Ayurveda

Unani

Siddha

and Homeopathy for psoriasis using outcome indicators employed in clinical practice and research.

Methods:

Searches were conducted between December 2019 and September 2020 in databases PubMed

Scopus

Web of Science and Ovid Medline using search terms including traditional

complementary

psoriasis

Kushtha

Ayurveda

Siddha

Unani

Homeopathy and clinical. Controlled trials

case series and case reports published from India were included.

Results:

Data of 17 selected studies were extracted. Treatment efficacy in terms of improvement in Psoriasis Area and Severity Index (PASI) score or/and percentage reduction in score (PASI 50

PASI 75 and PASI 90) or/and patientreported outcomes using instruments like Dermatology Life Quality Index and Psoriasis Disability Index were noted. All studies reported good improvement as per the study specific outcome. However

study characteristics

including study design

sample size

follow-up period

inclusion and exclusion criteria were heterogeneous

and the choice of outcome measures was not adequate to conclude the effectiveness of intervention. The use of some herbs as common ingredients in several formulations across different systems of medicines were noted in analyzing individual formulation.

Conclusions:

Future studies must incorporate a comprehensive study design with specific outcome measures like PASI

PASI 75

PASI 90

quality of life parameters

compliance to medications

adverse reactions

remission period

relapse rate and cost-effectiveness with long term follow-up. The currently available evidence on the roles of these herbs at molecular level in psoriasis is preliminary.

关键词

Keywords

psoriasistraditional treatmentIndianefficacyherbclinical

references

Parisi R, Symmons DPM, Griffiths CEM, Ashcroft DM. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol 2013;133:377-385.

Dogra S, Mahajan R. Psoriasis: epidemiology, clinical features, co-morbidities, and clinical scoring. Ind Dermatol Online J 2016;7:471.

Rendon A, Schäkel K. Psoriasis pathogenesis and treatment.Int J Mol Sci 2019;20:1-28.

Takeshita J, Grewal S, Langan SM, Mehta NN, Ogdie A,Voorhees AS, et al. Psoriasis and comorbid diseases:epidemiology. J Am Acad Dermatol 2017;76:377-390.

WHO Traditional Medicine Strategy 2002-2005. World Health Organization, Geneva, Switzerland 2002. WHO/EDM/TRM/2002.1.

Sharma AR, ed. Collection of Susruta of Maharshi susruta. AR 14th ed. Varanasi: Chukhambha prakashan; 2010:497.

Thas JJ. Siddha medicine—background and principles and the application for skin diseases. Clin Dermatol 2008;26:62-78.

Lone AH, Ahmad T, Naiyar AH. Clinical evaluation of efficacy of Majoon Ushba and Roghane Hindi in the management of psoriasis: a randomised single blind, placebo controlled study.J Ayurv Integr Med 2011;2:26-31.

Fredriksson T, Pettersson U. Severe psoriasis—oral therapy with a new retinoid. Dermatologica 1978;157:238-244.

Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use. Clin Exp Dermatol 1994;19:210-216.

Finlay AY, Kelly SE. Psoriasis—an index of disability. Clin Exp Dermatol 1987;12:8-11.

Ayur Med Info -. Ayurmedinfo.com. Available at: https://www.ayurmedinfo.comhttps://www.ayurmedinfo.com/Accessed on December 23, 2020.

Mehta CS, Dave AR, Shukla VD. A clinical study of some Ayurvedic compound drugs in the assessment quality of life of patients with Eka Kushtha (psoriasis). Ayurveda 2011;32:333-339.

Ramteke R, Meharjan T, Vinodkumar G. An open clinical trial to analyze Samyak Snigdha Lakshana of Shodhananga Snehapana with Mahatikthakam Ghritam in psoriasis. Ayurveda 2011;32:519.

Mitra A, Banerjee M, Das B, Ravte RK, Hazra J. Acquiescence of ayurvedic principles and practices in Kitibha (psoriasis) and excellent clinical responses—a case study. Ind J Tradit Knowl 2011;10:689-692.

Shamkuwar MK, Shrivas YK, Jaiswal L. Evaluation of panchakarma as an ayurvedic line of treatment in the management of psoriasis. J Chem Pharm Res 2011;3:17-21.

Mangal G, Sharma R, Mangal G. Clinical efficacy of Shodhana Karma and Shamana Karma in Mandala Kushtha (Psoriasis).Ayurveda 2012;33:224.

Keshao SM, Lalchand J, Kameshwar SY, Nitin J, Deepa M.Effect of matra basti of panchatikta ghrita in psoriasis. Int J Res Ayurv Pharm 2012;3:789-791.

Mehta C, Dave A, Shukla V. Comparative effect of Navayasa Rasayana Leha and Medhya Rasayana tablet along with Dhatryadhyo Lepa in Ekkushtha (psoriasis). Ayurveda 2013;34:243.

Singh S, Byadgi PS, Rai NP. Clinical evaluation of Virechan therapy and Haridradi Vati and oil for the management of Kitibh Kushtha(psoriasis). Int J Res Ayurv Pharm 2013;4:207-211.

Rohini S. Efficacy of Goghrita and Vajrak ghrita as abhyantar sneha in the management of Ekkushtha with special reference to psoriasis through vaman: a comparative study. Int J Res Ayurv Pharm 2014;5:284-289.

Mahesh Sharma M, Hegde G, Mythrey RC. A comparative clinical study on the management of psoriasis w.s.r. to ekakushta. Int J Res Ayurv Pharm 2013;4:84-89.

Bhattacharyya N, Pujar MP, Chaturvedi A, Kumar MA, Lohith BA,Sunil Kumar KN. A clinico-analytical study on seed of Wrightia antidysenterica Linn. as a therapeutic emetic agent (Vamaka Yoga)in the management of psoriasis. Pharmacogn Res 2016;8:S19-S25.

Krishna Kumar K, Chacko J. Thuvaraka rasayana regimen in psoriasis vulgaris—a case report. J Ayurv Integr Med 2019;10:41-44.

Shamim Khan M, Siddiqui MMH, Aleem S. Effect of Psoralia corylifolia Linn. and Marham-e-Gulabi in Da-al-sadaf (psoriasis).Ind J Tradit Knowl 2009;8:425-430.

Khanna N, Nazli T, Siddiqui KM, Kalaivani M. A non-inferiority randomized controlled clinical trial comparing Unani formulation &psoralen plus ultraviolet A sol in chronic plaque psoriasis. Ind J Med Res 2018;147:66-72.

Qureshi MA, Bano H. Clinical observation of unani medicine in the treatment of psoriasis: a case study. Ind J Tradit Knowl 2019;18:190-192.

Mahesh S, Shah V, Mallappa M, Vithoulkas G. Psoriasis cases of same diagnosis but different phenotypes—management through individualized homeopathic therapy. Clin Case Rep 2019;7:1499-1507.

Nimisha , Rizvi DA, Fatima Z, Neema , Kaur CD. Antipsoriatic and anti-inflammatory studies of Berberis aristata extract loaded nanovesicular gels. Pharmacogn Mag 2017;13:S587-S594.

Kang NJ, Han SC, Yoon SH, Sim JY, Maeng YH, Kang HK, et al.Cinnamomum camphora leaves alleviate allergic skin inflammatory responses in vitro and in vivo. Toxicol Res 2019;35:279-285.

Kumar S, Singh KK, Rao R. Enhanced anti-psoriatic efficacy and regulation of oxidative stress of a novel topical babchi oil(Psoralea corylifolia) cyclodextrin-based nanogel in a mouse tail model. J Microencapsul 2019;36:140-155.

Cho JY, Park J, Kim PS, Yoo ES, Baik KU, Park MH. Savinin a lignin from Pterocarpus santalinus inhibits tumour necrosis factor-alpha production and T-cell proliferation. Biol Pharm Bull 2001;24:167-171.

Mitra SK, Seshadri SJ, Venkatarangamma MV, Gopumadhavan S.Reversal of Parakeratosis, a feature of psoriasis by Wrightia tinctoria(in emulsion)—histological evaluation based on mouse tail test. Ind J Dermatol 1998;43:102-104.

Kim H, Han TH, Lee SG. Anti-inflammatory activity of a water extract of Acorus calamus L. leaves on keratinocyte HaCaT cells. J Ethnopharmacol 2009;122:149-156.

Arora N, Tripathi D, Pandey N, Rai KK, Rai SK, Pandey-rai S. Study of antioxidant, anti-inflammatory, and DNA-damage protection properties of some Indian medicinal plants reveal their possible role in combating psoriasis. Int J Appl Sci Biotechnol 2017;5:141-149.

Han X, Parker TL. Antiinflammatory activity of cinnamon(Cinnamomum zeylanicum) bark essential oil in a human skin disease model. Phyther Res 2017;31:1034-1038.

Rathee P, Chaudhary H, Rathee S, Rathee D, Kumar V, Kohli K.Mechanism of action of flavonoids as anti-inflammatory agents: a review. Inflamm Allergy Drug Targets 2009;8:229-235.

Sharma M, Levenson C, Clements I, Castella P, Gebauer K,Cox ME. East Indian sandalwood oil (EISO) alleviates inflammatory and proliferative pathologies of psoriasis. Front Pharmacol 2017;8:1-13.

Gulati K, Chaudhary S, Rai N, Ray A. Evaluation of anti-inflammatory and immunomodulatory effects of aqueous extract of Solanum xanthocarpum in experimental models of bronchial asthma. EC Pharmacol Toxicol 2016: 241-250.

An J, Li T, Dong Y, Li Z, Huo J. Terminalia chebulanin attenuates psoriatic skin lesion via regulation of heme oxygenase-1. Cell Physiol Biochem 2016;39:531-543.

Tjendraputra E, Tran VH, Liu-Brennan D, Roufogalis BD, Duke CC. Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorg Chem 2001;29:156-163.

Amuthan A, Santhi M. Cost effective management of chronic psoriasis using safe Siddha herbal drugs—a case report. J Ayurv Herb Med 2020;6:9-11.

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Department of Integrated Traditional Chinese and Western Medicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine

Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine

Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine

Department of Dermatology, Hebei Province Hospital of Chinese Medicine

Department of Nephrology, Pinggu Hospital, Beijing Hospital of Traditional Chinese Medicine

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