Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

ZHAO Wen-xiao; WANG Tong; ZHANG Ya-nan; CHEN Qian; WANG Yuan; XING Yan-qing; ZHENG Jun; DUAN Chen-chen; CHEN Li-jun; ZHAO Hai-jun; WANG Shi-jun

doi:10.1007/s11655-022-3522-y

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Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

Review | Updated：2024-02-22

- Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health
- Chinese Journal of Integrative Medicine Vol. 30, Issue 2, Pages: 171-180(2024)
- Affiliations：
  
  1.School of Nursing, Shandong University of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan (250355), China
  2.Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula, Shandong University of Traditional Chinese Medicine, Ji'nan (250355), China
  3.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan (250355), China
- Author bio：
  
  Dr. ZHAO Hai-jun, E-mail: higherzhao@126.com
- Funds：
- DOI：10.1007/s11655-022-3522-y
  CLC：
- Published：2024-02，
  
  Published Online：18 May 2022，
  
  Accepted：01 April 2021
Scan for full text
ZHAO Wen-xiao, WANG Tong, ZHANG Ya-nan, et al. Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health. [J]. Chinese Journal of Integrative Medicine 30(2):171-180(2024)
DOI：

ZHAO Wen-xiao, WANG Tong, ZHANG Ya-nan, et al. Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health. [J]. Chinese Journal of Integrative Medicine 30(2):171-180(2024) DOI： 10.1007/s11655-022-3522-y.

摘要

Abstract

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity

type 2 diabetes mellitus

heart failure

and non-alcoholic fatty liver disease. Polysaccharides extracted from Chinese medicine (CM) can not only alleviate pathological status but also promote health by anti-inflammatory

regulating immunity

lowering blood glucose and lipids

anti-cancer

and anti-oxidation. The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment. In addition

they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota. This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics for promoting health.

关键词

Keywords

Chinese medicinepolysaccharidesgut microbiotashort-chain fatty acidslipopolysaccharidesgut-organ axissynergistic actions

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