Progress in Mechanism of <italic style="font-style: italic">Astragalus membranaceus</italic> and Its Chemical Constituents on Multiple Sclerosis

PENG Yong; DENG Xiang; YANG Shan-shan; NIE Wei; TANG Yan-dan

doi:10.1007/s11655-022-3535-6

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Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis

Review | Updated：2023-01-05

- Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis
- Chinese Journal of Integrative Medicine Vol. 29, Issue 1, Pages: 89-95(2023)
- Affiliations：
  
  Department of Neurology, Affiliated First Hospital of Hunan Traditional Chinese Medical College, Zhuzhou, Hunan Province(412000), China
- Author bio：
  
  Prof. PENG Yong, E-mail: 1779342446@qq.com
- Funds：
- DOI：10.1007/s11655-022-3535-6
  CLC：
- Published：01 January 2023，
  
  Published Online：09 July 2022，
  
  Accepted：08 February 2022
Scan for full text
PENG Yong, DENG Xiang, YANG Shan-shan, et al. Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis. [J]. Chinese Journal of Integrative Medicine 29(1):89-95(2023)
DOI：

PENG Yong, DENG Xiang, YANG Shan-shan, et al. Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis. [J]. Chinese Journal of Integrative Medicine 29(1):89-95(2023) DOI： 10.1007/s11655-022-3535-6.

摘要

Abstract

The primary chemical components of

Astragalus membranaceus

include polysaccharides

saponins

flavonoids

and amino acids. Recent studies have shown that

Astragalus membranaceus

has multiple functions

including improving immune function and exerting antioxidative

anti-radiation

anti-tumor

antibacterial

antiviral

and hormone-like effects.

Astragalus membranaceus

and its extracts are widely used in clinical practice because they have obvious therapeutic effects against various autoimmune diseases and relatively less adverse reaction. Multiple sclerosis (MS) is an autoimmune disease of central nervous system (CNS)

which mainly caused by immune disorder that leads to inflammatory demyelination

inflammatory cell infiltration

and axonal degeneration in the CNS. In this review

the authors analyzed the clinical manifestations of MS and experimental autoimmune encephalomyelitis (EAE) and focused on the efficacy of

Astragalus membranaceus

and its chemical components in the treatment of MS/EAE.

关键词

Keywords

Astragalus membranaceuschemical componentsmultiple sclerosisexperimental autoimmune encephalomyelitisimmunoregulation

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Related Institution

Research Center of Neurobiology, the Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine

Department of Neurology, the First Affiliated Hospital, Shanxi Medical University

Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University

Department of Neurology, Datong Fifth People's Hospital

Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University

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Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis

DOI：10.1007/s11655-022-3535-6

摘要

Abstract

关键词

Keywords

references