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Progress on Prevention and Treatment of Cerebral Small Vascular Disease Using Integrative Medicine
- Chinese Journal of Integrative Medicine Vol. 29, Issue 2, Pages: 186-191(2023)
- Affiliations：
1.Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou (350122), China
2.the Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou (350122), China
- Author bio：
Prof. CAI Jing, E-mail: caij1@163.com
- Funds：
DOI：10.1007/s11655-022-3622-8
CLC：Published：2023-02，
Published Online：17 December 2022，
Accepted：01 July 2022
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ZHANG Chu-tian, CHENG Hui-ling, CHEN Kai-li, et al. Progress on Prevention and Treatment of Cerebral Small Vascular Disease Using Integrative Medicine. [J]. Chinese Journal of Integrative Medicine 29(2):186-191(2023)
ZHANG Chu-tian, CHENG Hui-ling, CHEN Kai-li, et al. Progress on Prevention and Treatment of Cerebral Small Vascular Disease Using Integrative Medicine. [J]. Chinese Journal of Integrative Medicine 29(2):186-191(2023) DOI： 10.1007/s11655-022-3622-8.
摘要
脑小血管病 (Cerebral Small Vessel Disease
CSVD) 是大脑小动脉、小动脉、小静脉和毛细血管结构、功能异常导致的老年性脑病. CSVD病因复杂
疾病早期往往无症状
随着疾病发展表现为中风、认知能力下降、运动障碍、情绪异常等中枢神经疾病
以及心脏、肾脏、眼睛等器官损伤. 随着人口持续老龄化
CSVD的危害性与日俱增. 目前
不仅针对CSVD预防性治疗和无症状-轻症阶段干预措施缺乏
还亟需寻找更优秀的CSVD的筛查方法和诊断标志物. 融合了中国医学整体观念和辨证论治的思维和现代医学的理念的中西医结合医学
在CSVD的防治中有着独特的优势. 因此
在这篇综述中
我们对与CSVD诊断筛查相关的生物学标志物、超声影像学特征、发病相关基因和疾病危险因素进行了归纳. 此外
我们进一步探讨了基于中西医结合的CSVD预治策略
以期有助于本领域的研究.
Abstract
Cerebral small vessel disease (CSVD) is a senile brain lesion caused by the abnormal structure and function of arterioles
venules and capillaries in the aging brain. The etiology of CSVD is complex
and disease is often asymptomatic in its early stages. However
as CSVD develops
brain disorders may occur
such as stroke
cognitive dysfunction
dyskinesia and mood disorders
and heart
kidney
eye and systemic disorders. As the population continues to age
the burden of CSVD is increasing. Moreover
there is an urgent need for better screening methods and diagnostic markers for CSVD
in addition to preventive and asymptomatic-and mild-stage treatments. Integrative medicine (IM)
which combines the holistic concepts and syndrome differentiations of Chinese medicine with modern medical perspectives
has unique advantages for the prevention and treatment of CSVD. In this review
we summarize the biological markers
ultrasound and imaging features
disease-related genes and risk factors relevant to CSVD diagnosis and screening. Furthermore
we discuss IM-based CSVD prevention and treatment strategies to stimulate further research in this field.
关键词
脑小血管病白质高信号中西医结合血脑屏障微血管功能障碍
Keywords
cerebral small vessel diseaseintegrative medicinewhite matter lesionsblood-brain barrier
references
Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010;9:689-701.
Litak J, Mazurek M, Kulesza B, et al. Cerebral small vessel disease. Int J Mol Sci 2020;21:9729.
Li Q, Yang Y, Reis C, et al. Cerebral small vessel disease.Cell Transplant 2018;27:1711-1722.
Thompson CS, Hakim AM. Living beyond our physiological means: small vessel disease of the brain is an expression of a systemic failure in arteriolar function: a unifying hypothesis. Stroke 2009;40:e322-330.
Low A, Mak E, Rowe JB, et al. Inflammation and cerebral small vessel disease: a systematic review. Ageing Res Rev 2019;53:100916.
Ma Y, Song A, Viswanathan A, et al. Blood pressure variability and cerebral small vessel disease: a systematic review and meta-analysis of population-based cohorts.Stroke 2020;51:82-89.
Li Y, Kalpouzos G, Laukka EJ, et al. Progression of neuroimaging markers of cerebral small vessel disease in older adults: a 6-year follow-up study. Neurobiol Aging 2022;112:204-211.
Saito R, Lioutas VA. Diagnosis and management of monogenic cerebral small vessel diseases. Eur J Neurol 2020;27:1097-1098.
Bordes C, Sargurupremraj M, Mishra A, et al. Genetics of common cerebral small vessel disease. Nat Rev Neurol 2022;18:84-101.
Rutten-Jacobs LCA, Rost NS. Emerging insights from the genetics of cerebral small-vessel disease. Ann N Y Acad Sci 2020;1471:5-17.
Lau AYL, Ip BYM, Ko H, et al. Pandemic of the aging society–sporadic cerebral small vessel disease. Chin Med J (Engl) 2021;134:143-150.
Zhang S, Wang Z, Liu P, et al. Development of cognition decline in non-acute symptomatic patients with cerebral small vessel disease: non-acute symptomatic cerebral ischemia registration study (NASCIR)-rationale and protocol for a prospective multicentre observational study. BMJ Open 2022;12:e050294.
Rensma SP, van Sloten TT, Launer LJ, et al. Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: a systematic review and meta-analysis. Neurosci Biobehav Rev 2018;90:164-173.
Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 2010;341:c3666.
Østergaard L, Engedal TS, Moreton F, et al. Cerebral small vessel disease: capillary pathways to stroke and cognitive decline. J Cereb Blood Flow Metab 2016;36:302-325.
Xu M, Li B, Zhong D, et al. Cerebral small vessel disease load predicts functional outcome and stroke recurrence after intracerebral hemorrhage: a median follow-up of 5 years. Front Aging Neurosci 2021;13:628271.
Teng Z, Dong Y, Zhang D, et al. Cerebral small vessel disease and post-stroke cognitive impairment. Int J Neurosci 2017;127:824-830.
Castello JP, Pasi M, Kubiszewski P, et al. Cerebral small vessel disease and depression among intracerebral hemorrhage survivors. Stroke 2022;53:523-531.
Ma R, Zhào H, Wei W, et al. Gait characteristics under single-/dual-task walking conditions in elderly patients with cerebral small vessel disease: analysis of gait variability, gait asymmetry and bilateral coordination of gait. Gait Posture 2022;92:65-70.
Zhào H, Liu Y, Xia Z, et al. Diagnosis and assessment of apathy in elderly chinese patients with cerebral small vessel disease. Front Psychiatry 2021;12:688685.
Wouts L, van Kessel M, Beekman ATF, et al. Empirical support for the vascular apathy hypothesis: a structured review. Int J Geriatr Psychiatry 2020;35:3-11.
Alexopoulos GS, Meyers BS, Young RC, et al. 'Vascular depression' hypothesis. Archives General Psychiatry 1997;54:915-922.
van Agtmaal MJM, Houben AJHM, Pouwer F, et al.Association of microvascular dysfunction with late-life depression: a systematic review and meta-analysis. JAMA Psychiatry 2017;74:729-739.
Evans LE, Taylor JL, Smith CJ, et al. Cardiovascular comorbidities, inflammation, and cerebral small vessel disease. Cardiovasc Res 2021;117:2575-2588.
Marini S, Georgakis MK, Anderson CD. Interactions between kidney function and cerebrovascular disease: vessel pathology that fires together wires together. Front Neurol 2021;12:785273.
Geerling CF, Terheyden JH, Langner SM, et al. Changes of the retinal and choroidal vasculature in cerebral small vessel disease. Sci Rep 2022;12:3660.
Makin SD, Cook FA, Dennis MS, et al. Cerebral small vessel disease and renal function: systematic review and meta-analysis. Cerebrovasc Dis 2015;39:39-52.
Wartolowska KA, Webb AJS. Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank cohort study. Eur Heart J 2021;42:750-757.
van Middelaar T, Argillander TE, Schreuder F, et al. Effect of antihypertensive medication on cerebral small vessel disease: a systematic review and meta-analysis. Stroke 2018;49:1531-1533.
Weber R, Weimar C, Blatchford J, et al. Telmisartan on top of antihypertensive treatment does not prevent progression of cerebral white matter lesions in the prevention regimen for effectively avoiding second strokes (PRoFESS) MRI substudy. Stroke 2012;43:2336-2342.
Peng J, Lu F, Wang Z, et al. Excessive lowering of blood pressure is not beneficial for progression of brain white matter hyperintensive and cognitive impairment in elderly hypertensive patients: 4-year follow-up study. J Am Med Dir Assoc 2014;15:904-910.
Mok VC, Lam WW, Fan YH, et al. Effects of statins on the progression of cerebral white matter lesion: post hoc analysis of the ROCAS (Regression of Cerebral Artery Stenosis) study. J Neurol 2009;256:750-757.
ten Dam VH, van den Heuvel DM, van Buchem MA, et al.Effect of pravastatin on cerebral infarcts and white matter lesions. Neurology 2005;64:1807-1809.
Das AS, Regenhardt RW, Vernooij MW, et al. Asymptomatic cerebral small vessel disease: insights from population-based studies. J Stroke 2019;21:121-138.
Zhang JH, Wu MS, Wang YF, et al. Medicine in future and advantages of integrated Chinese and Western medicine.Chin J Integr Med 2019;25:87-90.
Cao G, Ye X, Xu Y, et al. Yiqi Fumai Powder Injection ameliorates blood-brain barrier dysfunction and brain edema after focal cerebral ischemia-reperfusion injury in mice. Drug Des Devel Ther 2016;10:315-325.
Zhang Y, Hu Y, Li M, et al. The traditional Chinese medicine compound, GRS, alleviates blood-brain barrier dysfunction.Drug Des Devel Ther 2020;14:933-947.
Xie W, Wang X, Xiao T, et al. Protective effects and network analysis of ginsenoside Rb1 against cerebral ischemia injury: a pharmacological review. Front Pharmacol 2021;12:604811.
Ke SY, Yu SJ, Liu DH, et al. Ginsenoside Rb1 protects human umbilical vein endothelial cells against high glucose-induced mitochondria-related apoptosis through activating SIRT3 signalling pathway. Chin J Integr Med 2021;27:336-344.
Li Y, Liu XT, Zhang PL, et al. Hydroxysafflor yellow a blocks HIF-1α induction of NOX2 and protects ZO-1 protein in cerebral microvascular endothelium. Antioxidants (Basel)2022;11.
Guo Y, Yang JH, He Y, et al. Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist. Phytomedicine 2022;94:153849.
Li MT, Ke J, Guo SF, et al. The protective effect of quercetin on endothelial cells injured by hypoxia and reoxygenation.Front Pharmacol 2021;12:732874.
Xie Q, Li J, Dong T, et al. Neuroprotective effects of synthetic borneol and natural borneol based on the neurovascular unit against cerebral ischaemic injury. J Pharm Pharmacol 2022;74:236-249.
Wei JX, Lu ZQ, Feng GZ, et al. Which is safer, Chinese medicine or Western medicine? Comparative analysis based on chinese spontaneous reporting database. Chin J Integr Med 2022;28:138-144.
Wang J, Zhou Y, He Y, et al. Impact of different white matter hyperintensities patterns on cognition: a cross-sectional and longitudinal study. Neuroimage Clin 2022;34:102978.
Folsom AR, Yatsuya H, Mosley TH Jr. , et al. Risk of intraparenchymal hemorrhage with magnetic resonance imaging-defined leukoaraiosis and brain infarcts. Ann Neurol 2012;71:552-559.
Park JH, Heo SH, Lee MH, et al. White matter hyperintensities and recurrent stroke risk in patients with stroke with small-vessel disease. Eur J Neurol 2019;26:911-918.
Clancy U, Gilmartin D, Jochems ACC, et al. Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis. Lancet Psychiatry 2021;8:225-236.
Madden DJ, Bennett IJ, Burzynska A, et al. Diffusion tensor imaging of cerebral white matter integrity in cognitive aging.Biochim Biophys Acta 2012;1822:386-400.
De Vis JB, Peng SL, Chen X, et al. Arterial-spin-labeling (ASL) perfusion MRI predicts cognitive function in elderly individuals: a 4-year longitudinal study. J Magn Reson Imaging 2018;48:449-458.
Liu Z, Ma H, Guo ZN, et al. Impaired dynamic cerebral autoregulation is associated with the severity of neuroimaging features of cerebral small vessel disease.CNS Neurosci Ther 2022;28:298-306.
Smith EE, Saposnik G, Biessels GJ, et al. Prevention of stroke in patients with silent cerebrovascular disease: a scientific statement for healthcare professionals from the american heart association/American stroke association.Stroke 2017;48:e44-e71.
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