Efficacy of Curcumin on Cognitive Function Scores in Women with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blind, Placebo-Controlled Clinical Trial

Afsane Bahrami; Amir Masoud Jafari-Nozad; Samira Karbasi; Malaksima Ayadilord; Gordon A. Ferns

doi:10.1007/s11655-023-3732-3

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Efficacy of Curcumin on Cognitive Function Scores in Women with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blind, Placebo-Controlled Clinical Trial

Original Article | Updated：2023-04-27

- Efficacy of Curcumin on Cognitive Function Scores in Women with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blind, Placebo-Controlled Clinical Trial
- Chinese Journal of Integrative Medicine Vol. 29, Issue 5, Pages: 387-393(2023)
- Affiliations：
  
  1.Clinical Research Development Unit of Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  2.Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
  3.Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
  4.Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK
- Author bio：
  
  Dr. Afsane Bahrami, E-mail: Bahramia@bums.ac.ir & Afsbahramia931@gmail.com
- Funds：
- DOI：10.1007/s11655-023-3732-3
  CLC：
- Published：2023-05，
  
  Accepted：21 June 2021
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Afsane Bahrami, Amir Masoud Jafari-Nozad, Samira Karbasi, et al. Efficacy of Curcumin on Cognitive Function Scores in Women with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blind, Placebo-Controlled Clinical Trial. [J]. Chinese Journal of Integrative Medicine 29(5):387-393(2023)
DOI：

Afsane Bahrami, Amir Masoud Jafari-Nozad, Samira Karbasi, et al. Efficacy of Curcumin on Cognitive Function Scores in Women with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blind, Placebo-Controlled Clinical Trial. [J]. Chinese Journal of Integrative Medicine 29(5):387-393(2023) DOI： 10.1007/s11655-023-3732-3.

摘要

Abstract

Objective:

To assess the efficacy of a curcumin supplementation on cognitive abilities in women suffering from premenstrual syndrome (PMS) and dysmenorrhea.

Methods:

A randomized

triple-blind

placebo-controlled trial was conducted from December 2019 to March 2020. A total of 124 women who had both PMS and dysmenorrhea were enrolled

and were equally and randomly assigned to the curcumin group or placebo group

62 cases in each. Each subject received either a capsule containing 500 mg of curcuminoid

or a placebo daily

for 10 days (7 days before and until 3 days after the onset of menstrual bleeding) over 3 menstrual cycles. The cognitive abilities questionnaire was used to measures cognitive functions in 7 specific areas. Adverse reactions were monitored during and after the trial in both groups.

Results:

Administration of curcumin was associated with a significant increase in memory score (

=0.002)

inhibitory control and selective attention (

=0.020)

and total cognitive ability task (

=0.024). In addition

significant increments were found in scores of memory (3.5±3.1

. 0.4±3.8 in the curcumin and placebo groups

respectively;

=0.035)

inhibitory control and selective attention (3.0±3.7

. 0.4±3.7;

=0.027) and total cognitive abilities (8.3±12.3

. 2.2±12.4;

=0.025) in the curcumin group

versus

placebo groups. Curcumin was safe and well-tolerable in current clinical trial.

Conclusion:

Curcumin has a beneficial efficacy on cognitive function scores in women with PMS and dysmenorrhea

with improvements in memory

inhibitory control and selective attention. (Registration No. IRCT20191112045424N1

available at: https://www.irct.ir)

关键词

Keywords

curcuminmemorycognitiondysmenorrhealpremenstrual syndrometriple-blindplacebo-controlled clinical trial

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