Phellodendron

(PN) species

traditionally used in Chinese medicine for centuries

hold promise as a potential treatment for osteoporosis (OP) and osteoarthritis (OA) due to their bioactive compounds. The bioactive compounds

including berberine and palmatine

exhibit anti-inflammatory

antioxidant

and bone-protective properties

contributing to their potential therapeutic benefits in promoting bone health and preventing bone loss. However

challenges such as the need for standardized preparation and dosing

limited clinical studies

and potential interactions with other medications hinder their clinical use. Nonetheless

the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and OA. Further research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.