Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine
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Review|Updated:2024-04-23
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Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine
Chinese Journal of Integrative MedicineVol. 30, Issue 5, Pages: 468-479(2024)
Affiliations:
1.College of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney Diseases, Institute of Integrated Traditional Chinese and Western Medicine, Shijiazhuang(050200), China
2.Department of Cardiovascular Internal Medicine, the Second Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi Province (332000), China
3.Graduate School,Hebei Medical University, Shijiazhuang (050017), China
4.Rural Physician College, Hebei Medical University, Shijiazhuang(050017), China
5.Medical Department, the First Hospital of Hebei Medical University, Shijiazhuang (050030), China
ZHONG Yi, LI Xin-yue, LIANG Tian-jun, et al. Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine. [J]. Chinese Journal of Integrative Medicine 30(5):468-479(2024)
DOI:
ZHONG Yi, LI Xin-yue, LIANG Tian-jun, et al. Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine. [J]. Chinese Journal of Integrative Medicine 30(5):468-479(2024) DOI: 10.1007/s11655-024-3655-2.
Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine
Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases (CVDs)
such as diabetic cardiomyopathy
ischemia/reperfusion injury
myocardial infarction
heart failure and hypertension. Noncoding RNAs (ncRNAs) are important regulatory factors. Many Chinese medicine (CM) compounds
including their effective components
can regulate pyroptosis and exert myocardium-protecting effects. The mechanisms underlying this protection include inhibition of inflammasome protein expression
Toll-like receptor 4–NF-κB signal pathway activation
oxidative stress
endoplasmic reticulum stress (ERS)
and mixed lineage kinase 3 expression and the regulation of silent information regulator 1. The NLRP3 protein is an important regulatory target for CVD prevention and treatment with CM. Exploring the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.
关键词
细胞焦亡心血管疾病中药NLRP3机制
Keywords
pyroptosiscardiovascular diseasesChinese medicineNOD-like receptor protein 3mechanisms