Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury

LIU Chang-xing; GUO Xin-yi; ZHOU Ya-bin; WANG He

doi:10.1007/s11655-024-3657-0

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Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury

Review | Updated：2024-09-23

- Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury
- Chinese Journal of Integrative Medicine Vol. 30, Issue 10, Pages: 949-960(2024)
- Affiliations：
  
  1.First Clinical Medical School, Heilongjiang University of Chinese Medicine, Harbin (150040), China
  2.Clinical Medical School, Chengdu University of Traditional Chinese Medicine, Chengdu (610036), China
  3.Department of Cardiology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin (150040), China
- Author bio：
  
  WANG He, E-mail: hehe0808032@163.com
- Funds：
- DOI：10.1007/s11655-024-3657-0
  CLC：
- Published：2024-10，
  
  Published Online：08 February 2024，
  
  Accepted：01 December 2023
- Accepted：
Scan QR Code
LIU Chang-xing, GUO Xin-yi, ZHOU Ya-bin, et al. Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury. [J]. Chinese Journal of Integrative Medicine 30(10):949-960(2024)
DOI：

LIU Chang-xing, GUO Xin-yi, ZHOU Ya-bin, et al. Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury. [J]. Chinese Journal of Integrative Medicine 30(10):949-960(2024) DOI： 10.1007/s11655-024-3657-0.

摘要

急性心肌梗死 (AMI) 是一种具有高发病率和死亡率的疾病

对公共卫生构成严重威胁. 虽然再灌注治疗是AMI的首选治疗方法

但却常常会加剧心肌损伤

导致心肌缺血/再灌注损伤 (MI/RI) 的发生. 因此

减轻MI/RI的策略在心血管病的治疗中迫在眉睫. 中医药因其多组分、多途径和多靶点的特点

被认为是缓解MI/RI的一种新方法. 其中

核因子E2相关因子2 (Nrf2) /血红素氧合酶-1 (HO-1) 通路是一个关键领域

该通路在MI/RI中发挥重要调控作用

涉及炎症反应、氧化应激、细胞凋亡、内质网应激和铁死亡等多个方面. 本文综述了Nrf2/HO-1信号通路的结构及其对MI/RI的影响

并回顾了中医药调节Nrf2/HO-1通路在MI/RI治疗中的最新研究. 所提供的见解旨在为MI/RI的预防和治疗奠定理论基础.

Abstract

Acute myocardial infarction (AMI)

characterized by high incidence and mortality rates

poses a significant public health threat. Reperfusion therapy

though the preferred treatment for AMI

often exacerbates cardiac damage

leading to myocardial ischemia/reperfusion injury (MI/RI). Consequently

the development of strategies to reduce MI/RI is an urgent priority in cardiovascular therapy. Chinese medicine

recognized for its multi-component

multi-pathway

and multi-target capabilities

provides a novel approach for alleviating MI/RI. A key area of interest is the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. This pathway is instrumental in regulating inflammatory responses

oxidative stress

apoptosis

endoplasmic reticulum stress

and ferroptosis in MI/RI. This paper presents a comprehensive overview of the Nrf2/HO-1 signaling pathway's structure and its influence on MI/RI. Additionally

it reviews the latest research on leveraging Chinese medicine to modulate the Nrf2/HO-1 pathway in MI/RI treatment.

关键词

核因子E2相关因子2/血红素加氧酶1信号通路心肌缺血/再灌注损伤中医机制

Keywords

nuclear factor E2-related factor 2/heme oxygenase-1 signaling pathwaymyocardial ischemia/reperfusion injuryChinese medicinemechanisms

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