Hypertensive renal damage (HRD) is a major cause of end-stage renal disease. Among the causes of end-stage renal disease

HRD accounts for nearly 34% of the total number of cases. Antihypertensive treatment is primarily drug-based

but therapeutic efficacy is less effective and can have serious side effects. Chinese medicine (CM) has significant advantages in the treatment of HRD. CM is rich in various active ingredients and has the property of targeting multiple targets and channels. Therefore

the regulatory network of CM on disease is complex. A large number of CM have been employed to treat HRD

either as single applications or as part of compound formulations. The key possible mechanisms of CM for HRD include regulation of the renin-angiotensin-aldosterone system

antioxidation

anti-inflammation

rescue of endothelial function

regulation of vasoactive substance secretion and obesity-related factors

etc. This review summarized and discussed the recent advance in the basic research mechanisms of CM interventions for HRD and pointed out the challenges and future prospects.