Mechanism of Astragaloside Ⅳ in Treatment of Renal Tubulointerstitial Fibrosis<sup>*</sup>

WANG Xin-ru; LUAN Jing-xiang; GUO Zhao-an

doi:10.1007/s11655-024-3805-6

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Mechanism of Astragaloside Ⅳ in Treatment of Renal Tubulointerstitial Fibrosis^*

Review | Updated：2025-04-22

- Mechanism of Astragaloside Ⅳ in Treatment of Renal Tubulointerstitial Fibrosis^*
- Chinese Journal of Integrative Medicine Vol. 31, Issue 5, Pages: 474-480(2025)
- Affiliations：
  
  1.First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan (250014), China
  2.Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan (250014), China
- Author bio：
  
  Prof. GUO Zhao-an, E-mail: gza63@163.com
- Funds：
- DOI：10.1007/s11655-024-3805-6
  CLC：
- Accepted：2023-12-07，
  
  Published Online：08 June 2024，
  
  Published：2025-05
- Accepted：
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WANG Xin-ru, LUAN Jing-xiang, GUO Zhao-an. Mechanism of Astragaloside Ⅳ in Treatment of Renal Tubulointerstitial Fibrosis^*[J]. Chinese journal of integrative medicine, 2025, 31(5): 474-480.
DOI：

WANG Xin-ru, LUAN Jing-xiang, GUO Zhao-an. Mechanism of Astragaloside Ⅳ in Treatment of Renal Tubulointerstitial Fibrosis^*[J]. Chinese journal of integrative medicine, 2025, 31(5): 474-480. DOI： 10.1007/s11655-024-3805-6.

摘要

Abstract

Tubulointerstitial fibrosis (TIF) is one of the key indicators in evaluating the renal function of patients. Mild TIF can cause a vicious cycle of renal tubular glomerular injury and aggravate renal disease. Therefore

studying the mechanisms underlying TIF is essential to identify therapeutic targets

thereby protecting the renal function of patients with timely intervention. Astragaloside Ⅳ (AS-Ⅳ) is a Chinese medicine component that has been shown to inhibit the occurrence and progression of TIF via multiple pathways. Previous studies have reported that AS-Ⅳ protected against TIF by inhibiting inflammation

autophagy

endoplasmic reticulum stress

macrophages

and transforming growth factor-β1

which laid the foundation for the development of a new preventive and therapeutic option for TIF.

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