Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine<sup>*</sup>

GAO Lei; LI Yun-jia; ZHAO Jia-min; LIAO Yu-xin; QIN Meng-chen; LI Jun-jie; SHI Hao; Wong Nai-Kei; LYU Zhi-ping; SHEN Jian-gang

doi:10.1007/s11655-024-3810-9

Your Location：

Home >

Browse articles >

Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*

Review | Updated：2025-04-22

- Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*
- Chinese Journal of Integrative Medicine Vol. 31, Issue 5, Pages: 462-473(2025)
- Affiliations：
  
  1.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou (510515), China
  2.The First Affiliated Hospital/the First Clinical Medicine School of Guangdong Pharmaceutical University, Guangzhou (510006), China
  3.State Key Discipline of Infectious Diseases, Shenzhen Third People's Hospital, the Second Affiliated Hospital, Shenzhen University, Shenzhen (518112), Guangdong Province, China
  4.School of Chinese Medicine, the University of Hong Kong, Hong Kong SAR, China
- Author bio：
  
  Prof. SHEN Jian-gang, E-mail: shenjg@hku.hk
- Funds：
- DOI：10.1007/s11655-024-3810-9
  CLC：
- Accepted：2024-03-04，
  
  Published Online：28 June 2024，
  
  Published：2025-05
- Accepted：
Scan QR Code
GAO Lei, LI Yun-jia, ZHAO Jia-min, et al. Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*[J]. Chinese journal of integrative medicine, 2025, 31(5): 462-473.
DOI：

GAO Lei, LI Yun-jia, ZHAO Jia-min, et al. Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*[J]. Chinese journal of integrative medicine, 2025, 31(5): 462-473. DOI： 10.1007/s11655-024-3810-9.

摘要

Abstract

Liver ischemia-reperfusion injury (LIRI) is a pathological process involving multiple injury factors and cell types

with different stages. Currently

protective drugs targeting a single condition are limited in efficacy

and interventions on immune cells will also be accompanied by a series of side effects. In the current bottleneck research stage

the multi-target and obvious clinical efficacy of Chinese medicine (CM) is expected to become a breakthrough point in the research and development of new drugs. In this review

we summarize the roles of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in various stages of hepatic ischemia-reperfusion and on various types of cells. Combined with the current research progress in reducing ROS/RNS with CM

new therapies and mechanisms for the treatment of hepatic ischemia-reperfusion are discussed.

关键词

Keywords

references

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Mechanism of Astragaloside Ⅳ in Treatment of Renal Tubulointerstitial Fibrosis^*

Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review

Research Progress of Chinese Medicine Monomers in Treatment of Cholangiocarcinoma

Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

Progress on Regulation of NLRP3 Inflammasome by Chinese Medicine in Treatment of Ulcerative Colitis

Related Author

WANG Xin-ru

LUAN Jing-xiang

GUO Zhao-an

ZHU Bo-yu

LIU Zhi-chao

ZHAO Zhen-xi

HUANG Hui-ping

ZHANG Na

Related Institution

First Clinical Medical College, Shandong University of Traditional Chinese Medicine

Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Department of Rheumatology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine

Department of General Surgery, the Second Hospital of Dalian Medical University

Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰