Quercetin Confers Protection against Sepsis-Related Acute Respiratory Distress Syndrome by Suppressing ROS/p38 MAPK Pathway<sup>*</sup>

DING Wei-chao; CHEN Juan; LI Quan; REN Yi; WANG Meng-meng; ZHANG Wei; JI Xiao-hang; WU Xin-yao; NIE Shi-nan; HUANG Chang-bao; SUN Zhao-rui

doi:10.1007/s11655-025-3927-5

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Quercetin Confers Protection against Sepsis-Related Acute Respiratory Distress Syndrome by Suppressing ROS/p38 MAPK Pathway^*

Original Article | Updated：2025-10-23

- Quercetin Confers Protection against Sepsis-Related Acute Respiratory Distress Syndrome by Suppressing ROS/p38 MAPK Pathway^*
- Chinese Journal of Integrative Medicine Vol. 31, Issue 11, Pages: 1011-1020(2025)
- Affiliations：
  
  1.Department of Emergency Medicine, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province (221002), China
  2.Department of Emergency Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing (210002), China
  3.Department of Emergency Medicine, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing (210002), China
  4.Department of Emergency Medicine, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu Province (221000), China
  5.Intensive Care Unit, Suqian First Hospital, Suqian, Jiangsu Province (223800), China
  6.Department of Emergency Medicine, the First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui Province (241000), China
- Author bio：
  
  Prof. SUN Zhao-rui, E-mail: sunzhr84@163.com
- Funds：
- DOI：10.1007/s11655-025-3927-5
  CLC：
- Accepted：11 November 2024，
  
  Published Online：24 June 2025，
  
  Published：2025-11
- Accepted：
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DING Wei-chao, CHEN Juan, LI Quan, et al. Quercetin Confers Protection against Sepsis-Related Acute Respiratory Distress Syndrome by Suppressing ROS/p38 MAPK Pathway^*[J]. Chinese journal of integrative medicine, 2025, 31(11): 1011-1020.
DOI：

DING Wei-chao, CHEN Juan, LI Quan, et al. Quercetin Confers Protection against Sepsis-Related Acute Respiratory Distress Syndrome by Suppressing ROS/p38 MAPK Pathway^*[J]. Chinese journal of integrative medicine, 2025, 31(11): 1011-1020. DOI： 10.1007/s11655-025-3927-5.

摘要

Abstract

Objective:

To identify the underlying mechanism by which quercetin (Que) alleviates sepsis-related acute respiratory distress syndrome (ARDS).

Methods:

In vivo

C57BL/6 mice were assigned to sham

cecal ligation and puncture (CLP)

and CLP+Que (50 mg/kg) groups (

=15 per group) by using a random number table. The sepsis-related ARDS mouse model was established using the CLP method.

In vitro

the murine alveolar macrophages (MH-S) cells were classified into control

lipopolysaccharide (LPS)

LPS+Que (10 μmol/L)

and LPS+Que+acetylcysteine (NAC

5 mmol/L) groups. The effect of Que on oxidative stress

inflammation

and apoptosis in mice lungs and MH-S cells was determined

and the mechanism with reactive oxygen s

pecies (ROS)/p38 mitogen-activated protein kinase (MAPK) pathway was also explored both

in vivo

and

in vitro

Results:

Que alleviated lung injury in mice

as reflected by a reversal of pulmonary histopathologic changes as well as a reduction in lung wet/dry weight ratio and neutrophil infiltration (

0.05 or

0.01). Additionally

Que improved the survival rate and relieved gas exchange impairment in mice (

0.01). Que treatment also remarkedly reduced malondialdehyde formation

superoxide dismutase and catalase depletion

and cell apoptosis both

in vivo

and

in vitro

(

0.05 or

0.01). Moreover

Que treatment diminished the release of inflammatory factors interleukin (IL)-1β

tumor necrosis factor-α

and IL-6 both

in vivo

and

in vitro

(

0.05 or

0.01). Mechanistic investigation clarified that Que administration led to a decline in the phosphorylation of p38 MAPK in addition to the suppression of ROS expression (

0.01). Furthermore

in LPS-induced MH-S cells

ROS inhibitor NAC further inhibited ROS/p38 MAPK pathway

as well as oxidative stress

inflammation

and cell apoptosis on the basis of Que treatment (

0.05 or

0.01).

Conclusion:

Que was found to exert anti-oxidative

anti-inflammatory

and anti-apoptotic effects by suppressing the ROS/p38 MAPK pathway

thereby conferring protection for mice against sepsis-related ARDS.

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