

FOLLOWUS
The Second Clinical Medical College, Binzhou Medical University, Yantai, Shandong Province (264003), China
Breast Surgery Department, Yantai Yuhuangding Hospital, Yantai, Shandong Province (264000), China
Oncology Department, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong Province (264000), China
College of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong Province (264003), China
Department of Aging Medicine, Binzhou Medical University, Yantai, Shandong Province (264003), China
Correspondence to: LI Xing-hua, E-mail: lixh2023@bzmc.edu.cn
Accepted:23 July 2025,
Published:2026-11
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GUO Ji-qing, LIU Yan-qing, GAO Cai-xia, et al. Advances of Anti-aging Mechanism and Clinical Application of Salvia miltiorrhiza[J]. Chinese Journal of Integrative Medicine, 2026, 32(11): 1033-1040.
GUO Ji-qing, LIU Yan-qing, GAO Cai-xia, et al. Advances of Anti-aging Mechanism and Clinical Application of Salvia miltiorrhiza[J]. Chinese Journal of Integrative Medicine, 2026, 32(11): 1033-1040. DOI: 10.1007/s11655-025-4027-2.
McHugh D, Gil J. Senescence and aging: causes, consequences, and therapeutic avenues. J Cell Biol 2018;217:65-77
Lee DJW, Hodzic KA, Maier AB. Targeting ageing with rapamycin and its derivatives in humans: a systematic review. Lancet Healthy Longev 2024;5:e152-e162.
Bjelakovic G, Nikolova D, Gluud LL, et al. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2012;2012:CD007176.
Benjamin C, Crews R. Nicotinamide mononucleotide supplementation: understanding metabolic variability and clinical implications. Metabolites 2024;14:341.
Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China (2020 edition). Volume Ⅰ. 11th ed. Beijing: China Medical Science Press; 2020:77-79.
Lian B, Zeng R, Chen Y, et al. Sodium tanshinone ⅡA sulfonate for acute myocardial infarction: a systematic review and metaanalysis. J Tradit Chin Med 2021;41:26-35.
Huang YJ, Liu JY, Zhang YY, et al. Network meta-analysis of different Chinese patent medicine injections for promoting blood circulation and resolving stasis to prevent no-reflow after PCI. China J Chin Mater Med (Chin) 2021;52:5971-5983.
Wan XH, Wang YL, Zhou CZ, et al. Research progress on chemical constituents and pharmacological effects of Salvia miltiorrhiza. Chin Tradit Herb Drugs (Chin) 2020;51:788-798.
Zhao H, Han B, Li X, et al. Salvia miltiorrhiza in breast cancer treatment: a review of its phytochemistry, derivatives, nanoparticles, and potential mechanisms. Front Pharmacol 2022;13:872085.
Luo L, Xue J, Shao Z, et al. Recent developments in Salvia miltiorrhiza polysaccharides: isolation, purification, structural characteristics and biological activities. Front Pharmacol 2023;14:1139201.
Xiao Z, Liu W, Mu YP, et al. Pharmacological effects of salvianolic acid B against oxidative damage. Front Pharmacol 2020;11:572373.
Zhang L, Liu Y, Zhang Q, et al. Salvia miltiorrhiza polysaccharide mitigates AFB1-induced liver injury in rabbits. Ecotoxicol Environ Saf 2024;276:116344.
Cui WB, Zhang ZP, Bai X, et al. Cryptotanshinone alleviates oxidative stress and reduces the level of abnormally aggregated protein in caenorhabditis elegans AD models. Int J Mol Sci 2022;23:10030.
Vega Joubert MB, Ingaramo P, Oliva ME, et al. Salvia hispanica L. (chia) seed ameliorates liver injury and oxidative stress by modulating Nrf2 and NFκB expression in sucrose-rich diet-fed rats. Food Funct 2022;13:7333-7345.
Zeng M, Feng A, Ren Y, et al. Salvia miltiorrhiza Bunge extract and Przewalskin ameliorate bleomycin-induced pulmonary fibrosis by inhibition of apoptosis, oxidative stress and collagen deposition via the TGF-β1 pathway. Phytomedicine 2024;125:155339.
Wang X, Wang WM, Han H, et al. Tanshinone ⅡA protected against lipopolysaccharide-induced brain injury through the protective effect of the blood-brain barrier and the suppression of oxidant stress and inflammatory response. Food Funct 2022;13:8304-8312.
Chang CC, Chang YC, Hu WL, et al. Oxidative stress and Salvia miltiorrhiza in aging-associated cardiovascular diseases. Oxid Med Cell Longev 2016;2016:4797102.
Zeng X, Zhang YD, Ma RY, et al. Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3- exosome axis. Mil Med Res 2022;9:25.
Chen Q, Xu Q, Zhu H, et al. Salvianolic acid B promotes angiogenesis and inhibits cardiomyocyte apoptosis by regulating autophagy in myocardial ischemia. Chin Med 2023;18:155.
Wu X, Liu L, Zheng Q, et al. Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2. Acta Pharm Sin B 2021;11:3553-3566.
Qian S, Qian Y, Huo D, et al. Tanshinone ⅡA protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1. Eur J Pharmacol 2019;857:172419.
Meng H, Wu J, Shen L, et al. Microwave assisted extraction, characterization of a polysaccharide from Salvia miltiorrhiza Bunge and its antioxidant effects via ferroptosis- mediated activation of the Nrf2/HO-1 pathway. Int J Biol Macromol 2022;215:398-412.
Campisi J, Kapahi P, Lithgow GJ, et al. From discoveries in ageing research to therapeutics for healthy ageing. Nature 2019;571:183-192.
Guo W, Xu X, Xiao Y, et al. Salvianolic acid C attenuates cerebral ischemic injury through inhibiting neuroinflammation via the TLR4-TREM1-NF-κB pathway. Chin Med 2024;19:46.
Chien LH, Wu CT, Deng JS, et al. Salvianolic acid C protects against cisplatin-induced acute kidney injury through attenuation of inflammation, oxidative stress and apoptotic effects and activation of the CaMKK-AMPK- Sirt1-associated signaling pathway in mouse models. Antioxidants (Basel) 2021;10:1620.
Chien MY, Chuang CH, Chern CM, et al. Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice. Free Radic Biol Med 2016;99:508-519.
Zhang Q, Zeng M, Zhang B, et al. Salvianolactone acid A isolated from Salvia miltiorrhiza ameliorates lipopolysaccharideinduced acute lung injury in mice by regulating PPAR-γ. Phytomedicine 2022;105:154386.
Sieniawska E, Sawicki R, Marchev AS, et al. Tanshinones from Salvia miltiorrhiza inhibit mycobacterium tuberculosis via disruption of the cell envelope surface and oxidative stress. Food Chem Toxicol 2021;156:112405.
Baechle JJ, Chen N, Makhijani P, et al. Chronic inflammation and the hallmarks of aging. Mol Metab 2023;74:101755.
Ghazaei C. Advances in the study of bacterial toxins, their roles and mechanisms in pathogenesis. Malays J Med Sci 2022;29:4-17.
Jiang JM, Chen G, Chen YY, et al. The anti-infective activity of Salvia miltiorrhiza against Staphylococcus aureus by attenuating accessory gene regulator system-mediated virulence. Food Funct 2022;13:5050-5060.
Gao D, Mendoza A, Lu S, et al. Immunomodulatory effects of Danshen (Salvia miltiorrhiza) in BALB/c mice. ISRN Inflamm 2012;2012:954032.
Ji HY, Dai KY, Liu C, et al. Preparation, antioxidant and immunoregulatory activities of a macromolecular glycoprotein from Salvia miltiorrhiza. Foods 2022;11:705.
Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature 2013;496:445-455.
Li J, Chen YH, Li LZ, et al. Omics and transgenic analyses reveal that salvianolic acid B exhibits its anti-inflammatory effects through inhibiting the Mincle-Syk-related pathway in macrophages. J Proteome Res 2021;20:3734-3748.
Chen Y, Li H, Li M, et al. Salvia miltiorrhiza polysaccharide activates T lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways. J Ethnopharmacol 2017;200:165-173.
Parab A, Bhatt LK. T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction. Immunopharmacol Immunotoxicol 2024;46:378-384.
Hur YG, Suh CH, Kim S, et al. Rosmarinic acid induces apoptosis of activated T cells from rheumatoid arthritis patients via mitochondrial pathway. J Clin Immunol 2007;27:36-45.
Zhu Y, Yang X, Gu P, et al. The structural characterization of a polysaccharide from the dried root of Salvia miltiorrhiza and its use as a vaccine adjuvant to induce humoral and cellular immune responses. Int J Mol Sci 2024;25:7765.
Ye T, Xiong D, Chen L, et al. Effect of Danshen on TLR2- triggered inflammation in macrophages. Phytomedicine 2020;70:153228.
Zou T, Gao S, Yu Z, et al. Salvianolic acid B inhibits RAW264.7 cell polarization towards the M1 phenotype by inhibiting NF-κB and Akt/mTOR pathway activation. Sci Rep 2022;12:13857.
Guo Y, Yang JH, He Y, et al. Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist. Phytomedicine 2022;94:153849.
Qin R, Dai S, Zhang X, et al. Danshen attenuates intervertebral disc degeneration via antioxidation in SD rats. Oxid Med Cell Longev 2020;2020:6660429.
Wang C, Zhao R, Li B, et al. An in vivo and in vitro study: High-dosage Danshen injection induces peripheral vascular endothelial cells injury. Hum Exp Toxicol 2016;35:404-417.
Li J, Wang W, Huang H, et al. Tanshinone Ⅰ, tanshinone ⅡA, and cryptotanshinone: key bioactive components modulating vascular smooth muscle cell function. Front Pharmacol 2025;16:1688338.
Xue Y, Zhang L, Zhang L, et al. Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1/ ROS/mtDNA pathways without increasing bleeding risk. Phytomedicine 2022;104:154271.
Mao D, Wang H, Guo H, et al. Tanshinone ⅡA normalized hepatocellular carcinoma vessels and enhanced PD-1 inhibitor efficacy by inhibiting ELTD1. Phytomedicine 2024;123:155191.
Zhang Z, Ji J, Zhang D, et al. Protective effects and potential mechanism of salvianolic acid B on sodium laurate-induced thromboangiitis obliterans in rats. Phytomedicine 2020;66:153110.
Yang Y, Yuan L, Xiong H, et al. Inhibition of vascular calcification by Compound Danshen Dripping Pill through multiple mechanisms. Phytomedicine 2024;129:155618.
Son J, Phong NV, Cha MR, et al. AMPK-mediated hypolipidemic effects of a Salvia miltiorrhiza and Paeonia lactiflora mixed extract on high-fat diet-induced liver triglyceride accumulation: an in vivo and in vitro study. Nutrients 2024;16:3189.
Neves MAD, Ni TT, Mackeigan DT, et al. Salvianolic acid B inhibits thrombosis and directly blocks the thrombin catalytic site. Res Pract Thromb Haemost 2024;8:102443.
Hou WC, Tsay HS, Liang HJ, et al. Improving abnormal hemorheological parameters in aging guinea pigs by watersoluble extracts of Salvia miltiorrhiza Bunge. J Ethnopharmacol 2007;111:483-489.
Wu R, Zhou Y, Xu H, et al. Aqueous extract of Salvia miltiorrhiza Bunge reduces blood pressure through inhibiting oxidative stress, inflammation and fibrosis of adventitia in primary hypertension. Front Pharmacol 2023;14:1093669.
Li X, Liu R, Liu W, et al. Panax quinquefolium L. and Salvia miltiorrhiza Bunge. Enhances angiogenesis by regulating the miR-155-5p/HIF-1α/VEGF axis in acute myocardial infarction. Drug Des Devel Ther 2023;17:3249-3267.
Song Q, Zhang Y, Han X, et al. Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and in vitro. Biomed Pharmacother 2019;109:945-956.
Su W, Lv M, Wang D, et al. Tanshinone ⅡA alleviates traumatic brain injury by reducing ischemia-reperfusion via the miR-124-5p/ FoxO1 axis. Mediators Inflamm 2024;2024:7459054.
Wu C, Duan F, Yang R, et al. 15, 16-Dihydrotanshinone I protects against ischemic stroke by inhibiting ferroptosis via the activation of nuclear factor erythroid 2-related factor 2. Phytomedicine 2023;114:154790.
Li J, Wang N, Huang Q, et al. Acute treatment with salvianolic acid A produces neuroprotection in stroke models by inducing excitatory long-term synaptic depression. ACS Chem Neurosci 2025;16:659-672.
Ozarowski M, Mikolajczak PL, Piasecka A, et al. Effect of Salvia miltiorrhiza root extract on brain acetylcholinesterase and butyrylcholinesterase activities, their mRNA levels and memory evaluation in rats. Physiol Behav 2017;173:223-230.
Chen S, Sui YB. Research progress on Salvia miltiorrhiza and related preparations in treating coronary heart disease. J Emerg Tradit Chin Med (Chin) 2024;33:2237-2240.
He ZG, Zou Y. Effects of Salvia miltiorrhiza and Chuanxiong extract injection combined with trimetazidine on electrocardiogram and cardiac function in patients with unstable angina. J Clin Res Med (Chin) 2020;41:747-749.
Yang C, Mu Y, Li S, et al. Tanshinone ⅡA: a Chinese herbal ingredient for the treatment of atherosclerosis. Front Pharmacol 2023;14:1321880.
Liu L, Li J, Zhang Y, et al. Salvianolic acid B inhibits platelets as a P2Y12 antagonist and PDE inhibitor: evidence from clinic to laboratory. Thromb Res 2014;134:866-876.
Yang Y, Shao M, Yao J, et al. Neocryptotanshinone protects against myocardial ischemia-reperfusion injury by promoting autolysosome degradation of protein aggregates via the ERK1/2- Nrf2-LAMP2 pathway. Phytomedicine 2023;110:154625.
Wu YT, Zhang GY, Li L, et al. Salvia miltiorrhiza suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling. J Ethnopharmacol 2024;330:118214.
Wang J, Ye W, Zou J, et al. Targeting the smooth muscle cell Keap1-Nrf2-GSDMD-pyroptosis axis by cryptotanshinone prevents abdominal aortic aneurysm formation. Theranostics 2024;14:6516-6542.
Lyu MY, Yang Y, Liu JL, et al. Efficacy and safety of Lutai Danshen Baishao granules for treating female melasma: a randomized, double-blind, placebo-controlled trial. J Tradit Chin Med Sci 2025;12:71-78.
Xie N, Tang WY. Application of Salvia miltiorrhiza in traditional Chinese medicine in modern cosmetics. Jilin J Tradit Chin Med (Chin) 2018;38:700-702.
Meng H, Zhao MM, Yang RY, et al. Salvianolic acid B regulates collagen synthesis: indirect influence on human dermal fibroblasts through the microvascular endothelial cell pathway. J Cosmet Dermatol 2022;21:3007-3015.
Sun JM, Liu YX, Tsai YT, et al. Salvianolic acid B protects against UVB-induced HaCaT cell senescence and skin aging through NRF2 activation and ROS scavenging. J Photochem Photobiol B 2025;266:113139.
Tao S, Justiniano R, Zhang DD, et al. The Nrf2-inducers tanshinone Ⅰ and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV. Redox Biol 2013;1:532-541.
Zuo Z, He S, Qiu Y, et al. Salvianolic acid A prevents UVinduced skin damage by inhibiting the cGAS-STING pathway. Int Immunopharmacol 2024;132:111971.
Liu CD, Liu NN, Zhang S, et al. Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway. Acta Pharmacol Sin 2021;42:370-381.
Liu XQ, Hu T, Wu GL, et al. Tanshinone ⅡA, the key compound in Salvia miltiorrhiza, improves cognitive impairment by upregulating Aβ-degrading enzymes in APP/PS1 mice. Int J Biol Macromol 2024;254:127923.
Zhang W, Zheng L, Zhang Z, et al. Protective effect of a watersoluble polysaccharide from Salvia miltiorrhiza Bunge on insulin resistance in rats. Carbohydr Polym 2012;89:890-898.
Nagappan A, Kim JH, Jung DY, et al. Cryptotanshinone from the Salvia miltiorrhiza Bunge attenuates ethanol- induced liver injury by activation of AMPK/SIRT1 and Nrf2 signaling pathways. Int J Mol Sci 2019;21:265.
Xiang X, Cai HD, Su SL, et al. Salvia miltiorrhiza protects against diabetic nephropathy through metabolome regulation and wnt/β-catenin and TGF-β signaling inhibition. Pharmacol Res 2019;139:26-40.
Bai J, Qin Q, Li S, et al. Salvia miltiorrhiza inhibited lung cancer through aerobic glycolysis suppression. J Ethnopharmacol 2024;331:118281.
Lin H, Sui H, Yu Y, et al. Dihydrotanshinone Ⅰ potentiates the anti-tumor activity of cisplatin by activating ROS- mediated ER stress through targeting HSPD1 in lung cancer cells. Eur J Pharmacol 2025;994:177378.
Qin T, Rasul A, Sarfraz A, et al. Salvianolic acid A & B: potential cytotoxic polyphenols in battle against cancer via targeting multiple signaling pathways. Int J Biol Sci 2019;15:2256-2264.
Jin Q, Hu X, Deng Y, et al. Four new depsides isolated from Salvia miltiorrhiza and their significant nerve-protective activities. Molecules 2018;23:3274.
Tang J, Zhao X. Research progress on regulation of immune response by tanshinones and salvianolic acids of Danshen (Salvia miltiorrhiza Bunge). Molecules 2024;29:1201.
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