

FOLLOWUS
Institute of Basic Medical Science, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
Correspondence to: Prof. REN Jian-xun, E-mail: rjx131@sina.com
Accepted:05 November 2025,
Published:2026-11
Scan QR Code
FU Chang, ZHANG Ying, CHAI Sai-song, et al. Effect of Chinese Herbal Medicine and Active Ingredients on Diabetic Cardiomyopathy: Focus on Pyroptosis[J]. Chinese Journal of Integrative Medicine, 2026, 32(11): 1041-1047.
FU Chang, ZHANG Ying, CHAI Sai-song, et al. Effect of Chinese Herbal Medicine and Active Ingredients on Diabetic Cardiomyopathy: Focus on Pyroptosis[J]. Chinese Journal of Integrative Medicine, 2026, 32(11): 1041-1047. DOI: 10.1007/s11655-026-4040-0.
Shou Y, Li X, Fang Q, et al. Progress in the treatment of diabetic cardiomyopathy, a systematic review. Pharmacol Res Perspect 2024;12:e1177.
Seferovi PM, Paulus WJ, Rosano G, et al. Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases. Europ J Heart Failure 2024;26:1893-1903.
Jia G, Hill M A, Sowers J R. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ Res 2018;122:624-638.
Wang GJ, Ma TY, Huang K, et al. Role of pyroptosis in diabetic cardiomyopathy: an updated review. Front Endocrinol (Lausanne) 2022;12:791848.
Ma TY, Wang GJ, Huang K, et al. Pyroptosis and its regulation in diabetic cardiomyopathy. Front Physiol 2022;13:918765.
Toldo S, Abbate A. The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases Nat Rev Cardiol 2024;21:219-237.
Lv S, Wang H, Li X. The role of the interplay between autophagy and NLRP3 inflammasome in metabolic disorders. Front Cell Dev Biol 2021;16:634118.
Tang Z, Wang P, Dong C, et al. Oxidative stress signaling mediated pathogenesis of diabetic cardiomyopathy. Oxid Med Cell Longev 2022;2022:5913374.
Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011;17:179-188.
Liu Z, Chen Y, Mei Y, et al. Gasdermin D-mediated pyroptosis in diabetic cardiomyopathy: molecular mechanisms and pharmacological implications. Molecules 2023;28:7813.
Ding J, Wang K, Liu W, et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 2016;535:111-116.
Lee WS, Kim J. Diabetic cardiomyopathy: where we are and where we are going. Korean J Intern Med 2017;32:404.
Li B, Nasser MI, Masood M, et al. Efficiency of traditional Chinese medicine targeting the Nrf2/HO-1 signaling pathway. Biomed Pharmacother 2020;126:110074.
Liu Z, Wang C, Yang J, et al. Crystal structures of the fulllength murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization. Immunity 2019;51:43-49.
Zhang L, Ai C, Bai M, et al. NLRP3 inflammasome/ pyroptosis: a key driving force in diabetic cardiomyopathy. Int J Mol Sci 2022;23:10632.
Chen L, Ma X, Liu W, et al. Targeting pyroptosis through lipopolysaccharide-triggered noncanonical pathway for safe and efficient cancer immunotherapy. Nano Lett 2023;23:8725-8733.
Luan F, Lei Z, Peng X, et al. Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis. Chem Biol Interact 2022;368:110245.
Jiang M, Qi L, Li L, et al. Caspase-8: a key protein of crosstalk signal way in "PANoptosis" in cancer. Int J Cancer 2021;149:1408-1420.
Zhang J, Xia L, Zhang F, et al. A novel mechanism of diabetic vascular endothelial dysfunction: hypoadiponectinemiainduced NLRP3 inflammasome activation. Biochim Biophys Acta Mol Basis Dis 2017;1863:1556-1567.
Xie Y, Huang Y, Ling X, et al. Chemerin/CMKLR1 axis promotes inflammation and pyroptosis by activating NLRP3 inflammasome in diabetic cardiomyopathy rat. Front Physiol 2020;11:381.
Zhang LX, Ai CC, Guo CL, et al. UCP2 inhibition exaggerates diabetic cardiomyopathy by facilitating the activation of NLRP3 and pyroptosis. Diabetol Metab Syndr 2025;17:267.
Ding N, Yin Z, Chen C. Targeting non-coding RNAs in sEVs: the biological functions and potential therapeutic strategy of diabetic cardiomyopathy. Biomed Pharmacother 2023;163:114836.
Wu A, Sun W, Mou F. lncRNA MALAT1 promotes high glucose induced H9c2 cardiomyocyte pyroptosis by downregulating miR 141 3p expression. Mol Med Rep 2021;23:259.
Yang F, Qin Y, Lv J, et al. LncRNA KCNQ1OT1 mediates pyroptosis in diabetic cardiomyopathy. Cell Physiol Biochem 2018;50:1230-1244.
Xu Y, Fang H, Xu Q, et al. LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR. Cell Cycle 2020;19:3054-3065.
Yuan Q, Sun Y, Yang F, et al. CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes. Signal Transduct Target Ther 2023;8:99.
Yang F, Li A, Qin Y, et al. A novel circular RNA mediates pyroptosis of diabetic cardiomyopathy by functioning as a competing endogenous RNA. Mol Ther Nucleic Acids 2019;6:636-643.
Zhang B, Wu H, Zhang J, et al. The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy. Mol Cell Biochem 2024;479:1673-1696.
Zhang W, Zhou J, Kang PF, et al. Quercetin inhibits pyroptosis in diabetic cardiomyopathy through the Nrf2 pathway. J Diabetes Res 2022;2022:9723632.
Sun SC, Peng Y, Zhang XR, et al. Puerarin inhibits NLRP3/caspase-1/GSDMD-mediated pyroptosis via P2X7 receptor in cardiomyocytes and macrophages. Int J Mol Sci 2023;24:13169.
Sun S, Dawuti A, Gong D, et al. Puerarin-V improve mitochondrial respiration and cardiac function in a rat model of diabetic cardiomyopathy via inhibiting pyroptosis pathway through P2X7 receptors. Int J Mol Sci 2022;23:13015.
Zhang HL, Chen X, Zong BB, et al. Gypenosides improve diabetic cardiomyopathy by inhibiting ROS-mediated NLRP3 inflammasome activation. J Cell Mol Med 2018;22:4437-4448.
Zhang W, Kang PF, Zhou J, et al. Curcumin improves diabetic cardiomyopathy by inhibiting pyroptosis through AKT/Nrf2/ ARE pathway. Mediators Inflamm 2023;2023:3906043.
Wang G, Song X, Zhao L, et al. Resveratrol prevents diabetic cardiomyopathy by increasing Nrf2 expression and transcriptional activity. Biomed Res Int 2018;12:2150218.
Liu C, Han Y, Gu X, et al. Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy. Redox Biol 2021;46:102098.
Ji B, Yuan K, Li J, et al. Protocatechualdehyde restores endothelial dysfunction in streptozotocin-induced diabetic rats. Ann Transl Med 2021;9:711.
Guo XL, Ma FF, Zhou HJ. Inhibitory effect and mechanism of arbutin on myocardial injury in diabetic cardiomyopathy mice. Shandong Med J (Chin) 2023;63:5-10.
Yang L, Cheng CF, Li ZF, et al. Berberine blocks inflammasome activation and alleviates diabetic cardiomyopathy via the miR- 18a-3p/GSDMD pathway. Int J Mol Med 2023;51:49.
You LT, Yang CJ, Du YY, et al. A systematic review of the pharmacology, toxicology and pharmacokinetics of matrine. Front pharmacol 2020;11:01067.
Zou G, Zhong W, Wu F, et al. Catalpol attenuates cardiomyocyte apoptosis in diabetic cardiomyopathy via Neat1/miR-140-5p/HDAC4 axis. Biochimie 2019;165:90-99.
Yin B, Hou XW, Lu ML. Astragaloside Ⅳ attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways. Acta Pharmacol Sin 2019;40:599-607.
Lei S, Lu X, Yan L, et al. Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphateprotein kinase G signaling in diabetic mice. J Diabetes Investig 2024;15:823-834.
Liu H, Lan W. Alleviation of myocardial inflammation in diabetic rats by flavonoid extract of helichrysum arenarium and its effect on damaged myocardial cells induced by high glucose. Front Surg 2022;14:873010.
Fu Y, Chen NN, Peng JM, et al. Mechanism of action of trichosanthes, allium, and pinellia decoction in reducing myocardial cell apoptosis in type 2 diabetic rats with myocardial ischemia. J Nankai Univ (Chin) 2025;58:10-15.
Yan M, Li L, Wang Q, et al. The Chinese herbal medicine Fufang Zhenzhu Tiaozhi protects against diabetic cardiomyopathy by alleviating cardiac lipotoxicity-induced oxidative stress and NLRP3-dependent inflammasome activation Biomed Pharmacother 2022;148:112709.
Yin G, Hu ZQ, Li JY, et al. Shengmai Injection inhibits palmitic acid-induced myocardial cell inflammatory death via regulating NLRP3 inflammasome activation. Heliyon 2023;9:e21522.
Zhang M, Sun X, Gao X, et al. Huangqi Guizhi Wuwu Decoction alleviates diabetic cardiovascular autonomic neuropathy v ia AMPK/Tr kA/TRPM7 pathway. J Ethnopharmacol 2025;25:119644.
Chang LJ. Clinical study on Huangqi Yangxin Decoction in treating type 2 diabetic cardiomyopathy with yin deficiency and blood stasis syndrome. Guangming J Chin Med (Chin) 2023;38:2316-2319.
Zhao W, Yuan Y, Zhao H, et al. Aqueous extract of Salvia miltiorrhiza Bunge-Radix Puerariae herb pair ameliorates diabetic vascular injury by inhibiting oxidative stress in streptozotocin-induced diabetic rats. Food Chem Toxicol 2019;129:97-107.
Zhang YN, Ding YJ, Xu HZ, et al. Effects of Jiawei Taohe Chengqi Decoction with rhubarb on NLRP3 inflammasome in rats with diabetic cardiomyopathy. Chin J Exp Formula (Chin) 2022;28:59-65.
Wang Y, Guo YC, Liang QL, et al. Intervention effects of Shenmai Injection on myocardial fibrosis in rats with diabetic cardiomyopathy and exploration of related mechanisms. Chin J Pathophysiol (Chin) 2014;30:449-453.
Jiang H, Hu XW, Deng X, et al. Liuwei Dihuang Pills ameliorate renal injury in experimental type 2 diabetes mellitus rat by regulating host-gut microbiota interaction. Front Pharmacol 2026;16:1715600.
0
Views
2
Downloads
0
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution
京公网安备11010802024621