Latest Issue
Vol. 1 ， Issue 2 ， 1995
- Keywords：Quercetin;Blood Glucose Level;Traditional Chinese Medicine;herbal medicine;Naringenin
- 890
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- 837
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Published：2021-08-27 - Abstract：The effects of silybin on erythrocytic sorbitol level and peripheral nerve conduction velocity were studied in 14 cases of non-insulin dependent diabetes mellitus (NIDDM). After oral administration of silybin 231 mg/day for 4 weeks, no blood glucose change was observed in patients with NIDDM, while the erythrocytic sorbitol level was significantly decreased from 72.55±21.61 to 39.53±14.94 nmol/g · Hb (P<0.01). At the same time, peripheral nerve conduction velocity was also improved. These results indicate that silybin is an effective aldose reductase inhibitor which can improve the disorder of polyol pathway in NIDDM patients and prevent chronic complications of diabetes.Keywords：Silybin;sorbitol;chronic complications of diabetes;Aldose Reductase Inhibitor
- 818
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- 831
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Published：2021-08-27 - Keywords：Diabetic Neuropathy;Silybin;Aldose Reductase Inhibitor;Sorbinil;Tolrestat
- 22
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- 0
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Published：2021-08-27 - Abstract：Blood flow in the lower leg was determined in 50 cases of non-insulin dependent diabetes mellitus using an XLJ-2 bipolar rheoencephalometry impedance rheogram. In patients with leg pain (85 legs) and diabetic foot (15 legs), the blood flow of the lower leg was decreased as compared with healthy legs (P<0.01∼0.001). The group with diabetic foot showed a bigger decrease compared with the leg pain group (P<0.05). After treatment with the principle of vitalizing blood and solubilizing thrombus, 22 cases with leg pain (32 legs) showed a significant increase of blood flow in the lower leg (P<0.001). The group with diabetic foot failed to show any significant increase, indicating the importance of early treatment. This method of determining blood flow in the lower leg will help early discovery of abnormal changes of blood supply in the lower leg. Treatment with the principle of vitalizing blood and solubilizing thrombus can help improve the conditions of the patients.Keywords：blood flow in the lower leg;diabetic foot;Qi-Yin deficiency with blood stasis;deficiency of both Yin and Yang with blood stasis
- 760
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- 763
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Published：2021-08-27 - Abstract：The effects of berberine on 60 cases with non-insulin dependent diabetes mellitus and experimental research results were observed in this study. The results suggest berberine has significant effects on non-insulin dependent diabetes mellitus patients and experimental diabetes in animals in the reduction of blood glucose levels. The clinical symptoms basically disappeared and the level of serum insulin rose. The total effective rate was up to 90 percent and there were no significant side-effects. It was found that berberine has an effect on the recovery of pancreas islet β-cells, through pathological examination on the animal subjects.Keywords：Berberine;non-insulin dependent diabetes mellitus;animal model
- 877
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- 1010
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Published：2021-08-27 - Abstract：This study conducted clinical observation of the treatment of non-insulin dependent diabetes mellitus (type I) with Semen Persical decoction for purgation with addition (SPDPA) in comparison with a control group treated with glyburide. The results of the clinical observations show the total effective rate of SPDPA on 106 cases was 79%, which was equivalent to levels in the control group, but SPDPA was more effective in relieving symptoms. The animal experimental study showed SPDPA could reduce fasting blood sugar in diabetic patients and rats. Its mechanism may be due to improved secretion of insulin, inhibited excretion by the endocrine cell, increased endocrine pellet inhibition of insular β-cells and improved composition of hepatic glycogen. In traditional Chinese medical theory, the mechanism of therapeutic action of SPDPA in diabetes mellitus is based on synergistic regulation benefiting the vital energy and nourishing Yin, the activation of blood circulation to dissipate blood stasis and the loosening of the bowel to relieve constipation.Keywords：Semen Persical decoction for purgation;pharmacodynamics;non-insulin dependent diabetes mellitus;traditional Chinese medical therapy
- 864
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- 793
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Published：2021-08-27 - Abstract：Refined rhubarb tablets were used to treat 182 cases of acute hemorrhaging of the upper digestive tract with a total effective rate of 96.1% and an average hemostatic time of 2.8 days. Prospective and double blind comparative studies of the drug revealed that it had a remarkably higher hemostatic effect than compound western medicines (P<0.01) and was superior to crude rhubarb, which usually caused nausea and vomiting and had unstable therapeutic effects. Acute and subacute toxicity determinations, genetic toxicologic tests, as well as determinations of various indexes of blood vessels, pepsin, blood rheology, platelets, bleeding and blood coagulation factors were done, suggesting that refined rhubarb tablets were non-toxic, safe and effective in local hemostasis and general hemodilution-like hemostasis.Keywords：refined rhubarb tablets;acute hemorrhaging of upper digestive tract;hemostasis;hemostatic time
- 767
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- 770
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Published：2021-08-27 - Abstract：To seek an effective treatment to delay the development of chronic renal failure, the authors studied the effects of a therapy integrating Chinese and Western medicine with rhubarb as the main drug. Sixty hospitalized patients were divided into an integrated Chinese and Western medicine therapy group (test group, 30 cases) and a Western therapy group (control group, 30 cases). There were no differences in age, sex, underlying diseases and renal function of the two groups. The patients in both groups were treated for three weeks as a therapy course. The results show the levels of blood urea nitrogen and serum creatinine after treatment were higher than before treatment in the control group, but lower in the test group. The value of reciprocal coefficient (slope or b value) relationship between inverse serum creatinine slope and time in the control group was −1.198±3.931, but the slope (b value) in the test group was 0.125±2.252. There were no side-effects to be found in either group. The study suggests that integrated Chinese and Western medicine using rhubarb as a main drug can delay renal function deterioration and improve renal function in some cases.Keywords：chronic renal failure;rhubarb;treatment
- 864
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- 781
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Published：2021-08-27 - Abstract：The effects ofCordyceps sinensis (CS) on peripheral natural killer cells from healthy subjects and from leukemia patients were studied. The results showed CS could augment natural killer cell activity. The dose-dependent effect was found within the range of the dosage adopted for the tests (r=0.984,P<0.01; r=0.988,P<0.01). Furthermore, the results suggested CS could also improve CD16 marker expression on the surface of lymphocytes and the binding capacity of K562 cells. Cytotoxicity was not present when the peripheral blood mononuclear cells were co-incubated with CS. These results suggested CS could be exploited and utilized as a biological response modifier in the treatment of leukemia.Keywords：acute leukemia;Cordyceps sinensis;natural killer cells
- 772
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- 778
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Published：2021-08-27 - Abstract：The natural killer cell activity of peripheral blood mononuclear cells from 28 patients with systemic lupus erythematosus was measured using enzyme-release assay. The patients exhibited obviously decreased natural killer cell activity compared with the healthy subjects in the control group. The natural killer cell dysfunction was related to steroidal therapy, but not to three auto-antibodies. The release of a soluble natural killer cytotoxic factor by the peripheral blood mononuclear cells was tested by cytotoxicity assay induced in K562 cells. This release was significantly lower in the test group than in the control group. Pre-incubation of peripheral blood mononuclear cells withAstragalus membranaceus andTripterygium hypoglaucum considerably enhanced natural killer cytotoxicity by stimulating the release of soluble cytotoxic factors.Keywords：Astragalus membranaceus;Tripterygium hypoglaucum;natural killer cell activity;natural killer cytotoxic factor;systemic lupus erythematosus
- 824
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- 619
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Published：2021-08-27 - Abstract：Using Glyke, a Chinese Materia Medica, in treating 60 human immunodeficiency virus infected patients, the total effective rate was 35%, the rates of immunological improvement and stability were 68.3%∼90%, while those of symptoms amelioration were 35%∼64% respectively. Polymerase chain reaction was used to check one of two patients and revealed positive. Experimental study showed Glyke could inhibit simian immunodeficiency virus as well as enhance the patient’s immune function.Keywords：Glyke;human immunodeficiency virus infected patients;seronegative conversion
- 786
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- 801
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Published：2021-08-27 - Abstract：Sixty-seven cases of chronic hepatitis were treated with Radix Astragali. After treatment (2-month course), the clinical improvement rate in 38 cases of the Stagnation of the Liver-Qi and Deficiency of the Spleen type was 92.1%, and in 26 cases of the Deficiency of Liver Yin and Kidney Yin type was 88.5%, more effective than in the control group (P<0.05). The regulative effect to the levels of serum hormone was observed in the patients of the Stagnation of the Liver-Qi and Deficiency of the Spleen type treated with this medicine. The results showed that the levels of serum triiodothyronine, estradiol (female) and testosterone (male) were increased after treatment (1.40±1.38 ng/dl, 129.30±1.23 pg/ml and 496.24±1.47 ng/dl). Pre-treatment levels were 1.22±1.49 ng/dl, 104.60±1.45 pg/ml and 398. 17±1.55 ng/dl respectively (P<0.05); however, the level of serum prolactin (2.75±4.46 ng/ml) was lower after treatment than before treatment (3.20±3.82 ng/ml,P<0.05). No obvious changes were observed in the levels of serum follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, thyroxine, triiodothyronine uptake ratio and cortisol after treatment.Keywords：Radix Astragali;chronic hepatitis;serum hormone
- 835
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- 627
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- 0
Published：2021-08-27 - Abstract：The content of serum total bilirubin, serum alanine aminotransferase and hepatic enlargement were observed before and after the treatment for infantile hepatitis syndrome by using injections of Yinzhihuang. Peripheral blood T cell subproportions and levels of duodenal bilirubin were also detected in some patients. The results of this study suggest the injections of Yinzhihuang had a significant effect in resolving jaundice, but no effect in improving the disturbance of cellular immunity.Keywords：Yinzhihuang injection;infantile hepatitis syndrome;T cell subproportion
- 836
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- 729
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Published：2021-08-27 - Keywords：Hepatitis;Bilirubin;Chinese Medicine;Traditional Chinese Medicine;Cholestasis
- 37
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- 0
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Published：2021-08-27 - Abstract：To study the effects ofRheum officinale (RO) on epidermal growth factor (EGF) in renal hypertrophy in the diabetic rats were induced by streptozotocin. The results showed that renal hypertrophy occurred in the diabetic rats, but not in the RO-treated rats. Urine EGF was 38.2±16.6 ng/24 h at day 28 in the control, and it was significantly increased from day 7 in the diabetic rats (477.8±187.2 ng/24 h at day 7, 328.2±153.9 ng/24 h at day 28), while in the RO-treated rats it was significantly less than that in the diabetic rats (282.2±112.5 ng/24 h at day 7, 258.3±72.3 ng/24 h at day 28). Moreover, glomerular filtration rate and renal blood flow reduced in RO-treated diabetic rats as compared with streptozotocin diabetic rats. Because kidney is the main source of urine EGF and EGF has been shown to induce renal growth both in vitro and in vivo. It is indicated that EGF may be able to initiate renal hypertrophy in diabetic rats, and the effect of RO on the renal hypertrophy is probably relative to the inhibition of renal EGF production resulted from RO treatment.Keywords：kidney;hypertrophy;epidermal growth factor;diabetic rat
- 851
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- 791
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Published：2021-08-27 - Abstract：The authors have investigated the effect of Radix Ginseng on peroxidation injury in myocardium and erythrocytes of streptozocin-induced diabetic rats. In the ginseng administered group (ginseng solution 0.2 g/200 g body weight once daily lasting 15∼16 days), there was a significant decrease in the level of fasting blood glucose and lipid peroxide in myocardium and erythrocytes, in comparison with those of the model group (P<0.05). The superoxide dismutase activities in myocardium and erythrocytes of the ginseng group were increased (P<0.05), compared with those of the model group and the vitamin E treated group (vitamin E 10 mg/200 g·body weight once daily, lasting 15∼16 days). The results suggest that the mechanisms of antiperoxidation injury of ginseng might include the following: (1) lowering the level of fasting blood glucose, decreasing monosaccharide auto-oxidation and partially protecting the production of free radicals; (2) elevating the activity of enzymatic free radical scavenger in cells, such as superoxide dismutase; and (3) directly eliminating the superfluous free radicals.Keywords：Radix Ginseng;streptozocin;diabetes;lipid peroxide;superoxide dismutase
- 831
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- 724
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Published：2021-08-27 - Abstract：The inhibitory activities of more than 40 species of Chinese medicinal herbs or their single chemical components against simian immunodeficiency virus (SIV) have been studied. The study revealed that four species of medicinal herbs and a single chemical component had a more than 50% inhibition effect on SIV antigen expression, and the inhibitory rate of five other herbs on SIV antigen expression was between 30%∼50%. The results suggest Chinese medicinal herbs could inhibit SIV activity.Keywords：acquired immunodeficiency syndrome;Chinese medicinal herbs;simian immunodeficiency virus
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- 679
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Published：2021-08-27 - Keywords：Traditional Chinese Medicine;Tongue Color;Blood Pressure Time;Traditional Chinese Medicine Doctor;Modern Medical Science
- 762
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- 759
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Published：2021-08-27 - Keywords：Berberine;Chinese Medicinal Herb;Chinese Herb;Ming Dynasty;Biological Origin
- 839
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- 848
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Published：2021-08-27 - Abstract：The results of investigation on the immuno-pharmacologic activity of natural cordyceps and the cultivated mycelium of cordyceps indicate that they act at multiple sites of the immune systems. They stimulate or inhibit the function of lymphocyte subunits and their toxicity was shown to be very low(6). Neither effect on bone marrow and hemopoiesic function of the spleen nor toxicity to lymphocytes were found(14). It appears, therefore, that cordyceps would be a potential new type of immuno-suppressive agent. For earlier recommending cordyceps to the clinic for anti-cancer and anti-rejection to the grafts and immunomodulation, the separation and purification of the active principles from cordyceps as well as studying the mechanisms of its actions at the molecular level are very important.Keywords：Natural Killer Cell;Alcoholic Extract;DNCB;Cellular Immune Function;Cleaning Rate
- 759
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- 787
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Published：2021-08-27 -
- Keywords：Blood Stasis;Acupuncture Group;Ligustrazine;Blood Stasis Syndrome;Photosensitize Oxidation
- 813
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- 901
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Published：2021-08-27
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