Abstract:Objective: To assess the efficacy of artesunate on falciparum malaria.Methods: A randomized and controlled study on the treatment of 90 uncomplicated falciparum malaria patients was carried out respectively with 400 mg of artesunate tablet as the total dose in 3 days, 600 mg in 5 days and 800 mg in 7 days.Results: All patients were cured. Fever clearance time (FCT) and parasite clearance time (PCT) among the three groups were similar. Parasite recrudescence rates within 28 days were 39.3% (11/28) in the 3-day group, 6.9% (2/ 29) in the 5-day group and 3.4% (1/29) in the 7-day group (comparing the 5-day group with the 3-day group,P < 0.005, comparing 7-day group with the 3-day group,P < 0.005).Conclusion: Parasite recrudescence rate may be effectively decreased by prolonging the treatment course.  
Abstract:Objective: The effect of Radix Salviae Miltiorrhizae (RSM) on production of lung oxygen free radical products during cardiac operations was researched.Methods: Thirty cases of heart valve replacement were randomly divided into two groups: RSM treatment group (RSM group) and control group. Blood samples were taken from before (right atrium, RA) and after (left atrium, LA) pulmonary circulation before cardiopulmonary bypass operation and 10 minutes, 45 minutes, 2 hours, 6 hours after the aortic crossclamp removal to observe the level of peroxidation product and the changes in leucocyte count.Results: The number of leucocytes in LA was smaller than that in RA and the amount of peroxidation product in LA was higher than that in RA (P < 0.01-0.05) during the early phase of lung reperfusion in the control group. There was no significant difference (P >0.05) in the amount of peroxidation product and the leucocyte count between LA and RA in the RSM group.Conclusions: RSM could markedly prevent the lung leucocyte aggregation and reduce the production of lung free radical products. It suggested that the effect of RSM of reducing the lung oxygen free radical products was related to its effect of preventing the lung leucocyte aggregation.  
Abstract:Objective: To prove the effect of Allitridi in treating acute cerebral infarction.Methods: Millipore membrane filtering technique was adopted to systematically observe the blood rheology and the peripheral leucocytes filtering index of 53 healthy subjects and that of 33 patients before and after treatments, who suffered from acute cerebral infarction and were confirmatorily diagnosed through CT.Results: The filtering index of peripheral leucocytes during the acute period of cerebral infarction rose significantly (6.1397 ± 4.4602), and the difference was significant compared with that of the healthy subjects (0.8651+0. 4603,P < 0. 01). Treated with Allitridi, the patients’ symptoms got improved and at the same time the filtering index of leucocytes lowered markedly(l. 6261 ± 1.3472). The conditions of the patients before and after treatments were obviously different (P < 0.01). The index of the whole blood rheology was improved significantly.Conclusions: Allitridi could effectively improve the leucocytes deformation and the whole blood rheology as well, and alleviate clinical symptoms.  
Abstract:Objective: To observe the effect of Xilixin Granule combined with radiotherapy in treating malignant tumors.Methods: Thirty six patients of pulmonary or nasopharyngeal carcinoma were treated with Xilixin granule (XLXG) combined with radiotherapy and compared their efficacy with that of 31 patients treated by Zhenqi Fuzheng
granule combined with radiotherapy for control.Results: The symptoms of Yin Deficiency syndrome in the treated group were obviously improved, the leucocyte decreased by 5.6%, while in the control group it reached 25. 8%, the 3 year survival rate was significantly higher in the treated group (75. 0%) than that in the control group (51.6%). Animal experiment revealed that XLXG had the effects of tumor inhibition, it could increase white blood cells, platelets and hemoglobin of patients, especially in using large dosage.Conclusion: XLXG have some protective effect against radiotherapeutic damage in patients with malignant tumor.  
Abstract:Objective: To observe the clinical treatment of 105 patients of nasopharyngeal carcinoma with large metastatic cervical lymphnodes.Methods: The patients were divided randomly into three groups, 35 for each group. Group A was treated by combined therapy of Shenlong Liquid (SLL) with thermo- and radio-therapy, group B with combined therapy of thermo- and radio-therapy and group C with radiotherapy alone. The clinical conditions of the three groups were similar before treatment.Results: At the end of the treatment, the immediate regression rates of cervical lymphnodes of A, B and C group were 68.57%, 60.00% and 42.86% respectively, and the effect of group A was the best. In comparison of group A and C, the difference was significant (P < 0.05), but the comparison of group B with A, or B with C was insignificant (P >0.05).Conclusions: The combination therapy of SLL with thermo- and radio-therapy was preferable in treating large metastatic lymphnodes, as SLL was beneficial in increasing the sensitivity of tumor to thermotherapy, reducing their side-effect and preventing the hematogenous metastasis.  
Abstract:Objective: To study the effects of 24 Chinese medicinal herbs on nucleic acid, protein and cell cycle of human lung adenocarcinoma cells.Methods: Using flow cytometry the authors analysed the effects of 24 Chinese medicinal herbs (CMH) in compound recipe on proliferation index (PI), DNA index, protein index and ratio of various phases in cell cycle of human lung adenocarcinoma cells (SPC-A-1).Results: The PI was more than 20%, in 4 CMH, while 3 CMH, Gynostemma Pentaphylla, Radix Glehnia, and Radix Ginseng could strengthen the body resistance. That suggested using CMH of strengthening body resistance could not only serve as conventional tonic but also as tumor cell inhibitor. Meanwhile the action points of 24 CMH on cell cycle were different from one another.Conclusions: According to these results, Chinese recipes were more effective in clinical practice.  
Keywords:Chinese medicinal herbs of strengthening body resistance;Flow Cytometry;lung cancer;cell cycle;nucleic acid;protein
Abstract:Objective: A comparative study on immunologic effects of Composite Prescription in Mice. Methods:
Youguiyin prescription for tonifying Kidney), Sijunzi Decoction (
for invigorating Spleen) and Taohong Siwu Decoction (
for promoting blood circulation) were conducted in mice aged 18 months and divided into 4 groups. The above-mentioned prescriptions were given to group I - III respectively. Group IV was kept untreated for aged control. Another group of 3 month-old mice was selected as the adult control. Results: T-, B-lymphocyte transformation rate and OKT3 lymphocyte, subgroup in the aged control group were distinctly lower than those in the adult control group. After 4 weeks treatment with different composite prescriptions, the T-, B-lymphocyte transformation rate of group II and III were evidently higher than those of the aged control group and OKT3 lymphocyte subgroup was distinctly lower in group I than that of group IV.Conclusions: The prescription of tonifying Kidney acted on immunal function of aged animals in a way different from that of prescriptions for invigorating Spleen or for promoting blood circulation.  
Keywords:aging;composite prescription;comparative study
Abstract:Objective: In order to study the effects of Chinese Kidney-tonifying (KT) herbal medicine on the M-cholinergic receptor(M-R) and the acetylcholinesterase(AchE) activity in the models’ cerebral cortex.Methods: Dementia mimetic mice models were formed with aluminum chloride.Results: The Muscarine receptor total receptor concentration (M-Rt) lowered and the AchE increased in the model significantly compared with healthy young mice. KT could markedly reduce the increase of AchE and elevate the lowered M-Rt in cerebral cortex of the dementia mimetic mice and improve the memory.Conclusions: KT is effective in preventing the degeneration of cerebral function and presenile dementia.  
Abstract:Objective: To evaluate the possibility of Salvia Miltiorrhiza (SM) on the prevention of restenosis, the authors investigated the effects of SM on the intimal thickening of air-injured carotid artery of rats, and examined the effects of SM on the proliferation of rabbit aortic median smooth muscle cells (SMC) cultivated in vitro.Methods: Artery injury model of 17 rats about 4 months old was established by Fishman air-dry method. Fourteen days after operation, the maximal artery intimal and medial thickness of the control and SM group were measured on the image analysis system. Using cell counting and thymidine (3H-TdR) up-take method, the authors also examined the effects of SM on the proliferation of aortic median SMC from 4 rabbits.Results: SM inhibited the proliferation and3H-TdR up-take of SMC in a dose-dependent manner in vitro (P < 0.05 or 0.01 vs. control). It also inhibited the intimal thickening of rat arteries after deendothelialization. The maximal intimal thickness of the SM group was much thinner than that of the control (15.22 ± 2.19 μm vs. 80.17 ± 23.49 μm,P < 0.01).Conclusions: The study raises the possibility that SM can be used to prevent clinical restenosis.  
Abstract:Objective: To investigate the protective effect of Fructus Gardeniae on pancreatic subcellular organs in rats of acute pancreatitis.Methods: Acute pancreatitis (AP) was induced with sodium deoxy-cholate in SD rats. Succinic dehydrogenase (SDH), acid phosphatase (ACP) and cytochrome P450 were taken as marked enzymes in estimation of mitochondria, lysosome and microsome and for observation of the functional and structural changes of the pancreatic subcellular organs and the protective effects of Fructus Gardeniae (FG) in rats of acute pancreatitis. The histological change was observed simultaneously.Results: Pancreatic cellular SDH reduced significantly and the releasing rate of ACP raised obviously in AP, and in FG treated group, SDH was nearly normal, the releasing rate of ACP decreased and the content of P450 increased at the same time. Histologic observation showed that there was significant inflammatory change in pancreas and abnormal manifestation in structure of subcellular organs in AP. FG could alleviate the lesion.Conclusions: FG has a remarkable protective effect on the function and structure of the pancreatic subcellular organs in AP.