Abstract:Objective: To observe the effect of Zhenkeling (ZKL) oral liquid in treating cough in children. Methods: One hundred and seventy patients with cough were assigned into two groups at random. The 120 cases in the ZKL group were treated with ZKL, and pectoral syrup was given to the other 50 cases in the control group, Results: The total effective rates of ZKL group and the control group were 96.7% and 56.0% respectively, and the markedly effective rates were 80.8% and 18.0% respectively (P < 0.01). Animal experiments indicated that ZKL had the effect of relieving cough, reducing sputum and ameliorating wheeze. Also it had antibiotic and anti-inflammatory effect. Acute and chronic intoxicating test showed that ZKL has neither side-effect nor toxicity. Conclusion: ZKL is an effective Chinese herbal preparation in treating cough of children and is safe in use.  
Abstract:Objective: To evaluate the efficacy of Poria-Polyporus anti-diarrhea oral liquor (PPAOL) in treating infantile rotavirus diarrhea.Methods: PPAOL was administered to treat 30 cases of infantile rotavirus diarrhea, the effect was observed and compared with that of Smecta. And human rotavirus RNA of patients was detected.Results: The effective rate of the PPAOL group was 83.33 % and that of Smecta group was 90.00%. There was no significant difference between the effect of the two groups in respect of the duration of fever and diarrhea. Human rotavirus RNA showed positive result in 13 patients of PPAOL group and 19 in Smecta group. The duration of virus excretion in both groups was 2~7 days, which was much shorter than 9~21 days in the previous report.Conclusion: PPAOL is effective in treating infantile rotavirus diarrhea.  
Abstract:Objective: To explore the nutritional and health promoting effects of nutrient mixture (traditional Chinese tonics+nutrient fortification).Methods: (1) One hundred and three primigravid women were divided randomly into the test group and the control group treated with nutrient mixture and vitamins respectively and the effects of treatment were observed. (2) Effects of nutrient mixture were also observed in pregnant rats.Results: (1) Clinical study showed the serum levels of iron, zinc, hemoglobin of the test group were all raised after treatment, and these parameters and the concentration of iron in umbilical cord blood as well as the weight of the new-born baby of the test group were higher than those of the control group (P < 0.05 orP < 0.01). (2) Results of the experimental study showed that the food utilization rate, hemoglobin level, fetal growth and developing parameters of the test group were all higher than those of the control group significantly (P < 0.05 orP < 0.01).Conclusion: The nutrient mixture has a good nutritional and health promoting effect on pregnancy.  
Keywords:nutrition with traditional Chinese tonic;nutrient;pregnant women;pregnant rat;nutritional;health promoting effect
Abstract:Objective: To evaluate the effect of ligustrazine on kanamycin ototoxicity.Methods: By measuring superoxide dismutase (SOD) and malondialdehyde (MDA) in cochlear tissues, compound action potentials (CAP) and cochlear microphonics (CM) in guinea-pigs which were treated with kanamycin and ligustrazine. Results: Kanamycin produced a severe hearing loss and significant increase in SOD and MDA. Ligustrazine could reduce these changes significantly and improve hearing of animals. Conclusion: Lipid peroxidative reaction is correlated with kanamycin ototoxicity and ligustrazine could prevent and treat kanamycin ototoxicity by antioxidation.  
Abstract:Objective: To evaluate the clinical effect of integrated Chinese and Western medicine in treating acute retrobulbar optic neuritis.Methods: Combined Therapy of modified prescription of Danzhi Xiaoyao San and Taohong Siwu Decoction and Mailuoning was applied to 12 patients (13 diseased eyes) and changes of such criteria as visual acuity, optic fundus, visual field, fundus fluorescein angiogram, pattern visual evoked potential and contrast sensitivity were observed.Results: 5 eyes (38.46%) were cured, 5 (38.46%) markedly effective, 2 (15.38%) effective and 1 ineffective, the total effective rate being 92.31%. After treatment, visual acuity of 10 eyes was elevated to over 1.0, and the other criteria were also improved in various degrees.Conclusion: The program of integrated therapy was effective in treating acute retrobulbar optic neuritis.  
Abstract:Objective: To evaluate the clinical effect of Shezhu Mingmu powder (SZMMP) in treatment of early senile cataract.Methods: A comparison was made between the treatment group, 162 eyes of 92 cases of early senile cataract treated by SZMMP, and the control group, 57 eyes of 30 cases treated by drops baineitini. The treatment periods were one to three months.Results: The total effective rate for the treatment group was 79.01 % and the rate of obvious improvement was 25.31%. In the treatment group both rateswere clearly higher than the rates (36.84% and 7.02%) of the control group. After 4 to 8 months’ following up, treatment of 42 cases showed that most of them reached the best curative effect within 1 to 3 months.Conclusion: SZMMP is obviously effective in improving visual acuity of early senile cataract, but the lens opacity was not changed.  
Keywords:Shezhu Mingmu powder;early senile cataract;deficiency of Liver and Kidney
Abstract:Objective: To make a preliminary evaluation of the clinical efficacy of Shuxuening (SXN).Methods: One hundred and forty-nine chronic schizophrenic patients were divided randomly into the SXN group and the control group in a double-blind research. SXN was given to the SXN group and placebo to the control group, and patients of both groups went on receiving the previous antipsychotic treatment. Brief Psychiatric Rating Scale (BPRS), Scale for Assessment of Negative Symptoms (SANS) and Treatment Emergent Symptoms Scale (TESS) were used to assess the effects of treatment and side effects of the drug. The evaluation was done before and during the 2nd, 4th, 6th, 10th and 12 th weeks in the course of treatment.Results: SXN was effective by BPRS evaluation (P < 0.05), and even the more effective to negative symptoms than positive symptoms by SANS evaluation (P < 0.05). It was safe and with little side effect. In addition, it was found that the incipience of SXN’ s efficacy was somehow related with the course of disease and the daily dosage used.Conclusion: SXN is worthy of further study n the treatment of chronic schizophrenia.  
Abstract:Objective: To assess the efficacy of Lishen injection (LSI) in treating coronary heart disease (CHD).Methods: The effect of LSI on serum estradiol (E2) testosterone (T) and E2/T ratio in 30 postmenopausal patients with CHD of Kidney Deficiency (KD) were observed.Results: (l) Serum E2 and the E2/T ratio were lower (P < 0.01) in the group of Kidney Yang Deficiency type (KYaDT) and higher (P < 0.01) in the group of Kidney Yin Deficiency type (KYiDT) as compared with normal control. (2) After treatment with LSI the levels of serum E2 and the E2/T ratio were elevated in the KYaDT group (P < 0.01) and lowered in the KYiDT group (P < 0.01). Both approached the normal level (P >0.05). (3) The levels of T in both groups were unaffected (P >0.05) before and after treatment.Conclusion: The imbalance of Kidney-Yin and Kidney-Yang is correlated to the disturbance of sex hormones and LSI could not only regulate the Kidney-Yin and Kidney-Yang, improve the symptoms of KD, but also reverse the disturbance of sex hormone. With a good bidirectional regulatory effect on E2, it is beneficial on balance of sex hormones of both sexes in the inner environment of human body.  
Abstract:Objective: To evaluate the protective effect of Faeces Trogopterus (FT) on gastric mucosa.Methods: Thirty-four patients of gastric ulcer were treated with FT and compared with a control group treated with Ranitidine. In the experimental study, the Shay model of rats was used.Results: The curative rate of FT in treating duodenal ulcer of six weeks was 70.59 % and the total effective rate was 91.18%. Results of the experimental study showed the protective effects of FT on gastric mucosa.Conclusion: FT could inhibit gastric secretion and regulate gastric mucosal blood flow so as to enhance mucosal defense.  
Abstract:Objective: To evaluate the effect of Semen Persicae combined with cultured Cordyceps on Reversing Capillarization of Sinusoids in patients with hepato-cirrhosis.Methods: Forty-four patients were treated for 3 months, the clinical and pathological effects were observed.Results: Patients were improved clinically. Pathological examination on liver biopsy of 6 patients also showed improvement in of capillarization of sinusoid, which mainly manifested by reduction of enlarged interhepatocellular spaces and collagen fiber in it, increase of lipid droplets within fat-storing cells (FSC), and decrease of proliferation of Kupffer cells.Conclusion: The combined treatment used could reverse the capillarization of sinusoid, and the mechanism might be related with its inhibition on activity and function of FSC.  
Keywords:Semen Persicae;Cordyceps sinensis;amygdalin;hepato-cirrhosis;capillarization of sinusoids
Abstract:Objective: Try to find out the objective parameters of Syndrome Differentiation of diabetic nephropathy.Methods: By radio-immunoassay technique, some parameters, including glucoprotein, microglobulins, immunoglobulins, etc. of 41 diabetic nephropathy patients of the Deficiency of Spleen-Kidney and Qiblood type and Yang Deficiency causing edema with upward gush of Turbid Yin type were measured and analysed.Results: β2-microglobulin, α1-microglobulin in blood rose significantly in both types. There was significant difference between the two types in microglobulins, also in atrial natriuretic polypeptins, pancreatic glucagon in blood, and β2-microglobulin, immunoglobulin G, albumin, secretory immunoglobulin A in urine.Conclusion: Above-mentioned parameters offered some objective data on Syndrome Differentiation of diabetic nephropathy and this is vital in guiding the Syndrome Differentiation and treatment of this disease.  
Abstract:Objective: To explore the antiatherogenic mechanism of the action of Xueguantong at molecular level.Methods: After being established by feeding with high fat diet for 12 weeks, the quail atherosis models were given Xueguantong for 30 days. Then, their plasma endothelin and calcitonin gene-related peptide (CGRP) were determined with radioimmunoassay (RIA) and the effects of Xueguantong on plasma endothelin and CGRP in the models were observed.Results: The plasma endothelin increased and CGRP decreased during quail atherosis formation. The plasma endothelin was decreased (P < 0.05) and CGRP increased (P < 0.05) by Xueguantong.Conclusion: One of antiatherogenic mechanisms of Xueguantong was decreasing endothelin and increasing CGRP.  
Abstract:Objective: To explore the protective effect ofCordyceps sinensis (CS) on nephrotoxicity of cyclosporine A (CsA) and its mechanism.Methods: The renal function of isolated perfused rats was observed before and after three months treatment by CS.Results: CS could improve the renal function, increase the volume of urine, Na+ and K+ excretion and inulin clearance rate, and reduce the resistance of renal perfusion. It was found that the activities of urinary N-acetyl-β-glucosaminidase (NAG), γ-glutamyl transferase (γ-GT) and lactate dehydrogenase (LDH) were lower in the CS treatment group than those in the control group.Conclusion: CS could protect the kidney from damage against nephrotoxicity of CsA and improve the abnormality of renal hemodynamics.  
Keywords:yclosporine A;Cordyceps sinensis;urinary enzymes;isolated perfused rat