Latest Issue
Vol. 4 ， Issue 2 ， 1998
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- Abstract：Objective: To evaluate the therapeutic effect of Piweiping capsule (PWPC) in treating patients with metaplasia of gastric mucosa and explore its mechanism.Method: One hundred and forty-three patients were diagnosed as chronic superficial atrophic gastritis of gastric antrum or with metaplasia by means of gastroscopic observation with pathological biopsy examination. They were divided into 4 types (type I - IV) according to Syndrome Differentiation of traditional Chinese medicine, and each type was subdivided according to treatment into 2 groups, 75 in the PWPC group and 68 in the Sanjiu Weitai ( ) group. Patients of PWPC group were in accordance with the type to which they belong treated with PWPC I, II, HI, IV respectively, while patients of SJWT group were all treated with SJWT. After 3 - 6 months of treatment, the clinical effect, pathological examination of gastric mucosa and some other parameters were observed.Results: The improvements of gastric mucosa cyclic adenosing monophosphate (cAMP), deoxyribonucleic acid (DNA),3H-thymopyrimidine nucleoside and lymphocyte transformation of the treatment group were all superior to those of SJWT group,P < 0.05-0.001. In the PWPC group, the curative rate and total effective rate on symptom were 49.3 % and 92.0% respectively, and the curative rate and total effective rate on intestinal metaplasia were 45.3 % and 62.7%. As for the SJWT group, they were 29.4%, 67.6%, 10.3% and 29.4% respectively. The difference between the two groups was significant,P < 0.001. Conclusion: PWPC could reverse the intestinal metaplasia through improving the gastric cAMP, DNA and strengthening the cellular immunity and the effect would be enhanced when the treatment was based on Syndrome Differentiation.Keywords：intestinal metaplasia of gastric mucosa;deoxyribonucleic acid;cyclic adenosine monophosphate;Piweiping capsule
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Published：2021-08-27 - Keywords：Gastritis;Chronic Gastritis;Paraventricular Nucleus;Median Eminence;Hypothalamic Paraventricular Nucleus
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Published：2021-08-27 - Abstract：Objective: To evaluate the effect of garlicin in treating acute cerebral infarction.Methods: One hundred and one patients of acute cerebral infarction diagnosed by CT were treated with garlicin (garlicin group) and compared with another group of 53 patients treated with ligustrazine (control group). The neurologic deficiency score and neurologic function score were used for evaluation of effect.Results: The effective rates of garlicin and ligustrazine were 89. 36% and 84. 85% respectively. The improvement scores of neurologic function were 18.46±10.69 and 11.94 ± 6.79 respectively. The difference between the two groups was significant. Before treatment the serum level of MDA in the garlicin group was 6.015 ±1.26 nmol/ml, and it decreased to 4. 87 ± 1.16 nmol/ml after treatment, the change being more significant than that of the control group (from 6.02 ±0.73 nmol/ml to 6.47 ±1.04 nmol/ml). The rheological parameters and cerebral blood flow were also improved after garlicin treatment.Conclusion: Garlicin could increase the perfusion flow of brain, improve the microcirculation, and scavenge free radicals so as to relieve the ischemia and reperfusion injury of the brain.Keywords：garlicin;acute cerebral infarction;Ligustrazine;malonyldialdehyde;hemorheology
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Published：2021-08-27 - Abstract：Objective: To study the relationship between the circadian rhythm of Yin and Yang Syndrome on essential hypertension.Methods: The noninvasive ambulatory blood pressure monitoring was used in the clinical evaluation of 84 hypertensive inpatients.Results: The profile of ambulatory blood pressure in traditional Chinese medicine is characterized by the usual nocturnal decline in blood pressure, as well as by a prominent secondary fall in the early afternoon. The blood pressure to be highest is at Chen ( , 8:00am) on excess of Yang Syndrome and at You ( , 17:00 pm) on deficiency of Yin Syndrome, the lowest is at Zi ( , 0:00 am) and Wei (tic, 11:00am). The inverse circadian blood pressure is discovered in spontaneously hypertension rats (SHR).Conclusion: The pathogenesis of hypertension is due to the excessive Yang that is caused by incoordination between Yin and Yang. The TCM pattern differentiation of hypertension can be identified by Yin and Yang.Keywords：hypertension;ambulatory blood pressure monitoring;pattern identification
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Published：2021-08-27 - Abstract：Objective: To investigate the effects of integrated traditional Chinese and Western medicine in treating infantile protracted chronic pneumonia (IPCP).Methods: One hundred patients of IPCP were divided equally into two groups, the TCM-WM group treated with Maqin Qizhu Decoction combining with antibiotics and the control group treated with antibiotics alone. Efficacy of the two groups was compared after 1 course (15 days) of treatment.Results: The total effective rate of the TCM-WM group was better than that of the control group. Moreover, the days needed in curing coughing, dyspnea, rales and X-ray shadow absorption of the former were fewer than those of the latter.Conclusion: The integrated TCM-WM therapy in treating IPCP could both inhibit the pathogens effectively and improve the humoral immunity and resistant ability of organism.Keywords：infantile protracted chronic pneumonia;integrated traditional Chinese and Western medicine;immune function
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Published：2021-08-27 - Abstract：Objective: To observe the effect of Bushen Conger (BSCE) tablet, a pure Chinese herbal medicine for reinforcing Kidney, removing blood stasis and opening apertures, in treating sensorineural deafness.Methods: Three hundred and ten patients were treated by BSCE tablet and the effects were observed. At the same time the effects of BSCE tablet on hearing, SOD, LPO, etc. were also assayed in guinea pigs.Results: The clinical total effective rate of BSCE tablet was 71.9%. Animal experiment proved that the drug was effective in preventing and treating toxic deafness induced by aminoglycoside antibiotics.Conclusion: BSCE tablet could cure sensorineural deafness through adjusting the cochlear cyclic neucleotides as well as its SOD level, reducing the LPO level, and raising the thyroid and sexual glandular functions.Keywords：Bushen Conger tablet;sensorineural deafness;toxic deafness model
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Published：2021-08-27 -
Clinical observation on Syndrome Differentiation Staging therapy of central serous chorioretinopathy
Abstract：Objective: To observe the effect of traditional Chinese medicine in Syndrome Differentiation Staging therapy (SDST) in treating central serous chorioretinopathy (CSC).Methods: One hundred patients of CSC were divided into two groups, the TCM group and the control group, and were treated with SDST and western medicine respectively.Results: The total effective rate of the two groups was 98% and 82% respectively and their mean cure time 35 ± 7.0 days and 39+8.8 days respectively. Comparison between the two groups showed significant difference (P < 0.05), effect in the TCM group was superior to that in the control group.Conclusion: SDST treatment was helpful in curing CSC. Its basic action is to relieve Qi stagnation and blood stasis, which were taken as the basic physiopathologic change of CSC. And the staging therapy could enhance the therapeutic effect in different stages of the disease.Keywords：central serous chorioretinopathy;Syndrome Differentiation Staging Therapy of TCM- 18
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Published：2021-08-27 - Abstract：Objective: To observe the effect of treatment of Mailuoning Injection (MI) for pregnancy induced hypertension (PIH).Methods: Forty six PIH patients in the treated group were treated with intravenous dripping of MI and 40 patients in the control group treated with intravenous dripping of 25% magnesium sulfas.Results: Headache and edema were ameliorated significantly in the MI treated group in comparison with the control (P < 0.05). Both methods could the decrease levels of mean arterial pressure, improve hemorheologic change, and lower the hematocrit, but the effects of the former was better than those of the latter. No difference was found in albuminuria, delivery pattern, postpartum bleeding and neonatal Apgar Score between the two groups.Conclusion: MI could prevent the progress of pathological process of the PIH. The therapeutic mechanism of MI might be relevant to the dilatation of the arteriospasm, improvement of the abnormal microcirculation and hemorheologic character of the patients.Keywords：Mailuoning Injection;magnesium sulfas;pregnancy induced hypertension
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Published：2021-08-27 - Abstract：Objective: To find an effective treatment of oviduct pregnancy.Methods: One hundred and fifteen patients of oviduct pregnancy were treated by injecting trichosanthin in cervix.Results: One week after injection, 95.5% of the treated patients had their HCG turned to negative. Symptoms such as painful abdominal distention, and signs such as pelvic hydrops and vaginal bleeding, were also relieved obviously in most of the cases.Conclusion: Trichosanthin injection may be an effective treatment for oviduct pregnancy, but further improvement in its preparation, and method of medication and dosage are necessary.Keywords：oviduct pregnancy;trichosanthin injection
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Published：2021-08-27 - Keywords：rheumatoid arthritis;Arthritis;Adverse Reaction;Effective Rate;Affiliate Hospital
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Published：2021-08-27 - Abstract：Objective: To explore mechanism of the effect of Fuzheng Huayu Decoction on Ito cell proliferation and collagen synthesis.Methods: Biological effects of the drug serum taken from rats fed with Fuzheng Huayu decoction (FZHYD) on cell proliferation and collagen synthesis of Ito cell line were observed. Serum collected from rats at various times (1, 2 or 3 hours) after animals were fed with FZHYD once (It) or twice (2t, 2nd time repeated with the same dose), was incubated with Ito cell.Results: The lt-2h serum in 0. 46 g/kg FZHYD group, it seems to prevent cell proliferation, but had no significant difference. While all 2t drug serum could inhibit cell proliferation. The 2t-lh drug serum had no obvious effects on Ito cell morphology, but could improve cell viability, its effect on cell proliferation was dose and serum concentration dependent. Also the 2t-lh drug serum in all doses could inhibit Ito cells both intracellular and extracellular collagen production, the drug serum of 0.46 g/kg group had inhibitory effect in serum concentration dependent manner and similar effect as colchicine.Conclusion: Inhibition of Ito cells proliferation and collagen synthesis is perhaps one of main mechanism of FZHYD in antifibrotic action.Keywords：Fuzheng Huayu Decoction;Ito cell;collagen;cell proliferation
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Published：2021-08-27 - Abstract：Objective: To observe the effect of purified Xuefu Capsule (PXC) on endothelin (ET) and nitric oxide synthetase (NOS) gene expression and proliferation of vascular smooth muscle cell (VSMC) in atherosclerotic rabbits.Methods: Molecular biological techniques of dot blot and in situ hybridization were adopted.Results: The expression of ET mRNA in atherosclerosis (AS), plaques of the model group was higher, with the positive signals distributed mainly in arterial intimal AS plaques; while at the same time the expression in the PXC treated group was lower, with only few scattering signals found in arterial intimal AS plaques. NOS mRNA expression was less in the vascular wall of the AS model group, PXC could enhance NOS mRNA expression, positive signals could be found from intima to media.Conclusion: The effect of PXC on preventing and treating AS might be related to regulating the expression of ET mRNA and NOS mRNA in the vascular wall.Keywords：purified Xuefu capsule;endothelin;nitric oxide synthetase
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Published：2021-08-27 - Abstract：Objective: To investigate the effects of Reduqing (RDQ, ) on plasma interleukin-8 (IL-8), NO2 - /NO3 -, complement 5a (C5a) and polymorphonuclear neutrophilic leukocyte (PMN) chemotaxis Index (CI) in rabbits with endotoxin-induced disseminated intravascular coagulation (DIC).Methods: Endotoxin-in-duced DIC model made by injection of Lipopolysacchrides (LPS) was used in the experiment. Above-mentioned indexes were determined before and after RDQ treatment and compared with blank and dexamethasone treated group.Results: Plasma IL-8, NO2 - /NO3 -, C5a and CI level of PMN increased markedly in the model group, which were confirmed pathologically with obvious damage of tissues or organs. In the RDQ group, the abovem entiond parameters and damage of tissues or organs were reduced significantly (P < 0.01).Conclusion: IL-8 and NO might be involved in pathogenesis of endotoxin-induced DIC, and RDQ could be used in preventing or treating DIC through the mechanism of regulation of cytokines network.Keywords：interleukin-8;Nitric Oxide;Injectio Reduqing;disseminated intravascular coagulation;complement;chemotaxis
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Published：2021-08-27 - Keywords：Blood Stasis;Hypoxic Ischemic Encephalopathy;Intravenous Drip;Endoplasmic Reticu;Activate Blood Circulation
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Published：2021-08-27 - Keywords：Smooth Muscle Cell;Balloon Angioplasty;Blood Stasis;Intima Thickness;Root Powder
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Published：2021-08-27 - Keywords：Total Effective Rate;Phase Arrest;Murine Melanoma Cell;Convul;Acupoint Injection
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Published：2021-08-27 - Keywords：Melanoma;Diarrhea;Melanoma Cell;Total Effective Rate;Phase Arrest
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Published：2021-08-27 - Keywords：Virazole;Pharmaceutical Factory;Intestinal Blood Flow;Acupoint Injection;anisodamine
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Published：2021-08-27 - Keywords：Vaginitis;Atypical Hyperplasia;Benzalkonium;Cervical Scrape;Cervical Polyp
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Published：2021-08-27 - Keywords：Postoperational Bleeding;Local Application;Vaginitis;Atypical Hyperplasia;Intrauterine Device
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Published：2021-08-27 - Keywords：endometriosis;Western Medicine;Procaine;Blood Stasis;Megestrol
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Published：2021-08-27 - Keywords：Amenorrhea;Meli;Blood Stasis;Postoperative Recurrence;Chinese Drug
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Published：2021-08-27 - Keywords：Rhinitis;Total Effective Rate;Nasal Discharge;Cerebral Vascular Disease;Dilate Blood Vessel
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Published：2021-08-27 -
- Keywords：Total Effective Rate;Integrative Medicine;Marquis;Angina Pectoris Patient;Inhibit Gene Expression
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Published：2021-08-27 -
- Keywords：Metformin;Bone Marrow Cell;Berberine;Troglitazone;Integrate Medicine
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Published：2021-08-27 - Keywords：Traditional Chinese Medicine;Chinese Language;High Nervous Activity;Thin Fluid;Essential Substance
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Published：2021-08-27 - Keywords：Cataract;Traditional Chinese Medicine;Qing Dynasty;Blood Stasis;Song Dynasty
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Published：2021-08-27 - Keywords：Mannitol;Brain Edema;Intracranial Hypertension;Cerebral Spinal Fluid;Baicalin
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Published：2021-08-27
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