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      Vol. 5 ， Issue 2 ， 1999
      • Guoqiang Chen,Xun Cai,Yulei Shen,Li Zhou,Qi Zhu,Yun Yu,Peimin Jia,Xinhua Zhu,Saijuan Chen,Zhenyi Wang,Zhu Chen
        Vol. 5, Issue 2, Pages: 82-88(1999) DOI: 10.1007/BF02934648
        Keywords：Arsenic;Chronic Myeloid Leukemia;Arsenite;Acute Promyelocytic Leukemia;Arsenic Trioxide   
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      • Zhang Tingdong
        Vol. 5, Issue 2, Pages: 89-94(1999) DOI: 10.1007/BF02934649
        Keywords：Arsenic;Chronic Myeloid Leukemia;acute leukemia;Blood Stasis;Arsenic Trioxide   
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      • Li Jing,Li Xinqun,Li Jiabang,Liang Qinghua,Xiang Yueqian,Yuan Jun,Tang Lili
        Vol. 5, Issue 2, Pages: 95-100(1999) DOI: 10.1007/BF02934650
        Abstract：Objective: To study on Fuzheng Baozhen Decoction (FZBZD) enhancing effect of radio- and chemotherapy for malignant tumors. Methods: One hundred and Seventeen cases of malignant tumors treated with chemotherapy or/and radiotherapy. Among them 55 cases were treated together with FZBZD (group A), 30 cases together with Zhenqi Fuzheng Granules (group B), and the other 32 cases treated with radio- and chemotherapy alone (group C). Mechanism of FZBZD enhancing effect of chemotherapy in treating transplanted human lung adenocarcinoma (SPC-A-1) and sarcoma (S180) bearing mice was conducted experimentally. Results: Effective rates (CR+PR) of group A, B and C were 63.6%, 43.3% and 37.5% respectively, that of group A being the best (P < 0.05). The survival quality of life was improved the most in group A (P < 0.05). The picture of peripheral blood (WBC, Hb, PLT count) of group A after treatment was better than that of the other two groups (P < 0.05). And CD3, CD4, NK activity, interleukin-2 levels were also improved more significantly in group A (P < 0.01) than those in the other two. Animal experiment showed that FZBZD could improve the effect of chemotherapy in inhibiting tumor growth (P < 0.01), raising cAMP/cGMP ratio (P < 0. 01) by increasing the cAMP level in cancer tissue, and enhancing cells ofG0/G1 phase and reducing cells of S phase. Conclusion: FZBZD inhibited tumor growth and enhanced the effect of radio- and chemotherapy by improving immune and hematopoietic function, cAMP/cGMP ratio and halting tumor cells in G0/G1 phase.  
        Keywords：Fuzheng Baozhen Decoction;malignant tumor;chemotherapy;radiotherapy;cells cycle   
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        Published：2021-08-27
      • Liu Huiwen,Zhang Tiezhong,Li Guangwei,Jiang Yayun
        Vol. 5, Issue 2, Pages: 100(1999) DOI: 10.1007/BF02934651
        Keywords：Insulin Sensitivity;Hypertensive Patient;Syndrome Differentiation;Friendship Hospital;Deficiency Type   
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      • Wang Huaizhang
        Vol. 5, Issue 2, Pages: 101-104(1999) DOI: 10.1007/BF02934652
        Abstract：Objective: To probe the relationship between survival period and immune function of hepatic carcinoma patients after embolization chemotherapy.Methods: One hundred and eight patients of hepatocarcinoma were randomly divided into three groups. Group A was treated by embolization chemotherapy (ECT) alone, immunotherapy and Chinese herbal medicine were given to Group B and C respectively after ECT.Results: The short-term effective rate of Group A, B and C was 61.1%, 83.3% and 80.6% respectively, the three-year survival rate 28.6%, 39.1% and 47.3%, and the median survival time 11 months, 17 months and 15 months respectively. Observation on immune function after treatment showed that patients who received ECT alone had a lower immunity while those who received immunotherapy or Chinese herbal medicine had a strengthened immunity.Conclusion: Survival period of hepatocarcinoma patients is related with their immune function, strengthening patients’ immunity could extend their survival period relatively.  
        Keywords：hepatocarcinoma;embolization chemotherapy;immune function   
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      • Xianfu Wang,Changjin Ma,Wang Xiuqing
        Vol. 5, Issue 2, Pages: 105-107(1999) DOI: 10.1007/BF02934653
        Abstract：Objective: To study the effect of Kanglaite (KLT) in treating pulmonary carcinoma (PC) patients with Lung-Qi Deficiency and immunologic inadequacy (LDII) after pneumonectomy.Methods: Thirtysix patients of PC-LDII were treated with KLT and the lymphocyte subset was examined before and after treatment.Results: The markedly effective rate of treatment was 50.0% and the total effective rate 66.7%. Immunological examination showed that the lymphocyte subset of patients tended to get normal and the difference between pre-treatment and post-treatment was significant.Conclusion: KLT could improve the symptom of Lung-Qi Deficiency and markedly strengthen the immune function of PC patients.  
        Keywords：Kanglaite;pulmonary carcinoma;Lung-Qi Deficiency;immune function   
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      • Zhang Peitong,Pei Yingxia,Qi Xin,Piao Bingkui
        Vol. 5, Issue 2, Pages: 107(1999) DOI: 10.1007/BF02934654
        Keywords：Thrombin;Lung Cancer Patient;Boyden Chamber;Tanshinone;Invasive Capability   
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      • Zhou Jianfang,Song Shiguo
        Vol. 5, Issue 2, Pages: 108-110(1999) DOI: 10.1007/BF02934655
        Abstract：Objective: To find effective treatment with less side-effect for hepatocarcinoma.Methods: Seventy patients were divided into two groups, treated with cinobufotalin plus chemicals and chemicals alone by arterial perfusion respectively. The symptoms, hematological picture, tumor size and viral marker of patients were observed and compared.Results: The treatment with cinobufotalin plus chemicals was more effective than that of chemicals alone in body weight increasing, pain relieving, liver function recovering and virus marker negative inversing.Conclusion: Cinobufotalin could improve the effect of chemo-embolization therapy of hepatocarcinoma.  
        Keywords：Primary Hepatocarcinoma;cinobufotalin;Arterial Perfusion;chemotherapy   
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      • Sun Fei,Yu Jin
        Vol. 5, Issue 2, Pages: 110(1999) DOI: 10.1007/BF02934656
        Keywords：Chinese Herbal Medicine;Primary Hepatocarcinoma;Arterial Perfusion;Threatened Abortion;Placental Endocrine   
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      • Jin Yiqiang,Hu Suiyu,Zhang Xiang,Wang Yonghua,Yan Donghong,Liu Aiping,Zhu Chongxue
        Vol. 5, Issue 2, Pages: 111-114(1999) DOI: 10.1007/BF02934657
        Abstract：Objective: To study the characteristics of plasma norepinephrine (NE) and epinephrine (E) contents alternation and vegetative nervous function disturbance in patients with various Liver Syndrome of TCM.Methods: Subjects were selected on the principle of combination of disease diagnosis and Syndrome Differentiation. Plasma NE and E contents were determined by high performance liquid chromatography (HPLC) and electrochemical detector. The vegetative nervous function were assessed by comprehensive analysis of sympathetic and parasympathetic hyperfunction symptoms, physiologic indexes and physical loading tests.Results: Patients of Liver Excess Syndrome had an elevated plasma NE and E contents and those with the vegetative nervous system disturbance mainly hypersympathetic. On the contrary, patients of Liver Deficiency Syndrome had lowered plasma NE and E contents and those with the vegetative nervous system disturbance mainly hyper-parasympathetic.Conclusion: Plasma NE and E contents and vegetative nervous function disturbance can be taken as the auxiliary laboratory diagnostic indexes for Syndrome Differentiation of Liver Excess and Liver Deficiency.  
        Keywords：Liver Syndrome of TCM;Plasma Norepinephrine;plasma epinephrine;vegetative nervous function   
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        Published：2021-08-27
      • Yang Zhibo,Ouyang Heng,Li Xianchun
        Vol. 5, Issue 2, Pages: 115-117(1999) DOI: 10.1007/BF02934658
        Abstract：Objective: To investigate the effect of Composite Divitriol Infusion (CDI) in treating tinea manum and study its antimycotic action.Methods: CDI was used to treat 139 patients with tinea manum and compared with Tinea Unguium Infusion in treating 77 cases as control. The experimental study in vivo was done, and electron microscopy (EM) was used to observe the therapeutical effect of CDI.Results: Among the 139 patients of the CDI group, 104 were cured, 21 markedly effective, 10 improved and 4 ineffective, the cure and markedly effective rate being 89.9%. The difference of effect between the CDI group and the control group was significant statistically (X 2>12.84,P < 0.005). The antimycotic action of CDI was studied in vitro. The minimum inhibitory concentration (MIC) of CDI were about 0.25% for Trichophyton rubrum and 0.5% for Trichophyton gypseum and Microsporum gypseum. Trichophyton rubrum immersed with CDI showed that the mycelia became roughened, deformed, and macroconidium became smaller under EM.Conclusion: CDI is valuable in treating tinea manum.  
        Keywords：Composite Divitriol Infusion;tinea manum;Chinese herbal medicine therapy   
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        Published：2021-08-27
      • Wang Deqing,Wang Chengbin,Tian Yaping,Sheng Wenmei,Wang Caiyun,Zhou Heping,Yan Guangtao
        Vol. 5, Issue 2, Pages: 117(1999) DOI: 10.1007/BF02934659
        Keywords：Nitric Oxide;Chloroquine;Ischemia Reperfusion Injury;Nitroxide;Total Flavonoid   
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      • Zhang Xiangyang,Qian Xinmei
        Vol. 5, Issue 2, Pages: 118-121(1999) DOI: 10.1007/BF02934660
        Abstract：Objective: To explore the mechanisms of integrated traditional Chinese and western medicine (TCM-WM) in treating sudden deafness.Methods: One hundred and forty-six patients suffered from sudden deafness were divided into two groups, 64 cases in the treated group were treated with TCM-WM therapy and the other 82 cases treated with western medicine alone for control.Results: The total effective rate of the treated group was 92.19%, that of the control group was 75.61%. The difference between the two groups was significant,P < 0.01.Conclusion: The TCM-WM therapy is very effective in treating sudden deafness. Its mechanism might be: (1) Decrease of the blood viscosity and increase of the red blood cell’s tenacity, so that the blood stream could pass through unimpededly. (2) Decrease of the plasma TXA2 level and increase of the PGI2 level, to benefit the blood supply for inner ear. (3) Increase of the activity of SOD and clearing away the free radicals so as to reduce the damage to the inner ear.  
        Keywords：Sudden Deafness;integrated traditional Chinese and Western medicine;Clinical Study   
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      • Zhou Ronglin,Zhang Juncai
        Vol. 5, Issue 2, Pages: 122-125(1999) DOI: 10.1007/BF02934661
        Abstract：Objective: To explore the effect of combined acupoint desensitizing therapy.Methods: A total of 419 cases of allergic rhinitis accompanied with asthma were treated by combined acupoint desensitizing therapy with positive allergen extract on acupoints of head and upper back region.Results: After 3 courses of treatment, skin test repeated with responding allergen extract showed that the scope of redness and swelling of skin were smaller than those before treatment,P < 0.01. The3H-TdR incorporation lymphocyte transformation rate, acidophil count, IgA, IgG level and E-rosette formation rate of acupoint desensitizing group were different significantly from those of the two control groups (the acupoint 0.85% normal saline injection group and the subcutaneous desensitizing group),P < 0.01 orP < 0.05. Follow-up study for over 3 years showed that the markedly effective rate of the acupoint desensitizing group was 68.73%, the effective rate 29.12% and total effective rate, 97.85%. The effect was higher than that of the two control groups, P<0.01.Conclusion: Combined acupoint desensitizing therapy is valuable and worthy of popularizing in treating patients of allergic rhinitis accompanied asthma.  
        Keywords：Allergic Rhinitis;allergic asthma;combined acupoint desensitizing therapy;allergen;3H-TdR incorporation;lymphocyte transformation   
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        Published：2021-08-27
      • Yu Chaoqin,Ling Changquan,Huang Xueqiang,Pan Ruiping,Zhang Denghai
        Vol. 5, Issue 2, Pages: 126-130(1999) DOI: 10.1007/BF02934662
        Abstract：Objective: To explore the law and role of apoptosis inducing effect of allicin on human acute T-lymphocyte leukemia cell line (6T-CEM).Methods: Terminal deoxylnucleotide transferase directed X-UTP nick and end labeling (TUNEL) assay, DNA gel electrophoresis, light microscopy and revers transcription-polymerase chair reaction (RT-PCR) were used to observe apoptosis of cells.Results: Allicin showed significant inducing effect on apoptosis of 6T-CEM cell when the concentration was 0.1 μg/ml, reaching its peak effect when the concentration was 50 μg/ml, with the apoptosis rate as 36.4%. Allicin (15 μg/ml) acted on 6T-CEM for 2 h and induced obvious cell apoptosis, the highest effect reached after 24 h of action, with the apoptosis rate as 56.9%. Actidione or actinomycin D could induce apoptosis of 6T-CEM, the allicin could not enhance their apoptosis inducing effect. Allicin could cause significant reduction of bcl-2 and bax gene expression of 6T-CEM, especially the bcl-2.Conclusion: Allicin could induce cell apoptosis of 6T-CEM with significant time and dose effect. Mechanism of the effect is through inhibiting the bcl-2 gene expression to reduce bcl-2/bax ratio.  
        Keywords：6T-CEM cell;allicin;apoptosis;terminal deoxylnucleotide transferase directed X-UTP nick and end labeling mark   
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      • Duan Yuanli,Zhang Xinmin,Shen Ziyin,Wang Wenjian,Chen Weihua
        Vol. 5, Issue 2, Pages: 130(1999) DOI: 10.1007/BF02934663
        Keywords：Breast Adenocarcinoma;Intracerebroventricular Injection;Macromolecular Synthesis;Chain Signaling;Recombinant Inter   
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      • Fang Zhibin,Wang Yuelan,Zhou Yiping
        Vol. 5, Issue 2, Pages: 131-133(1999) DOI: 10.1007/BF02934664
        Abstract：Objective: To explore the relationship between Heart Meridian (HM) and cardiac function.Methods: Forty-eight rabbits with acute myocardial ischemia resulting from intravenous pituitrin injection was established. Electroacupuncture (EA) on the HM and the Lung Meridian, 3 points for each, was applied and their change of arterial pressure was observed.Results: Distinct difference existed in the improvement of arterial pressure on the HM and Lung Meridian with EA. The regulatory action of EA in HM on the cardiac function was significantly better than that of EA in Lung Meridian.Conclusion: HM was closely related to the cardiac function.  
        Keywords：Heart Meridian;Myocardial ischemia;arterial blood pressure;electroacupuncture   
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      • Lin Lan,Li Mingdi,Liu Ximing,Wang Zhaoli,Chu Xiaoyan,Zhang Runyun
        Vol. 5, Issue 2, Pages: 133(1999) DOI: 10.1007/BF02934665
        Keywords：Myocardial ischemia;hyperthyroidism;atrial natriuretic peptide;Trol Group;Increase Body Weight   
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      • Zhang Kejian,Liu Gengtao
        Vol. 5, Issue 2, Pages: 134-137(1999) DOI: 10.1007/BF02934666
        Abstract：Objective: To explore the effects of Schisanhenol (Sal) on generation of reactive oxygen species (ROS) including superoxide anion, hydrogen peroxide and hydroxyl radical as well as on the activity of superoxide dismutase (SOD) and catalase in respiratory burst of rat neutrophils.Methods: Rat neutrophils were prepared from male Wistar rats. Superoxide anion, hydrogen peroxide, hydroxyl radical, SOD and catalase activity were measured.Results: Sal (1, 10, 100 μmol/L) inhibited generation of ROS of rat neutrophils during respiratory burst induced by formyl-methionyleucylphenylalanine (FMLP) and phorbol myristate acetate (PMA) dosedependently, and it enhanced SOD and catalase activities.Conclusion: Sal may inhibit generation of ROS and enhance activity of anti-oxidant enzymes of neutrophils to reduce oxidative injury to tissues.  
        Keywords：Schisanhenol;neutrophils;free radicals;superoxide dismutase;catalase   
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      • Lu Pei,Shi Yumin,Xu Lingen
        Vol. 5, Issue 2, Pages: 138-139(1999) DOI: 10.1007/BF02934667
        Keywords：Allergic Rhinitis;Western Medicine;Nasal Polyp;perennial allergic rhinitis   
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      • Zhou Duanqiu,Gong Chengchu
        Vol. 5, Issue 2, Pages: 140-141(1999) DOI: 10.1007/BF02934668
        Keywords：Total Effective Rate;Acupuncture Group;Sodium Benzoate;Chinese Drug;Method Clinical Data   
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      • Li Jing,Xiao Jianhua,Dong Guirong
        Vol. 5, Issue 2, Pages: 141(1999) DOI: 10.1007/BF02934669
        Keywords：Constipation;Benzoic Acid;thromboxane;cerebral hemorrhage;Aminomethyl   
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      • Hu Ling
        Vol. 5, Issue 2, Pages: 142-145(1999) DOI: 10.1007/BF02934670
        Keywords：Gastric Cancer;Gastric Carcinoma;Induce Cancer Cell Apoptosis;Gastric Mucous Cell;Apoptosis Cell Death   
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      • Dai Xiaohua,Zhou Yixuan,Yu Xingqun,Han Mingxiang
        Vol. 5, Issue 2, Pages: 145(1999) DOI: 10.1007/BF02934671
        Keywords：Gastric Cancer;congestive heart failure;Thyroid Hormone;Gastritis;Gastric Carcinoma   
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      • Vol. 5, Issue 2, Pages: 146-147(1999) DOI: 10.1007/BF02934672
          
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      • Zhang Min,Liang Donghui,Zeng Zhaolong,Li Xiaoming,Chen Yunqin,Qian Xuexian,Yin Bingsheng
        Vol. 5, Issue 2, Pages: 147(1999) DOI: 10.1007/BF02934673
        Keywords：Total Cholesterol;Malaria;Syndrome Differentiation;Toxic Hepatitis;Ideal Criterion   
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      • Vol. 5, Issue 2, Pages: 148(1999) DOI: 10.1007/BF02934674
          
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      • Xie Zhufan
        Vol. 5, Issue 2, Pages: 149-151(1999) DOI: 10.1007/BF02934675
        Keywords：Excessive Heat;Blood Stasis;Effective Fraction;Tongue Coating;Superficial Portion   
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      • Fu Shicong,Du Ning,Shi Weibin,Zhang Hao,Qin Guowei,Zhou Tianxi,She Qilong
        Vol. 5, Issue 2, Pages: 151(1999) DOI: 10.1007/BF02934676
        Keywords：Excessive Heat;Blood Stasis;Radial Fracture;Effective Fraction;Heart Blood   
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      • Yang Tonghua,Deng Daochang
        Vol. 5, Issue 2, Pages: 152-156(1999) DOI: 10.1007/BF02934677
          
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      • Ma Lihong,Jiao Zengmian,Zhang Ruihua
        Vol. 5, Issue 2, Pages: 156(1999) DOI: 10.1007/BF02934678
        Keywords：Drug Treatment;Clinical Observation;Tine;Respiratory Symptom;Good Effect   
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      • Song Jun,Peter Gigante,Han Jin'an,Sun Zenghui,Hu Weiyi
        Vol. 5, Issue 2, Pages: 157-158(1999) DOI: 10.1007/BF02934679
          
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      • Han Jin’an,Sun Zenghui,Hu Weiyi
        Vol. 5, Issue 2, Pages: 158(1999) DOI: 10.1007/BF02934680
        Keywords：Common Cold;Primary Symptom;Patent Medicine;Panax Notoginseng Saponin;Craniocerebral Injury   
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      • Vol. 5, Issue 2, Pages: 159-160(1999) DOI: 10.1007/BF02934681
        Keywords：Brain Edema;Evans Blue;Baicalin;Brain Water Content;Normal Saline Group   
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      • Chen Guangfu,Yu Peilan,Jin Liming,Yang Yujia,Liu Yunsheng,Tao Yongguang
        Vol. 5, Issue 2, Pages: 160(1999) DOI: 10.1007/BF02934682
        Keywords：Brain Edema;Intracranial Hypertension;Evans Blue;Baicalin;Brain Water Content   
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