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      Vol. 5 ， Issue 4 ， 1999
      • Zhou Jinhuang
        Vol. 5, Issue 4, Pages: 242-246(1999) DOI: 10.1007/BF02935391
        Keywords：Traditional Chinese Medicine;Western Medicine;Paroxysmal Nocturnal Hemoglobinuria;Chinese Drug;Tional Chinese Medicine   
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        Published：2021-08-27
      • Quan Dafang,Lu Yongkui,Li Zuoqing
        Vol. 5, Issue 4, Pages: 246(1999) DOI: 10.1007/BF02935392
        Keywords：brain metastasis;Traditional Chinese Medicine;Rational Idea;Chinese Drug;Median Survival Period   
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        Published：2021-08-27
      • Zhou Suning,Duan Changli,Wei Qing,Shao Wei
        Vol. 5, Issue 4, Pages: 247-249(1999) DOI: 10.1007/BF02935393
        Abstract：Objective: To observe the preventing and treating effect of Salvia Miltiorrhiza Compsita (SMC) in patients with ischemic coronary heart disease (CHD) undergoing non-heart surgery.Methods: One hundred and eight patients were randomly divided into control group and treatment group. During operation, the control group was treated by heteropathy such as nitrate ester, while the treatment group was treated with SMC intravenously. ECG, heart rate (HR), mean arterial pressure (MAP) and sphygmous blood oxygen saturation (SpO2) and quantity of blood loss were observed during and at the end of the operation. The efficacy of treatment was judged according to the change of ECG.Results: The total effective rate in the treatment group was 90.7% (49/54 cases), while in the control group it was 35.2% (19/54 cases). There was significant difference between the two groups (P < 0. 01). HR of the patients in the treatment group was not changed significantly, but in the control group, it became faster (P < 0.05). No significant difference was found in MAP and SpO2 between the two groups, or in comparison of data before and after operation. Also no significant difference in quantity of blood loss was shown between the two groups.Conclusion: SMC could effectively protect heart function from myocardial ischemia in patients with CHD undergoing non-heart surgery, neither shows any side effect. Therefore, it is an effective and safe measure.  
        Keywords：Salvia miltiorrhiza composita;coronary heart disease;non-heart surgery;myocardial ischemia during operation   
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        Published：2021-08-27
      • Qiu Ruixiang,He Jingbo,Lan Jun
        Vol. 5, Issue 4, Pages: 250-253(1999) DOI: 10.1007/BF02935394
        Abstract：Objective: To assess the effect of Xinmaitong (XMT) capsule in treating coronary heart disease (CHD).Methods: The 38 patients of coronary heart disease with myocardial ischemia were divided randomly into XMT group (20 cases) and control group (18 cases). Conventional western medical therapy was given to both groups and the XMT group received XMT treatment in addition. The changes of endothelin (ET) and calcitonin gene-related peptide (CGRP) levels, ST segment of ECG and clinical symptoms after treatment in all the patients were observed. 14 healthy persons were taken as normal control.Results: The ET level of all patients was significantly higher than that of normal control (P < 0. 001), and level of CGRP in patients was not significantly different from normal (P > 0. 05). After treatment, results showed that: (1) The ET levels and the scores of clinical symptoms of both groups decreased significantly (P < 0. 01), and the depressed ST segment elevated markedly (P < 0.01) as compared with that before treatment, and the changes revealed more evidently in XMT group in comparison with those in the control group (P < 0. 05~0. 01). (2) The level of CGRP was significantly increased in XMT group (P < 0. 01) while it was unchanged in the control group (P > 0. 05).Conclusion: Thereis a severs damage of vascular endothelial cells (VEC) in patients of coronary heart disease. XMT could not only reduce significantly the plasma ET content, but also enhance markesdly the production and release of CGRP, so it has a good anti-ischemic effect, which may be closely correlated with its action on improving the function of VEC and regulating metabolism of ET and CGRP.  
        Keywords：Xinmaitong capsule, vascular endothelial cells;endothlin;calcitonin gene-related peptide   
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        Published：2021-08-27
      • Zhao Zhiming,Yang Xiaoying,Zhang Yongzhen,Xiao Zhengyi
        Vol. 5, Issue 4, Pages: 254-256(1999) DOI: 10.1007/BF02935395
        Abstract：Objective: To observe the clinical efficacy of puerarin in treating patients with unstable angina (UA).Methods: Frequency of angina occurrences, consumed doses of nitrates, heart rate (HR), blood pressure, rest electrocardiogram (ECG) and myocardial oxygen consumption were observed before and after drug therapy in puerarin group (21 cases) and control group (18 cases) respectively.Results: The effect in the puerarin group not only showed to be better than that in the control group in reducing frequency of angina occurrence and consumed doses of nitrates, and improving abnormal rest ECG, but also appeared to be preferable to the control group in reducing myocardial oxygen consumption and increasing exercise duration (P < 0. 05).  
        Keywords：Puerarin;Unstable Angina;Myocardial Oxygen Consumption   
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        Published：2021-08-27
      • Han Liya,Cai Dingfang
        Vol. 5, Issue 4, Pages: 257-260(1999) DOI: 10.1007/BF02935396
        Abstract：Objective: To evaluate the effect of Acanthopanacis Senticosi in treating acute cerebral infarction and its mechanism.Methods: Clinical study using single-blind, control trial, in which 60-80 ml of Acanthopanax Injection (AI) added to 500 ml of 0.9% normal saline were given by intravenous drip once a day for 14 days in the AI group, while 500 ml of low molecular dextran were given in the same way to the control group. In experimental study, rabbit model of acute incomplete cerebral ischemia was made by ligation of bilateral common carotid artery. 10 ml of AI were given once daily intravenously for 7 days to the AI group and 10 ml of normal saline was given to the control group in the same way. Clinical effects (in clinical study) and effect of AI on cerebral oxygen free radicals (OFR), superoxide dismutase (SOD), and serum concentration of ACTH and cortisone were all observed (in experimental study).Results: The total effective rate in the AI group was higher than that in the control group while nervous functional deficit score was lower in the AI group than that in the control group significantly. The cerebral level of OFR, serum level of ACTH and cortisone decreased while SOD increased after treatment in AI group.Conclusion: AI was effective in treating acute cerebral infarction, the mechanism is probably by ameliorating peroxidation in brain and improving hypothalamic-pituitary-a-drenocortical axis function.  
        Keywords：Acanthopancis Seniticosi;Cerebral Infarction;oxygen free radical   
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        Published：2021-08-27
      • Li Ji,Zheng Jin,Wang Dazeng
        Vol. 5, Issue 4, Pages: 260(1999) DOI: 10.1007/BF02935397
        Keywords：Tamoxifen;endometriosis;Cerebral Infarction;Acute Ischemic Stroke;acute cerebral infarction   
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        Published：2021-08-27
      • Wang Huaizhang,Lin Zhuotang
        Vol. 5, Issue 4, Pages: 261-264(1999) DOI: 10.1007/BF02935398
        Abstract：Objective: To observe the clinical efficacy of Kang’aibao oral liquid (KABL), a Chinese herbal preparation in treating malignant tumor of middle or advanced stage.Methods: A comparative study was done by observing the effect of 103 patients treated with KABL, and another 90 patients treated with chemotherapy at the same time were taken as the control group.Results: The immunologic function, short-term effective rate (complete relieved rate and partial relieved rate), survival quality, 1-, 2- and 3-year survival rate, median survival time, and carcinoembryonic antigen (CEA) declining rate of the KABL group were significantly higher than those of the control group.Conclusion: KABL has the effects of inhibiting tumor growth, prolonging survival time and improving survival quality of tumor patients.  
        Keywords：alignant tumor of middle or advanced stage;Kang’aibao oral liquid;Survival Time;survival quality   
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        Published：2021-08-27
      • Liu Jun,Liu Huitu,Wang Yan,Liang Yunyan,Wang Daishu
        Vol. 5, Issue 4, Pages: 264(1999) DOI: 10.1007/BF02935399
        Keywords：Nude Mouse;Soft Agar;Chinese Herbal Medicine;Chinese Herb;Beijing Institute   
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        Published：2021-08-27
      • Li Jing,Xiao Jianhua,Dong Guirong
        Vol. 5, Issue 4, Pages: 265-268(1999) DOI: 10.1007/BF02935400
        Abstract：Objective: To study the therapeutic effect of scalp-acupuncture in treating acute cerebral hemorrhage and its mechanism.Methods: Sixty-four patients were randomly divided into two groups, the acupuncture group and the control group. All were treated with mannitol and furosemide to reduce intracranial pressure, and p-aminomethyl benzoic acid for hemostasis. The acupuncture group received scalp-acupuncture additionally. Neurofunction deficit scoring (NDS), hemorheology, thromboxane, prostacyclin, endothelin and transcranial Doppler (TCD) ultrasonic examination were carried out before and after treatment.Results: NDS of the acupuncture group was markedly better than that of the control group, especially in function recovering of limbs and speech. Blood viscosity, thromboxane and endothelin level in the acupuncture group lowered obviously after treatment, as compared with those in the control group, and the difference was significant, P < 0.01. TCD showed that the cerebral blood flow was markedly improved in the acupuncture group.  
        Keywords：erebral hemorrhage;scalp-acupuncture;thromboxane;endothelin;prostacyclin   
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        Published：2021-08-27
      • Lai Xinsheng,Mo Feizhi,Jiang Ganghui,Li Jianqiang,Chen Jingliang,Kuang Zaoyuan,Zhang Zheng,Zhang Jiawei,Zheng Zongchang,Peng Zengfu
        Vol. 5, Issue 4, Pages: 269-274(1999) DOI: 10.1007/BF02935401
        Abstract：Objective: To observe the clinical effect of electro acupuncture and acupuncture on superoxide dismutase (SOD), lipid peroxide (LPO) and nitric oxide (NO) in vascular dementia (VaD) patients.Methods: Forty-six cases of VaD were randomly divided into two groups, the electroacupuncture group (EA group) and the acupuncture group (AP group). Assessment of Hasgawa’s Dementia Scale (HDS), Functional activities Questionnaire (FAQ) and neurologic deficit scoring (NDS) were determined before and after treatment, and the changes in SOD, LPO and NO levels were observed.Results: After treatment, in the EA group, HDS of patients got elevated, FAQ lowered, SOD increased and LPO and NO decreased. The changes were significant as compared with pretreatment, P < 0. 01. But these parameters underwent no significant changes in the AP group after treatment. The clinical symptoms were improved in both groups, but the reduction in NDS was not significant. The total effective rate of the EA group was higher than that of the AP group.  
        Keywords：Vascular Dementia;acupuncture;electroacupuncture;superoxide dismutase;lipid peroxide;Nitric Oxide   
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        Published：2021-08-27
      • Yan Meizhen,Ye Wenhua,Song Hongyue,Zhang Liming,Wu Yinhong,Zhou Zhongming
        Vol. 5, Issue 4, Pages: 274(1999) DOI: 10.1007/BF02935402
        Keywords：Lactobacillus;Traditional Chinese Medicine;Adherence Rate;Bacterial Adherence;Intestinal Flora   
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        Published：2021-08-27
      • Wang Xiaofang,Liu Jiangang,Shi Dazhuo,Bao Xiaofeng
        Vol. 5, Issue 4, Pages: 275-278(1999) DOI: 10.1007/BF02935403
        Abstract：Objective: To observe the effects of Xin’an capsule (XAC) on experimental ventricular arrhythmia (EVA) in animals and to explore the possible mechanism.Methods: Three types of animal arrhythmic model (ventricular arrythmia in guinea pigs induced by Ouabin, in rats caused by reperfusion after ligation of descending anterior branch of coronary artery and by CaCl2) were used to study the effects of XAC on ventricular arrhythmia (VA).Results: After XAC treatment, the dosage of Ouabin needed for inducing ventricular premature beat (VPB), ventricular tachycardia (VT) and ventricular fibrillation (VF) increased in guinea pigs. The sustaining time of reperfusion induced VT and total occurrence of ventricular arrhythmias decreased. XAC also showed an effect in increasing CaCl2 dosage needed to cause VA, and decreased the occurrence of VF and death in rats  
        Keywords：Xin’an capsule;ventricular arrhythmia;Ouabin;reperfusion;calcium chloride   
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        Published：2021-08-27
      • Sun Baoliang,Xia Zuoli,Zheng Chengbi,Li Wenxia,Fang Yuzhen
        Vol. 5, Issue 4, Pages: 279-282(1999) DOI: 10.1007/BF02935404
        Abstract：Objective: To investigate the role of endothelin-1 (ET-1) in development of ischemic brain damage after subarachnoid hemorrhage (SAH), and the protective effect of Ginkgo biloba extract (GBE) on it.Methods: Noncraniotomy SAH models of Wistar rat were divided into SAH group and GBE treated group, the diameter of basilar artery (BA), dynamic changes of regional cerebral blood flow (rCBF) and ET-1 content of in-tracranial plasma within 24 hours after SAH of both groups were determined. And pathological examination of CA1 region of hippocampus was performed 3 days later.Results: rCBF decreased and ET-1 content increased obviously and steadily in 24 hours after SAH. Spasm of BA occurred half an hour after SAH and neurons of hippocampus CA1 region were damaged severely. GBE could antagonize the above-mentioned pathological changes effectively  
        Keywords：subarachnoid hemorrhage;cerebral vasospasm;Ischemic Brain Damage;endothelin;Ginkgo Biloba Extract   
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        Published：2021-08-27
      • Liu Hedi,Li En
        Vol. 5, Issue 4, Pages: 283-287(1999) DOI: 10.1007/BF02935405
        Abstract：Objective: To explorate the influence of replenishing Kidney herbs on dexamethasone (DXM) or retinoic acid (RA) induced osteoporosis in rats.Methods: Model animal of osteoporosis was made by DXM injection or RA through gastrogavage, and some animals received replenishing Kidney herbs during modelling. Changes of serum calcium, phosphate, alkaline phosphatase (ALP), estrogen (E), prostaglandin E2(PGE2), 1, 25-dihydroxyvitamin D3(VD3), uric hydroxyproline (UHP), intestinal calcium absorption, bone ash weight, bone density, bone histopathology as well as the change of intestinal calcium absorption vector-Ca-binding protein D9K (CaBp-D9K) gene and its mRNA expression were examined and compared.Results: DXM or RA could markedly induce bone metabolism disorder, showed as morphologic and histologic changes of bone, in DXM group, decrease of E2, VD3, bone density, bone ash weight, intestinal calcium absorption, increase of PGE2, and in RA group, decrease of serum E2, calcium, phosphate, ALP, UHP, bone density, bone ash weight, and intestinal calcium absorption. These changes could be reduced significantly when rats received replenishing Kidney herbs during modelling, and approached to normal.Conclusion: Osteoporosis induced by long-term application of DXM and low calcium diet feeding is a good animal model for experimental research. Replenishing Kidney herbs could significantly improve bone metabolism disorder induced by DXM or RA  
        Keywords：Osteoporosis;dexamethasone;retinoic acid;replenishing Kidney herb   
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        Published：2021-08-27
      • Li Ningjun,Li Jingzi,Xin Gang,Xu Yuan,Hong Jianmei,Wang Haiyan
        Vol. 5, Issue 4, Pages: 287(1999) DOI: 10.1007/BF02935406
        Keywords：Brush Border Membrane Vesicle;Cholesterol Acyltransferase;LCAT Activ;Regulate Lipid Metabolism;climacteric syndrome   
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        Published：2021-08-27
      • Zhang Jiping,Li Changling,Guo Xinxin,Wang Yinye
        Vol. 5, Issue 4, Pages: 288-291(1999) DOI: 10.1007/BF02935407
        Abstract：Objective: To observe the influence of Buyang Huanwu Decoction (BYHWD) on the activity of blood platelet activating factor receptor (PAFR).Methods: BYHWD was administered to rabbits in vitro or in vivo and its effect on PAFR was observed by radioligand receptor binding method.Results: BYHWD tended to increase the specific binding amount of washed-platelet-PAFR with radioligand in vivo, which was similar to that of Ginkgo leaf extract. And in vitro, it showed an inhibition on the specific binding of washed-platelet-PAFR.Conclusion: BYHWD has certain effect on PAFR amount in vivo and PAFR activity in vitro  
        Keywords：Buyang Huanwu Decoction;platelet activating factor;radioligand receptor binding   
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        Published：2021-08-27
      • Zhang Qunhao,Lin Zhibin
        Vol. 5, Issue 4, Pages: 291(1999) DOI: 10.1007/BF02935408
        Keywords：Public Health;Tumor Cell;mRNA Expression;Blood Cell;Polysaccharide   
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      • Vol. 5, Issue 4, Pages: 292-293(1999) DOI: 10.1007/BF02935409
          
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      • Vol. 5, Issue 4, Pages: 294-295(1999) DOI: 10.1007/BF02935410
          
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        Published：2021-08-27
      • Xu Yong,Yu Jun,Song Qinzhu,Gu Shilling
        Vol. 5, Issue 4, Pages: 295(1999) DOI: 10.1007/BF02935411
        Keywords：Ofloxacin;Western Medicine;Chinese Herbal Medicine;Acute Abdomen;National Invention   
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        Published：2021-08-27
      • Hong Wuli
        Vol. 5, Issue 4, Pages: 296-299(1999) DOI: 10.1007/BF02935412
        Keywords：Blood Stasis;Ayurvedic Medicine;Barley Flour;Moxibustion Therapy;Tibetan Medicine   
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        Published：2021-08-27
      • Jiang Zhaoshun,Zhang Shenglan,Xing Wanjia,Yan Hui,Yin Geping,Kou Tianqin
        Vol. 5, Issue 4, Pages: 299(1999) DOI: 10.1007/BF02935413
        Keywords：Diabetes Mellitus Patient;Blood Stasis;Ayurvedic Medicine;Tibetan Medicine;Cytome   
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        Published：2021-08-27
      • Xie Zhufan
        Vol. 5, Issue 4, Pages: 300-302(1999) DOI: 10.1007/BF02935414
        Keywords：Tongue Coating;Rapid Pulse;Cold Symptom;Excess Syndrome;Loose Bowel   
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        Published：2021-08-27
      • Chen Xing,Zhu Guoying,Feng Meifu
        Vol. 5, Issue 4, Pages: 302(1999) DOI: 10.1007/BF02935415
        Keywords：Fetal Calf Serum;Vascular Smooth Muscle Cell;Amenorrhea;free calcium;Cold Symptom   
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        Published：2021-08-27
      • Zhou Daihan
        Vol. 5, Issue 4, Pages: 303-308(1999) DOI: 10.1007/BF02935416
          
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        Published：2021-08-27
      • Li Guoqin,Qi Wensheng,Xiong Kangmei,Yang Xiujie,Fu Yalong,Zhao Bing,Song Qingqiao
        Vol. 5, Issue 4, Pages: 308(1999) DOI: 10.1007/BF02935417
        Keywords：heart failure;congestive heart failure;acute myocardial infarction;Medical Journal;combination treatment   
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        Published：2021-08-27
      • Xie Meilin,Chen Keji
        Vol. 5, Issue 4, Pages: 309-313(1999) DOI: 10.1007/BF02935418
          
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        Published：2021-08-27
      • Vol. 5, Issue 4, Pages: 314(1999) DOI: 10.1007/BF02935420
        Keywords：uremia;Arteriosclerosis;Dysentery;Borneol;Hepatic Coma   
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      • Vol. 5, Issue 4, Pages: 314(1999) DOI: 10.1007/BF02935419
        Keywords：uremia;Arteriosclerosis;Dysentery;Borneol;Hepatic Coma   
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      • Vol. 5, Issue 4, Pages: 315-317(1999) DOI: 10.1007/BF02935421
        Keywords：Zhejiang Province;Anhui Province;Shanxi Province;Hainan Province;Rheumatoid Disease   
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