Latest Issue
Vol. 6 ， Issue 1 ， 2000
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- Abstract：Objective: To explore the mechanism of Buyang Huanwu Decoction (BYHWD) in treating primary nephrotic syndrome (PNS).Methods: Based on the treatment of prednisone acetate and cytoxan, two groups of PNS patients were treated with aspirin and persantin (western medicine group, WM, 35 patients) and BYHWD plus WM (TCM-WM group, 35 patients) respectively. The effect on anticoagulation was observed and compared. Plasma levels of thromboxane B2 (TXB2 ), 6-keto-prostaglandin F1α (6-K-PGF1α), endothelin (ET), calcitonin gene related peptide (CGRP) were determined before and after treatment, at the reducing dose and shifting to maintenance dose of prednisone. The therapeutic effect of the two groups were also observed. Another group of 30 healthy subjects was established for control.Results: The differences of TXB2, 6-K-PGF1α, ET and CGRP between patients and healthy subjects were very significant before treatment (P < 0. 001). The above-mentioned 4 parameters improved synchronously with the clinical improvement in the therapeutic course and they were better in the TCM-WM group than those in the WM group (P < 0.001 ), and the complete remission rate of the former group was also higher than that of the latter (62.9 % vs 37.1 %, χ2 = 4.63, P < 0.05).Conclusion: BHD could improve the therapeutic effect in treating PNS through the mechanism of improving TXB2, 6-K-PGF1α, ET and CGRP levels.Keywords：Buyang Huanwu Decoction;primary nephrotic syndrome;thromboxane B2;6-keto-prostaglandin F1α;endothelin;calcitonin gene related peptide
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Published：2021-08-27 - Abstract：Objective: To investigate the effect of Yishen Huanshuai recipe (YSHSR) on the progression of chronic renal failure (CRF).Methods: Forty-six patients with CRF were divided into two groups: group A (self-controlled group, n= 18), whose treatment plan was subdivided into two phases. During the first phase, the patients treated with low protein diet and controlling blood pressure, while in the second phase, YSHSR was given. Group B (n = 28), whose treatment plan was similar with that of group A in the second phase. The rate of progression of CRF was estimated by slope of the creatinine reciprocal (dl/mg) with time (month).Results: Mean slope of the creatinine reciprocal with time from the group A during the first phase was - 0. 0104 ± 0. 0021, while during the second phase, it was - 0. 0034 ± 0. 0018. There was significant difference between them (P<0.05). Mean slope from the group B was - 0.0047 ± 0.0020. There was also significant difference between that from the group B and that from the group A during the first phase (P<0.05).Conclusion: Low protein diet and controlling blood pressure combined with YSHSR therapy could markedly retard the rate of progression of CRF.Keywords：chronic renal failure;Yishen Huanshuai recipe;estimating progression of chronic renal failure
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Published：2021-08-27 - Abstract：Objective: To explore the ameliorative effect and mechanism of Panax notoginseng (PNG) and Ticlid in treating early diabetic nephropathy (DN).Method: Fifty-eight patients were divided randomly into two groups, 28 patients of the Ticlid group treated with Ticlid 250 mg orally, once a day and 30 patients of the PNG group treated with PNG 8 ml in 250 ml of normal saline intravenous drip once a day. The therapeutic effect and relative indexes of the two groups were observed and compared.Results: After treatment, in both groups, the thromboxane B2 markedly reduced and was more prominent in the Ticlid group (P<0.05), while the 6-keto-prostaglandin F1α increased obviously, so as to cause a significant lowering of T/K ratio, P<0. 01. Levels of urinary albumin, β2 microglobulin and blood ±1 microglobulin of both groups were lowered significantly, P<0. 01. A significant positive linear correlation was found in the Ticlid group between urinary albumin and T/K ratio (r = 0.41, P < 0.01), as well as in blood ±1 microglobulin with T/K ratio (r = 0. 34, P < 0.05), while it was not found in the PNG group.Conclusion: Ticlid and PNG were beneficial to resume the balance of T/K ratio and improve microcirculation, reduce whole blood viscosity and decrease urinary albumin so as to retard the progress of DN.Keywords：diabetic nephropathy;Panax Notoginseng;Ticlid
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Published：2021-08-27 - Abstract：Objective: To investigate the effects on myocardial injury and sarcoplasmic reticulum (SR) Ca2+ - ATPase of viral myocarditis mice treated with Astragaloside (AS) and Astragalus Injection (AI).Methods: Viral myocarditis model was created by intraperitoneal inoculation with coxsackievirus B3m (CVB3m ) solution and were divided into model, AS, AI and normal control groups. The mortality, myocardial pathological changes, serum cardiac troponin I (cTnl) and the activity of myocardial Sarco/Endoplasmic Ca2+-ATPase (SER-CA) were observed.Results: The mortality of model was higher than that of the normal control (P = 0. 0042), AS and AI (P<0.05). The serum level of cTnl of model was significantly higher than that of the normal control (P<0.001), AS (P<0.025) and AI (P < 0.05). The myocardial necrosis and inflammatory changes of AS and AI groups were alleviated than that of model (P < 0.01). The activity of myocardial SERCA of model were significantly lower than that of normal control (P<0.001), AS (P<0.01) and AI (P < 0.05).Conclusions: AS and AI have some protecting effects on myocardial injury of viral myocarditis mice. AS is the effective component ofAstragalus membranaceus in treating viral myocarditis. One of the mechanisms ofAstragalus membranaceus and AS for viral myocarditis mice depriving of the myocardial injury may be due to improve the activity of myocardial SERCA in the mice.Keywords：Myocarditis;Myocardial Injury;Normal Control Group;Viral Myocarditis;Astragaloside
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Published：2021-08-27 - Abstract：Objective: To elevate the efficacy of dialysis in uremia patients treated with maintaining hemodialysis.Methods: Thirty patients of terminal stage uremia were treated with Tongmai oral liquid and rhubarb capsule combined with hemodialysis were observed and compared with a control group of 30 patients treated with hemodialysis alone. The therapeutic course of both groups was 1 month and the observation lasted for 3 months consecutively.Results: The mean time urea nitrogen concentration (TACurea), protein catabolic rate (PCR) and the KT/V value of the treated group were all better than those of the control group (P< 0.05).Conclusion: Uremia patients treated with Tongmai oral liquid and rhubarb capsule combined with hemodialysis were better in full utilization of hemodialysis and life quality of patients in comparison with patients treated with hemodialysis alone.Keywords：uremia;hemodialysis;Traditional Chinese Medicine;therapy
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Published：2021-08-27 - Abstract：Objective: To investigate the protective effect of Dingxin Recipe (DXR) on arrhythmia and injury induced by ischemia and reperfusion.Methods: Rabbits were randomly divided into four groups and administered orally with DXR of high dose, low dose, propanolol and distilled water. Two-step coronary artery ligature was used to form ischemia and reperfusion model. Superoxide dismutase (SOD), cyclic adenosine monophosphate (cAMP), norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), myocyte ultrastructural injury and occurrence of arrhythmia were investigated.Results: DXR could obviously antagonize arrhythmia induced by myocardial infarction or ischemia and reperfusion in rabbits. Compared with the control group, DXR of high and low doses could improve the changes in ST-T. In rabbits treated with DXR, the levels of SOD were elevated while cAMP, NE, DA, 5-HT and the whole blood viscosity were lowered.Conclusions: DXR could obviously antagonize arrhythmia and injury induced by ischemia and reperfusion, DXR may clear oxygen free radical, regulate the second messenger, inhibit sympathetic nerve system, improve local circulation, protect mitochondria and prevent the activation of lysosome and safeguard the cardiac myocyte to be free from injury.Keywords：ischemia;superoxide dismutase;Nephrosis;Cardiac Myocyte;Blood Viscosity
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Published：2021-08-27 - Abstract：Objective: To study the relationship between blood stasis syndrome (BSS) and platelet activation and its influencing factors in type 2 diabetic mellitus (DM).Methods: Platelet CD62p, CD63 expressions were determined in 30 type 2 DM patients with BSS, 27 type 2 DM patients without BSS and 20 normal controls by flow cytometry.Results: CD62p, CD63 levels were significantly higher in type 2 DM group with BSS than those in the type 2 DM group without BSS and in the normal controls. CD62p was positively correlated with CD63, while positive correlation existed between HbA1c, LDL-C and CD62p in DM patients with BSS.Conclusions: The increased level of platelet activation was the primary molecular basis of BSS in type 2 DM. It was important to perform the syndrome differentiation of BSS and treatment of activating blood flow to remove BSS in type 2 DM.Keywords：type 2 diabetes mellitus;platelet activation;Blood Stasis Syndrome;Flow Cytometry
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Published：2021-08-27 - Abstract：Objective: To observe the effect of Yiqi Huoxue (replenishing Qi and activating blood circulation, YQHX) recipe in patients with advanced stage of esophageal cancer treated with radiotherapy and intervention chemotherapy.Methods: In comparing 31 patients who were treated with radio-chemotherapy (RCT, Group A), and 31 patients treated with RCT plus YQHX recipe (Group B).Results: Immediate effective rates were 48.4 % in Group A and 64.5 % in Group B(P>0.05). The function of bone marrow in Group B was obviously better than that in Group A. The 1 year metastasis rate in Group A was higher than that in Group B, but the long-term survival rate of Group B was obviously higher than that in Group A (P<0.05).Conclusion: YQHX recipe could reduce the bone marrow suppression caused by RCT, lower the metastasis rate, prolong the long-term survival and improve the quality of life.Keywords：esophageal cancer;radiotherapy;intervention chemotherapy;Yiqi Huoxue recipe
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Published：2021-08-27 - Abstract：Objective: To observe the effect of Ginseng injection on congestive heart failure (CHF) and its influence on thyroid hormones.Methods: Fifty-four patients of CHF were divided into two groups. On the basis of conventional treatment of western medicine, the Ginseng injection was given to the treated group additionally. Blood level of triiodothyronine (T3), thyroxine (T4), reverse triiodothyronine (rT3) and thyroid stimulating hormone of all patients were determined before and after treatment by radioimmunoassay.Results: There were significant difference between the treated group and the control group in cure rate and mean course of therapy. The levels of T3 and T4 of all patients were lower than those of the normal control before treatment, and rT3 were higher. Two weeks after treatment, T3 and T4 level in all patients increased significantly and rT3 level significantly decreased (P < 0.05,P < 0.01).Conclusion: Ginseng injection has a good effect on patients with CHF. It also has regulatory effect on thyroid hormones.Keywords：congestive heart failure;Ginseng injection;Thyroid Hormone
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Published：2021-08-27 - Abstract：Objective: To probe the relationship of glucocorticoid receptor and some Chinese medicinal herbs.Methods: The model of Qi-Yang exhaustion and Qi-Yin exhaustion were made with hemorrhagic rats and heat-stressed rats respectively. The effect of Shenfu decoction (SFD) and Shengmai powder (SMP) on plasma glucocorticoid (GC) and its receptor (GcR) in hepatic cytosol of the models were measured respectively.Results: The activity of GcR decreased in both models, while their blood level of GC increased markedly. SFD and SMP showed no regulating effect on blood GC, but displayed obvious up-regulation on GcR level in both models.Conclusion: SFD and SMP could up-regulate the activity of GcR in Qi-Yang and Qi-Ying exhaustion models.Keywords：Shenfu decoction;Shengmai powder;glucocorticoid receptor
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Published：2021-08-27 - Abstract：Objective: To investigate the mechanism of Astragalus-Angelica Mixture (AAM) ’s effects on lipid metabolism disturbance in nephrotic rats.Methods: To examine the effects of AAM on serum albumin, lipid levels, and activities of lipoprotein lipase (LPL) and lecithin-cholesterol acyltransferase (LCAT), which are key enzymes for metabolism of lipid in immune-induced nephrotic hyperlipidemia rats and exogenous hyperlipidemia rats.Results: In nephrotic rats, serum albumin was reduced, lipid increased significantly, LPL activity decreased markedly and the LCAT activity was relatively insufficient. Activities of LPL and LCAT increased obviously in AAM treated nephrotic rats. There were no change of activities of LPL and LCAT in exogenous hyperlipidemia rats and AAM showed no effect on the activities of these two enzymes.Conclusion: The effect of AAM on regulating lipid metabolism might be due to enhance the clearance of both triglyceride-rich and cholesterol-rich apoB containing lipoprotein by improving the activities of LPL and LCAT.Keywords：Astragalus-Angelica Mixture;Nephrotic Syndrome;Lipoprotein Lipase;lecithin-cholesterol acyltransferase;hyperlipidemia
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Published：2021-08-27 - Abstract：Objective: To explore the mechanism of multi-infarct dementia (MID) treated with the principle of Yijing Tishen (YJTS, reinforcing Kidney-essence and refreshing mental activities).Methods: MID rat models were established successfully with injecting sterile and naturally dried blood clots of the homologous rat into common carotid artery and screened by the first jumping-off latency of diving-platform reflex, based on which, the effect of YJTS in learning and memorizing, monoamine neurotransmitters content in brain tissue, malondialdehyde (MDA) content and Superoxide dismutase (SOD) activity in serum and brain tissue, and brain morphosis of multi-infarct rats were observed.Results: Obvious malfunction of learning and memorizing was found in MID rat models, and there were also significant decreasing of monoamine neurotransmitters content in partial brain zones, decreasing of SOD activity in brain and increasing of MDA content in serum and brain. YJTS could obviously improve learning and memorizing, raise SOD activity and monoamine neurotransmitters content in brain tissue, lower MDA content in serum and brain of MID rat models, protect brain morphosis of multi-infarct rats.Conclusion: YJTS might treat MID by restraining lipid peroxidation, improving monoamine neurotransmitters content in partial brain zones and decreasing ischemic damage of brain tissue.Keywords：principle of Yijing Tishen;Vascular Dementia;malondialdehyde;superoxide dismutase;monoamine neurotransmitters
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Published：2021-08-27 - Abstract：Objective: To study the effect of Tongbiling (TBL) on the proliferation of synovial fibroblast and interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α) and prostaglandin E2(PGE2) secreted by synoviocytes in adjuvant arthritis (AA) rats.Methods: Synovial fibroblast was derived from culture of tissue piece. The effect of primary synoviocyte culture supernatants on the fibroblast proliferation were assayed and IL-1, TNF-α bioactivity and PGE2 content of supernatants of cultured synoviocytes were measured.Results: TBL could significantly inhibit the synovial fibroblast proliferation (P < 0.001), and down-regulate IL-1, TNF-α and PGE2 productions (P < 0. 001); indomethacin could obviously promote the synovial fibroblast proliferation (P < 0.001). It significantly inhibited PGE2 production, but further up-regulated IL-1 and TNF-α secreted by synoviocytes (P<0.01).Conclusion: The therapeutical effect of TBL on AA might be associated with its down-regulating the secretory function of synoviocyte, then restoring the abnormal proliferation of fibroblast to normal levels.Keywords：Adjuvant Arthritis;synovial membrane;cell culture;fibroblast;cell proliferation;cytokine;Tongbiling
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Published：2021-08-27 - Abstract：Objective: To observe the therapeutic effect of compound decoction of Comcide (CDC), a traditional Chinese medicine (TCM) in treating the withdrawal reaction (WR) of heroin dependent rhesuses (HDR).Methods: To study therapeutic effects of CDC and methadone in treating WR of HDR models induced by administering of heroin. Through observing, comparing and evaluating the scores of all groups gained during the first 4 days when the WR was most severe.Results: CDC and methadone had the same therapeutic effects on WR of HDR. There were significant differences between the scores of CDC and methadone, and that of natural withdrawal,P < 0. 01; while there were insignificant difference between the scores of CDC and that of methadone,P > 0.05.Conclusion: CDC had the therapeutic effect in treating WR of HDR.Keywords：heroin dependent rhesuses;withdrawal therapy;compound decoction of Comcide
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Published：2021-08-27 - Keywords：Traditional Chinese Medicine;Nephritis;Total Effective Rate;Traditional Chinese Medicine Syndrome;Western Medicine Treatment
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Published：2021-08-27 -
- Keywords：Blood Urea Nitrogen;Hemorrhagic Fever With Renal Syndrome;Carthamus Tinctorius;Astragalus membranaceus;Nail Fold
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Published：2021-08-27 - Keywords：Vocal Cord;Western Medicine;Chinese Herbal Medicine;Total Effective Rate;Laryngitis
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Published：2021-08-27 - Keywords：Salicylic Acid;Puerarin;Total Effective Rate;Sexual Transmit Disease;Keratosis
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Published：2021-08-27 - Abstract：Objective: To observe the clinical effect of the treatment of infantile viral myocarditis with puerarin.Methods: Puerarin was administered intravenously together with conventional treatment in the treated group, while that of conventional treatment solely was given in the control group. Creatine kinase isoenzyme, lactate dehydrogenase isoenzyme, cardiac function and clinical manifestations before and after treatment were observed.Results: Puerarin could significantly relieve the symptoms of patients of infantile viral myocarditis, enhance the metabolism of myocardium and improve the cardiac function. The total effective rate of the treated group was 87.04 %, significantly higher than that of the control group, the difference between them was significant (P < 0.05).Conclusion: Puerarin can be used to treat patients with infantile viral myocarditis with a satisfactory result.Keywords：cardiac function;Conventional Treatment;Puerarin;Total Effective Rate;Killing Effect
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Published：2021-08-27 - Keywords：acute respiratory infection;Puerarin;Peking Union Medical College;Viral Pneumonia;Surveillance Site
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Published：2021-08-27 - Abstract：Objective: To observe the effect of puerarin on superoxide dismutase (SOD), lipid peroxidation (LPO), tissue plasminogen (TPA) and plasminogen activator inhibitor (PAI-1) of coronary heart disease (CHD) patients.Methods: Forty-eight patients were divided into two groups (treated group and control group). Treated group was given intravenously 600 mg puerarin, once daily for one week, also the same treatment as that of control was given. Nitrite colorimetric method, radioimmunoassay (RIA), TBA fluorescent development process and fibrinolysin specific colorbase substrate decomposition development process were used to determine SOD activity, SOD, LPO, TPA and PAI-1.Results: After the treatment with puerarin, SOD activity was increased, LPO reduced, while without any changes in the control group. There was insignificant changes of SOD between the treated and the control groups. TPA and PAI-1 were increased significantly in the treated group, but was insignificantly changed in the control group.Conclusion: Puerarin can increase the SOD activity, decrease LPO level and enhance the activity of fibrinolysis.Keywords：superoxide dismutase;Plasminogen;Plasminogen Activator Inhibitor;Tissue Plasminogen;Fibrinolytic Activity
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Published：2021-08-27 - Keywords：Scopolamine;Naltrexone;aplastic anemia;Drug Addict;Opiate Withdrawal
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Published：2021-08-27 - Keywords：Blood Stasis;Syndrome Differentiation;Morbid Condition;Impede Flow;Febrile Disease
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Published：2021-08-27 - Keywords：Curcuma Longa;Glycyrrhiza Uralensis;Clear Heat;Commercial Information;Angelica Dahurica
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Published：2021-08-27 - Keywords：Traditional Chinese Medicine;Viral Disease;Western Medicine;Syndrome Differentiation;Outward Appearance
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Published：2021-08-27 - Abstract：DNA technology based molecular profiling provides the ultimate and definitive means of authentication for Chinese drugs. RFLP, RP-PCR and microsatellite-SSR examine the whole genome. With the appropriate primer, it is in principle possible to differentiate closely related species and even one individual from another. PCR-SR, PCR-RFLP, AFLP, SCAR, DALP and DNA sequencing examine a defined region on the genome and produce well-defined conclusions. Since different regions on the genome evolve to different extents, by choosing the target DNA carefully, organisms of different systematic levels can be compared. Of these molecular techniques mentioned above, genomic fingerprints and DNA sequences are equally successful in identification of Chinese drugs. Although RFLP, RP-PCR methods do not require prior to genetic background of the genome and can detect DNA polymorphism, the reliability of these fingerprint results can be greatly influenced by experimental conditions. DNA sequencing method focuses on a defined locus on the genome and may provide a definitive means for authentication of Chinese drugs. We, therefore, conclude that it is essential to combine genomic fingerprinting with DNA sequencing analysis in order to increase the accuracy of quality control.Keywords：Internal Transcribe Spacer;Restriction Fragment Length Polymorphism;Amplify Fragment Length Polymorphism;Panax Ginseng;American Ginseng
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Published：2021-08-27 - Keywords：sorbitol;Diabetic Neuropathy;Aldose Reductase;Silymarin;Baicalin
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Published：2021-08-27 - Keywords：Randomized Control Trial;Irritable Bowel Syndrome;Evidence Base Approach;Clinical Trial Design;Small Randomized Control Trial
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Published：2021-08-27
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