Latest Issue
Vol. 6 ， Issue 3 ， 2000
- Abstract：Objective: To observe the therapeutic effect of Zhixie Buye mixture , ZX-BYM) on infantile diarrhea patients with mild or middle degree of dehydration.Methods: Controlled observation method was adopted in the clinical and experimental study.Results: There was no significant difference in the treatment of dehydration between the ZXBYM group and oral rehydration solution (ORS) group(P > 0.05), at the same time it was more effective for ZXBYM to eliminate such symptoms as vomiting and abdominal distension (P < 0.01). In addition, it was confirmed that the ion concentration of sodium, potassium, chlorine, glucose and osmotic pressure in the mixture was similar to those in ORS. Animal experiment showed that ZXBYM has the effect of rat intestine peristalsis suppression and water absorption promotion in colon. And there was statistical difference in antidiarrhea effect between the mixture and ORS (P < 0.01).Conclusion: ZXBYM is an effective mixture in the treatment of diarrhea with dehydration. It has a good prospect for the development and application.Keywords：Zhixie Buye mixture;infantile diarrhea with dehydration;oral rehydration solution;acute;infantile enteritis
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Published：2021-08-27 - Keywords：Diarrhea;Western Medicine;Potassium Salt;Total Effective Rate;Infantile Diarrhea
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Published：2021-08-27 - Abstract：Objective To explore the treatment on infantile intractable diarrhea with integrated traditional Chinese and western medicine.Methods: Paired control method was used to study 54 cases of infantile intractable diarrhea patients, who were randomly divided into the treated group and the control group (western medicine treated group). The treated group was further subdivided into two syndrome-types: Spleen deficiency diarrhea type and Spleen-Kidney Yang deficiency diarrhea type, and modified Shenling Baizhu powder and Sijunzi decoction with modified Sishen pill were used for them respectively, while the control group was given only the conventional western drugs. At the same time, immunoglobulin (IG) and T lymphocyte transformation rate (TLTR) were observed.Results: Before treatment, IgG, IgA and TLTR of all the patients in both groups were lowered; after treatment, all of them improved, and the improvement of the treated group was more significant than that of control group (P<0.01). In the treated group, the cure rate and total effective rate were significantly higher than that of control group (P<0.01).Conclusion: Using integrated traditional Chinese and western method, the immune function of the patients were enhanced, and the function of Spleen-Stomach was recuperated, therefore satisfactory results were reached.Keywords：intractable disease;Infantile Diarrhea;integrated traditional Chinese and Western medicine
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Published：2021-08-27 - Keywords：Rickets;Anorectal Manometry;Double Infection;Body Resistance;Infantile Diarrhea
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Published：2021-08-27 - Abstract：Objective To study the effect of Huodan tablet ,HDT) in treating infantile viral myocarditis.Methods: Clinical manifestations and physical signs as well as laboratory examinations have been observed.Results: The markedly effective rate was 68%, and total effective rate 91.67% in the treated group, while in the control group, the markedly effective rate was 30.83 %, and the total effective rate 70.84 %. According toRidit analysis, significant difference was shown between the two groups,r-treated group = 0. 5000, r-control group = 0.295 + 2x0. 025 respectively.Conclusion: HDT has no toxic side-effect and can be taken safely and conveniently, it conforms to the demands of WHO on new drug for prevention and cure of myocarditis.Keywords：Huodan tablet;Coxsackie virus B3;Qi-deficiency and blood stasis syndrome;infantile viral myocarditis
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Published：2021-08-27 - Abstract：Objective: To observe the clinical effect of puerarin in treatment of infantile viral myocarditis.Methods: Puerarin was administered intravenously together with conventional treatment in the treated group, while conventional treatment alone was given to the control group. Creatine kinase isoenzyme, lactate dehydrogenase isoenzyme, cardiac function and clinical manifestations before and after treatment were observed.Results: Puerarin could significantly relieve the symptoms in patients of infantile viral myocarditis, enhance the metabolism of myocardium and improve the cardiac function. The total effective rate in the treated group was 87.04 %, significantly higher than that of the control group, the difference between them was significant (P < 0.05).Conclusion: Puerarin can be used to treat patients with infantile viral myocarditis with satisfactory results.Keywords：Puerarin;Viral Myocarditis;children
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Published：2021-08-27 - Abstract：Objective: To study the effect and side-effects of Duodongning (DDN), a traditional Chinese medicine (TCM) granule in treating attention-deficit/hyperactivity disorder (ADHD).Methods: Double blind method was used to compare DDN with ritalin for ADHD in clinical practice from December 1995 to December 1996. The total number of cases was 70.Results: There were 37 cases in DDN group, with 17 cases (45.9 %) markedly effective, 16 cases (43.2%) effective, the Conners hyperactive index (HI) 2. 01 ± 0. 83 (before treatment), 1.17 ± 0.76 (after 4 weeks ’ treatment); and there were 33 cases in the ritalin group, with 15 cases (45.5%) markedly effective, 14 cases (42.4%) effective, HI2.07±0.91 (before treatment), 1.47±0.79 (after 4 weeks’ treatment). Insignificant difference existed between the effectiveness in these 2 groups (P > 0.05). The chief side-effects were 3 cases (8.1%) of anorexia in DDN group, and 7 cases (21.2%) in ritalin group.Conclusion: The effect of DDN is not significantly different from that of ritalin, and the side-effects in ritalin group were more than those in DDN group.Keywords：attention-deficit/hyperactivity disorder;Duoduoning;ritalin
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Published：2021-08-27 - Abstract：Objective: To investigate the effects of Tiaojining granule TJNG) combined with corticosterone (CS) in treating infantile primary nephrotic syndrome (IPNS).Methods: Sixty inpatients with IPNS were divided into two groups, 30 cases as the treated group treated by TJNG combined with CS, and the other 30 cases as the control group treated by CS alone for 8 weeks. The changes of urinary protein, serum albumin, blood cholesterol, platelet and blood pressure before and after treatment were observed.Results: The total effective rate of the treated group was significantly higher than that of the control group (P<0.01). The time for urinary protein disappearance of the treated group was significantly shorter than that of the control group (P <0.05). In preventing hypertension, lowering lipidemia and platelets, TJNG were obviously better than CS used in the control group (P<0.01).Conclusion: TJNG could enhance the therapeutic effects of CS on IPNS and safely and effectively reduce the side-effects of CS.Keywords：Tiaojining granule;Corticosterone;infantile primary nephrotic syndrome
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Published：2021-08-27 - Keywords：Therapeutic Effect;Prednisone;Traditional Chinese Medicine;Nephrotic Syndrome;Thyroxin
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Published：2021-08-27 - Abstract：Objective To evaluate the effect of Chinese medicinal herbs on digestive function, nutritional status, immune function and complication rate in patients after total gastrectomy.Methods: Thirty-nine patients performed total gastrectomy were divided into two groups and had their small intestine intubated for administering medicine postoperatively. Twenty-one of them belonged to the treated group and had Chinese medicinal herbs dripped into their small intestine intraluminally during the early postoperative stage, while the 18 cases in the control group were dripped with 0.9% sodium chloride.Results: The digestive function of the treated group recovered rapidly, and the nutritional status and immune function improved markedly as compared with those of the control group (P<0.01-0.05).Conclusion: Early application of Chinese medicinal herbs after total gastrectomy could promote the digestive function to recover to normal, and improve the nutritional status and immune function. And occurrence of complication was reduced.Keywords：total gastrectomy;Chinese medicinal herbs;clinical application
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Published：2021-08-27 - Abstract：Objective: To study the therapeutic effect of Chinese herbal medicine (CHM) for supplementing Qi, activating blood circulation and tonifying Kidney on prevention and treatment of diabetes in middle and aged women with Kidney Deficiency and bone metabolic disturbance.Methods: Clinical observation was taken in 52 patients, who were divided into two groups, the control group (treated with hypoglycemic agent alone) and the treated group (treated with hypoglycemic agent and CHM).Results: Before treatment, patients in both groups showed obviously higher blood alkaline phosphatase, β2-microglobulin (β2-MG) level, urinary β2-MG, calcium and phosphorus level, but lower serum estradiol level than those in normal subjects. After 3 months’ treatment, no apparent change in serum estradiol level was observed, but other parameters were all lowered obviously in the two groups, with the changes revealed more obviously in the treated group. The symptoms of Kidney Deficiency, such as lumbodorsal pain, fatigue, palpitation and vertigo, were improved after treatment, which was also more obviously in the treated group.Conclusion: CHM for supplementing Qi, activating blood circulation and tonifying Kidney was effective in improving Kidney Deficiency and mineral substance loss in bones in middle and aged diabetic women patients. The CHM and western drugs acted synergistically.Keywords：middle and aged women;diabetes mellitus;Kidney Deficiency;bone metabolism disturbance;integration of traditional Chinese and western medicine
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Published：2021-08-27 - Keywords：PGE2;Activate Blood Circulation;Free Radical Metabolism;Etric Method;Tonifying Kidney
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Published：2021-08-27 - Abstract：Objective: To investigate the cellular and molecular mechanisms of some Chinese drugs on apoptosis of thyrocytes in Graves’ disease.Methods: Two to ten weeks before and after using Chinese drugs on 13 Graves’ disease patients with anti-thyroid drugs, patients’ thyroid tissue was aspired with percutaneous puncturing needle. The effects of some Chinese drugs on thyrocytes was studied by applying cell morphology (stained with nuclear fast red, NFR), flow cytometry (stained with propidium iodide, PI), and terminal uridine deoxynucleotidyl end-labelling (TUNEL) technique (alkaline phosphatase and CBIP/NBT, NFR). The size of thyroid gland was measured by color Doppler ultrasonography.Results: After Chinese drug treatment, compared with single anti-thyroid drug group, the size of thyroid was significantly reduced (P<0.01). The apoptosis of thyrocytes can be observed by cell morphology such as chromatin condensation and nuclear fragmentation. The apoptosis rate is 18.66% ±20.01% (n=13) in anti-thyroid drugs plus Chinese drugs group, 2.11% ±1.78% (n= 13) in single anti-thyroid drug group (P<0. 01). For up to 2–10 weeks, more TUNEL-positive cells were found after treatment with Chinese drugs than those treated with anti-thyroid drug alone.Conclusion: Some Chinese drugs when used in combination with anti-thyroid drugs in treating Graves’ disease could induce apoptosis of thyrocytes.Keywords：Graves’ disease;thyrocytes;apoptosis;Chinese drugs
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Published：2021-08-27 -
Clinical study on shenmai injection in promoting postoperative recovery in patients of breast cancer
Keywords：Breast Cancer;Adenosine Diphosphate;Neutrophil Apoptosis;Form Growth Factor;Wound Healing Time- 23
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Published：2021-08-27 - Abstract：Objective: To observe the behavioral and biochemical effects of a traditional Chinese medicine Huanshao Dan (HSD) on learning and memory deficits in transient cerebral ischemia model in mice.Methods: Step-through experiments, receptor binding test and choline acetyltransferase (ChAT) activities determination were performed.Results: Mice undertaken transient ischemia commited much more mistakes in step-through experiments and showed relatively higher3 H-MK801 binding in cerebral cortex and hippocampus than in sham operated animals. HSD decoction was most effective in reducing these mistakes in mice. At the same time, and3 H-MK801 binding of cerebral cortex and hippocampus tissues were also significantly decreased, while ChAT activities in the same tissues were increased.Conclusion: HSD might antagonize ischemic injury of brain through inhibition of glutamate N-methyl-D-Aspartic acid receptor overactivity.Keywords：Huanshao Dan;excitoxin;transient cerebral ischemia;N-methyl-D-Aspartic acid receptor;choline acyltransferase
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Published：2021-08-27 - Abstract：Objective: To explore the effect of Guzhen recipe , GZR) on mRNA expression of interleukin-2 (IL-2) and interleukin-6 (IL-6) in senile rats as well as the relationship between dehydroepi-androsterone (DHEA) and its sulfate (DHEAS) and the immune function regulation of GZR.Methods: Northern Blot and reverse transcriptase-polymerase chain reaction (RT-PCR) were used to detect the mRNA expression of IL-2 and IL-6, meanwhile coating-antibody-counting method was used to detect DHEA(S) level in serum.Results: Compared with the young group, the splenocyte mRNA expression of IL-2 in senile rats was lowered and that of IL-6 was increased along with the decrease of serum DHEA(S) level. GZR, however, could improve the above indices in the senile rats.Conclusion: GZR might regulate the immune function of aged rats through increasing the serum level of DHEA(S).Keywords：Guzhen recipe;interleukin-2 mRNA;interleukin-6 mRNA;dehydroepiandrosterone (sulfate)
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Published：2021-08-27 - Abstract：Objective: To evaluate the relationship between chronic kidney dysfunction after transplantation and chronic vascular rejection (CVR), and to evaluate the efficacy and safety of Tanshinone (Tan) and Herba Lysimachiae (Lys) combined with Mycophenolate Mofetil (MMF) to fight against CVR, and to reduce the incidence of chronic dysfunction in rat renal transplantation model.Methods: Sixty-five male SD rats as donors and sixty-five male Wistar rats as recipients were used. The recipients were divided into five Groups, including Group A: Lys + Cyclosporine A (CsA), Group B: Tan+CsA, Group C: MMF+CsA, Group D: CsA, and Group E: normal saline. Kidney function and morphological changes were assessed at 2, 4, and 6 weeks after transplantation. All sections of renal grafts were stained with monoclonal antibodies (McAB),. including major histocompability complex class II (OX-6), lymphocyte function antigen-1 (CDllb/CD18), intercellular adhesive molecular-1 (IA29), CD8+ (OX-8), and proliferation cell nuclear antigen (PCNA) (5A10, IgGlk) were used. Results:The two control groups developed typical chronic rejection episodes, and the histologic feature indication of kidney chronic rejection includes loss of renal units and presence of an obliteration arteriopathy involving large renal arteries. These were associated with serum levels of BUN and SCr increased and different degrees of glomerulosclerosis. Their mean survival time was lower than that of other groups. By contrast, serum levels of cytokine in control groups was significantly increased when compared with group B and C (P<0.05). Both group B and C had minimum changes in glomeruli and arteries, and expression levels of PCNA on the glomeruli and tubular cells were higher than those of other groups (P<0. 05). However, there was no significant difference (P>0.05) between group B and C.Conclusions: CVR may activate the risk of the factor responsible for the development of graft chronic dysfunction that causes slow, progressive destruction of the transplanted kidney. Tanshinone was extracted from Salvia miltiorrhiza and purified for use in medicine. Especially when Tanshinone combined with a low-dose of CsA, it may fight against the CVR by inhibiting cell infiltration, and improving microcirculation of the graft, and thus the incidence of CVR is reduced. It is suggested that Tanshinone can be applied to treat patients with chronic renal dysfunction when used in combination with a low-dose Cyclosporine.Keywords：rat renal transplantation;chronic vascular rejection;Tanshinone;Herba Lysimachiae
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Published：2021-08-27 - Keywords：Traditional Chinese Medicine;Thyroxin;Thyroid Stimulate Hormone;Grave Disease;Total Effective Rate
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Published：2021-08-27 - Keywords：Total Effective Rate;General Score;Observatory Parameter;Peripheral Blood Neutrophil;Oral Liquid
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Published：2021-08-27 - Keywords：Total Effective Rate;Panniculitis;Promote Blood Circulation;Glycyrrhiza Uralensis;Remission Stage
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Published：2021-08-27 - Keywords：Blood Circulation;Chinese Herbal Medicine;Fast Blood Sugar;Facial Paralysis;Activate Blood Circulation
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Published：2021-08-27 - Keywords：Acute Pancreatitis;Traditional Chinese Medicine;Western Medicine;Common Bile Duct Stone
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Published：2021-08-27 - Abstract：Objective: To investigate the clinical effect of Rhinitis Spray (RS) in treating chronic rhinitis.Methods: Eighty patients with chronic rhinitis were divided into three groups, and treated with RS, ephedrine and normal saline respectively.Results: The short-term effective rate in the three groups was 89. 3 %, 66. 7 % and 8.0% respectively. RS was effective in alleviating symptoms, increasing IgG level in nasal discharge, improving ventilation of nasal cavity and transfer function of cilia of nasal mucosa obviously.Conclusion: The therapeutic effect of RS in treating chronic rhinitis is good.Keywords：Transfer Function;Clinical Effect;Normal Saline;Rhinitis;Traditional Chinese Medicine
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Published：2021-08-27 - Keywords：Transfer Function;Normal Saline;Rhinitis;Traditional Chinese Medicine;Medical Practice
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Published：2021-08-27 - Keywords：Traditional Chinese Medicine;Peking Union Medical College;Chinese Drug;Ligustrazine;Circulate Endothelial Cell
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Published：2021-08-27 - Abstract：Objective: To study the effect of ligustrazine injection (LI) on vascular endothelial cell of the patients with arteriosclerosis obliterans (ASO) and explore the new pathway of investigating effective vascular protective agents in Chinese medicinal herbs.Methods: Forty-six patients with ASO in the LI group treated by LI were observed, their circulating endothelial cells (CEC) were detected quantitatively before and after treatment. The results were compared with the CEC of 53 cases of healthy persons (control group) in the same period.Results: In the LI group, the immediate cure rate was 45. 7% (21 cases), markedly effective rate 36.9% (17 cases) and the effective rate 17.4% (8 cases). The CEC of patients before treatment was 4. 39 ± 1. 76/0. 9μl, which was significantly higher than that of the healthy persons (1. 53 ± 0. 42/0. 9μl). It could be reduced after treatment, along with the improvement of symptoms and signs, to 2.43 ± 0.87/0.9μl, P<0.01.Conclusion: LI in treating ASO not only displays extraordinary effect, but also has good effect in curing the damage of endothelial cells.Keywords：Vascular Endothelial Cell;Effective Rate;Healthy Person;Chinese Medicinal Herb;Peking Union Medical College
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Published：2021-08-27 - Keywords：State Council;Peking Union Medical College;Chinese Drug;Friendship Hospital;Chinese Herbal Drug
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Published：2021-08-27 - Keywords：Acute Otitis Medium;Morbid Condition;Night Blindness;Model Control Group;Reddened Tongue
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Published：2021-08-27 - Abstract：Objective: To evaluate the therapeutic effect and mechanism of folium Ginkgo biloba (FGB) in treating pulmonary interstitial fibrosis (PIF) induced by bleomycin in rats.Methods: PIF models of bleomycin-A5-induced pulmonary fibrosis were established in rats, they were treated by Bailuda, a preparation of FGB, and the pathological changes, collagen protein level, nuclear factor kB(NF-kB) activity, transforming growth factor β (TGF-β) mRNA expression and protein level of the lung tissue were measured.Results: In the Bailuda treated group after treatment, amelioration of the pulmonary alveolitis and fibrosis were shown in pathological section (P < 0.05) and collagen protein content was lesser (P<0.01) as compared with those in the model control group. After 1 week of Bailuda treatment, the NF-kB activity of pulmonary alveola macrophage lowered by 47. 3 %, and levels of TGF-β mRNA expression and protein were all decreased (P < 0.05).Conclusions: Bailuda has definite effect in treating PIF. The mechanism may be through inhibiting the activity of NF-kB, decreasing TGF-β mRNA expression and protein, so as to ameliorate the inflammation and fibrosis.Keywords：Bleomycin;Febrile Convulsion;Pathological Section;Model Control Group;Tongue Coating
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Published：2021-08-27 - Keywords：Normal Control Group;Coronary Heart Disease Patient;Blood Stasis Syndrome;Licorice Root;Carbuncle
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Published：2021-08-27 - Abstract：Objective: To explore and compare the changes of coagulant/fibrinolytic activity in coronary heart disease (CHD) patients with Blood Stasis Syndrome of TCM and evaluate the roles of these changes.Methods: Eighty patients of CHD were divided into two groups by Syndrome Differentiation of TCM, the Blood-Stasis (BS) group (30 cases) and the non-Blood-Stasis (NBS) group (50 cases, including 27 cases of Phlegm-Dampness Syndrome and 23 cases of Qi-Stagnation Syndrome); and 20 healthy persons were enrolled as normal control group. Tissue type plas-minogen activator (t-PA) and its inhibitor (PAI-1) in plasma and in human peripheral blood monocyte cell (PBMC), as well as the procoagulant activity (PCA) in PBMC were measured by chromogenic substrate method.Results: The plasma PAI-1 activity and PCA of PBMC in the BS group were significantly higher than those in the NBS group and the normal control group (P<0.01). PAI-1 activity of PBMC in the two groups of CHD patients was higher than those in the normal control group significantly (P<0.01), but no significant difference was found between the BS group and the NBS group (P > 0.05). The difference of plasma t-PA activity between the two groups of CHD was insignificant. The PBMC t-PA activity in the BS group was lower than that in the NBS and normal control groups (P<0.01).Conclusion: In the CHD patients with BS, the PBMC PCA was increased and the fibrinolytic activity at both plasma and monocyte levels lowered significantly, these changes in coagulant/fibrinolytic activity may be the important pathologic factors in forming BS which suggests that CHD patients with BS were in the prothrombotic state.Keywords：coronary heart disease;Normal Control Group;Fibrinolytic Activity;Coronary Heart Disease Patient;Syndrome Differentiation
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Published：2021-08-27 - Keywords：Irritable Bowel Syndrome;Traditional Chinese Medicine;Achalasia;Gastroparesis;Gastrointestinal Motility
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Published：2021-08-27
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