Latest Issue
      Vol. 7 ， Issue 1 ， 2001
      • De-chang Chen,Xing-yi Yang,Xing-lu Jiang,Hong-jiang Li,Bing-wen Jing
        Vol. 7, Issue 1, Pages: 2-6(2001) DOI: 10.1007/BF02935096
        Abstract：Objective: To investigate the effect of rhubarb on gastrointestinal blood perfusion in critical illness and hemorrhagic shocked rats.Methods: Clinical Study: Sixty-four septic patients, who suffered from stress ulcer, were treated with rhubarb at a dose of 25 mg/kg. Twenty-five non-septic patients were taken as control. The gastrointestinal perfusion was evaluated by intramural pH (pHi). Animal study: SD rats were anesthetized with intraperitoneal sodium pentobarbital at a dose of 20 mg/kg. Blood-letting were performed in the animals. Blood pressure reduced to 5.32 kPa and maintained for 120 mins. They were resuscitated at the end of shock by reinfusing all of the shed blood. The rats were randomly divided into four groups: Normal control, shock group, therapeutic group (shocked rats were treated with 50 mg/kg rhubarb at the end of shock) and rhubarb group (normal rats were treated with rhubarb). Laser Doppler was applied to estimate the gastrointestinal blood perfusion.Results: Clinical Study: The gastrointestinal pHi in septic patients was much lower than that in the control, whereas rhubarb could obviously elevate gastrointestinal pHi (P < 0.001). In addition, rhubarb also had good effect on gastric hemorrhage caused by stress ulcer. Animal Study: Although the shocked rats were resuscitated completely, their gastrointestinal blood perfusion was much lower than that in the control. Rhubarb could significantly improve the blood perfusion in gastrointestinal mucosa and mesentery (P < 0.01). Furthermore, rhubarb also increase the gastrointestinal perfusion in normal rats.Conclusion: Rhubarb could improve gastrointestinal blood perfusion in critical illness and shocked rats.  
        Keywords：rhubarb;sepsis;shock;stomach;intestine;volume of blood flow   
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        Published：2021-08-27
      • Xi-ran Lin,Cai-xia Tu,Xian-min Meng,Chun-mei Yang,Ming-yang Gao,Ling Gu
        Vol. 7, Issue 1, Pages: 7-11(2001) DOI: 10.1007/BF02935097
        Abstract：Objective: To study Chinese herbal prescription for treatment of eczema on the basis of the suppressive effect of Chinese herbal medicine with type IV allergic reaction.Methods: Various formulae composed of Chinese herbal medicines possessing suppressive effect on murine allergic contact dermatitis were formed following the therapeutic principles of traditional Chinese medicine in treating eczema, and their effect on ear swelling, ear flake weight, dermal inflammatory infiltration cell count and plasma level of calcitonin gene related peptide (CGRP) were examined in mice with dinitrofluorobenzene induced dermatitis. The prescription, Composite Poria Decoction was formulated and made into granule form, which was used to treat 63 cases of eczema (atopic dermatitis was excluded), and compared with 59 cases treated with antihistaminic that was aimed at the type I allergic reaction.Results: Experimental study showed that all the 4 Chinese prescriptions had the effect of anti-type IV allergic reaction, among them, the formula for cooling blood and removing Heat, Wind and Dampness evil possessed the most potent effect in suppressing murine dermatitis, and it was also able to up-regulate the plasma CGRP concentration. The clinical cure rate of Composite Poria Granule treatment was 47.6%, and that of the control was 22.0 %. The difference was significant between the two groups (u = 2.9555, P< 0.01).Conclusions: Chinese herbal medicine has the effect of anti-type IV allergic reaction. Composite Poria Granule has good effect in treating eczema.  
        Keywords：eczema;type IV allergic reaction;Chinese herbal medicine prescription   
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        Published：2021-08-27
      • Baojin Hua,Ai-ping Wang,Wei Hou
        Vol. 7, Issue 1, Pages: 12-15(2001) DOI: 10.1007/BF02935098
        Abstract：Objective: To assess the effect and mechanism of compound Xiansu capsule ( ), (XSC) combined with chemotherapy in treating gastric carcinoma of mid-late stage.Methods: Sixty-one patients of the test group were treated by XSC combined with chemotherapy and 30 patients of the control group treated with chemotherapy alone. The effect of treatment and cell mediated immunity of patients were observed.Results: The effective rate of the test group and the control group was 32.8% and 13.3% respectively (P < 0.05), the toxic reaction occurrence caused by chemotherapy was less in the former than that in the latter group (P < 0.01). The CD8 level of patients in the test group decreased, and CD4/CD8 level was raised obviously, which suggested that XSC had immuno-regulating effect on T-cell.Conclusion: XSC could enhance the efficacy and reduce the toxic and side-effect of chemotherapy. To regulate the cell mediated immunity of patients is possibly its mechanism.  
        Keywords：compound Xiansu capsule;chemotherapy;T-lymphocyte subset;Gastric Carcinoma   
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        Published：2021-08-27
      • Gao Bing-ai,Xu Xian
        Vol. 7, Issue 1, Pages: 15(2001) DOI: 10.1007/BF02935099
        Keywords：Total Effective Rate;Normal Healthy Control;Chinese Drug;Cellular Immune Function;Hepatic Artery Ligation   
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        Published：2021-08-27
      • Ming-liang Cheng,Yin-ying Lu,Jun Wu,Tian-yong Luo,Yi-sheng Ding
        Vol. 7, Issue 1, Pages: 16-18(2001) DOI: 10.1007/BF02935100
        Abstract：Objective: To observe the therapeutic effect on hepatic fibrosis of chronic hepatitis B by Chinese medicine—Handan Ganle capsule (HDGLC).Methods: A total of 104 patients with chronic hepatitis B has been treated by HDGLC for 6 months, liver fibrosis indexes and the serum biochemical indexes were detected before treatment, during the curative period and by the end of treatment. Hepatic biopsy was performed before or after the treatment.Results: The improvement rate of clinical symptoms was 79.0% - 90.6%, and the recovery rate of ALT was 72.6 %, serum fibrosis indexes such as HA, type IV collagen and LN were significantly decreased along with the extending course of disease (P < 0.05). The pathohistological score of liver was decreased from 7.82 ± 6.22 before treatment to 5.16 ± 3.75 after treatment (P < 0.05) and the score of hepatic fibrosis was decreased from 7.49 ± 5.45 before treatment to 5.16 ± 4.26 after treatment (P < 0.05).Conclusion: HDGLC has remarkable therapeutic and reversing effect on chronic hepatitis B induced hepatic fibrosis.  
        Keywords：Liver Fibrosis;hepatitis B;Handan Ganle capsule   
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        Published：2021-08-27
      • Bo Jiang,Jiang Lin,Yi-fan Zhang
        Vol. 7, Issue 1, Pages: 19-21(2001) DOI: 10.1007/BF02935101
        Abstract：Objective: To explore the relationship between mental symptoms and functional dyspepsia (FD), and the effect of Xiaoyu decoction (XYD) plus psychotherapy on FD.Methods: SCL-90 scale and FD symptom scale were used to estimate the condition of 56 healthy subjects and 56 patients of FD before and after 4 weeks treatment with XYD plus psychotherapy.Results: There was significant difference in SCL-90 scales between the healthy subjects and the FD patients before treatment (P < 0. 01). After treatment, the mental symptoms and the symptom of FD in the patients were markedly improved, as compared with those before treatment, the difference was significant (P < 0.01).Conclusion: Mental symptoms, such as depression and anxiety existed commonly in FD patients, were closely related to FD. XYD plus psychotherapy could cure it effectively.  
        Keywords：functional dyspepsia;mental symptoms;Xiaoyu decoction   
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        Published：2021-08-27
      • Jiang Zhao,Da-jun Wang,Xing-wu Li
        Vol. 7, Issue 1, Pages: 22-25(2001) DOI: 10.1007/BF02935102
        Abstract：Objective: To find a method for inducing Chinese drugs to adhere to the esophageal mucosa to control bleeding from ruptured esophageal varices.Methods: The site and time that the Chinese drugs adhere to esophageal mucosa were observed in 30 healthy volunteers under the specific condition of standing and lying posture. Seventy episodes bled with ruptured esophageal varices patients (treated group 36 episodes in 25 patients and control group 34 episodes in 27 patients) suffering from cirrhosis of liver were treated by the technique of drug adhesion.Results: (1) The adhesion of Chinese hemostatie drugs remained in the lower segment of esophagus for more than 15 minutes in lying posture, longer than that in standing posture (P < 0.01). (2) The effectiveness of controlling bleeding esophageal varices had no significant difference between the balloon tamponade and adhesion of Chinese hemostatie drugs (P >0. 05).Conclusion: This drug adhesion technique provides a new approach to control hemorrhage from ruptured esophageal Variees.  
        Keywords：esophageal varices;Traditional Chinese Medicine;hemostatie drug;adhesion technique   
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        Published：2021-08-27
      • Han-cheng Chen,Lun-hua Weng
        Vol. 7, Issue 1, Pages: 26-29(2001) DOI: 10.1007/BF02935103
        Abstract：Objective: To observe the efficacy of Astragalus-Polygonum Anti-Fibrosis decoction (APAFD) and Jinshuibao capsule (JSBC) in treating liver fibrosis of chronic hepatitis B.Methods: Ninety-two cases of liver fibrosis of chronic hepatitis B were randomly divided into group A and group B. Patients in group A received APAFD for 48 weeks, and in group B, they received JSBC for 48 weeks. The effects on the level change of hyaluronic acid (HA), laminin (LN), pro-collagen III (PCIII) and collagen IV (CIV) as well as liver functional tests and liver biochemical parameters before and after treatment were observed.Results: Level of serum HA, LN, PCIII and CIV in group A declined more obviously than that of group B, the difference was significant (P < 0.01). The liver functional tests such as total bilirubin (TB), alanine aminotransferase (ALT), albumin/ globulin (A/G) ratio, hepatitis related serum biochemical parameters such as cholylglycine (CG), serum ferritin (SF), prealbumin (PC) of group A were all improved more significantly than that of group B (P < 0.01).Conclusion: APAFD is more effective than JSBC in treating liver fibrosis of chronic hepatitis B and in the inhibition of hepatic inflammation, hence it is a good composite Chinese herbal preparation against liver fibrosis.  
        Keywords：chronic hepatitis B;Liver Fibrosis;Astragalus-Polygonum Anti-Fibrosis decoction;Jinshuibao capsule   
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        Published：2021-08-27
      • Li-huang Zhang,Jia-geng Wu,Hang-ping Yao,Min-wei Li
        Vol. 7, Issue 1, Pages: 29(2001) DOI: 10.1007/BF02935104
        Keywords：Liver Fibrosis;Chinese Herbal Medicine;Hepatocyte Apoptosis;Improve Liver Function;Promote Blood Circulation   
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        Published：2021-08-27
      • Liu Zhi-jun,Fan-cheng Li,Shun-hua Zhang
        Vol. 7, Issue 1, Pages: 30-32(2001) DOI: 10.1007/BF02935105
        Abstract：Objective: To investigate the clinical effect of Rhinitis Spray (RS) in treating chronic simple and hypertrophic rhinitis.Methods: Eighty patients with chronic rhinitis were divided into three groups and treated with RS, ephedrine and normal saline respectively.Results: The short-term effective rate in the three groups was 89.3%, 66.7% and 8.0% respectively. RS was effective in alleviating symptoms, increasing IgG level in nasal discharge, improving ventilatory function of nasal cavity and transfer function of nasal muosa cilia obviously.Conclusion: The therapeutic effect of RS in treating chronic rhinitis is satisfactory.  
        Keywords：Rhinitis Spray;chronic rhinitis;immunohemoglobulin level in nasal discharge;transfer function of nasal mucosa cilia;ventilation of nasal cavity   
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        Published：2021-08-27
      • Dong-hai Jiao,Xue-min Shen,Ya-ping Gao,Min-xian Chen,Mei-li Wang
        Vol. 7, Issue 1, Pages: 33-35(2001) DOI: 10.1007/BF02935106
        Abstract：Objective: To study the clinical efficacy of Jinghuang tablet (Rhubarb extract tablet, RET) in treating simple obesity.Methods: Four hundred and seventy-two simple obesity patients were randomly divided into 3 pairs of groups: (1) RET-2 treated group (50 cases): treated with RET vs western drug fenfluramine control group (50 cases). (2) RET treated group vs Chinese patent drug Xiaopangmei (XPM) control group with 50 cases randomly divided into each. (3) RET-1 treated group with 137 cases vs blank control of 135 cases. The aim was to observe markedly effective rate, effective rate and side-effect of RET group and fenfluramine and XPM control groups. At the same time, the slimming efficacy of RET-1 treated group and the blank control group were observed.Results: The slimming effective rate of RET is similar to that of fenfluramine (P < 0. 05), and better than domestically well accepted slimming Chinese patent drug XPM (P < 0.05). In comparing RET-1 group with blank control group, the difference of weight loss of the 2 groups after 1 week treatment was 0.93 kg on average, which was significant.Conclusion: The efficacy of RET in treating simple obesity was similar to that of fenfluramine, but the side-effect was obviously less than that of fenfluramine, while the markedly effective rate and effective rate in slimming were significantly better than that of XPM.  
        Keywords：Jinghuang tablet;Rhubarb extract tablet;fenfluramine;Xiaopangmei;obesity   
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        Published：2021-08-27
      • Li Hong-guang,Li Jin-geng
        Vol. 7, Issue 1, Pages: 36-38(2001) DOI: 10.1007/BF02935107
        Abstract：Objective: To observe the clinical efficacy of Yunnan Baiyao ( , YNBY) combined with antibiotics in treating Helicobacter pylori (HP) related duodenal ulcer (DU).Methods: Eighty-two HP positive DU patients were randomly divided into two groups: Treated group (44 cases) used YNBY plus amoxicillin and metronidazole; control group (38 cases) used de-nol plus amoxicillin and metronidazole).Results: After a 2-week treatment course, the effect of epigastric pain relief was 68.3% in treated group, and 44.4% in control group, the difference between them was significant (P < 0.05). Marked effect in acid regurgitation and belching relief was observed in both groups. The rate of DU healing in treated and control group was respectively 88.6% and 89.5%; the clearance of HP 84.1% and 89.5%; and the side-effects 4.5% and 13.5%, with insignificant difference between these two groups.Conclusion: YNBY combined with antibiotics in treating DU, and clearance of HP is an economic, safe and effective therapy.  
        Keywords：Duodenal Ulcer;Helicobacter pylori;Yunnan Baiyao;antibiotics   
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        Published：2021-08-27
      • Chen Xiang-jian,Lu Shu,Ji-nan Zhang,Wen-zhu Ma
        Vol. 7, Issue 1, Pages: 39-42(2001) DOI: 10.1007/BF02935108
        Abstract：Objective: To compare the therapeutic effects of Astragaloside and Perindopril on myocardial sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) activity and the SERCA type 2 mRNA level in Coxsack-ievirus B3 (CVB3)-infected cardiomyocytes.Methods: Cultured cardiomyocytes of rats were divided into normal, model, Astragaloside and Perindopril groups. The model, Astragaloside and Perindopril groups were infected with CVB3. Meanwhile, the Astragaloside and the Perindopril groups were treated with Astragaloside (10 μg/ml) and Perindopril (1.3 μg/ml) respectively. Cytopathic effect (CPE), cardiac troponin I (cTnI), the SERCA activity and mRNA level of the SERCA type 2 were observed after 96 hours.Results: The CPE and cTnI of model group were significantly higher than those of normal, Astragaloside and Perindopril groups (P< 0.01). The activity and the mRNA expression of myocardial SERCA of model group were significantly lower than those of normal, Astragaloside and Perindopril groups (P < 0.01-0.05). Compared with Astragaloside group, the CPE, cTnI of Perindopril group were higher and the activity and mRNA level of Perindopril group were lower. But there were no significant difference between the two groups (P >0.05).Conclusion: Astragaloside and Perindopril were able to reverse the down-regulations of cardiac SERCA activity and mRNA expression caused by virus infection to alleviate the cardiomyocyte injury.  
        Keywords：Astragaloside;Perindopril;cardiomyocyte culture;Coxsackievirus B3;sarco/endoplasmic reticulum Ca2+ -ATPase   
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        Published：2021-08-27
      • Ke-xiong Lin,Chang-zheng Wang,Gui-sheng Qian
        Vol. 7, Issue 1, Pages: 42(2001) DOI: 10.1007/BF02935109
        Keywords：Peripheral Blood Mononuclear Cell;Myocarditis;Asthma Patient;Perindopril;Cardiac Troponin   
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        Published：2021-08-27
      • Yi Zhong,Bing-Kuang Zhu,Shi-Fu Zheng
        Vol. 7, Issue 1, Pages: 43-47(2001) DOI: 10.1007/BF02935110
        Abstract：Objective: To observe the effect of Yishou Tiaozhi tablet(YSTZT) on lipid metabolism and aortic intimal atherosclerotic plaque coverage in rabbit model of experimental hyperlipemia and atherosclerosis.Methods: Thirty-two rabbits were randomly divided into four groups, Group A, B, C and D, 8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of YSTZT was fed to Group A every day; for Group B, 22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; for Group C, hyperlipid forage was given and for Group D, only ordinary forage was given. Biochemical parameters were measured and pathomorpho-logical examinations were carried out 6 weeks later.Results: (1) YSTZT obviously lowered the levels of serum total cholesterol(TC), triglyceride(TG), atherosclerotic index(AI), apoprotein(ApoB), lipoprotein [Lp(a)], oxygen-low density lipoprotein cholesterol (ox-LDL), hydroxyproline(HYP), plasma Ca2+, thromboxane B2 (TXB2), and increased the levels of serum high-density lipoprotein cholesterol(HDL-C), apoprotein A1 (Apo A1), ApoA1/ApoB, plasma 6-keto-PGFlα (P < 0.01). (2) Pathomorphological examination showed that in Group A aortic intimal atherosclerotic plaque area and arterial intima thickness were obviously reduced, smooth muscle cell hyperplasia and elastic fibers were not seen.Conclusion: YSTZT can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis.  
        Keywords：Yishou Tiaozhi tablet;hyperlipemia;atherosclerosis   
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        Published：2021-08-27
      • Wei-Jun Cheng
        Vol. 7, Issue 1, Pages: 47(2001) DOI: 10.1007/BF02935111
        Keywords：Dilate Blood Vessel;Helsinki Heart Study;Archive Publishing;Hydrolytic Decomposition;Cerative Colitis   
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        Published：2021-08-27
      • Zhong-qi Yang,Shao-xiang Xian,Ming-ping Liu,Qian-wei Chen,Hui-ping Zheng,Li-cheng Zhao
        Vol. 7, Issue 1, Pages: 48-49(2001) DOI: 10.1007/BF02935112
        Abstract：Objective: To study the protective action of Astragalus Injection (AI) on ouabain-induced cardiac toxicity.Methods: Forty guinea-pigs were randomly divided into the AI group and the control group, AI injected intravenously in the AI group and 0.9% normal saline injected in the control group, ouabain was injected in contralateral of both groups intravenously 8 mins later. The time of cardiac ventricular tachycardia (VT) and cardiac ventricular fibrillation (VF), and the dose of ouabain were documented.Results: Compared with the control group AI could markedly prolong the time of VT and VF, and increase the dose of ouabain induces VT and VF (P < 0.01).Conclusion: AI decreases the incidence of digitalism.  
        Keywords：Radix Astragalis;ouabain;cardiac toxicity   
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        Published：2021-08-27
      • En-fu Li,Yu-yan Feng
        Vol. 7, Issue 1, Pages: 50-52(2001) DOI: 10.1007/BF02935113
        Keywords：peptic ulcer;Gastric Acid Secretion;Total Effective Rate;Peptic Ulcer Patient;Basal Acid Output   
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        Published：2021-08-27
      • Hong-pu Liu,Hua-chang Liu,Guan-yong Li
        Vol. 7, Issue 1, Pages: 53(2001) DOI: 10.1007/BF02935114
        Keywords：psoriasis;Total Effective Rate;Psoriatic Patient;Blood Stasis Syndrome;Activate Blood Circulation   
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        Published：2021-08-27
      • Dun Guo,You-ren Zhang
        Vol. 7, Issue 1, Pages: 55-56(2001) DOI: 10.1007/BF02935115
        Keywords：Total Effective Rate;Calcium Gluconate;Hand Eczema;Pharmaceutical Factory;Licorice Root   
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        Published：2021-08-27
      • Tian-wen Zheng,Jian-dong Hong,Lian-qiao Li
        Vol. 7, Issue 1, Pages: 57-58(2001) DOI: 10.1007/BF02935116
        Keywords：Western Medicine;Chlorphenamine;Mild Type;Glycyrrhiza Uralensis;Method Clinical Data   
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        Published：2021-08-27
      • Han-qing Xu,Jie Feng,Jun-feng Ren
        Vol. 7, Issue 1, Pages: 59-61(2001) DOI: 10.1007/BF02935117
        Keywords：psoriasis;Psoriatic Patient;Serum Copper Level;Plasma Fibronectin;Blood Phenylalanine   
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      • Xi-hua Wang,Zu-yi Zhang
        Vol. 7, Issue 1, Pages: 61(2001) DOI: 10.1007/BF02935118
        Keywords：psoriasis;Asthma Patient;Dark Skin;Pustular Psoriasis;Pathological Character   
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      • Yi-qiang Jin
        Vol. 7, Issue 1, Pages: 62(2001) DOI: 10.1007/BF02935119
          
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      • Ming Ou
        Vol. 7, Issue 1, Pages: 63(2001) DOI: 10.1007/BF02935120
          
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      • Zhufan Xie
        Vol. 7, Issue 1, Pages: 64-66(2001) DOI: 10.1007/BF02935121
        Keywords：Measle;Therapeutic Method;Febrile Disease;Yang Meridi;Pathogenic Wind   
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      • Vol. 7, Issue 1, Pages: 67(2001) DOI: 10.1007/BF02935123
          
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      • Vol. 7, Issue 1, Pages: 67(2001) DOI: 10.1007/BF02935122
          
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        Published：2021-08-27
      • Ming-fan Hong,Gong-qiang Wang,Ren-min Yang,Ji-yuan Hu,Xiao-ping Wang,Da-ping Lu
        Vol. 7, Issue 1, Pages: 68(2001) DOI: 10.1007/BF02935124
        Keywords：liver cirrhosis;Disodium;Western Medicine;Hepatolenticular Degeneration;Superior Quality   
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      • Ji Li,Jing-cheng Dong
        Vol. 7, Issue 1, Pages: 69-74(2001) DOI: 10.1007/BF02935125
          
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        Published：2021-08-27
      • Jia Shaowei,Wang Fan,Hai-Long Huang
        Vol. 7, Issue 1, Pages: 75-80(2001) DOI: 10.1007/BF02935126
          
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