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      Vol. 7 ， Issue 3 ， 2001
      • Dai Xi-wen,Rao Xiang-rong,Li Shen
        Vol. 7, Issue 3, Pages: 162-166(2001) DOI: 10.1007/BF03178480
        Keywords：Renal Damage;Chinese Herb;Aristolochic Acid;Kaempferi;Fanconi Syndrome   
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        Published：2021-08-27
      • Leung Ting Hung,Fung Yu Kei
        Vol. 7, Issue 3, Pages: 167-169(2001) DOI: 10.1007/BF03178481
        Keywords：Chinese Medicine;Western Medicine;Special Administrative Region;Public Health Care System;Hong Kong Special Administrative Region   
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      • Sun Yan-bing,Chen Bing-liang,Jia Qiang,Yao Zheng
        Vol. 7, Issue 3, Pages: 170-174(2001) DOI: 10.1007/BF03178482
        Abstract：Objective: To investigate the clinical effect of Xinqingning (XQN), a preparation of rhubarb, combined with low dose continuous gastrointestinal dialysis in treating uremia.Methods: Patients of uremia were divided into three groups at random, 18 patients in group A were treated with 1000 ml gastrointestinal dialysate (non-absorbed mannitol solution) orally 2–3 times a day, 20 patients in group B treated with the same therapy as that in group A, also combined with XQN 5–10 tablets 3 times per day and 19 patients in group C treated with orally taken coated aldehyde oxystarch 5–10 g, 3 times a day. The therapeutic course for the three groups was 11 months. The changes in clinical manifestation, renal function, nutritional condition, and electrolytes before and after treatment were observed.Results: After treatment, significant improvement was revealed in aspects of uremic symptoms, quality of life, nutritional condition, serum creatinine, urea nitrogen, serum phosphate, uric acid, CO2 combining power, creatine clearance, body weight and arm muscular circumference in group A and B, as compared with those in group C. In comparison of group A with B, group B showed a lower serum triglyceride and a slower progression of chronic renal failure (CRF). All the criteria were not improved in group C and with serum creatinine being raised significantly.Conclusion: XQN combined with low dose continuous gastrointestinal dialysis therapy was definitely effective in treating uremia. It provides a new therapeutic means of non-replacement therapy for CRF with uremia.  
        Keywords：chronic renal failure;uremia;continuous gastrointestinal dialysis;rhubarb;Mannitol   
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        Published：2021-08-27
      • Zhu Pi-jiang,Wei Xian-Jin,Zhao Wei-bing,Zhao Hua,Tian Jun-min,Qiu Jian-jun
        Vol. 7, Issue 3, Pages: 175-179(2001) DOI: 10.1007/BF03178483
        Abstract：Objective: To explore the protective effect of Baoyuan Qiangshen Capsule No. II (BYQS) and its mechanism in treating chronic renal failure (CRF).Methods: Sixty CRF patients were divided into 2 groups randomly, the treated group used BYQS combined with Lotensin and the control group administered with essential amino acid combined with Lotensin. Changes of renal functions and tubular labelled proteins were observed.Results: The markedly effective rate and total effective rate of the treated group were 63.3% and 93.3% respectively, and those of the control group were 30.0% and 56.7% respectively, the effect of the treated group was obviously better than that of the control group (P < 0.01). In the treated group after medication, blood urea nitrogen, serum creatinine and clearance rate of creatinine were improved significantly (P < 0.01), while Tamm-Horfau protein increased significantly (P < 0.01).Conclusion: BYQS could alleviate tubular interstitial injury significantly so as to improve the renal function and enhance the effective rate in treating CRF.  
        Keywords：Baoyuan Qiangshen Capsule No. II;chronic renal failure;urine retinol binding protein;β2-microglobulin;N-acetyl-β-D-glucosamindase;Tamm-Horfau protein   
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        Published：2021-08-27
      • Xiao Qing,Zhao Xue-lan,Guo Min,Zhang Yao
        Vol. 7, Issue 3, Pages: 180-182(2001) DOI: 10.1007/BF03178484
        Abstract：Objective: To evaluate the effect of Chinese herbal medicine (CHM) in the process of corticosterone (CS) reduction in nephrotic syndrome.Methods: One hundred and twenty patients of indiopathic nephrotic syndrome sensitive to prednisone treatment were divided into two groups randomly. The dosage of prednisone used was conventionally reduced in both groups but CHM herbal treatment was added to the treated group in the period of prednisone reduction. The effect of CHM was estimated by observing the recurrence rate of disease and side-effects of prednisone.Results: The recurrence rate of disease and the occurrence rate of side-effects of prednisone in the treated group were less than those in the control group significantly (P < 0.01).Conclusion: Additional CHM in the process of CS reduction in treating CS sensitive nephrotic syndrome could markedly abate the recurrence rate of disease and the side-effect of CS reduction.  
        Keywords：Chinese Herbal Medicine;Nephrotic Syndrome;corticosterone reduction;recurrence;side-effects   
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        Published：2021-08-27
      • Yu Yue-ming,Cui Jian-qiang,Zhang Fan,Wang Tao,Zhang Ren-jie,Guo Dong-yang,Chen Zhao-jie
        Vol. 7, Issue 3, Pages: 183-185(2001) DOI: 10.1007/BF03178485
        Abstract：Objective: To investigate the effect of Chinese drugs (CD) that invigorate Spleen to remove Dampness and activate the blood circulation to eliminate Turbid for retarding progression of chronic renal failure (CRF).Methods: Thirty-nine patients with CRF were divided into two groups at random: the 18 patients in group A (the control group) were treated with low protein diet and controlling blood pressure and 21 patients in group B (the treatment group) were treated similarly with that of the control group and additional CD. Levels of serous creatinine (SCr), blood urea nitrogen (BUN), blood albumin (Alb), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and hemoglobin (Hb) were checked every two months and the rate of progression of CRF was estimated by slope of the creatinine reciprocal (1/SCr) with time (months).Results: Levels of SCr and BUn in group B were lower and HDL higher than those in group A significantly,P < 0.05. Mean slopes of the creatinine reciprocal with time in the two groups were markedly different,P < 0.01.Conclusion: Additional CD treatment based upon the low protein diet and controlling blood pressure could retard the rate of progression of CRF evidently.  
        Keywords：chronic renal faiure;invigorating Spleen to remove Dampness;activating blood circulation to eliminate Turbid;Renal Function;blood lipid   
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        Published：2021-08-27
      • Zhou Yong-ming,Huang Zhen-qiao,Huang Tao,Xue Zhi-zhong,Zhou Shao-hong,Lu Jia-hui,Li Yan-hong
        Vol. 7, Issue 3, Pages: 186-189(2001) DOI: 10.1007/BF03178486
        Abstract：Objecive: To observe the clinical effect of Shengxue Mixture (SXM) in treating aplastic anemia and study the possible mechanism.Methods: Eighty-four patients in the treated group with Spleen-Kidney Yang deficiency syndrome and Spleen-Kidney Yin deficiency syndrome were treated with SXM-I and SXM-II respectively, and 30 patients in the control group were treated with Stanozolol. The clinical effect and several experimental parameters were also observed.Results: The basic cure was gained in 18 cases, remission in 23, markedly improved in 32, ineffective 11, total effective rate and cure remission rate of the treated group were 86.90% and 48.81% respectively, which were obviously better than those of the control group (P < 0.05) with no obvious side-effect. While the patient’s symptoms were alleviated, the peripheral blood cells increased, the ratio of T lymphocyte subsets tended to balance, the level of natural killer cell activity increased, interleukin-2 reduced, and reproduction of the bone marrow were markedly improved in most of the patients treated by SXM.Conclusions: SXM is an effective and safe drug for aplastic anemia. Its mechanism might be likely due to its regulating the immune function, which facilitates the recovery of the bone marrow hematopoiesis function.  
        Keywords：Shengxue Mixture;aplastic anemia;Clinical Study   
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        Published：2021-08-27
      • Andrew Jay Strauss,Charlie Changli Xue
        Vol. 7, Issue 3, Pages: 190-194(2001) DOI: 10.1007/BF03178487
        Abstract：Objective: To evaluate the efficacy of acupuncture in treating chronic non-specific low back pain.Methods: Ten patients with chronic low back pain were selected to receive 9 acupuncture treatments over a three-week period with point selection based on syndrome differentiation in Chinese medicine. The BROM Instrument for assessment of back range of motion; subjective evaluation with Visual Analog Scale of Pain (VASP) ratings, Oswestry Disability ratings, objective measurements including Algometry, and Flexion and Extension ratings to investigate the range of motion were used for comparing the large, medium and small effect sizes of baseline, treatment and follow-up phases.Results: Clinical significance of pain relief was shown in all parameters assessed. A large effect size was detected in VASP, Oswestry and Algometry. A small effect size was demonstrated in Flexion/Extension. Needling over short period time (3 weeks) could relieve the pain, but the muscular-skeletal function measured by BROM persists. To treat patients exclusively by needling for statistical purposes can not be justified, because by merely relieving pain, permanent improvement in function may not be achieved.Conclusion: Acupuncture offers an effective alternative for the clinical management of chronic low back pain, significant improvement in most of the parameters evaluated, but the functional improvement was not as satisfactory as pain relieving. Further study with larger sample size focuses on long-term efficacy and functional improvement for chronic low back pain is recommended.  
        Keywords：acupuncture;low back pain;case series;Syndrome Differentiation;Chinese Medicine   
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        Published：2021-08-27
      • Wu Huan-lin,Ruan Xin-min,Zhang Min-zhou,Huang Chun-lin,Deng Tie-tao
        Vol. 7, Issue 3, Pages: 195-198(2001) DOI: 10.1007/BF03178488
        Abstract：Objective: To explore the patterns of Syndrome Differentiation (SD) of coronary heart disease (CHD) patients in peri-operative stage of coronary artery bypass graft (CABG).Methods: One week after operation, thirty-seven CHD patients, who received CABG of internal mammary artery or great saphena vein under conventional general anesthesia with low or middle temperature extracorporeal circulation were differentiated as various syndromes, with the pre- or post-operational EKG, color Doppler echocardiography were done during and after operation. The hemodynamic parameters were monitored.Results: In the CHD patients, 64.9% were differentiated as Qi-Yin deficiency, 67.6% were complicated with phlegm syndrome and 62.2% with blood stasis, suggesting that Qi-deficiency, phlegm and stasis are the basic pathogenetic factors in patients with CABG. Moreover, the peri-operative syndrome was correlated with the condition of coronary artery lesion, heart and lung functions before operation, and the extracorporeal circulation time during the operation.Conclusion: TCM SD conducting in peri-operative stage might be useful in exploring the patterns of syndrome alteration which provided a basis for preventing peri-operative complications and elevating success rate of operation.  
        Keywords：coronary heart disease;coronary artery bypass graft;peri-operative stage;Syndrome Differentiation of TCM;Qi-Yang deficiency;Yin deficiency;Phlegm Syndrome;Blood Stasis   
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        Published：2021-08-27
      • Sun Guang-xiu M. D.,Liu Qing-jie,Zhang Wen-rong,Zhang Rui-qin
        Vol. 7, Issue 3, Pages: 199-204(2001) DOI: 10.1007/BF03178489
        Abstract：Objective: To explore the clinical efficacy of Chinese and western integrative medicine (TCM-WM) in treating repeatedly recurrent chronic pyelonephritis (CPN) and its therapeutic mechanism.Methods: Ninety-one repeatedly recurrent CPN patients were randomly divided into 2 groups, the control group (45 cases) treated with sufficient amount of sensitive antibiotics and other WM, the treated group (46 cases) treated with above-mentioned WM complemented with TCM syndrome differentiation (SD).Results: In the treated group completely cured was 14 cases (30.4%), markedly effective 14 cases (30.4%), the total effective rate was 91.3%; while that of the control group was 4 (8.9%), 5 (11.1%), and 48.9% respectively, (P < 0.05) and (P < 0.01); the mean days of urinary bacteria and urinary routine negative conversion were in the treated group 19.6±12.6 days and 24.3±11.5 days, obviously shorter than those of the control group (35.6±14.6 days and 53.6±16.4 days),P<0.01; the various symptoms of the treated group improved or disappeared in a short time, while in the control group a few patients improved in a longer period (P < 0.01); the various immune parameters improved in the treated group, while in the control group only IgA was elevated to some extent (P < 0.05), in comparing these data, the difference was significant (P < 0.01).Conclusion: The TCM-WM integrative treatment could obviously raise the clinical efficacy, accelerate the symptom improvement, and enhance the immune function.  
        Keywords：chronic pyelonephritis;repeated recurrence;Chinese and western integrative medicine;compound TCM recipe   
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        Published：2021-08-27
      • Liu Guan-xian M. D.,Ye Ren-gao,Tan Zhi-ming,Zhong Wei-qiang,Yang Yong-ming,Zhang Guo-qiang,Fang Jing-ai
        Vol. 7, Issue 3, Pages: 205-208(2001) DOI: 10.1007/BF03178490
        Abstract：Objective: To observe the effect of emodin on the biological behavior of human fibroblasts (FB) in culture of kidney in patients with lupus nephritis (LN).Methods: FB were isolated from kidney culture of LN patients, and the effect of emodin on3H-TdR incorporated rate of FB was observed. The apoptosis and c-myc gene expression were detected in the same way by flow cytometry.Results: Emodin could markedly inhibit the proliferation of human kidney FB, and inducing cell apoptosis through up-regulating c-myc gene expression in human renal FB.Conclusion: Emodin can inhibit proliferation and promote apoptosis of FB, which may be important in ameliorating interstitial fibrosis, and thus improve prognosis of LN.  
        Keywords：Emodin;fibroblast;proliferation;apoptosis;c-myc protein   
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        Published：2021-08-27
      • Yin Zong-zhu M. D.,Jin Hai-ling,Yin Xue-zhe,Quan Ji-shu,Jin Ming,Piao Chun-mei,Zhang Hong-ying
        Vol. 7, Issue 3, Pages: 209-213(2001) DOI: 10.1007/BF03178491
        Abstract：Objective: To investigate the anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica (BR).Methods: The expression of tumor marker, GST-P, p53 and p21ras proteins in promotion stage of rat chemical hepatocarcinogenesis were examined by immunohistochemical technique ABC method. Anti-tumor effect of BR was investigated by inhibitory test on Sarcoma180. Anti-inflammatory activity of BR was tested by xylene-induced mouse ear swelling method.Results: BR-H2O extract (the H2O extract fractionated from BR-Methanol extract with CH2Cl2 and H2O) 500 mg/kg has inhibitory effect on the formation of diethylnitrosamine (DEN)-induced glutathione S-transferase placental form (GST-P) positive foci in rat liver with the expression of mutant p53 and p21ras proteins lower than those of non-treated hepatic preneoplastic lesions. BR extract showed inhibitory effect on Sarcoma180 and anti-inflammatory effect in mice by xylene-induced mouse ear swelling tests.conclusion: BR-H2O extract exerted inhibitory effect on DEN-induced preneoplastic hepatic foci in promotion stage of rat chemical hepatocarcinogenesis and might suppress the growth of solid Sarcoma180 in mice. Both CH2Cl2 and H2O extract from BR exerted anti-inflammatory effect in mice.  
        Keywords：Boschniakia rossica;placental form glutathione S-transferase;p53;chemical hepatocarcinogenesis;Sarcoma180;anti-inflammation   
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      • Vol. 7, Issue 3, Pages: 213(2001) DOI: 10.1007/BF03178492
        Keywords：Ginsenoside;Iridoid Glycoside;Diethylnitrosamine;Placental Form;Rectal Cancer Cell   
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      • Yin Xiao-qiang,Zhang Su-fen,Kong Ying-lun,Zheng De-zhu
        Vol. 7, Issue 3, Pages: 214-216(2001) DOI: 10.1007/BF03178493
        Keywords：Gliclazid;Blood Stasis;Total Effective Rate;Blood Stasis Syndrome;Western Drug   
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        Published：2021-08-27
      • Zhou Yu-hong,Yu Rong-xi,Luo Xiu-su,Shen Yi-ping
        Vol. 7, Issue 3, Pages: 217-219(2001) DOI: 10.1007/BF03178494
        Keywords：Ginsenosides;Total Effective Rate;Aplastic Anemic Patient;Acanthopanax Senticosus;Ridit Analysis   
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      • Vol. 7, Issue 3, Pages: 220-221(2001) DOI: 10.1007/BF03178495
        Keywords：Plasminogen Activator Inhibitor;Liaoning Province;Activate Partial Thromboplastin Time;Biliary Stone;Educational Commission   
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      • Vol. 7, Issue 3, Pages: 221(2001) DOI: 10.1007/BF03178496
        Keywords：Prothrombin Time;Plasminogen Activator Inhibitor;Liaoning Province;Activate Partial Thromboplastin Time;Postgraduate Education   
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      • Vol. 7, Issue 3, Pages: 222(2001) DOI: 10.1007/BF03178497
        Keywords：Mental Disease;Western Medicine;Blood Stasis;Syndrome Differentiation;Integrate Mental Health   
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      • Xie Zhu-fan
        Vol. 7, Issue 3, Pages: 223-226(2001) DOI: 10.1007/BF03178498
        Keywords：Hemorrhoid;Therapeutic Method;Blood Stasis;Excessive Sweating;Undigested Food   
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      • Lu Wei-bo
        Vol. 7, Issue 3, Pages: 227-228(2001) DOI: 10.1007/BF03178500
        Keywords：Song Dynasty;Light Yellow Powder;Polygoni Avicularis;Commercial Information;Chinese Date   
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      • Vol. 7, Issue 3, Pages: 227(2001) DOI: 10.1007/BF03178499
        Keywords：Cystitis;Powder Form;Drug Standard;Lower Abdomen;Song Dynasty   
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      • Vol. 7, Issue 3, Pages: 228(2001) DOI: 10.1007/BF03178501
        Keywords：Gastritis;Loose Stool;Traditional Factory;Light Yellow Powder;Commercial Information   
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      • Liu Yu-ping,Cao Hui Ph. D.,Katsuko Komatsu,Paul Pui-Hay But
        Vol. 7, Issue 3, Pages: 229-234(2001) DOI: 10.1007/BF03178502
        Keywords：Internal Transcribe Space;Panax Ginseng;American Ginseng;Ginseng Plant;Panax Species   
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      • Vol. 7, Issue 3, Pages: 235-237(2001) DOI: 10.1007/BF03178503
        Keywords：Nephrotic Syndrome;Therapeutic Method;World Medical Association;Institutional Affiliation;World Medical Association Declaration   
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      • Vol. 7, Issue 3, Pages: 237(2001) DOI: 10.1007/BF03178504
        Keywords：Nephrotic Syndrome;Normal Control Group;Therapeutic Method;Genetic Expression;Ethical Obliga   
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      • Xu Hao,Zhang Qun-hao
        Vol. 7, Issue 3, Pages: 238-240(2001) DOI: 10.1007/BF03178505
        Keywords：Traditional Chinese Medicine;Western Medicine;Harvard Medical School;Complementary Medicine;China Academy   
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