Latest Issue

    Vol. 7 Issue 4 2001
    • Cheng-lin Liu,Yuan-dong Wang,Yuan-dong Jin,Li-ping Liu,Qing-wei Yu,Yu-cheng Cai
      Vol. 7, Issue 4, Pages: 242-246(2001) DOI: 10.1007/BF02934361
      Abstract:To study the therapeutic effect of Chinese herbal medicine (CHM) combined with bronchial arterial chemotherapy (BAC) in treating lung cancer. Ninety patients with mid-advanced non-small cell lung cancer (NSCLC) were randomly divided into two groups. The 45 cases in Group A were treated with CHM combined with BAC and the 45 cases in Group B treated with BAC alone The short-term and long-term effect, follow-up survival rate, quality of life, changes of clinical symptoms and peripheral blood figures in the patients were observed. After treatment, the rate of CR + PR + NC in the two groups was 88.89% and 68.89% respectively, the inter-group comparison showed a significant difference (P<0.05). The 0.5-, 1- and 2-year survival rate in Group A was 75.56%, 55.56% and 48.89% respectively and in Group B71.11%, 46.67% and 24.44% respectively. The 2-year survival rate in the former was better than that in the latter (P<0.05) Moreover, the improvement of clinical symptoms, Karnofsky scoring, body weight and peripheral blood figure in Group A was superior to those in Group B. Therapeutic effect of BAC could be enhanced by combining it with CHM.  
      Keywords:lung tumor;interventional chemotherapy;bronchial arterial chemotherapy;Chinese Herbal Medicine   
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      Published:2021-08-27
    • Jia-xiang Liu,Zhi-ming Shi,He-gen Li,Zhen-ye Xu,Yan-wei Zhu,Li-hong Zhao,Hong Gao,Ling-shuang Liu,Hui-rong Zhu,Hui Zhang
      Vol. 7, Issue 4, Pages: 247-250(2001) DOI: 10.1007/BF02934362
      Abstract:To observe the effects of Yifei Kangliu Yin(YFKLY) in treating non-small cell lung cancer (NSCLC). Two hundred and seventy-one patients with NSCLC were randomly divided into three groups, Group A treated only by YFKLY, Group B treated by the combination of YFKLY and chemotherapy, and Group C treated only by chemotherapy as the control group for control. (1) Of the 127 cases in Group A, 1 case got complete remission (CR), 13 got partial remission (PR), 89 had no change (NC), and 24 had progression of disease (PD), thus CR+PR+NC accounting for 81.10%, of the 80 patients in Group B, 17 got PR , 53 got NC, 10 got PD, PR+NC accounting for 87.50%, of the 64 cases of chemotherapy group, 7 cases got PR, 39 cases got NC, 18 cases got PD, PR+NC accounting for 71.88% (P<0.01). (2) The metastasis rate was 23.52% in Group A, 20.00% in Group B and 35.71% in Group C respectively after treatment. (3) The 1-, 2-, 3- and 4-year survival rate were 73.09%, 32.01%, 13.18% and 13.18% in Group A, 71.85%, 46.35%, 29.19% and 23.35% in Group Band 37. 61%, 13 67%, 9.7% and 0% in Group C. The symptoms were improved, and Kamofsky score was elevated in Group A and B. YFKLY could increase survival rate and quality of life, decrease metastasis rate, and enhance the immune function in NSCLC patients.  
      Keywords:Yifei Kangliu Yin;non-small cell lung cancer;traditional Chinese medical therapy   
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      Published:2021-08-27
    • Guo-rong Fan,Wen-jiu Zong,Jin-fu Zuo,Jue-wen Hu,Xiao-ling Wang
      Vol. 7, Issue 4, Pages: 251-255(2001) DOI: 10.1007/BF02934363
      Abstract:To study the dynamic changes and its clinical significance of integrated traditional Chinese and western medicine (TCM-WM) on IL-2 system, T cell and erythrocyte immune system in patients of lung cancer. Forty-eight patients with lung cancer were randomly divided into two groups: TCM-WM group (Group I ) and the chemotherapy group(Group II). The relevant immune indices, clinical symptoms and signs, changes of solid tumor and quality of life were dynamically observed and compared with those in 20 healthy subjects for control. The serum IL-2 level of lung cancer patients were originally significantly lower, while sIL-2R level higher than that of the healthy subjects. And they were raised and lowered respectively after treatment, especially in Group I, but still remained different from the control group yet. And there were highly negative correlation between IL-2 and sIL-2R levels. The percentage of CD3, CD4 and the CD4/CD8 ratio were decreased markedly in both groups. And the percentage of RBC-C3bRR was obviously lower, while that of RBC-ICR obviously higher. But the above-mentioned indices could be improved after treatment, especially in Group I, and there were highly positive correlation between CD4/CD8 ratio and RBC-C3bRR. However, in regard to the degree of improvement, the patients of Group I were in better position than those of Group II. At the same time, improvement of their clinical symptoms and signs, change of entity tumor and quality of life of Group I all proved to be better than those of Group II. The therapeutic superiority of TCM-WM on lung cancer may be related to the modulation on immune function. The effect of TCM-WM is better than that of chemotherapy alone.  
      Keywords:the integration of traditional and western medicine;lung cancer;interleukin-2 system;T cell;erythrocyte immune   
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      Published:2021-08-27
    • Chang-quan Ling,Zhe Chen,De-zeng Zhu,Chao-qin Yu,Xue-qiang Huang,Xu-ying Wan,Jin Li,Jian Chen,Jian Shen,Guang-shun Yang,Meng-chao Wu
      Vol. 7, Issue 4, Pages: 256-260(2001) DOI: 10.1007/BF02934364
      Abstract:To evaluate objectively the clinical effect and superiority of integrated traditional Chinese and western medicine (TCM-WM) in treating mid-late hepatocarcinoma. The 313 patients observed were divided randomly into 3 groups, Group I, II and III, they were treated with protocol TACE, protocol PEI and comprehensive conservative therapy respectively. Each group was sub-divided into 2 sub-groups, sub-group A and B, and sub-group As was treated coordinately with different Chinese herbal medicine, Sisheng Decoction to sub-group I A and II A, and cinobufacin or norcantharidin to III A respectively. And Chinese herbal medicine prescribed according to TCM Syndrome Differentiation was also given to all the sub-group As. The integrated therapy showed significant effect in treating mid-late hepatocarcinoma, as it could improve significantly the clinical symptoms and signs, raise the quality of life and prolong the survival time in patients. When TCM-WM cooperated with TACE, it could alleviate the toxic effect and enhance the therapeutic effect of chemotherapy. There was statistical significant difference in clinical effect between the TCM-WM treated groups and the western medicine treated groups (P<0.05). TCM-WM therapy displays not only the action in enhancing the short-term therapeutic effect of treatment in treating mid-late hepatocarcinoma but also shows significant effect in enhancing long-term therapeutic effect and prolonging survival time in patients. It is worth further spreading.  
      Keywords:mid-late primary hepatocarcinoma;integrated traditional Chinese and Western medicine;prospective contrast study   
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      Published:2021-08-27
    • Yin-quan Deng,Xiao-fen Fan
      Vol. 7, Issue 4, Pages: 260(2001) DOI: 10.1007/BF02934365
      Abstract:To explore the relationship between the liver fibrosis criteria and TCM Syndrome type in patients suffering from non-alcoholic fatty liver. Seventynine patients with non-alcoholic fatty liver diagnosed by B ultrasonography were classified by TCM Syndrome Differentiation and their liver fibrosis criteria was determined and compared with those of the healthy subjects as control. Levels of procollagen I (PCIII), hyaluronic acid (HA), collagen IV(CIV) and laminin (LN) in the fatty liver group were significantly higher than those in the control group (P<0.05,P< 0.01). In respect to the TCM Syndrome-types, PC III, C IV and LN in patients of Phlegm-stasis combined type were significantly higher than those in patients of Spleen deficiency-Phlegm dampness Syndrome-type and Damp-Heat Syndrome-type (P<0.05,P < 0.01), while HA in different groups was insignificantly different (P> 0. 05 ). There was trend of liver fibrosis in fatty liver patients. It was indicated that the Phlegm-stasis combined Syndrome-type possibly was the main TCM pathologic factor of the increasing of fibrosis criteria for non-alcoholic fatty liver.  
      Keywords:hyaluronic acid;laminin;Fatty Liver;Liver Fibrosis;Therapeutic Strat   
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      Published:2021-08-27
    • Jian-hua Cheng,Gang Chang,Wan-yin Wu,Wei-sheng Liu,Zhi-gang Yang,Fan-zhe Meng,Kai Xu,Liu-ning Li,Di-ying Zhu,Chun-yong Chen,Hai-ying Luo
      Vol. 7, Issue 4, Pages: 261-267(2001) DOI: 10.1007/BF02934366
      Abstract:To evaluate the effect, side-effect and prospect of hepatic arterial perfusion embolization (HAPE) with Zedoary turmeric oil (ZTO) in treating primary hepatic carcinoma (PHC). Clinical study was carried out by administration of 1/2-3 ml ZTO through arterial catheter to induce embolism in 32 patients of PHC, and compared with 32 patients treated by hepatic arterial perfusion embolization with chemical agents (HAPE-C) in the control group. The Chinese herbal medicine was given orally to both groups according to Syndrome Differentiation of TCM. In the experimental study, transplantation hepatic carcinoma model was established in 40 rats. They were randomly divided into the treated group and the control group, 20 in each group, and were perfused with 10 mg/kg ZTO and 0.2/2-0.3 ml normal saline respectively to observe the effect of treatment. The effect of treatment in the ZTO group was CR in 1 case and PR in 13 cases, the total effective rate being 43.75%, with AFP negative reversed in 7 cases, titer decreased in 7; while in the control group it was PR in 10 cases, the total effective rate being 31. 25%, AFP negative reversed in 5, titer decreased in 2, and the difference of therapeutic effect between the two groups was insignificant (P>0.05). The post-perfusion thrombotic syndrome occurrence, with the symptoms of fever, abdominal pain, vomiting, etc. in the two groups was similar, but no bone marrow inhibition occurred in the ZTO group, which was different from the control group (P<0. 01,P<0.05). The mean survival time, median survival time, 1-, 2-, 3- and 4-year survival rate in the ZTO group was 13.84 months, 10 months, 37.5%, 18.87%, 9.70% and 6.4% respectively, and in the control group, 8.03 months, 6 months, 15.6%, 6. 27%, 0% and 0% respectively, the mean survival time, median survival time and 1-year survival rate in the ZTO group were significantly superior to those in the control group (P<0.05). Experimental study showed that the effect in the treated group was better than that in the control group in tumor growth inhibition with the tumor growth rate as 10.8±4.5%% vs 20.6±12.7%,P<0.05, tumor necrosis degree (P<0.01) and survival time prolonged (14.8±3.4 days vs 11.7±1. 9 days,P<0.05) HAPE-ZTO in treating PHC showed the therapeutic effect similar to that of HAPE-C, but superior to the latter in survival time prolongation and bone marrow inhibition.  
      Keywords:Zedoary turmeric oil;hepatic arterial perfusion embolization;Primary Hepatocarcinoma   
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      Published:2021-08-27
    • Xiao-dong Zhu,An-yu Wang,Shao-feng Wang,Ren-sheng Wang,Long Chen,Lin Li,Hai-jie Lu
      Vol. 7, Issue 4, Pages: 268-272(2001) DOI: 10.1007/BF02934367
      Abstract:To observe the effect of Shenlong Oral Liquid(SLOL)combined with radiotherapy in treating nasopharyngeal carcinoma (NPC). Effects of the combined therapy, including clinical effects, changes of cellular immunity and side effects, in treating 60 NPC patients (in the treated group) were observed and compared with those of the other 60 patients treated with radiotherapy alone (in the control group). (1)The side effects of radiation in the treated group were lower than those in the control group significantly (P<0.05). (2) The short-term remission rate of nasopharyngeal and neck metastatic tumor in the two groups was not significantly different (P>0.05). (3) The dose for complete remission of nasopharyngeal and neck tumor in the treated group was lower than that in the control group (P<0.01). (4) No change of T-lymphocyte subsets was found in the treated group after treatment, but in the control group , OKT3, OKT4, and OKT4/OKT8 ratio were markedly decreased (P<0.05). (5) The survival rate in the treated group was higher than that in the control group, but with no statistical significance (P=0.0518). The combined therapy of NPC with SLOL and radiotherapy is able to reduce side-effect of radiotherapy, improve the cellular immunity, reduce the dose of radiation for tumor remission and enhance the therapeutic effect of radiotherapy. It showed a trend of raising the long-term survival rate of NPC patients.  
      Keywords:nasopharyngeal carcinoma;radiotherapy;Chinese Herbal Medicine;T-lymphocyte subsets   
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      Published:2021-08-27
    • Yue-xiang Lian,Xioa-ying Long,Wan-fen Wu,Zhi-biao Yin
      Vol. 7, Issue 4, Pages: 272(2001) DOI: 10.1007/BF02934368
      Abstract:To observe the effect of Shuangcao Tuihuang Granule-1 (SCTH-1) in treating severe jaundice of acute icterohepatitis and to study its mechanism. Thirty-four patients with severe jaundice of acute icterohepatitis were treated with conventional western medicine and SCTH-1, the therapeutic effects were analyzed and compared with that in the control group (treated with western medicine alone). In the animal experimental studies, the influences of SCTH-1 on acute liver injury, liver superoxide dismutase (SOD) and serum ALT and AST in mice were monitored. The markedly effective rate in the treated group and the control group was 73. 5% and 59.1% respectively, and the effective rate was 23.5% and 40. 9% respectively. The markedly effective rate in the treated group was obviously higher than that in the control group (P <0.05). Experimental study showed that SCTH-1 could reduce the level of serum transaminase and liver tissue damage in mice with acute liver damage. In addition, SCTH-1 could raise the activity of liver SOD (p<0. 05). SCTH-1 could accelerate the jaundice subsidence, improve the liver function and ameliorate the liver injury, its mechanism was possibly correlated with raising SOD activity and scavenging oxygen free radicals.  
      Keywords:Effective Rate;nasopharyngeal carcinoma;Western Medicine;Acute Liver Injury;Animal Experimental Study   
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      Published:2021-08-27
    • Fang-yun Xie,Zhi-fan Zeng,Hui-ying Huang,Chong Zhao,Tai-xiang Lu
      Vol. 7, Issue 4, Pages: 273-276(2001) DOI: 10.1007/BF02934369
      Abstract:To observe the effect of radiotherapy (RT) combined with ginseng polysaccharide (GSP) injection in treating nasopharyngeal carcinoma (NPC) and its influence on immune function. One hundred and thirty-one patients of NPC were randomly divided into two groups, the RTGSP group (n=64) treated with RT and GSP, and the control group (n=67) treated with conventional radiotherapy, to observe the local cancer remission rate, 1-year total survival rate, no tumor survival rate and no remote metastasis survival rate. Moreover, the changes of T-lymphocyte subsets, natural killer cell (NK) activity and lymphokine-activated killer cell (LAK) activity before and after treatment were determined. Clinical examination conducted 3 months after treatment showed that the complete remission rate in the RT-GSP group was 96.6%, and in the control group 93.3%, the complete remission rate of cervical lymph node metastasis in the two groups was 85. 7% and 78. 0%, the NPC remission rate shown by CT 60.3% and 51.7%, respectively. Re-examination carried out 1 year after treatment showed that the total survival rate in the two groups was 100% and 96. 5%, tumor free survival rate 84.4% and 74.6%, and no remote metastasis survival rate 93. 8% and 88.1% respectively. The activity of NK cell and LAK cell as well as T3, T4 value in peripheral blood increased significantly in the RT-GSP group (allP<0.05) after treatment, while with the control group, no significant influence on NK and LAK activities were shown but significant lowering of T3, T4 was,P<0.05. No toxic-adverse reaction of GSP was found. GSP has certain immune function improving effect in NPC patients during RT, and it could also eliminate the occurred adverse reaction to RT and improve the general condition of patients.  
      Keywords:nasopharyngeal cancer;radiotherapy;ginseng polysaccharide injection   
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      Published:2021-08-27
    • Yu Wu,Ji-cheng Li,Lian-gen Mao,Xiao-qiao Dong
      Vol. 7, Issue 4, Pages: 276(2001) DOI: 10.1007/BF02934370
      Abstract:To study the therapeutic effect of Chinese herbal medicines (CHM) in treating ascites and to elucidate its mechanism in regulating the lymphatic stomata and promoting the absorption of ascites from the peritoneal cavity. Using scanning electron microscope ( SEM), computerized image processing and quantitative analytic assay, the effect of CHM extract, consisting of Atractylodes macrocephala, Salvia miltiorrhiza, Codonopsis pilosula, Alismatis orientale and Leonurus heterophyllus, was studied. Intraperitoneal injection of nitric oxide, (NO) supplier (Sodium nitroprussiate) or CHM administration could cause the average area of lymphatic stomata obviously enlarged (P <0.05), and the numbers of opening stomata significantly increased (P<0.01) in normal healthy mice. When L-notroarginine, a NO synthetase suppressor, was injected after CHM administration, the regulating effect of CHM on lymphatic stomata was inverted obviously, i.e. the average area and the density of lymphatic stomata were markedly reduced (P< 0.01). CHM might treat ascites through increasing the endogenous NO concentration to open the lymphatic stomata and in turn to conduct the peritoneal water through lymphatic path.  
      Keywords:Nitric Oxide;Clin Oncol;nasopharyngeal carcinoma;Average Area;Chinese Herbal Medicine   
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      Published:2021-08-27
    • Zhen-ye Xu,Yan-wei Zhu,Wei-dong Zhou,Hui Zhang,Yan-fang Ju,Li-hong Zhao,Hai-bin Deng,Ji Wu,De-yi Shen,Hui-xin Zhang
      Vol. 7, Issue 4, Pages: 277-282(2001) DOI: 10.1007/BF02934371
      Abstract:To observe the leucocyte increasing effect of Shuanghuang Shengbai Granule (SHSBG) in tumor patients treated by chemotherapy and the bone marrow microenvironment protecting effect in mice. Patients of non-small-cell pulmonary, mammary, gastric or intestinal cancer, who were ready for receiving re-treatment of chemotherapy, were enrolled and divided into 4 groups randomly. The 28 cases in SHSBG group A received chemotherapy combined with SHSBG; the 27 in the SHSBG group B received chemotherapy alone at first, and SHSBG was added when their peripheral white blood cell (WBC) count lowered to <4×109/L; the 33 in control group A and 24 in control group B were treated by the method similar to that applied to SHSBG group A and B respectively but with Rubidate instead of SHSBG. Experimental study of electron microscopic observation on bone marrow ultrastructure in mice was also conducted. The total leukocyte increasing effective rate occurred in SHSBG group A and B was 75.00% and 88.89%, while in control group A and B, 54.55% and 58.33% respectively, and the difference between the SHSBG groups and the control groups was significant (P<0. 01). Experimental study showed that SHSBG has good bone marrow hematopoietic microenvironment protecting and improving effect in mice. SHSBG has obvious protecting and treating effect on chemotherapy induced bone marrow suppression in tumor patients.  
      Keywords:Shuanghuang Shengbai Granule;chemotherapy-caused bone marrow suppression;leukocyte increasing;bone marrow microenvironment   
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      Published:2021-08-27
    • Yong-Gang Xu,Rou Ma,Nai-ping Hu,Feng Liu,Jing-min Yang,Ling Ma,Xiao-mei Hu
      Vol. 7, Issue 4, Pages: 283-287(2001) DOI: 10.1007/BF02934372
      Abstract:To observe the effects of Fuzheng Kangbai Granule (FZKBG) on immune function and survival time in minimal residual leukemia (MRL) model mice and explore its mechanism. MRL model mice were established by hypodermic inoculation with L7212 cells 1×106 following intraperitoneal injection of cytoxan (CTX) 250 mg/kg 3 days later, and divided into the control group and FZKBG treated group. The changes of T-lymphocyte subsets, including CD3 +, CD4 + and CD8 +, and the survival time in model mice were observed. Compared with the control, FZKBG could obviously increase both the percentage and absolute value of CD3 + and CD4 + lymphocytes and prolong the survival time of model mice, the prolongation rate being 29. 6% – 60. 4%. FZKBG could markedly prolong the survival time of MRL mice, and its mechanism might be through elevating the immunologic function and inhibiting the leukemia cells in model mice.  
      Keywords:Fuzheng Kangbai Granule;minimal residual leukemia;immune function   
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      Published:2021-08-27
    • Wei-bo Lu
      Vol. 7, Issue 4, Pages: 287(2001) DOI: 10.1007/BF02934373
        
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      Published:2021-08-27
    • Yun Sun,Yang-mei Deng,De-jun Wang,Chun-feng Shen,Xiao-mei Liu,Hong-quan Zhang
      Vol. 7, Issue 4, Pages: 288-292(2001) DOI: 10.1007/BF02934374
      Abstract:To observe the effects of Cistanche desertica polysaccharides (CDP) on the learning and memory functions and cerebral ultrastructure in experimental aging mice. CDP was administrated intragastrically 50 or 100 mg/kg per day for 64 successive days to experimental aging model mice induced by D-galactose, then the learning and memory functions of mice were estimated by step-down test and Y-maze test; organelles of brain tissue and cerebral ultrastructure were observed by transmission electron microscope and physical strength was determined by swimming test. CDP could obviously enhance the learning and memory functions (P<0.01) and prolong the swimming time (P<0.05), decrease the number of lipofuscin and slow down the degeneration of mitochondria in neurons(P<0.05), and improve the degeneration of cerebral ultra-structure in aging mice. CDP could improve the impaired physiological function and alleviate cerebral morphological change in experimental aging mice.  
      Keywords:aging;learning and memory functions;Cistanche desertica polysaccharides;ultra-structure;D-galactose   
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      Published:2021-08-27
    • Wei Mao,Wu Ye,Qiang Liu,Zhao-quan Huang,Shen-jie Chen,Nan-ping Qin
      Vol. 7, Issue 4, Pages: 292(2001) DOI: 10.1007/BF02934375
      Abstract:Objective To observe the relationship between TCM Syndrome-type and insulin resistance (ISR) in coronary heart disease (CHD). Fifty patients were divided into 3 groups according to the Syndrome Differentiation-typing in TCM, the Heart blood stasis (HBS) Syndrome group, the Phlegm-Turbid stagnation (PTS) Syndrome group and both Qi-Yin Deficiency (QYD) Syndrome group. The fasting blood glucose (FBG), fasting blood insulin (Ins), insulin antibody (IAA), islet cell antibody (ICA), glutamic acid decarboxylase antibody (GADAb) and related blood lipid parameters in patients were determined and insulin sensitive index (ISI) was calculated simultaneously. Then the above-mentioned data were compared with those determined in 20 healthy control subjects. The levels of FBG and Ins in CHD group were higher than those in the healthy control group significantly (P<0.05), but ISI level was obviously lower (P<0.01). Moreover, the positive percentage of IAA (40%) was higher in CHD group than that in the control group (5%) significantly (P<0.01). Comparison between the 3 TCM Syndrome-type groups and the control group showed that ISI level in HBS and PTS group was obviously lower than that in the control and the QYD (P< 0.05) respectively, and the IAA positive percentage in the former 2 groups (50%, 47.37%) was higher than that in the latter two(5%,P<0.01 and 15.38%,P<0.05) markedly. While Ins level increased only in the HBS group (P<0.05). Besides, patients of HBS and PTS Syndrome were accompanied by lipid metabolic disturbance. ISR presents in part of CHD patients particularly in those with HBS and PTS Syndrome, which was partly due to the existence of serum IAA in patients.  
      Keywords:coronary heart disease;Fasting Blood Glucose;Healthy Control Group;Coronary Heart Disease Patient;Insulin Sensitive Index   
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      Published:2021-08-27
    • Lu-lu Ge,Wei Zhang,Yun Dai,Yan Zang,Chun-jie Huang
      Vol. 7, Issue 4, Pages: 293-296(2001) DOI: 10.1007/BF02934376
      Abstract:To observe the effects of essential garlic oil (EGO) on vascular cell adhesive molecule-1 (VCAM-1) expression of endothelial cells and monocyte-endothelial cell adhesion rate induced by interleukin-lα(IL-lα). Human umbilical vein endothelial cells (HUVEC) were isolated by trypsin digestion method and co-cultured with IL-1α or EGO + IL-lα in the absence or presence of U937 monocyte. Monocyte-endothelial cell adhesion rate was examined with reverted microscope. VCAM-1 expression of endothelial cells was measured by ACAS 570 confocal microscope, and the data were presented as mean fluorescent intensity. EGO significantly inhibited IL-lα-induced endothelial expression of VCAM-1, and thus markedly decreased monocyte-endothelial cell adhesion rate. EGO has the effect on antagonizing adhesion of monocyte and vascular endothelial cell, which might be due to its inhibition on adhesive molecular expression on the surface of endothelial cells.  
      Keywords:essential garlic oil;endothelial cells;monocytes;vascular cell adhesive molecule-1;interleukin-lα   
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      Published:2021-08-27
    • Xiao-hong Wang,Yu-mao Liu
      Vol. 7, Issue 4, Pages: 297-299(2001) DOI: 10.1007/BF02934377
      Keywords:Mitochondrion Membrane Potential;Peripheral White Blood Cell Count;Membrane Potential Lowering;Femoral Arterial Catheterization   
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      Published:2021-08-27
    • Yu-hua Jia,Xue-gang Sun,Xiao-shan Zhao
      Vol. 7, Issue 4, Pages: 299(2001) DOI: 10.1007/BF02934378
      Abstract:To elucidate the molecular mechanism on anti-arrhythmic function of Dingxin Recipe (DXR). Cardiac myocytes isolated by trypsin method were cultured and labeled with various fluorescence stains. DXR contained serum induced changes of cellular calcium concentration [Ca2+]i, cell membrane potential (MP) and mitochondria membrane potential (MMP) were determined with laser confocal microscopy. Hypoxia caused increase of [Ca2+]i and MMP, and decrease of MP, while DXR contained serum lowered the [Ca2+]i in normal or hypoxic myocytes, improved hypoxia induced MP reduction and maintain MMP at baseline level under hypoxia circumstances. Through inhibiting the hypoxia caused [Ca2+]i and MMP elevation and MP lowering, DXR displays its action in protecting myocardial cells to prevent and treat arrhythmia.  
      Keywords:Membrane Potential;Mitochondrion Membrane Potential;Cardiac Myocytes;Cell Membrane Potential;Intracellular Free Calcium   
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      Published:2021-08-27
    • Yan Lu
      Vol. 7, Issue 4, Pages: 300-301(2001) DOI: 10.1007/BF02934379
      Keywords:Purpura;Idiopathic Thrombocytopenic Purpura;Total Effective Rate;Blood Picture;Hemorrhagic Disease   
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      Published:2021-08-27
    • Wan-zhang Qin
      Vol. 7, Issue 4, Pages: 302-303(2001) DOI: 10.1007/BF02934380
      Keywords:systemic lupus erythematosus;psoriasis;Traditional Chinese Medicine;Connective Tissue Disease;Western Medicine   
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      Published:2021-08-27
    • Jian-zhong Xu
      Vol. 7, Issue 4, Pages: 304-305(2001) DOI: 10.1007/BF02934381
      Keywords:Chronic Obstructive Pulmonary Disease;Interstitial Lung Disease;Western Medicine;Integrative Medicine;China Academy   
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      Published:2021-08-27
    • Yue Zhang,Min Wei,Qian Wang,Fei Chu,Jing Yan,Bo-guang Li,Xu Jia
      Vol. 7, Issue 4, Pages: 305(2001) DOI: 10.1007/BF02934382
      Abstract:To explore the therapeutic effect and mechanism of Bushen Huoxue Xiezhuo Decoction (BHXD) in treating minute lesion nephropathy (MLN) in rats. The MLN model rats established by a single intravenous injection of Adriamycin were divided into the model and the BHXD groups, and a normal group was set up for control. The effects of treatment on renal function, hemorrheologic parameters, renal tissue transforming growth factor β1 (TGF-β1 ) expression and poly-anion sites on glomerular basement membrane were observed dynamically. After treatment, all the parameters between the BHXD group and the model group were significantly different respectively, morphological observation also showed the pathological changes in the BHXD group were milder than those in the model group. BHXD treatment could markedly improve the renal function, alleviate blood hypercoagulability and hyperviscosity, protect the anion barrier and delay the progression of glomerular fibrosis and sclerosis.  
      Keywords:Experimental Study;Renal Function;Therapeutic Effect;Pathological Change;Normal Group   
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    • Shihu Yeguang Wan
      Vol. 7, Issue 4, Pages: 306(2001) DOI: 10.1007/BF02934383
      Keywords:Retinitis;Panax Ginseng;Chinese Pharmacopoeia;Bolus Weight;Yuan Dynasty   
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    • Xiao-mei Hu,Cheng-shan Deng,Rou Ma
      Vol. 7, Issue 4, Pages: 307-311(2001) DOI: 10.1007/BF02934384
      Keywords:Granulocyte Colony Stimulate Factor;Drug Resistance Cell;Tetrandrine;Arsenic Oxide;Human Mammary Cancer   
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    • Vol. 7, Issue 4, Pages: 312-314(2001) DOI: 10.1007/BF02934385
        
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    • Vol. 7, Issue 4, Pages: 315-317(2001) DOI: 10.1007/BF02934386
      Keywords:diabetes mellitus;Rheumatic Disease;Allergic Disease;Western Medicine;Liaoning Province   
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