Latest Issue
Vol. 8 ， Issue 3 ， 2002
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Clinical study of xiongshao capsule in preventing restenosis after coronary interventional treatment
Abstract：To evaluate the effect of Xiongshao Capsule in preventing clinical and angiographic restenosis after coronary angioplasty or/and stenting. The total of 108 coronary heart disease patients with successful coronary angioplasty or/and stenting were randomly divided into the control group (55 cases, routine treatment) and the XS group (53 cases, routine treatment combined with XS). The recurrence of angina, clinical end-point events, changing of blood-stasis syndrome score (BSSS) and coronary angiography within 6 month after coronary angioplasty or/and stenting were observed. Follow-up angiography was performed in 42 patients including 18 cases in the XS group (restenosis was observed in 7 patients) and 24 cases in the control group (restenosis was observed in 17 patients), there was significant difference between the occurrence of restenosis in XS and that in control group (P < 0.05). The occurrence of clinical end-point events (death, nonfatal target lesion myocardial infarction, coronary artery bypass graft surgery, or repeat target-vessel angioplasty) in the XS group (18.8%) was significantly lower than that in the control group (40%)(P <0.05). The recurrent angina was observed in 13 cases in the XS group, there was significant difference as compared with 27 cases in the control group (P <0.05). There was also remarkable significance for the difference of base-line and follow-up BSSS between groups (P < 0. 01). Logistic multivariate stepwise regress analysis and multivariate regress analysis of the related factors with restenosis confirmed by coronary angiography showed that, the base-line BSSS and the difference of base-line and follow-up BSSS were important influencing factors on the occurrence of restenosis after interventional treatment (P < 0.05). XS could markedly reduce the occurrence of angiographic restenosis, clinical end-point events and recurrent angina, improve condition of blood-stasis after coronary angioplasty or/and stenting. The severity of blood-stasis syndrome was an important influencing factor on the occurrence of restenosis. It still needs to be further demonstrated by large-scale, double-blinded, randomized and controlled study.Keywords：Xiongshao capsule;angioplasty;stent;restenosis- 719
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Published：2021-08-27 - Abstract：To evaluate the effect of anti-platelet regimens and it’s combination with Shuxinyin (SXY,) on in-stent restenosis after stent implantation. Forty-four patients with successful stent implantation in a coronary artery were randomly assigned to the treated group (n = 20) and the control group (n = 24). The treated group received SXY and anti-platelet therapy. The control group were treated with anti-platelet regimens only. Platelet activation was assessed before and immediately after the stenting by flow cy-tometry, the expression of P-selectin (CD62P) and glycoprotein(GP) П b/Ш a receptor. It was reassessed on the 30th day after stenting. Plasma fibrinogen (Fg) and C-reaction protein (CRP) were measured by biuret and laser scattering turbidimetry respectively at the same time. Observation was made on the scoring of the symptoms of Qi deficiency syndrome, Qi-Yin deficiency syndrome and blood stasis syndrome in the two groups. Differences between groups were compared. Compared with the control group, combination with SXY and anti-platelet therapy was remarkable in reducing plasma CRP (P < 0.05), and also with the tendency to decrease plasma Fg, GP П b/Шa and CD62P. It could also evidently decrease the scoring of Qi-Yin deficiency syndrome, Qi deficiency syndrome and blood stasis syndrome after stenting (P <0.05, 0.01, 0.01) respectively. Followup survey found 40 % relapse of angina pectoris with 4 cases of in-stent restenosis proved by angiography in the treated group. But the relapse of angina pectoris in the control group was 67% with 2 cases of mypcardial infarction (MI), 7 cases of in-stent restenosis proved by angiography and one death. Combination with SXY and anti-platelet regimens can prevent stent thrombosis and in-stent restenosis after stent implantation, and it seems superior to anti-platelet therapy only.Keywords：angioplasty;stenting;in-stent restenosis;platelets;glycoprotein;Shuxinyin
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Published：2021-08-27 - Abstract：To observe the myocardial protecting effects of Ginaton (Ginkgo biloba extract) on ischemic-reperfusion injured myocardium during cardiopulmonary bypass (CPB). Twenty patients selected undergoing mitral valvular replacement were randomly divided into two groups. Control group: 10 patients, intermittent intra-aortic infusion with cold St. Thomas solution during hypothermic CPB. Ginaton group: 10 patients, intermittent intra-aortic infusion with cold St. Thomas solution containing Ginaton (0.5 mg’kg1). Changes of ultrastructure levels of adenosine triphosphate (ATP), malondialdehyde (MDA) and hemodynamic data were measured. Hemodynamic parameters in the Ginaton group were maintained better than those in the control group. MDA in the control group was significantly elevated during ischemic-reperfusion (P<0.05), while in the Ginaton group, there were no obvious change. The levels of ATP and energy change in the Ginaton group were obviously higher than those in the control group at declamping aorta (P< 0. 05). The percentage of normal mitochondria and glycogen content were significantly higher in the Ginaton group than that in the control group at declamping aorta (P< 0.05). Ginkgo biloba extract may provide a beneficial effect on myocardial protection in ultrastructural preservation, prevention of high energy phosphate depletion, reduction in free radicals production and improvement of myocardial function.Keywords：Ginkgo Biloba Extract;ischemic-reperfusion injury;myocardial protection
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Published：2021-08-27 - Abstract：To observe the effects of Ixeris sonchifolia Hance (ISH) on platelet function and hemorrheology in type 2 diabetes mellitus (DM) patients. Thirty-three type 2 DM patients were treated with 20 ml ISH per day, intravenously dripping for 15 days; 31 patients in the red sage treated group were treated with composite red sage injection intravenous dripping for 15 days, and their changes of platelet membrane glycoprotein П b/Ш a compound (GPП b/Шa), granular membrane protein-140 (GMP-140), platelet aggregation rate (PAgR) and hemorrheology were observed. After treatment with ISH, the GPП b/Ш a compound positive rate of 33 type 2 DM patients were lowered (P< 0.05), GMP-140 showed lowering trend, PAgR obviously reduced, and compared with before treatment it showed significant difference; comparison between the two groups after treatment, it showed significant difference (P < 0. 05,P < 0. 01). At the same time, the various parameters of hemorrheology displayed significant improvement. There was no adverse effect during the course of treatment. ISH could improve platelet function and abnormal hemorrheology of type 2 DM patients, which is vital for the treatment of DM and their vascular lesion.Keywords：type 2 diabetes mellitus;Ixeris sonchifolia Hance;platelet glycoprotein;platelet aggregation rate;hemorrheology
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Published：2021-08-27 - Abstract：To observe the clinical efficacy of Kaixin Capsule (KXC), a Chinese compound preparation, in treating type 2 diabetes mellitus (DM) complicated with abnormal lipidemia. Seventy-two DM inpatients were medicated on the basis of administering conventional hypoglycemics, and KXC was orally taken. They were compared with those patients only taking hypoglycemics to observe the change of blood lipid before and after treatment. The total cholesterol of KXC combined with hypoglycemics group had their blood lipid lowered by 14% after treatment and triglyceride lowered by 36%, HDL-C raised by 11 % , and LDL-C lowered by 24% . Compared with only hypoglycemics treatment, there was significant difference (p <0.01). KXC has good blood lipid regulating effect on DM complicated with abnormal lipidemia.Keywords：Kaixin Capsule;type 2 diabetes mellitus;abnormal lipidemia;clinical efficacy
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Published：2021-08-27 - Abstract：To investigate the change of T-lymphocyte subsets in peripheral blood of rheumatoid arthritis (RA) patients and analyze the effects of Fuzheng Qubi Decoction (FZQBD) on T-cell subsets. Thirty RA patients were randomly divided into two groups, and treated with FZQBD or western medicine combination therapy respectively for one month, the percentage of peripheral CD3 +, CD4 + , CD8 + as well as the serum IgG and IgA levels were determined. The percentage of peripheral CD4 + , CD4 + /CD8 + ratio, IgG and IgA levels increased significantly (p < 0.001) in RA patients before treatment. After 1 month of FZQBD treatment, the CD4 + /CD8 + ratio decreased obviously < 0.05). Abnormal cellular immunity exists in RA patients, FZQBD could adjust the abnormal T-lymphocyte subsets to normalize it.Keywords：Rheumatoid Arthritis Patient;Simvastatin;American Ginseng;Activate Blood Circu;Phlegm Turbidity
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Published：2021-08-27 - Abstract：To study the changes of endothelin (ET), tumor necrosis factor-α (TNF-a) before and after puerarin treatment in patients with diabetes mellitus vascular complications (DMVC). Ninety-eight DMVC patients were divided into 2 groups, they were given puerarin (n= 68) and normal saline (n = 30) respectively, 20 diabetic patients without vascular complications (NDMVC) were taken as control, who were also given puerarin. All the patients were treated on the basis of controlling blood glucose. Plasma ET and serum TNF-α were determined by radioimmunoassay (RIA) before and after treatment. Plasma ET and serum TNF-a in DMVC got higher than that of NDMVC patients (p <0.05), and ET level was correlated with TNF-a (r = 0.69,r = 0.73,p <0.01). After treatment, the levels of ET and TNF-a were significantly lower than those before treatment of DMVC patients with puerarin (p < 0. 05). Puerarin could regulate the levels of plasma ET and serum TNF-α of DMVC patients, suggesting that it has the function of regulating endothelial cells.Keywords：Puerarin;type 2 diabetes mellitus;vascular complication;endothelin;tumor necrosis factor-α
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Published：2021-08-27 - Abstract：To explore the clinical effect of three different dosage-forms of Zhishi Xiaopi Pill (ZSXPP, ) recipe on functional dyspepsia (FD). The total of 158 patients were included in this study and were randomly divided into four groups. Three group patients of FD were respectively treated with three different dosage-forms of ZSXPP, while the control group were treated with cisapride. The treatment outcome indicated that there was no difference in the total therapeutic efficacies of these four groups. The tension of vagus nerve and the plasma level of motilin in FD patients were significantly increased by the treatment with ZSXPP; the impaired contraction function of lower esophageal sphincter in some FD patients was improved, too. All of three different dosage-forms of ZSXPP were as effective as cisapride on FD. The efficacy was partly due to the improvement of esophageal and gastric dynamics which was probably related to the increasing of the tension of vagus nerve and the plasma level of motilin.Keywords：functional dyspepsia;Traditional Chinese Medicine Treatment;vagus nerve;gastrointestinal hormone;motilin
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Published：2021-08-27 - Abstract：To observe the clinical effect of Yiqi Jianpi Bushen recipe (YQJPBS,) in antagonizing nephrotoxicity and hematological toxicity by cisplatin (CDDP). The patients with different types of carcinomas were divided into two groups. One group was treated by western medicine (WM), i.e. cisplatin combined with diuretic therapy. The other group by Chinese medicine (CM). One day before chemotherapy, YQJPBS was given orally. Urinary enzyme (NAG,Y-GT, ALP) and serum erythropoietin (Epo) were used as the key monitoring indicator. The early renal damage by CDDP remains near proximal convoluted tubule, which leads to the rising of urinary enzyme. So urinary enzyme of the CM group was obviously lower than that of the WM group. The lesion of renal interstitial cells that produce Epo did not cause the serum Epo of WM group to rise obviously 15 days later. As a result there was 40% patients whose RBC and Hb became lower than the standard count. While serum Epo of CM group was higher than that of WM group, only 5% patients in the CM group had their RBC and Hb lowered. YQJPBS can effectively antagonize nephrotoxicity and hematological toxicity induced by CDDP.Keywords：Yiqi Jianpi Bushen recipe;cisplatin;nephrotoxicity;urinary enzyme;erythropoietin
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Published：2021-08-27 - Abstract：To elucidate the molecular mechanism of the differentiation of acute promyelocytic leukemia (APL) cell line NB4 induced by realgar. The response of NB4 cell to realgar was explored with a cDNA microarray representing 1003 different human genes. The analysis of gene expression profiles indicated that 8 genes were up-regulated and 33 genes were down-regulated 48 hrs after realgar treatment. Among the 8 up-regulated genes, 2 genes were involved in ubiquitin proteasome degradation pathway. Some genes related to RNA processing, protein synthesis and signal transduction were down-regulated. The ubiquitin-proteasome degradation pathway may play an important role in the degradatipn of PML/ RAR a fusion protein and the differentiation of NB4 cells.Keywords：realgar;DNA microarray;Acute Promyelocytic Leukemia
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Published：2021-08-27 - Abstract：To observe the difference in therapeutic effect of Chinese herbal granule decocted separately and mingly. One hundred patients of functional dyspepsia of Spleen deficiency and Liver stagnancy type were treated with Jianweishu Granule (JWSG, ,a self-formulated recipe by the authors). Half of the patients received JWSG decocted separately, half of them received that decocted mingly. The therapeutic effects between the two groups were compared. Experimental observation on the effects of differently decocted remedies in rats was also conducted. The therapeutic effects obtained in the two groups were similar, with respective cure rate of 72 % and 70 % and the total effective rate 96 % in both group. There was insig1nificant difference between the two groups (P <0.05). Experimental study all showed no difference between the differently decocted remedies in inhibiting gastric acid, pepsin activity, gastric function regulation, small intestine movement improvement and pain alleviation in rats. The therapeutic effects of JWSG decocted separately or mingly are the same. This fact provides a scientific basis for clinical use of granule form of single Chinese herbs.Keywords：functional dyspepsia;Total Effective Rate;Tirone;Movement Improvement;Small Intestine Movement
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Published：2021-08-27 - Abstract：To study the effect of Acanthopanax senticosus saponin (ASS) on free radical injury induced neuron aging. On day 7 of fetal mice, cortical neuron primary passage cultures were divided into the normal control group, model group and ASS groups. The model group using free radical (FeSO4 plus H2O2) injury mode prepared in vivo cultured ICR mice cortical neuron aging model; ASS groups: 24 hrs before and after treated with H2O2 and FeSO4, different concentration of ASS was added, according to biochemical parameters such as lactate dehydrogenase (LDH), superoxide dismutase (SOD) and malondialdehyde (MDA) etc. and histomorphologic change to observe the protection of ASS on aging neurons. The LDH, SOD,MDA of the model group were compared with the normal group, < 0. 01; ASS groups added 1.25 mg/100 ml, 2.5 mg/100 ml, 5 mg/100 ml concentration of ASS, their LDH, SOD, MDA compared with the model group π.05-0.01, the difference was significant. In medicated groups the SOD activity of oxidization injured nerve cells obviously elevated, LDH activity and MDA content apparently lowered. Microscope and scanning electron microscopic observation showed that supplemented with ASS to protect the nerve cell injury abated, part of the cellular structure tended to normalize. ASS could act against free radical toxic effect, increase the anti-oxidase activity, strengthen the protection of neuron cells. It is assumed that the effect against nerve cell aging was possibly through scavenging oxygen free radical, strengthening the stability of cell membrane, thus delaying the development of aging.Keywords：Acanthopanax senticosus saponin;free radical;nerve cell culture;aging
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Published：2021-08-27 - Abstract：To explore the mechanism of anti-rheumatic effect of the active fraction of Siegesbeckia pubescens (AFSP). Adjuvant arthritis (AA) model of rat was produced to observe the effect of AFSP on lymphocyte proliferation, interleukin-1 and -2 (IL-1,-2) activity, pathologic section of ankle joint, and analgesic effect, in model rat. AFSP could reduce the inflammatory pathologic response of ankle joint. It has good analgesic effect, the analgesic rate being 65% . AFSP could also strengthen T-lymphocyte proliferation, promote IL-2 activity and inhibit IL-1 activity. Compared with the control group, the difference was significant (P<0.01). By means of regulating the immune function of organism, AFSP could improve the local pathologic response to antagonize against rheumatism, therefore, it is an effective anti-rheumatism herbal medicine.Keywords：active fraction of Siegesbeckia pubescens;immunity;anti-rheumatism
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Published：2021-08-27 - Abstract：To observe the efficacy of Renal Failure Granule (RFG) in treating uremia and explore its mechanism. Piatt’s method was used to establish the chronic renal failure model. Forty-eight rats were divided into normal group, model group, Jiangzhuo recipe group, Fuzheng recipe group, RFG group and aldehyde-oxygen encapsulated starch group, 8 rats in each group, to observe the effects of RFG on serum creatinine (SCr), blood urea nitrogen (BUN), plasma calcium (Ca), plasma phosphorus (P), parathyroid hormone (PTH), middle molecular substance (MMS), methylguanidine (MG), guanidino-succinic acid (GSA) and other parameters. Comparison of SCr and BUN changes after medication for 30 and 60 days, the RFG group, the Fuzheng recipe group and the Jiangzhuo recipe group, with the aldehyde-oxygen encapsulated starch group or model group, demonstrated that the difference was significant (P<0.05,P<0.01), For PTH, Ca, P, MMS, MG and GSA, RFG was clearly different with the model group (P<0.05,P<0.01). Jiangzhuo recipe and Fuzheng recipe group also were variously efficacious in above-mentioned parameters. RFG can retard the development of uremia, and its mechanism may be related to the decrease of uremic toxin.Keywords：uremia;Renal Failure Granule;toxin
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Published：2021-08-27 - Abstract：To investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type I. Osteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X-ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also. JGG could significantly increase BMD and uterus index, improve the levels of E2 and CT in serum, at the same time reduce the BGP level. JGG can efficiently prevent type I primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD.Keywords：Bone Mineral Density;Osteocalcin;uremia;Primary Osteoporosis;Soft Tissue Calcification
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Published：2021-08-27 - Abstract：To study the pharmacological effect of Xiaoke Granule on blood sugar and blood rheological property in the diabetic animals. Alloxan induced diabetic mice or rats were grouped randomly. The effects of XKG on blood sugar, appetite, capacity of drinking, glucose tolerance, blood lipid and blood rheological property were observed and compared among groups. XKG showed a trend in reducing the appetite and capacity of drinking, increasing the body weight, and significantly inhibiting the increase of blood sugar coused by ectogenic glucose in mice, and could improve the blood lipid and blood rheological property in rats. XKG is effective in reducing serum total cholesterol, lowering the blood viscosity, improving the blood rheological property of alloxan induced diabetic animals. Therefore, it might effective in treating and preventing the occurrence of diabetes mellitus and the complications of blood stasis.Keywords：Xiaoke Granule;Blood Sugar;blood rheological property;glucose tolerance;diabetes mellitus
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Published：2021-08-27 - Keywords：Blood Sugar;Fasting Blood Glucose;Alloxan;Diabetes Mellitus Patient;Blood Stasis
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Published：2021-08-27 - Keywords：diabetic nephropathy;Nephrotic Syndrome;Urinary Protein;Blood Stasis;Astragaloside
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Published：2021-08-27 - Keywords：Ankylose Spondylitis;unstable angina pectoris;Combination Group;Total Effective Rate;Sinomenine
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Published：2021-08-27 - Abstract：To investigate the effect of Tongxinluo capsule (TXLC) on the patients with unstable angina pectoris (UAP). Patients of UAP were divided into two groups, the treated group (n = 60) was treated with TXLC and the Danshen group (n = 30) was treated with composite Danshen tablet. The plasma endothelin (ET) and calcitonin gene related peptide (CGRP) were measured before and after treatment. Data were compared between the two groups and also compared with those measured in 20 healthy subjects for control. ET level was higher and CGRP level lower significantly in UAP patients than that in healthy subjects significantly (P<0.05). After TXLC treatment, ET significantly lowered (P<0.01) and CGRP increased (P<0.05 ) . But in the Danshen group after treatment, the former decreased (P<0.05), while the latter remained unchanged (P>0.05). The effect of TXLC was better than that of composite Danshen tablet. TXLC is an effective drug for UAP treatment, which could efficiently regulate the ET and CGRP metabolism and ameliorate the degree of myocardial ischemia damage.Keywords：Spondylitis;unstable angina pectoris;Sulfasalazine;calcitonin gene related peptide;Combination Group
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Published：2021-08-27 - Keywords：rheumatoid arthritis;Erythrocyte Sedimentation Rate;Chinese Medicine;Rheumatoid Factor;Western Medicine
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Published：2021-08-27 - Keywords：Echinococcosis;Mebendazole;Training Class;Organization Committee;Achievement Award
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Published：2021-08-27 - Keywords：Traditional Chinese Medicine;Guangdong Province;Western Medicine;Vice President;Integrative Medicine
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Published：2021-08-27 - Keywords：Cinnabar;Standard Nomenclature;Standard Term;Literal Translation;Anatomical Term
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Published：2021-08-27 - Abstract：CHF is a common cardiovascular complication, and also is a result of all kinds of cardiopathies. Common cardiotonic and diuretic treatment don’t have a good effect and patients could easily get digitalism because of poor tolerance of digitalis. Recently, good curative effects have been achieved by the therapy of integrative Chinese and western medicine. Especially in recent few years, Chinese medicine has reached a fairly depth and achieved positive results in studying CHF with the raising level of medical research. Even so, because of lacking n a great many controlled observation, further research of the effect on CHF with Chinese medicine is remained to be studied from biochemical and biomolecular level, or from clinical practice.Keywords：Coronary Blood Flow;Puerarin;Diuretic Effect;Aconitine;Chinese Drug
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Published：2021-08-27
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