Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease

Shen Li; Xiang-rong Rao; Su-xia Wang; Gai-hua Zhang; Xiao-mei Li; Xi-wen Dai; Ke-ji Chen

doi:10.1007/s11655-009-0170-4

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Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease

OriginalPaper | Updated：2021-08-27

- Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease
- Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease
- 中国结合医学杂志（英文版） 2009年15卷第3期页码：170-176
- Affiliations：
  
  1. Department of Nephrology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Department of Nephrology, the First Hospital of Peking University,Beijing,China
  3. Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by Scientific Research Fund of State Administration of Traditional Chinese Medicine of the P. R. China (No. 04-05JQ07)
- DOI：10.1007/s11655-009-0170-4
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2009-7-2，
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Li, S., Rao, Xr., Wang, Sx. et al. Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease., Chin. J. Integr. Med. 15, 170–176 (2009). https://doi.org/10.1007/s11655-009-0170-4

Shen Li, Xiang-rong Rao, Su-xia Wang, et al. Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease[J]. Chinese Journal of Integrative Medicine, 2009,15(3):170-176.
Li, S., Rao, Xr., Wang, Sx. et al. Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease., Chin. J. Integr. Med. 15, 170–176 (2009). https://doi.org/10.1007/s11655-009-0170-4 DOI：

Shen Li, Xiang-rong Rao, Su-xia Wang, et al. Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease[J]. Chinese Journal of Integrative Medicine, 2009,15(3):170-176. DOI： 10.1007/s11655-009-0170-4.

摘要

To investigate the relationship between the severity of Chinese medicine (CM) bloodstasis syndrome (BSS) with clinical features and renal lesion indexes of the primary glomerular disease. An epidemiological survey was conducted to collect the data of 227 patients diagnosed as chronic primary glomerular diseases

and their severity of BSS were scored three days before renal biopsies were performed. The following clinical indexes were analyzed: age

course of glomerular diseases

24-h urine protein ration (Upro)

hypertension and blood pressure (BP) progress

serum creatinine levels (Scr)

estimation of glomerular filtration rate based on the predigesting equation of MDRD (eGFR)

blood urea nitrogen (BUN)

uric acid (UA)

triglyceride (TG)

cholesterol (CHO)

haematoglobin (HGB)

albumin (ALB)

and the correlation among renal pathological types

pathology lesion indexes

and BSS scores. (1) Among the 227 patients

207 (91.19%) were diagnosed as BSS

in which 95 cases were considered as moderate and the rest 112 cases as severe. (2) There was a negative correlation between age

gender

grades of the hypertension

and the BSS score. Multiple stepwise regression analysis showed that Upro

CHO

and eGFR were positively related to the BSS score (P<0.05). (3) The BSS score has a positive correlation with indexes of chronic renal pathology

especially the tubular atrophy and interstitial fibrosis. The severity of proliferation and glomerular sclerosis was accompanied with higher BSS scores with a significant difference (P<0.05). BSS is one of the most common CM syndromes among patients with the primary glomerular diseases; the BSS score has a positive correlation with Upro

CHO

eGFR

as well as the index of chronic renal pathology. Based on these observations

the BSS may be used as an indicator of the development of renal diseases. Being positively diagnosed as BSS could indicate the beginning of the chronic phase of the primary glomerular diseases.

Abstract

and their severity of BSS were scored three days before renal biopsies were performed. The following clinical indexes were analyzed: age

course of glomerular diseases

24-h urine protein ration (Upro)

hypertension and blood pressure (BP) progress

serum creatinine levels (Scr)

estimation of glomerular filtration rate based on the predigesting equation of MDRD (eGFR)

blood urea nitrogen (BUN)

uric acid (UA)

triglyceride (TG)

cholesterol (CHO)

haematoglobin (HGB)

albumin (ALB)

and the correlation among renal pathological types

pathology lesion indexes

and BSS scores. (1) Among the 227 patients

207 (91.19%) were diagnosed as BSS

in which 95 cases were considered as moderate and the rest 112 cases as severe. (2) There was a negative correlation between age

gender

grades of the hypertension

and the BSS score. Multiple stepwise regression analysis showed that Upro

CHO

and eGFR were positively related to the BSS score (P<0.05). (3) The BSS score has a positive correlation with indexes of chronic renal pathology

CHO

eGFR

as well as the index of chronic renal pathology. Based on these observations

the BSS may be used as an indicator of the development of renal diseases. Being positively diagnosed as BSS could indicate the beginning of the chronic phase of the primary glomerular diseases.

关键词

primary glomerular diseasesblood-stasis syndromeclinical indexpathology of the renal biopsy

Keywords

primary glomerular diseasesblood-stasis syndromeclinical indexpathology of the renal biopsy

references

Chen XM, Chen YP, Li P, Chen J, Shen YP, Zhou ZL, et al. A multi-centeric epidemiological survey on TCM syndrome in 1 016 patients with IgA nephropathy and analysis of its relevant factors. Chin J Integr Tradit West Med (Chin) 2006;26:197–201.

Wei CY, Chen XM, Zhao DY, Zhuang YZ. Study on the relationship between blood stasis syndrome and clinical pathology in patients with IgA nephropathy. Chin J Integr Tradit West Med (Chin) 2005;25:687–690.

Levey AS, Coresh J, Greene T, Marsh J, Stevens LA, Kusek JW, et al. Expressing the modification of diet in renal disease study equation for estimating glomerular filtration rate with standardized serum creatinine values. Clin Chem 2007;53:766–772.

Chen KJ, Shi ZX, eds. Practical science of blood-stasis syndrome. 1st ed. Beijing: People’s Medical Publishing House; 1999:22.

Churg J, Berinstein J, Glassok RJ. World Health Organization (WHO) Monograph. Renal disease: Classification and atlas of glomerular diseases. 2nd ed. Tokyo: Igaku-Shoin; 1995.

Jiang L, Lu JC, Chen WF, Wang SX, Zou WZ, Liu G, et al. A concise semi-quantitative pathological scoring method for IgA nephropathy and its relation to renal outcome. Chin J Nephrol (Chin) 2007; 23:278–282.

Shi SZ, Shi ZY, Chen JQ, Li XM. The study of correlation of blood-stasis syndrome and platelet activation. Chin J Basic Med Tradit Chin Med (Chin) 1996;1(4):24.

Wang YJ, Zhang MO. Phlegm stagnancy and blood stasis is the groundwork of micro-mass in kidney. Chin J Integr Ttradit West Med Nephrol (Chin) 2003;4:1–3.

Sun JS, Fu ZC, Wang YH, Hu YQ. Relationship between renal pathology and the differentiation syndromes of traditional Chinese medicines in IgA nephropathy. Chin J Integr Tradit West Med Nephrol (Chin) 2004;5:510–514.

Radford MGJr, Donadio JVJr, Bergstrahl EJ, Grande JP, et al. Predicting renal outcome in IgA nephropathy. J Am Soc Nephrol 1997; 8:199–207.

Szeto CC, Lai FM, To KF, Wong TY, Chow KM, Choi PC, et al. The natural history of immunoglobulin a nephropathy among patients with hematuria and minimal proteinuria. Am J Med 2001;110: 434–437.

Donadio JV, Bergstralh EJ, Grande JP, Rademcher DM. Proteinuria patterns and their association with subsequent end-stage renal disease in IgA nephropathy. Nephrol Dial Transplant 2002;17:1197–1203.

Kessler L, Wiesel ML, Attali P, Mossard JM, Cazenave JP, Pinget M. von Willebrand factor in diabetic angiopathy. Diabetes Metab 1998;24:327–336.

Nosadini R, Cipollina MR, Solini A, Sambataro M, Morocutti A, Doria Am, et al. Close relationship between microalbuminuria and insulin resistance in essential hypertension and non-insulin dependent diabetes mellitus. J Am Soc Neprol 1992;3(Suppl 4):S56–63.

The Committee of Prevention and Cure Guideline for Lipid Metabolism Disorder in Chinese Adults. Guideline of prevention and cure for lipid metabolism disorder in Chinese adults. Chin J Cardiovasc Med (Chin) 2007;35:390–410.

Qian WD, Pang DC, Zhu XY, Qian XQ. Discussion on traditional Chinese medicine pathogenesis of hyperlipemia. Hubei J Tradit Chin Med (Chin) 2001;3(11):5–6.

Hostetter TH. Chronic kidney disease predicts cardiovascular disease. New Engl J Med 2004;351:1344–1346.

Nath KA. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 1992;20:1–17.

Remuzzi G, Ruggenenti P, Benigin A. Understanding the nature of renal diseases progression. Kidney Int 1997;51:2–15.

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