Multicenter clinical study on the treatment of children’s tic disorder with Qufeng Zhidong Recipe (祛风止动方)

Min Wu; Guang-hua Xiao; Min Yao; Jian-ming Zhang; Xin Zhang; Ya-bing Zhou; Jing-yan Zhang; Shu-xia Wang; Bo Ma; Yan-ping Chen

doi:10.1007/s11655-009-0254-1

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Multicenter clinical study on the treatment of children’s tic disorder with Qufeng Zhidong Recipe (祛风止动方)

OriginalPaper | Updated：2021-08-27

- Multicenter clinical study on the treatment of children’s tic disorder with Qufeng Zhidong Recipe (祛风止动方)
- Multicenter clinical study on the treatment of children’s tic disorder with Qufeng Zhidong Recipe (祛风止动方)
- 中国结合医学杂志（英文版） 2009年15卷第4期页码：254-260
- Affiliations：
  
  1. Xinhua Hospital Affiliated to Medical School of Shanghai Jiaotong University,Shanghai,China
  2. Medical School of Shanghai Jiaotong University,Shanghai,China
  3. Yueyang Hospital of Integrative Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China
  4. Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China
- Author bio：
- Funds：
  
  Supported by Funds from Shanghai Bureau of Health (No. 2006L014);Developing Center of Shanghai Shenkang Hospital (No. SHDC12007409);and Second Group of Construction Projects of Traditional Chinese Medicine Clinical Predominant Item (No. 2008YSZK003)
- DOI：10.1007/s11655-009-0254-1
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2009-8-18，
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Wu, M., Xiao, Gh., Yao, M. et al. Multicenter clinical study on the treatment of children’s tic disorder with Qufeng Zhidong Recipe (祛风止动方)., Chin. J. Integr. Med. 15, 254–260 (2009). https://doi.org/10.1007/s11655-009-0254-1

Min Wu, Guang-hua Xiao, Min Yao, et al. Multicenter clinical study on the treatment of children’s tic disorder with Qufeng Zhidong Recipe (祛风止动方)[J]. Chinese Journal of Integrative Medicine, 2009,15(4):254-260.
Wu, M., Xiao, Gh., Yao, M. et al. Multicenter clinical study on the treatment of children’s tic disorder with Qufeng Zhidong Recipe (祛风止动方)., Chin. J. Integr. Med. 15, 254–260 (2009). https://doi.org/10.1007/s11655-009-0254-1 DOI：

Min Wu, Guang-hua Xiao, Min Yao, et al. Multicenter clinical study on the treatment of children’s tic disorder with Qufeng Zhidong Recipe (祛风止动方)[J]. Chinese Journal of Integrative Medicine, 2009,15(4):254-260. DOI： 10.1007/s11655-009-0254-1.

摘要

To assess the effect and adverse reaction of Qufeng Zhidong Recipe (祛风止动方

QZR) in treating children’s tic disorder (TD). With multicenter randomized parallel open-controlled method adopted

the patients enrolled were assigned to two groups

41 cases in the Chinese medicine (CM) group and 40 in the Western medicine (WM) group. They were treated by QZR and haloperidol plus trihexyphenidyl respectively for 12 weeks as one course. In total

two courses of treatment were given. The curative effect and adverse reactions were evaluated by scoring with Yale Global Tic Severity Scale (YGTSS)

Traditional Chinese Medicine Syndrome Scale (TCMSS)

and Treatment Emergent Symptom Scale (TESS)

as well as results of laboratory examinations. After one course of treatment

the markedly effective rate in the CM and the WM group was 14.6% and 17.5%

respectively

and the total effective rate 43.9% and 47.5%

respectively

which showed insignificant difference between groups (P>0.05). However

after two courses of treatment

markedly effective rate in them was 73.2% and 7.5%

and the total effective rate was 100.0% and 57.5%

both showing significant differences between groups (P<0.05). Besides

the adverse reactions occurred in the CM group was less than that in the WM group obviously. QZR has definite curative effect with no apparent adverse reaction in treating TD

and it can obviously improve the symptoms and signs and upgrade the quality of life and learning capacities in such patients.

Abstract

To assess the effect and adverse reaction of Qufeng Zhidong Recipe (祛风止动方

QZR) in treating children’s tic disorder (TD). With multicenter randomized parallel open-controlled method adopted

the patients enrolled were assigned to two groups

41 cases in the Chinese medicine (CM) group and 40 in the Western medicine (WM) group. They were treated by QZR and haloperidol plus trihexyphenidyl respectively for 12 weeks as one course. In total

two courses of treatment were given. The curative effect and adverse reactions were evaluated by scoring with Yale Global Tic Severity Scale (YGTSS)

Traditional Chinese Medicine Syndrome Scale (TCMSS)

and Treatment Emergent Symptom Scale (TESS)

as well as results of laboratory examinations. After one course of treatment

the markedly effective rate in the CM and the WM group was 14.6% and 17.5%

respectively

and the total effective rate 43.9% and 47.5%

respectively

which showed insignificant difference between groups (P>0.05). However

after two courses of treatment

markedly effective rate in them was 73.2% and 7.5%

and the total effective rate was 100.0% and 57.5%

both showing significant differences between groups (P<0.05). Besides

the adverse reactions occurred in the CM group was less than that in the WM group obviously. QZR has definite curative effect with no apparent adverse reaction in treating TD

and it can obviously improve the symptoms and signs and upgrade the quality of life and learning capacities in such patients.

关键词

tic disorderChinese MedicineQufeng Zhidong Recipehaloperidolmulticenter study

Keywords

tic disorderChinese MedicineQufeng Zhidong Recipehaloperidolmulticenter study

references

Zheng Y. New concept and progress of diagnosis and treatment on Tourette’s syndrome. Chin J Child Health Care (Chin) 2006;14:111–112.

Liu ZS, Jing J. Infantile psychologic and behavior disorder. Beijing: People’s Medical Publishing House; 2007:138.

Wu M, Zhang X. Experimental study on acute toxicity of “Qufeng Zhidong Decoction” and its scorpion in mice. Shanghai J Tradit Chin Med (Chin) 2008;42:77–79.

Fan XD, Wang XD, Yu X. Translate. ICD-10, classification, clinical description, and diagnostic notes of mental and behavior disorder. Beijing: People’s Medical Publishing House;1993:55.

Wu JH. Diagnostic and statistical manual for mental disorders (DSM-IV). Chin J Pediatr (Chin) 1996;34:352.

State Bureau of Technical Supervision. GB/T 16751.2-1997. Clinic terminology of traditional Chinese medical diagnosis and treatment-syndromes. Beijing: Standards Press of China; 1997:7–84.

Wang SC. Traditional Chinese pediatrics. Beijing: China Press of Traditional Chinese Medicine;2002:137–140.

Leckman JF, Eiddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, et al. The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 1989;28:566–573.

Zhang MY. Manual for rating scale of psychopathy. 2nd ed. Changsha: Hunan Science Press; 1998:150–153.

Li DN. Modern neurologic medicine. Jinan: Shandong Science and Technology Publishing House; 2004:542.

Xiao GH, Wu M. Study on Tourette’s syndrome and dopamine relative genes. Shanxi Med J (Chin) 2008;37:716–717.

Liu BC, Wang JH, Chen D, Wang HL. Review of clinical researches on TCM treatment of Gilles de la Tourette’s syndrome. J Beijing Univ Tradit Chin Med (Chin) 1996;19:2–6.

Wu M, Ni HB, Ge AK, Zhou YB, Lu WW. Clinical study on liver-lung harmonization therapy for children’s Tourette’s syndrome. Shanghai J Tradit Chin Med (Chin) 2005;39:35–36.

WU M, Lu WW, Zhang JM. Clinical effect of traditional Chinese medicine on childhood Gilles de la Tourette’s syndrome. Chin J Inf Tradit Chin Med (Chin) 2006;13:68–69.

Spencer T, Biederman J, Coffey B, Geller D, Crawford M, Bearman SK, et al. A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attentiondeficit/hyperactivity disorder. Arch Gen Psychiatry 2002;59:649–656.

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