Effects of Xuezhikang (血脂康) and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension

Li Lu; Jian-zhong Zhou; Li Wang; Tie-xu Zhang

doi:10.1007/s11655-009-0266-x

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Effects of Xuezhikang (血脂康) and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension

OriginalPaper | Updated：2021-08-27

- Effects of Xuezhikang (血脂康) and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension
- Effects of Xuezhikang (血脂康) and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension
- 中国结合医学杂志（英文版） 2009年15卷第4期页码：266-271
- Affiliations：
  
  1. The First Affiliated Hospital of Chongqing Medical University,Chongqing,China
  2. The First People’s Hospital of Jiulongpo District,Chongqing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-009-0266-x
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2009-8-18，
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Lu, L., Zhou, Jz., Wang, L. et al. Effects of Xuezhikang (血脂康) and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension., Chin. J. Integr. Med. 15, 266 (2009). https://doi.org/10.1007/s11655-009-0266-x

Li Lu, Jian-zhong Zhou, Li Wang, et al. Effects of Xuezhikang (血脂康) and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension[J]. Chinese Journal of Integrative Medicine, 2009,15(4):266-271.
Lu, L., Zhou, Jz., Wang, L. et al. Effects of Xuezhikang (血脂康) and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension., Chin. J. Integr. Med. 15, 266 (2009). https://doi.org/10.1007/s11655-009-0266-x DOI：

Li Lu, Jian-zhong Zhou, Li Wang, et al. Effects of Xuezhikang (血脂康) and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension[J]. Chinese Journal of Integrative Medicine, 2009,15(4):266-271. DOI： 10.1007/s11655-009-0266-x.

摘要

To investigate the impacts of Xuezhikang (血脂康

XZK) or pravastatin combined with antihypertensive drugs on circulating endothelial progenitor cells (CEPCs) in essential hypertensive (EH) patients. Eighty-eight EH patients were enrolled into the study and randomly assigned to the antihypertensive drug treatment group (ATH group

29 cases)

the pravastatin treatment group (PRA group

29 cases) and the Xuezhikang treatment group (XZK group

30 cases). Patients in the 3 groups were treated with routine antihypertensive drugs. In addition

pravastatin and Xuezhikang were given to the patients in the PRA group and XZK group

respectively. After an eight-week treatment

CEPCs were counted using a laser scanning confocal microscope

and their proliferation function was evaluated by the MTT colorimetric assay and the adherent cell number was counted to estimate the adhesion function. After the treatment

CEPCs in the PRA group (116.60±5.70) and XZK group (114.40±6.55) was significantly higher than that in the ATH group (88.00±6.32

P<0.01). CEPCs proliferation capability and the adhesion function in the PRA group (0.406±0.016

33.60±4.26) and XZK group (0.415±0.018

34.30±3.77) were obviously superior to those in the ATH group (0.333±0.021

P<0.01; 23.30±3.19

P<0.01). No significant difference was found between the pravastatin group and the XZK group. Combined use of XZK or pravastatin with the anti-hypertensive therapy could increase the CEPCs number and improve their function in EH patients with the blood pressure controlled by antihypertensive drugs

leading to benefits independent of pressure-lowering effects.

Abstract

To investigate the impacts of Xuezhikang (血脂康

29 cases)

the pravastatin treatment group (PRA group

29 cases) and the Xuezhikang treatment group (XZK group

30 cases). Patients in the 3 groups were treated with routine antihypertensive drugs. In addition

pravastatin and Xuezhikang were given to the patients in the PRA group and XZK group

respectively. After an eight-week treatment

CEPCs were counted using a laser scanning confocal microscope

and their proliferation function was evaluated by the MTT colorimetric assay and the adherent cell number was counted to estimate the adhesion function. After the treatment

CEPCs in the PRA group (116.60±5.70) and XZK group (114.40±6.55) was significantly higher than that in the ATH group (88.00±6.32

P<0.01). CEPCs proliferation capability and the adhesion function in the PRA group (0.406±0.016

33.60±4.26) and XZK group (0.415±0.018

34.30±3.77) were obviously superior to those in the ATH group (0.333±0.021

P<0.01; 23.30±3.19

leading to benefits independent of pressure-lowering effects.

关键词

Essential Hypertensionendothelial progenitor cellpravastatinXuezhikang

Keywords

Essential Hypertensionendothelial progenitor cellpravastatinXuezhikang

references

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Zhao SP, Liu L, Cheng YC, Shishehbor MH, Liu MH, Peng DQ, et al. Xuezhikang, an extract of cholestin, protects endothelial function through antiinflammatory and lipid-lowering mechanisms in patients with coronary heart disease. Circulation 2004;110:915–920.

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