Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula

Shao-tang Li; Bo Cao; Wen-Ling Deng; Zhi Li

doi:10.1007/s11655-009-0279-5

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Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula

OriginalPaper | Updated：2021-08-27

- Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula
- Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula
- 中国结合医学杂志（英文版） 2009年15卷第4期页码：279-283
- Affiliations：
  
  1. Fujian Medical University,Fuzhou,China
  2. Department of Anorectal Diseases, the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine,Guiyang,China
- Author bio：
- Funds：
  
  Supported by the Funds of Guiyang College of Traditional Chinese Medicine (No. 200607)
- DOI：10.1007/s11655-009-0279-5
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2009-8-18，
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Li, St., Cao, B., Deng, WL. et al. Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula., Chin. J. Integr. Med. 15, 279–283 (2009). https://doi.org/10.1007/s11655-009-0279-5

Shao-tang Li, Bo Cao, Wen-Ling Deng, et al. Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula[J]. Chinese Journal of Integrative Medicine, 2009,15(4):279-283.
Li, St., Cao, B., Deng, WL. et al. Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula., Chin. J. Integr. Med. 15, 279–283 (2009). https://doi.org/10.1007/s11655-009-0279-5 DOI：

Shao-tang Li, Bo Cao, Wen-Ling Deng, et al. Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula[J]. Chinese Journal of Integrative Medicine, 2009,15(4):279-283. DOI： 10.1007/s11655-009-0279-5.

摘要

To observe the effects of the external application of Qiyu oil (芪榆油) gauze (QYOG) for promoting post-operational healing in patients with anal fistula and to explore its mechanism of action so as to provide a beneficial scientific basis for its wide use. Sixty patients with anal fistula scheduled to receive simple low anal fistulectomy were equally assigned

according to the sequence of hospitalization

to the tested group and the control group

and their wounds were classified according to longitudinal diameter into three grades (Grade I with a diameter below 2 cm; Grade II

2–5 cm; and Grade III

over 5 cm). After the operation was completed and the operational wound was sterilized with benzalkonium bromide

the wound substratum was packed with QYOG in the test group and with vaseline gauze in the control group. The packing gauze was changed every day till the wound was healed. The healing time of the patients was observed

and the number of capillaries and positive cell percentages of vascular endothelial growth factor (VEGF)

basic fibroblast growth factor (bFGF)

and epidermal growth factor (EGF) in wound granulation tissues were counted on the 5th day after the operation. The wound healing time was 17.80±5.46 days in the test group

which was significantly shorter than that in the control group (21.90±6.32 days

P<0.01). The number of capillaries and positive cell percentages of VEGF and bFGF in wound granulation tissues on the 5th day in the tested group were higher than those in the control group (P<0.01)

though the difference in EGF between the two groups was insignificant (P>0.05). QYOG could shorten the wound healing time after anal fistulectomy

which suggests that it participates in the stimulation of wound granulation tissues to produce VEGF and bFGF

and thus promotes capillary genesis and improves blood circulation in wounds so as to promote wound healing.

Abstract

according to the sequence of hospitalization

to the tested group and the control group

and their wounds were classified according to longitudinal diameter into three grades (Grade I with a diameter below 2 cm; Grade II

2–5 cm; and Grade III

over 5 cm). After the operation was completed and the operational wound was sterilized with benzalkonium bromide

and the number of capillaries and positive cell percentages of vascular endothelial growth factor (VEGF)

basic fibroblast growth factor (bFGF)

and epidermal growth factor (EGF) in wound granulation tissues were counted on the 5th day after the operation. The wound healing time was 17.80±5.46 days in the test group

which was significantly shorter than that in the control group (21.90±6.32 days

P<0.01). The number of capillaries and positive cell percentages of VEGF and bFGF in wound granulation tissues on the 5th day in the tested group were higher than those in the control group (P<0.01)

though the difference in EGF between the two groups was insignificant (P>0.05). QYOG could shorten the wound healing time after anal fistulectomy

which suggests that it participates in the stimulation of wound granulation tissues to produce VEGF and bFGF

and thus promotes capillary genesis and improves blood circulation in wounds so as to promote wound healing.

关键词

Qiyu oil gauzeanal fistulawound healingvascular endothelial growth factorbasic fibroblast growth factorepidermal growth factornumber of blood capillary

Keywords

Qiyu oil gauzeanal fistulawound healingvascular endothelial growth factorbasic fibroblast growth factorepidermal growth factornumber of blood capillary

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