Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays

Yu-long Chen; Wei-wen Chen; Ying-fang Wang; Ru-liu Li; Wen-feng Guo; Shao-xian Lao; Jian-hua Wang; Sui-ping Huang

doi:10.1007/s11655-009-0341-3

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Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays

OriginalPaper | Updated：2021-08-27

- Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays
- Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays
- 中国结合医学杂志（英文版） 2009年15卷第5期页码：341-346
- Affiliations：
  
  1. Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou,Pi,China
  2. Institute of Traditional Chinese Medicine Internal Medicine, Shanghai Municipal Education Committee, Shanghai,E,China
  3. Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 90209004) and E-Institute Construction Plan Project of Shanghai Municipal Education Committee (No. E03008)
- DOI：10.1007/s11655-009-0341-3
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2009-10-3，
Scan for full text
Chen, Yl., Chen, Ww., Wang, Yf. et al. Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays., Chin. J. Integr. Med. 15, 341–346 (2009). https://doi.org/10.1007/s11655-009-0341-3

Yu-long Chen, Wei-wen Chen, Ying-fang Wang, et al. Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays[J]. Chinese Journal of Integrative Medicine, 2009,15(5):341-346.
Chen, Yl., Chen, Ww., Wang, Yf. et al. Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays., Chin. J. Integr. Med. 15, 341–346 (2009). https://doi.org/10.1007/s11655-009-0341-3 DOI：

Yu-long Chen, Wei-wen Chen, Ying-fang Wang, et al. Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays[J]. Chinese Journal of Integrative Medicine, 2009,15(5):341-346. DOI： 10.1007/s11655-009-0341-3.

摘要

To determine the bioinformatical characteristics of differential gene expression in patients with chronic superficial gastritis (CSG) with the Pi-deficiency syndrome (PDS) and those of the non-Pi-deficiency syndrome (non-PDS)

i.e. patients of CSG with Pi (脾)-Wei (胃) dampnese-heat syndrome and healthy persons. With the BRB-Array Tools software package

original data collection and bioinformatic: analysis of gene arrays were conducted in 6 CSG patients of PDS (CSG-PDS)

6 CSG patients of non-PDS (CSG-nPDS)

and 6 healthy volunteers (Normal). Compared with non-PDS

the gene expressions: in PDS with regards to protein synthesis

energy metabolism

immune reaction and ionic transport tended to be down-regulated

while those concerning secretion

cytoskeleton and ubiquitinization were up-regulated dominantly. The two kinds of samples

CSG-PDS/Normal and CSG-PDS/CSG-nPDS

have their respective gene expression profiles with different characteristics. Gene expression profile has certain referential significance in syndrome classification.

Abstract

i.e. patients of CSG with Pi (脾)-Wei (胃) dampnese-heat syndrome and healthy persons. With the BRB-Array Tools software package

original data collection and bioinformatic: analysis of gene arrays were conducted in 6 CSG patients of PDS (CSG-PDS)

6 CSG patients of non-PDS (CSG-nPDS)

and 6 healthy volunteers (Normal). Compared with non-PDS

the gene expressions: in PDS with regards to protein synthesis

energy metabolism

immune reaction and ionic transport tended to be down-regulated

while those concerning secretion

cytoskeleton and ubiquitinization were up-regulated dominantly. The two kinds of samples

CSG-PDS/Normal and CSG-PDS/CSG-nPDS

have their respective gene expression profiles with different characteristics. Gene expression profile has certain referential significance in syndrome classification.

关键词

chronic superficial gastritisPi-deficiency syndromegene chipbio-information analysisBRB-Array Tool software package Array

Keywords

chronic superficial gastritisPi-deficiency syndromegene chipbio-information analysisBRB-Array Tool software package Array

references

Quackenbush J. Microarray analysis and tumor classification. N Engl J Med 2006;354:2463–2472.

Wang YF, Chen WW, Lao SX, Li Rl, Guo WF, Huang SP, et al. Comparison of differentially expressed genes between deficiency of spleen-qi syndrome and splenogastric hygropyrexia syndrome patients with chronic gastritis. Chin J Pathophysiol (Chin) 2008;24:320–324.

Chen WW, Wang YF, Lao SX, Li Rl, Guo WF, Huang SP, et al. Profile of gene differential expression in chronic gastritis with deficiency of spleen-qi patients. Chin J Pathophysiol (Chin) 2008;24:148–152.

Chinese Society of Digestive Diseases, the Chinese Association of Medicine. Common views arrived at the national conference on chronic gastritis. Chin J Gastroenterol (Chin) 2000;5:77–79.

Chinese Society of Digestive Endoscopy, the Chinese Association of Medicine. The standard for treatment and endoscopic typing and grading of chronic gastritis (Trial). Chin J Dig Endosc (Chin) 2004;21:77–78.

Ministry of Health. China. Guiding principle of clinical research on new drugs of Chinese medicine. Vol 2. 1995:114–117.

Lafontaine DL, Tollervey D. The function and synthesis of ribosomes. Nat Rev Mol Cell Biol 2001;2:514–520.

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