Clinically controlled study on children’s infectious mononucleosis treated by Chinese medicine

Yuan Yao; Hong-mei Duan; Hui-min Yan; Xiao-fang Zhen; Yu-chen Pan; Yao Yao; Li Chen; Xue-fang Jing; Hai-lun Chen

doi:10.1007/s11655-009-0347-x

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Clinically controlled study on children’s infectious mononucleosis treated by Chinese medicine

OriginalPaper | Updated：2021-08-27

- Clinically controlled study on children’s infectious mononucleosis treated by Chinese medicine
- Clinically controlled study on children’s infectious mononucleosis treated by Chinese medicine
- 中国结合医学杂志（英文版） 2009年15卷第5期页码：347-352
- Affiliations：
  
  1. Beijing Children’s Hospital Affiliated to Capital Medical University,Beijing,China
  2. School of Nursing, Beijing University of Chinese Medicine,Beijing,China
  3. Department of Immunology, Basic Medical College of Capital Medical University,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation of Beijing Municipal Science and Technology Committee (No. z0005190042511);the Basic-clinical Cooperative Foundation of Capital Medical University (No. 2006JL50)
- DOI：10.1007/s11655-009-0347-x
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2009-10-3，
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Yao, Y., Duan, Hm., Yan, Hm. et al. Clinically controlled study on children’s infectious mononucleosis treated by Chinese medicine., Chin. J. Integr. Med. 15, 347–352 (2009). https://doi.org/10.1007/s11655-009-0347-x

Yuan Yao, Hong-mei Duan, Hui-min Yan, et al. Clinically controlled study on children’s infectious mononucleosis treated by Chinese medicine[J]. Chinese Journal of Integrative Medicine, 2009,15(5):347-352.
Yao, Y., Duan, Hm., Yan, Hm. et al. Clinically controlled study on children’s infectious mononucleosis treated by Chinese medicine., Chin. J. Integr. Med. 15, 347–352 (2009). https://doi.org/10.1007/s11655-009-0347-x DOI：

Yuan Yao, Hong-mei Duan, Hui-min Yan, et al. Clinically controlled study on children’s infectious mononucleosis treated by Chinese medicine[J]. Chinese Journal of Integrative Medicine, 2009,15(5):347-352. DOI： 10.1007/s11655-009-0347-x.

摘要

To evaluate the clinical efficacy and safety of Chinese drugs for the treatment of children’s infectious mononucleosis (CIM). Sixty CIM patients were assigned into the treated group and the control group

patients in the treated group were administered with Chinese herbal decoction

and those in the control group were treated with intravenous dripping of ganciclovir 10 mg/kg per day

for a treatment course of 14 days. The total effective rate was 96.0% in the treated group and 97.1% in the control group

showing insignificant difference between groups. The efficacy in the treated group was superior to that in the control group on the fever clearance time (3.0±1.5 days vs 4.9±3.9 days ) and the disappearance time of cervical lymph node swelling (0.8±1.0 score vs 1.5±1.2 score)

showing statistical significance (all P<0.05). T-cell subsets were markedly improved in both groups after treatment. Adverse reaction occurred in four cases of the control group. Using Chinese herbs for clearing heat

removing toxin

activating blood circulation

and dissolving stasis is effective and safe for the treatment of CIM. It can effectively improve the clinical symptoms and shows a certain effect on immune regulation.

Abstract

patients in the treated group were administered with Chinese herbal decoction

and those in the control group were treated with intravenous dripping of ganciclovir 10 mg/kg per day

for a treatment course of 14 days. The total effective rate was 96.0% in the treated group and 97.1% in the control group

removing toxin

activating blood circulation

and dissolving stasis is effective and safe for the treatment of CIM. It can effectively improve the clinical symptoms and shows a certain effect on immune regulation.

关键词

children’s infectious mononucleosisEpstein-Barr virusChinese medicinal therapy

Keywords

children’s infectious mononucleosisEpstein-Barr virusChinese medicinal therapy

references

Hu YM, Jiang ZF, eds. Text book of Pediactrics. 7th ed. Beijing: People’s Medical Publishing House; 2002: 821–826

Thompson SK, Doerr TD, Hengerer AS. Infectious mononucleosis and corticosteroids: management practices and outcomes. Arch Otolaryngol Head Neck Surg 2005;131:900–904.

Zheng XY, ed. Guiding principle of clinical research on new drugs of traditional Chinese medicine. Beijng: China Press of Traditional Chinese Medicine; 2002:260–263.

Berger C, Day P, Meier G, Zingg W, Bossart W, Nadal D. Dynamics of Epstein-Barr virus DNA levels in serum during EBV-associated disease. J Med Virol 2001;64:505–512.

Torrel D, Tambini R. Acyclovir for treatment of infectious mononucleosis: A Meta-analysis. J Infect Dis 1999;31:543–547.

Yang RX, Yang JH, Xu YJ. Effect of removing toxic substances with bitter-cold drugs therapy in 56 cases with children’s infectious mononucleosis. J Sichuan Tradit Chin Med (Chin) 2007;25:82–83.

Pi ZM, Mo YK, Zheng YM, Cheng JR, Tang MZ. Study on the effect of Chinese herbs inhibit the expression of EB antigen. Chin J Microbiol Immunol (Chin) 2000; 20:173–174.

Sun XY, Mei QX, Zhou ZJ, Gao YQ. Progress in effect of Chinese herbs on anti-Epstein-Barr virus. J Chin Med Materi (Chin) 2008; 31:320–322.

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