Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial

Xiang-xia Luo; Jun-guo Duan; Pin-zheng Liao; Lie Wu; Yang-gui Yu; Bo Qiu; Yu-liang Wang; Yu-min Li; Zheng-qin Yin; Xiao-ling Liu; Ke Yao

doi:10.1007/s11655-009-0384-5

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Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial

OriginalPaper | Updated：2021-08-27

- Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial
- Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial
- 中国结合医学杂志（英文版） 2009年15卷第5期页码：384-388
- Affiliations：
  
  1. Department of Ophthalmology, Chengdu University of Traditional Chinese Medicine,Chengdu,China
  2. Guang’ anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  3. The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou,China
  4. Guangdong Hospital of Traditional Chinese Medicine,Guangzhou,China
  5. Jiangsu Hospital of Traditional Chinese Medicine,Nanjing,China
  6. The First Affiliated Hospital of College of Medicine, Zhejiang University,Hangzhou,China
  7. Southwest Hospital,Chongqing,China
  8. Hospital of Optometry and Ophthalmology, Wenzhou Medical College,Zhejiang Province,China
  9. The Second Affiliated Hospital of College of Medicine, Zhejiang University,Hangzhou,China
- Author bio：
- Funds：
  
  Supported by the National Key Technologies R&D Programme for the 10th Five-year Plan (No. 2001BA701A13a)
- DOI：10.1007/s11655-009-0384-5
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2009-10-3，
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Luo, Xx., Duan, Jg., Liao, Pz. et al. Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial., Chin. J. Integr. Med. 15, 384–388 (2009). https://doi.org/10.1007/s11655-009-0384-5

Xiang-xia Luo, Jun-guo Duan, Pin-zheng Liao, et al. Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial[J]. Chinese Journal of Integrative Medicine, 2009,15(5):384-388.
Luo, Xx., Duan, Jg., Liao, Pz. et al. Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial., Chin. J. Integr. Med. 15, 384–388 (2009). https://doi.org/10.1007/s11655-009-0384-5 DOI：

Xiang-xia Luo, Jun-guo Duan, Pin-zheng Liao, et al. Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial[J]. Chinese Journal of Integrative Medicine, 2009,15(5):384-388. DOI： 10.1007/s11655-009-0384-5.

摘要

To objectively assess the effect of Qiming Granule (芪明颗粒) in the treatment of diabetic retinopathy (DR) by fluorescence fundus angiography (FFA). In a multi-center

randomized

parallel controlled clinical trial

patients with DR were randomly assigned to the control group (calcium dobesilate capsule) and the test group (Qiming Granule). Changes in the retinal blood circulation time were recorded by FFA after 3 months of medication. Significant reduction was observed in the retinal arterio-venous circulation time (AVCT) in both groups (P<0.01)

the value was 7.635±3.149 s before treatment and 5.165 ±3.382 s after treatment in the treated group

and 7.737±3.413 s and 5.313±3.472 s in the control group respectively. Qiming Granule also reduced the arm-to-retinal circulation time (ARCT

P<0.05). The value was 17.867±3.872 s before treatment and 15.643±4.648 s after treatment in the treated group

and 17.217±3.833 s and 16.312±3.613 s in the control group (P>0.05) respectively. The ARCT in the tested group was reduced

with a statistically significant difference post-medication (P<0.01). As a Chinese medicine complex prescription

Qiming Granule may alleviate retinal hypoxia and ischemia by increasing retinal blood flow and improving the blood circulation.

Abstract

To objectively assess the effect of Qiming Granule (芪明颗粒) in the treatment of diabetic retinopathy (DR) by fluorescence fundus angiography (FFA). In a multi-center

randomized

parallel controlled clinical trial

the value was 7.635±3.149 s before treatment and 5.165 ±3.382 s after treatment in the treated group

and 7.737±3.413 s and 5.313±3.472 s in the control group respectively. Qiming Granule also reduced the arm-to-retinal circulation time (ARCT

P<0.05). The value was 17.867±3.872 s before treatment and 15.643±4.648 s after treatment in the treated group

and 17.217±3.833 s and 16.312±3.613 s in the control group (P>0.05) respectively. The ARCT in the tested group was reduced

with a statistically significant difference post-medication (P<0.01). As a Chinese medicine complex prescription

Qiming Granule may alleviate retinal hypoxia and ischemia by increasing retinal blood flow and improving the blood circulation.

关键词

diabetic retinopathyfluorescence fundus angiographyretinal blood circulation timeQiming Granule

Keywords

diabetic retinopathyfluorescence fundus angiographyretinal blood circulation timeQiming Granule

references

Duan JG, Liao PZ, Wu L, Li YM, Yu YG, Qiu B, et al. Randomized controlled double-blind multicentric clinical trail on non-proliferative diabetic retinopathy treated by Qiming Granule. J Chengdu Univ Tradit Chin Med (Chin) 2006;29(2):1–5.

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Leite EB, Mota MC, Abreu JR, Cunha-Vaz JG. Effect of calcium dobesilate on the blood-retinal barrier in early diabetic retinopathy. Int Ophthalmol1990;14:81–88.

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Jin FD. Pharmacological effects of Radix Astragali research and clinical application. J Pract Med Tech (Chin) 2008;15:2702–2704.

Ji ZQ, Gao XX. Experimental study on anti-human platelet aggregation with 63 kinds of regulating lipids Chinese medicine. Shandong J Tradit Chin Med (Chin) 1998;17:365–367.

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Liu AQ, Liao PZ, Zheng YL, Duan JG. Effect of Qiming Granule on antioxidatizing reaction in the retinal tissue of diabetic rats. J Tradit Chin Ophthalmol (Chin) 2003;13(3):128–130.

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