Effect of new Pulian Ointment (新普连膏) in treating psoriasis of blood-heat syndrome: A randomized controlled trial

Ning Zhou; Yan-ping Bai; Xiao-hong Man; Yun-bi Zhang; Yu-hong Kong; Hai Ju; Ming Chang

doi:10.1007/s11655-009-0409-0

Your Location：

Home >

Browse articles >

Effect of new Pulian Ointment (新普连膏) in treating psoriasis of blood-heat syndrome: A randomized controlled trial

OriginalPaper | Updated：2021-08-27

- Effect of new Pulian Ointment (新普连膏) in treating psoriasis of blood-heat syndrome: A randomized controlled trial
- Effect of new Pulian Ointment (新普连膏) in treating psoriasis of blood-heat syndrome: A randomized controlled trial
- 中国结合医学杂志（英文版） 2009年15卷第6期页码：409-414
- Affiliations：
  
  1. Department of Dermatology, China-Japan Friendship Hospital,Beijing,China
  2. Department of Dermatology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing,China
  3. Department of Dermatology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Funds of Capital Medicine Development Program (No. 2005-SF-3-086)
- DOI：10.1007/s11655-009-0409-0
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2010-1-18，
Scan for full text
Zhou, N., Bai, Yp., Man, Xh. et al. Effect of new Pulian Ointment (新普连膏) in treating psoriasis of blood-heat syndrome: A randomized controlled trial., Chin. J. Integr. Med. 15, 409–414 (2009). https://doi.org/10.1007/s11655-009-0409-0

Ning Zhou, Yan-ping Bai, Xiao-hong Man, et al. Effect of new Pulian Ointment (新普连膏) in treating psoriasis of blood-heat syndrome: A randomized controlled trial[J]. Chinese Journal of Integrative Medicine, 2009,15(6):409-414.
Zhou, N., Bai, Yp., Man, Xh. et al. Effect of new Pulian Ointment (新普连膏) in treating psoriasis of blood-heat syndrome: A randomized controlled trial., Chin. J. Integr. Med. 15, 409–414 (2009). https://doi.org/10.1007/s11655-009-0409-0 DOI：

Ning Zhou, Yan-ping Bai, Xiao-hong Man, et al. Effect of new Pulian Ointment (新普连膏) in treating psoriasis of blood-heat syndrome: A randomized controlled trial[J]. Chinese Journal of Integrative Medicine, 2009,15(6):409-414. DOI： 10.1007/s11655-009-0409-0.

摘要

To objectively assess the clinical efficacy and safety of a new Pulian Ointment (新普连膏

NPLO) in treating psoriasis of blood-heat syndrome of Chinese medicine. A total of 108 patients with psoriasis of blood-heat syndrome were equally assigned

using a randomizing digital table

to the test group treated externally with NPLO and the control group treated with placebo; the medication was done using a singleblinded method twice a day. Meanwhile

all patients received by oral intake a conventional Chinese decoction for clearing heat and cooling blood; the therapeutic course was 4 weeks for both groups. The therapeutic efficacy

changes in the Psoriasis Area and Severity Index (PASI) score and various aspects of the lesion

including scaly eruption

erythema

infiltration

size

score of itching as well as adverse reactions were observed. The trial was completed in 100 patients

51 in the test group and 49 in the control group. The remarkably effective rate was 45.10% and the total effective rate was 84.31% in the test group

which were significantly higher than those in the control group

12.24% and 51.02%

respectively

showing a significant difference between groups (P<0.01). The test group also showed better effects in the improvement of the PASI score of the lesions and scores on erythema

infiltration

size of lesion as well as itching. No adverse event was found in either group. NPLO is a Chinese remedy for the external treatment of psoriasis of the blood-heat syndrome with a reliable therapeutic efficacy and good safety.

Abstract

To objectively assess the clinical efficacy and safety of a new Pulian Ointment (新普连膏

NPLO) in treating psoriasis of blood-heat syndrome of Chinese medicine. A total of 108 patients with psoriasis of blood-heat syndrome were equally assigned

using a randomizing digital table

to the test group treated externally with NPLO and the control group treated with placebo; the medication was done using a singleblinded method twice a day. Meanwhile

all patients received by oral intake a conventional Chinese decoction for clearing heat and cooling blood; the therapeutic course was 4 weeks for both groups. The therapeutic efficacy

changes in the Psoriasis Area and Severity Index (PASI) score and various aspects of the lesion

including scaly eruption

erythema

infiltration

size

score of itching as well as adverse reactions were observed. The trial was completed in 100 patients

51 in the test group and 49 in the control group. The remarkably effective rate was 45.10% and the total effective rate was 84.31% in the test group

which were significantly higher than those in the control group

12.24% and 51.02%

respectively

showing a significant difference between groups (P<0.01). The test group also showed better effects in the improvement of the PASI score of the lesions and scores on erythema

infiltration

关键词

curative efficacy assessmentnew Pulian Ointmentblood heat syndromepsoriasis

Keywords

curative efficacy assessmentnew Pulian Ointmentblood heat syndromepsoriasis

references

Zhang LX, Yang DQ, Song PH, Bai YP, You LP, Liu Y. The application of Pulian ointment in the treatment of psoriasis. J Extern Ther Tradit Chin Med (Chin) 2000;9(5):22–23.

Zhao B, ed. Clinical dermatology. 3rd ed. Nanjing: Jiangsu Science and Technology Publishing House; 2001:759–772.

Zheng XY, ed. Guiding principle of clinical research on new drugs of traditional chinese medicine. Beijing: China Medic-Pharmaceutical Sciences and Technology Publishing House; 2002:299–302.

Berth-Jones J, Grotzinger K, Rainville C, Pham B, Huang J, Daly S, et al. A study examining inter- and intrarater reliability of three scales for measuring severity of psoriasis: Psoriasis Area and Severity Index, Physician’s Global Assessment and Lattice System Physician’s Global Assessment. Br J Dermatol 2006;155:707–713.

Bai YP, Zeng JJ, Yang DQ. Causal analysis of blood heat syndrome in psoriasis vulgaris. Chin Arch Tradit Chin Med (Chin) 2007;22:537–540.

Lin HB, An Y, Lu JX, Dai XM, Lin JQ, Lin JQ. The research progress of Baikal Skullcap Root. Asia-Pacific Tradit Med (Chin) 2008;4(10):136–138.

Wang YN, Bi XL, Gu J, Gao SQ. Study on the mechanism of Baicalin in psoriasis treatment. Chin J Dermatovenerol Integr Tradit West Med (Chin) 2003;2:209–211.

Kuo CL, Chi CW, Liu TY. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett 2004;20:127–137.

Song LR, ed. Modern Chinese material medica. Beijing: People’s Medical Publishing House; 2001:142.

Xiao PG, ed. Newly compiled Chinese materia medica. Beijing: Chemical Industry Press; 2002:976–986.

Ge F, Wang XD, Wang YC. Advances in studies on medicinal Radix Arnebiae Seu Lithospermi. Chin Tradit Herbal Drugs (Chin) 2003;34(9 Supp):6–9.

Sun LY, Deng BX, Chen K, Wang H. Influence on apoptosis of zndirubin and shikonin of cultured keratinocytes. Chin J Dermvenereol (Chin) 2004;18:336–339.

FULL TEXT LINK

More>

浏览量

363

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Disease-syndrome combination clinical study of psoriasis: Present status, advantages, and prospects

Oral herbal medicines for psoriasis: A review of clinical studies

Application of the dermatology life quality index in clinical trials of biologics for psoriasis

Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review

Xiaoyin Recipe (消银方) for psoriasis induces a Th1/Th2 balance drift toward Th2 in peripheral blood mononuclear cells of experimental autoimmune thyroiditis rats