Clinical efficacy and safety of Gubitong Recipe (骨痹通方) in treating osteoarthritis of knee joint

Qing-wen Tao; Yuan Xu; Di-er Jin; Xiao-ping Yan

doi:10.1007/s11655-009-0458-4

Your Location：

Home >

Browse articles >

Clinical efficacy and safety of Gubitong Recipe (骨痹通方) in treating osteoarthritis of knee joint

OriginalPaper | Updated：2021-08-27

- Clinical efficacy and safety of Gubitong Recipe (骨痹通方) in treating osteoarthritis of knee joint
- Clinical efficacy and safety of Gubitong Recipe (骨痹通方) in treating osteoarthritis of knee joint
- 中国结合医学杂志（英文版） 2009年15卷第6期页码：458-461
- Affiliations：
  
  Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-009-0458-4
  中图分类号：
- 纸质出版日期：2009，
  
  网络出版日期：2010-1-18，
Scan for full text
Tao, Qw., Xu, Y., Jin, De. et al. Clinical efficacy and safety of Gubitong Recipe (骨痹通方) in treating osteoarthritis of knee joint., Chin. J. Integr. Med. 15, 458–461 (2009). https://doi.org/10.1007/s11655-009-0458-4

Qing-wen Tao, Yuan Xu, Di-er Jin, et al. Clinical efficacy and safety of Gubitong Recipe (骨痹通方) in treating osteoarthritis of knee joint[J]. Chinese Journal of Integrative Medicine, 2009,15(6):458-461.
Tao, Qw., Xu, Y., Jin, De. et al. Clinical efficacy and safety of Gubitong Recipe (骨痹通方) in treating osteoarthritis of knee joint., Chin. J. Integr. Med. 15, 458–461 (2009). https://doi.org/10.1007/s11655-009-0458-4 DOI：

Qing-wen Tao, Yuan Xu, Di-er Jin, et al. Clinical efficacy and safety of Gubitong Recipe (骨痹通方) in treating osteoarthritis of knee joint[J]. Chinese Journal of Integrative Medicine, 2009,15(6):458-461. DOI： 10.1007/s11655-009-0458-4.

摘要

To observe the therapeutic efficacy and safety of Gubitong Recipe (骨痹通方

GBT) in treating osteoarthritis (OA) of knee joint. Ninety patients with knee osteoarthritis were equally assigned

according to a randomizing digital table

to the treatment group and the control group. The treatment group was treated with GBT Decoction one dose every day and the control group with glucosamine sulfate 500 mg thrice a day

respectively

for eight successive weeks. Besides

diclofenac sodium could be given as supplementary dugs with the dosage used recorded if necessary. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC

an index reflecting the degree of joint pain

stiffness

and dysfunction) in patients was assessed before and after treatment

and the patients’ symptoms were evaluated by visual analogue scale (VAS) as well. Moreover

erythrocyte sedimentation rate (ESR)

blood C-reactive protein (CRP)

blood and urinary routine tests

liver and kidney function examination

and the adverse reaction that occurred during the treatment period were observed. WOMAC index and integral VAS value were lowered in both groups after treatment

showing significant statistical difference as compared with before treatment (P<0.05)

but the decrement of WOMAC index in the treatment group was more significant than that in the control group (P<0.05). ESR and CRP levels remained unchanged in all patients

and the proportion and mean dosage of diclofenac sodium used were similar in the two groups. No evident adverse reaction occurred during the treatment period. GBT is an effective and safe recipe for the treatment of osteoarthritis of knee joint

which could alleviate the joint pain

stiffness

and dysfunction.

Abstract

To observe the therapeutic efficacy and safety of Gubitong Recipe (骨痹通方

GBT) in treating osteoarthritis (OA) of knee joint. Ninety patients with knee osteoarthritis were equally assigned

according to a randomizing digital table

to the treatment group and the control group. The treatment group was treated with GBT Decoction one dose every day and the control group with glucosamine sulfate 500 mg thrice a day

respectively

for eight successive weeks. Besides

diclofenac sodium could be given as supplementary dugs with the dosage used recorded if necessary. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC

an index reflecting the degree of joint pain

stiffness

and dysfunction) in patients was assessed before and after treatment

and the patients’ symptoms were evaluated by visual analogue scale (VAS) as well. Moreover

erythrocyte sedimentation rate (ESR)

blood C-reactive protein (CRP)

blood and urinary routine tests

liver and kidney function examination

and the adverse reaction that occurred during the treatment period were observed. WOMAC index and integral VAS value were lowered in both groups after treatment

showing significant statistical difference as compared with before treatment (P<0.05)

but the decrement of WOMAC index in the treatment group was more significant than that in the control group (P<0.05). ESR and CRP levels remained unchanged in all patients

which could alleviate the joint pain

stiffness

and dysfunction.

关键词

osteoarthritisGubitong RecipeChinese Drug

Keywords

osteoarthritisGubitong RecipeChinese Drug

references

Chinese Society of Orthopedics, Chinese Medical Association. Diagnosis guide of osteoarthritis (2007). Chin J Clin (Chin) 2008;36:28–30.

Altman RD. Classification of disease: osteoarthritis. Semin Arthritis Rheum 1991;20:40–47.

Chinese Society of Rheumatology, Chinese Medical Association. Diagnosis guide of osteoarthritis. Chin J Rheumatol (Chin) 2003;7:702–704.

Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: A health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988;15:1833–1840.

Pavelká K, Gatterová J, Olejarová M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162:2113–2123.

Jiang Y, Li RX, Cao WF. Progress on study of osteoarthritis with Chinese medicine. J Pract Tradit Chin Med (Chin) 2007;23:336–337.

Creamer P, Hochberg MC. Osteoarthritis. Lancet 1997;350:503–508.

Kim HA, Lee YJ, Seong SC, Choe KW, Song YW. Apoptotic chondrocyte death in human osteoarthritis. J Rheumatol 2000;27:455–462.

Reboul P, Pelletier JP, Tardif G, Cloutier JM, Martel-Pelletier J. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest 1996;97:2011–2019.

Rédini F, Mauviel A, Pronost S, Loyau G, Pujol JP. Transforming growth factor beta exerts opposite effects from interleukin-1 beta on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression. Arthritis Rheum 1993;36:44–50.

Connor JR, Manning PT, Settle SL, Moore WM, Jerome GM, Webber RK, et al. Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur J Pharmacol 1995;273:15–24.

Wang XL, Wang NL, Huang WX, Yao XS. Phenylpropanoids compounds isolated from Drynaria fortunei and their proliferation effects on UMR 106 cell. J Shenyang Pharm Univ (Chin) 2008;25:242–248.

Gong XJ, Li YM, An BP, Liu GQ. Effect of total flavonoids of Rhizoma Drynariae on experimental knee osteoarthritis. Chin J Nat Med (Chin) 2006;4:215–218.

Yang RP, Shou QY, Tu YQ, Wang BH. Effects of Fructus Psoraleae on proliferation and differentiation of cultured osteoblast isolated from neonatal rat’s calvarium. Tradit Chin Drug Res Clin Pharmacol (Chin) 2007;18:32–34.

Li SL, Gao H, Zhang KH, Fu J. Effects of Epimedium on proliferation, function and apoptosis of mouse osteoblasts in vitro. J Peking Univ (Health Sci, Chin) 2008;40:43–46.

Wang YH, Xu HQ, Di LQ, Liu SJ. Effects of raw and salt prepared eucommia bark on immunological and antifatigue function of mouse in vitro. Pharmocol Clin Chin Materia Med (Chin) 2008;24:49–50.

Yuan Z, Yu JT, Su SW. Determination of the contents of protocatechuic acid and caffeic acid in Rhizoma Cibotii and Rhizoma Pteris by TLCs. J Shenyang Pharm Univ (Chin) 2000;17:338–339.

Chen GX, Wang PX, Liu QP, Tong J, Shen XY, Huang QC, et al. The mechanism of immunosuppressive effect of sinominine on collagen induced arthritis of rat. Curr Immunol (Chin) 2008;28:142–145.

FULL TEXT LINK

More>

浏览量

338

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Effect of Ermiao Recipe (二妙方) with medicinal guide Angelicae Pubescentis Radix on promoting the homing of bone marrow stem cells to treat cartilage damage in osteoarthritis rats

Zhuanggu Jianxi Decoction (壮骨健膝方) limits interleukin-1 β-induced degeneration chondrocytes via the caveolin-p38 MAPK signal pathway

Metabolic regulatory and anti-oxidative effects of modified bushen huoxue decoction (补肾活血方) on experimental rabbit model of osteoarthritis

Effects of Baduanjin (八段锦) exercise on knee osteoarthritis: A one-year study

Potential synergistic and multitarget effect of herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall on osteoarthritis disease: A computational pharmacology approach