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Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction
Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction
- 中国结合医学杂志（英文版） 2010年16卷第1期 页码：54-60
- Affiliations：
1. The Laboratory of Collateral Diseases, Pharmaceutical Research Academy, Hebei Medical University,Shijiazhuang,China
2. The Laboratory of Epidemiology and Health Statistics, Public Health Institute, Hebei Medical University,Shijiazhuang,China
- Author bio：
- Funds：Supported by the National Basic Research Program of China (973 Program, No. 2005CB523301), the International Science and Technology Cooperation Program (No. 2006DFB32460)
DOI：10.1007/s11655-010-0054-7
中图分类号：纸质出版日期：2010，
网络出版日期：2010-2-4，
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Yuan, Gq., Jia, Zh., Yang, Ht. et al. Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction., Chin. J. Integr. Med. 16, 54–60 (2010). https://doi.org/10.1007/s11655-010-0054-7
Guo-qiang Yuan, Zhen-hua Jia, Hai-tao Yang, et al. Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction[J]. Chinese Journal of Integrative Medicine, 2010,16(1):54-60.
Yuan, Gq., Jia, Zh., Yang, Ht. et al. Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction., Chin. J. Integr. Med. 16, 54–60 (2010). https://doi.org/10.1007/s11655-010-0054-7 DOI：
Guo-qiang Yuan, Zhen-hua Jia, Hai-tao Yang, et al. Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction[J]. Chinese Journal of Integrative Medicine, 2010,16(1):54-60. DOI： 10.1007/s11655-010-0054-7.
摘要
To observe the changes of vascular endothelial functions and general neuro-endocrine-immunity (NEI) network under the state of qi-deficiency syndrome induced by excessive idleness and to approach their internal relevance and illuminate initially the pathophysiological mechanism of vascular lesion induced by excessive idleness. A total of 100 male Wistar rats were randomly divided into the control group and the qi-deficiency syndrome model group
50 rats in each group. The qi-deficiency syndrome model was established by feeding the animals with hyper-alimentation diet in combination with restricting movement for 10 weeks. Changes of common chemical signal molecules related to NEI and vascular endothelial functions were measured by the end of the experiment. Furthermore
their internal relevance was analyzed by the method of canonical correlation analysis. The vascular endothelial structure and function were obviously injured in the model group. Compared with the control group
the chemical signal molecules
such as 5-hydroxytryptamine (5-HT)
corticosterone (CORT)
triiodothyronine (T3)
tetraiodothyronine (T4)
angiotensin II (Ang II)
interleukin-1 (IL-1)
and tumor necrosis factor-α (TNF-α) in peripheral blood of the model group (n=43) were changed significantly (P<0.05 or P<0.01). Canonical correlation analysis showed that vascular endothelial dysfunction was correlated to the changes of these signal molecules in the NEI network. Comfort-based lifestyle induced not only vascular endothelial dysfunction but also an imbalance of the NEI network. Vascular endothelial dysfunction and the imbalanced NEI network interacted with each other
and an imbalance of the NEI network may be the pathophysiologic basis for the genesis and development of vascular endothelial dysfunction
even diseases of the blood vessel.
Abstract
To observe the changes of vascular endothelial functions and general neuro-endocrine-immunity (NEI) network under the state of qi-deficiency syndrome induced by excessive idleness and to approach their internal relevance and illuminate initially the pathophysiological mechanism of vascular lesion induced by excessive idleness. A total of 100 male Wistar rats were randomly divided into the control group and the qi-deficiency syndrome model group
50 rats in each group. The qi-deficiency syndrome model was established by feeding the animals with hyper-alimentation diet in combination with restricting movement for 10 weeks. Changes of common chemical signal molecules related to NEI and vascular endothelial functions were measured by the end of the experiment. Furthermore
their internal relevance was analyzed by the method of canonical correlation analysis. The vascular endothelial structure and function were obviously injured in the model group. Compared with the control group
the chemical signal molecules
such as 5-hydroxytryptamine (5-HT)
corticosterone (CORT)
triiodothyronine (T3)
tetraiodothyronine (T4)
angiotensin II (Ang II)
interleukin-1 (IL-1)
and tumor necrosis factor-α (TNF-α) in peripheral blood of the model group (n=43) were changed significantly (P<0.05 or P<0.01). Canonical correlation analysis showed that vascular endothelial dysfunction was correlated to the changes of these signal molecules in the NEI network. Comfort-based lifestyle induced not only vascular endothelial dysfunction but also an imbalance of the NEI network. Vascular endothelial dysfunction and the imbalanced NEI network interacted with each other
and an imbalance of the NEI network may be the pathophysiologic basis for the genesis and development of vascular endothelial dysfunction
even diseases of the blood vessel.
关键词
qi-deficiency syndromevascular endothelial functionneuro-endocrine-immunity networkchemical signal molecules
Keywords
qi-deficiency syndromevascular endothelial functionneuro-endocrine-immunity networkchemical signal molecules
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